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Leif Groop

Leif Groop

Principal investigator

Leif Groop

Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus

Author

  • Natalie R. van Zuydam
  • Leif Groop
  • Colin N. A. Palmer

Summary, in English

Background: Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D). Methods: To test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66 643 subjects (27 708 with CAD and 24 259 with T2D). Variants showing apparent association with CAD in stratified analyses or evidence of interaction were evaluated in a further 117 787 subjects (16 694 with CAD and 11 537 with T2D). Results: None of the previously characterized CAD loci was found to have specific effects on CAD in T2D individuals, and a genome-wide interaction analysis found no new variants for CAD that could be considered T2D specific. When we considered the overall genetic correlations between CAD and its risk factors, we found no substantial differences in these relationships by T2D background. Conclusions: This study found no evidence that the genetic architecture of CAD differs in those with T2D compared with those without T2D. © 2020 Cambridge University Press. All rights reserved.

Department/s

  • Genomics, Diabetes and Endocrinology
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2020

Language

English

Pages

640-648

Publication/Series

Circulation: Genomic and Precision Medicine

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Endocrinology and Diabetes
  • Medical Genetics
  • Cardiac and Cardiovascular Systems

Keywords

  • blood pressure
  • coronary artery disease
  • diabetes mellitus
  • genome-wide association study
  • risk factors

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 2574-8300