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Leif Groop

Leif Groop

Principal investigator

Leif Groop

Association testing of the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes in 7,883 people

Author

  • J C Florez
  • C M Agapakis
  • N P Burtt
  • M Sun
  • Peter Almgren
  • Lennart Råstam
  • T Tuomi
  • D Gaudet
  • T J Hudson
  • M J Daly
  • K G Ardlie
  • J N Hirschhorn
  • Leif Groop
  • B Altshuler

Summary, in English

Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 gene, inactivates the insulin signal transduction cascade by dephosphorylating phosphotyrosine residues in insulin signaling molecules. Due to its chromosomal location under a chromosome 20 linkage peak and the metabolic effects of its absence in knockout mice, it is a candidate gene for type 2 diabetes. Recent studies have associated common sequence variants in PTPN1 with type 2 diabetes and diabetes-related phenotypes. We sought to replicate the association of common single nucleotide polymorphisms (SNPs) and haplotypes in PTPN1 with type 2 diabetes, fasting plasma glucose, and insulin sensitivity in a large collection of subjects. We assessed linkage disequilibrium, selected tag SNPs, and typed these markers in 3,347 cases of type 2 diabetes and 3,347 control subjects as well as 1,189 siblings discordant for type 2 diabetes. Despite power estimated at > 95% to replicate the previously reported associations, no statistically significant evidence of association was observed between PTPN1 SNPs or common haplotypes with type 2 diabetes or with diabetic phenotypes.

Department/s

  • Genomics, Diabetes and Endocrinology
  • Community Medicine

Publishing year

2005

Language

English

Pages

1884-1891

Publication/Series

Diabetes

Volume

54

Issue

6

Document type

Journal article

Publisher

American Diabetes Association Inc.

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology
  • Community Medicine

ISBN/ISSN/Other

  • ISSN: 1939-327X