The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here:

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Leif Groop

Leif Groop

Principal investigator

Leif Groop

The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects


  • Helene Choquet
  • Christine Cavalcanti-Proenca
  • Cecile Lecoeur
  • Christian Dina
  • Stephane Cauchi
  • Martine Vaxillaire
  • Samy Hadjadj
  • Fritz Horber
  • Natasha Potoczna
  • Guillaume Charpentier
  • Juan Ruiz
  • Serge Hercberg
  • Suliya Maimaitiming
  • Ronan Roussel
  • Michael Boenhnke
  • Anne U. Jackson
  • Wolfgang Patsch
  • Franz Krempler
  • Benjamin F. Voight
  • David Altshuler
  • Leif Groop
  • Gudmar Thorleifsson
  • Valgerdur Steinthorsdottir
  • Kari Stefansson
  • Beverley Balkau
  • Philippe Froguel
  • David Meyre

Summary, in English

A recent study reported an association between the brain natriuretic peptide (BNP) promoter T-381C polymorphism (rs198389) and protection against type 2 diabetes (T2D). As replication in several studies is mandatory to confirm genetic results, we analyzed the T-381C polymorphism in seven independent case-control cohorts and in 291 T2D-enriched pedigrees totalling 39 557 subjects of European origin. A meta-analysis of the seven case-control studies (n = 39 040) showed a nominal protective effect [odds ratio (OR) = 0.86 (0.79-0.94), P = 0.0006] of the CC genotype on T2D risk, consistent with the previous study. By combining all available data (n = 49 279), we further confirmed a modest contribution of the BNP T-381C polymorphism for protection against T2D [OR = 0.86 (0.80-0.92), P = 1.4 x 10(-5)]. Potential confounders such as gender, age, obesity status or family history were tested in 4335 T2D and 4179 normoglycemic subjects and they had no influence on T2D risk. This study provides further evidence of a modest contribution of the BNP T-381C polymorphism in protection against T2D and illustrates the difficulty of unambiguously proving modest-sized associations even with large sample sizes.


  • Genomics, Diabetes and Endocrinology

Publishing year







Human Molecular Genetics





Document type

Journal article


Oxford University Press


  • Medical Genetics



Research group

  • Genomics, Diabetes and Endocrinology


  • ISSN: 0964-6906