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Leif Groop

Leif Groop

Principal investigator

Leif Groop

Association of microsatellite polymorphisms of the human 14q13.2 region with type 2 diabetes mellitus in latvian and finnish populations

Author

  • T. Sjakste
  • M. Kalis
  • I. Poudziunas
  • V. Pirags
  • M. Lazdins
  • Leif Groop
  • N. Sjakste

Summary, in English

A polymorphic microsatellite in intron 6 of the human proteasome core particle PSMA6 gene (HSMS006), and four other microsatellites localized upstream on human chromosome 14q13.2 (HSMS801, HSMS702, HSMS701, HSMS602), were genotyped in 104 type 2 diabetic patients and 129 age-matched control subjects from Latvia and replicated in 91 type 2 diabetic patients and 88 age-matched healthy control subjects from the Botnia Study in Finland. In type 2 diabetic patients from both populations the HSMS006 (TG)22 allele was two times more frequent compared to the control group. In the Latvian population the (CAA)8 allele of the HSMS602 marker was less frequent in the diabetic group, as was the (AC)24 allele of microsatellite HSMS801. Allele frequencies of the HSMS701 and 702 repeats were similar in healthy controls and type 2 diabetic patients. In conclusion, our data suggest that variants in the PSMA6 gene on chromosome 14q13.2 are associated with type 2 diabetes.

Department/s

  • Genomics, Diabetes and Endocrinology

Publishing year

2007

Language

English

Pages

772-776

Publication/Series

Annals of Human Genetics

Volume

71

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Endocrinology and Diabetes

Keywords

  • proteasomes
  • Chromosome 14
  • type 2 diabetes mellitus
  • microsatellites
  • PSMA6
  • polymorphism

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 1469-1809