The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Leif Groop

Leif Groop

Principal investigator

Leif Groop

A common variant of HMGA2 is associated with adult and childhood height in the general population

Author

  • Michael N. Weedon
  • Guillaume Lettre
  • Rachel M. Freathy
  • Cecilia M. Lindgren
  • Benjamin F. Voight
  • John R. B. Perry
  • Katherine S. Elliott
  • Rachel Hackett
  • Candace Guiducci
  • Beverley Shields
  • Eleftheria Zeggini
  • Hana Lango
  • Valeriya Lyssenko
  • Nicholas J. Timpson
  • Noel P. Burtt
  • Nigel W. Rayner
  • Richa Saxena
  • Kristin Ardlie
  • Jonathan H. Tobias
  • Andrew R. Ness
  • Susan M. Ring
  • Colin N. A. Palmer
  • Andrew D. Morris
  • Leena Peltonen
  • Veikko Salomaa
  • George Davey Smith
  • Leif Groop
  • Andrew T. Hattersley
  • Mark I. McCarthy
  • Joel N. Hirschhorn
  • Timothy M. Frayling

Summary, in English

Human height is a classic, highly heritable quantitative trait. To begin to identify genetic variants influencing height, we examined genome-wide association data from 4,921 individuals. Common variants in the HMGA2 oncogene, exemplified by rs1042725, were associated with height (P= 4x10(-8)). HMGA2 is also a strong biological candidate for height, as rare, severe mutations in this gene alter body size in mice and humans, so we tested rs1042725 in additional samples. We confirmed the association in 19,064 adults from four further studies (P= 3x10(-11), overall P= 4x10(-16), including the genome-wide association data). We also observed the association in children (P=1x 10(-6), N= 6,827) and a tall/short case-control study (P= 4x10(-6), N=3,207). We estimate that rs1042725 explains similar to 0.3% of population variation in height (similar to 0.4 cm increased adult height per C allele). There are few examples of common genetic variants reproducibly associated with human quantitative traits; these results represent, to our knowledge, the first consistently replicated association with adult and childhood height.

Department/s

  • Genomics, Diabetes and Endocrinology

Publishing year

2007

Language

English

Pages

1245-1250

Publication/Series

Nature Genetics

Volume

39

Issue

10

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 1546-1718