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Leif Groop

Leif Groop

Principal investigator

Leif Groop

Hypothalamic-pituitary-adrenal response to different tests in type 1 diabetes mellitus

Author

  • E G Almqvist
  • Leif Groop
  • P J Manhem

Summary, in English

OBJECTIVE: To determine whether different tests of the adrenocorticotropic hormone (ACTH) reserve are influenced by diabetic state and metabolic control in newly diagnosed type 1 diabetic patients. DESIGN AND METHODS: We evaluated the ACTH reserve in 10 patients with uncomplicated type 1 diabetes during periods of poor and improved metabolic control and in 10 healthy subjects. The ACTH-cortisol secretion was assessed by a diurnal profile, an intravenous corticotropin-releasing hormone (CRH) test and an insulin tolerance test (ITT). RESULTS: The diurnal profiles were similar in all groups. CRH resulted in a diminished ACTH response during poor compared with improved metabolic control (mean+/-SD) (AUC 4950+/-4227 vs. 5847+/-3788 ng/L min, p<0.05). The response in the diabetic patients during improved metabolic control was of the same magnitude as in the control subjects (5934+/-1778 ng/L x min). ITT elicited a similar ACTH and cortisol response in the diabetic patients during poor and improved metabolic control as in the healthy control subjects. CONCLUSIONS: The ITT was uninfluenced by diabetic state and metabolic control and should therefore be considered the method of choice in evaluation of the ACTH reserve in patients with type 1 diabetes.

Department/s

  • Genomics, Diabetes and Endocrinology

Publishing year

2001

Language

English

Pages

557-565

Publication/Series

Scandinavian Journal of Clinical & Laboratory Investigation

Volume

61

Issue

7

Document type

Journal article

Publisher

Informa Healthcare

Topic

  • Endocrinology and Diabetes

Keywords

  • Corticotropin-RELEASING
  • Acth
  • Hormone
  • Cortisol
  • Hypoglycaemia
  • Insulin
  • Pituitary-ADRENAL
  • Function
  • Tests

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 1502-7686