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Leif Groop

Leif Groop

Principal investigator

Leif Groop

5 ' flanking variants of resistin are associated with obesity

Author

  • JC Engert
  • MC Vohl
  • SM Williams
  • P Lepage
  • JC Loredo-Osti
  • J Faith
  • C Dore
  • Y Renaud
  • NP Burtt
  • A Villeneuve
  • JN Hirschhorn
  • D Altshuler
  • Leif Groop
  • JP Despres
  • D Gaudet
  • TJ Hudson

Summary, in English

Diabetes and obesity have long been known to be related. The recently characterized adipocyte hormone resistin (also called FIZZ3/ADSF) has been implicated as a molecular link between impaired glucose tolerance (IGT) and obesity in mice. A search for sequence variants at the human resistin locus identified nine single-nucleotide polymorphisms (SNPs) but no coding variants. An investigation into the association of these SNPs with diabetes and obesity revealed two 5' flanking variants (g.-537 and g.-420), in strong linkage disequilibrium, that are associated with BMI. In nondiabetic individuals from the Quebec City area and the Saguenay-Lac-St-Jean region of Quebec, the g.-537 mutation (allelic frequency = 0.04) was significantly associated with an increase in BMI (P = 0.03 and P = 0.01, respectively). When the data from these two populations were combined and adjusted for age and sex, both the g.-537 (odds ratio [OR] 2.72, 95% Cl 1.28-5.81) and the g.-420 variants (1.58, 1.06-2.35) were associated with an increased risk for a BMI greater than or equal to30 kg/m(2). In contrast, in case/control and family-based study populations from Scandinavia, we saw no effect on BMI with either of these promoter variants. No association was seen with diabetes in any of the population samples.

Department/s

  • Genomics, Diabetes and Endocrinology

Publishing year

2002

Language

English

Pages

1629-1634

Publication/Series

Diabetes

Volume

51

Issue

5

Document type

Journal article

Publisher

American Diabetes Association Inc.

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 1939-327X