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Leif Groop

Leif Groop

Principal investigator

Leif Groop

Prevalence of diabetic retinopathy in relation to age at onset of the diabetes, treatment, duration and glycemic control

Author

  • Marianne Henricsson
  • Anders Nilsson
  • Leif Groop
  • Anders Heijl
  • Lars Janzon

Summary, in English

To study the frequency of diabetic retinopathy in relation to age at diagnosis, treatment, duration of diabetes and glycemic control as measured by means of HbA(1c) levels, we performed a cross-sectional, register-based study in the Helsingborg area of southern Sweden, comprising 2232 diabetic patients. Of the known diabetic population < 75 years old, approximately 70% were estimated to be included. We graded retinopathy according to the alternative classification of the Wisconsin study. With an age at diagnosis < 30 years (19% of patients) the prevalence of retinopathy was 64%, whereas with an age at diagnosis ≤ 30 years the prevalence of retinopathy was 57% in insulin-treated, and 26% in non-insulin treated patients. Levels of glycated hemoglobin and duration of diabetes were associated with retinopathy in the group with younger onset. In the older-onset group, there was a relationship between retinopathy and duration of diabetes and insulin treatment; glycated hemoglobin had a relationship which was of borderline significance with any retinopathy, but clearly significant with the pooled group: severe non-proliferative, proliferative retinopathy and/or macular edema. Hyperglycemia and duration of diabetes were thus associated with retinopathy in both younger- and older-onset diabetes, but hyperglycemia less so in the older-onset group.

Department/s

  • Ophthalmology (Malmö)
  • Genomics, Diabetes and Endocrinology
  • Community Medicine

Publishing year

1996-12

Language

English

Pages

523-527

Publication/Series

Acta Ophthalmologica Scandinavica

Volume

74

Issue

6

Document type

Journal article

Publisher

Wiley

Topic

  • Ophthalmology

Keywords

  • Diabetes mellitus
  • Diabetic retinopathy
  • Glycemic control
  • Insulin treatment

Status

Published

Research group

  • Ophthalmology (Malmö)
  • Genomics, Diabetes and Endocrinology
  • Community Medicine

ISBN/ISSN/Other

  • ISSN: 1395-3907