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Leif Groop

Leif Groop

Principal investigator

Leif Groop

Insulin sensitivity in adults with growth hormone deficiency and effect of growth hormone treatment.

Author

  • Leif Groop
  • Mikael Segerlantz
  • Margareta Bramnert

Summary, in English

Adult growth hormone deficiency (GHD) is a multifactorial disorder in which pituitary dysfunction associated with pituitary adenomas or their treatment plays a major role. The introduction of recombinant growth hormone (GH) for the treatment of GHD has opened up new treatment avenues but has also raised concerns about possible untoward long-term metabolic effects of GH, such as the potential effect of GH on insulin sensitivity and a deterioration in glucose tolerance. Research has shown that GH induces insulin resistance by the stimulation of lipolysis and a concomitant switch from oxidation of glucose to oxidation of lipids, during both acute and chronic treatment. However, although this is a consistent effect of GH therapy, it does not mean per se that it leads to abnormal glucose tolerance and diabetes mellitus. This article discusses this and other potential long-term metabolic effects of GH, and raises a number of questions to be addressed by future research.

Department/s

  • Genomics, Diabetes and Endocrinology
  • Palliative care
  • Department of Clinical Sciences, Malmö

Publishing year

2005

Language

English

Pages

45-50

Publication/Series

Hormone Research

Volume

64

Issue

Suppl 3

Document type

Journal article

Publisher

Karger

Topic

  • Clinical Medicine
  • Endocrinology and Diabetes

Keywords

  • insulin sensitivity
  • adults
  • growth hormone
  • treatment
  • growth hormone deficiency

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 0301-0163