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Leif Groop

Leif Groop

Principal investigator

Leif Groop

Petition to replace current OGTT criteria for diagnosing prediabetes with the 1-hour post-load plasma glucose ≥ 155 mg/dl (8.6 mmol/L)

Author

  • Michael Bergman
  • Melania Manco
  • Giorgio Sesti
  • Rachel Dankner
  • Manan Pareek
  • Ram Jagannathan
  • Angela Chetrit
  • Muhammad Abdul-Ghani
  • Martin Buysschaert
  • Michael H. Olsen
  • Peter M. Nilsson
  • José Luis Medina
  • Jesse Roth
  • Leif Groop
  • Stefano del Prato
  • Itamar Raz
  • Antonio Ceriello

Summary, in English

Many individuals with prediabetes, as presently defined, will progress to diabetes (T2D) despite the considerable benefit of lifestyle modification. Therefore, it is paramount to screen individuals at increased risk with a more sensitive method capable of identifying prediabetes at an even earlier time point in the lengthy trajectory to T2D. This petition reviews findings demonstrating that the 1-hour (1-h) postload plasma glucose (PG) ≥ 155 mg/dl (8.6 mmol/L) in those with normal glucose tolerance (NGT) during an oral glucose tolerance test (OGTT) is highly predictive for detecting progression to T2D, micro- and macrovascular complications and mortality in individuals at increased risk. Furthermore, the STOP DIABETES Study documented effective interventions that reduce the future risk of T2D in those with NGT and a 1-h PG ≥ 155 mg/dl (8·6 mmol/L). The 1-h OGTT represents a valuable opportunity to extend the proven benefit of diabetes prevention to the sizeable and growing population of individuals at increased risk of progression to T2D. The substantial evidence provided in this petition strongly supports redefining current diagnostic criteria for prediabetes with the elevated 1-h PG level. The authors therefore advocate a 1-h OGTT to detect prediabetes and hence, thwart the global diabetes epidemic.

Department/s

  • Internal Medicine - Epidemiology
  • EpiHealth: Epidemiology for Health
  • Genomics, Diabetes and Endocrinology
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2018

Language

English

Pages

18-33

Publication/Series

Diabetes Research and Clinical Practice

Volume

146

Document type

Journal article review

Publisher

Elsevier

Topic

  • Endocrinology and Diabetes

Keywords

  • Diabetes
  • Dysglycemia
  • HbA
  • Impaired fasting glucose
  • Impaired glucose tolerance
  • Oral glucose tolerance test
  • Prediabetes

Status

Published

Research group

  • Internal Medicine - Epidemiology
  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 0168-8227