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Leif Groop

Leif Groop

Principal investigator

Leif Groop

Combined lifestyle factors and the risk of LADA and type 2 diabetes – Results from a Swedish population-based case-control study

Author

  • Katharina Herzog
  • Emma Ahlqvist
  • Lars Alfredsson
  • Leif Groop
  • Rebecka Hjort
  • Josefin E. Löfvenborg
  • Tiinamaija Tuomi
  • Sofia Carlsson

Summary, in English

Aims: We investigated the risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes in relation to a healthy lifestyle, the proportion of patients attributable to an unhealthy lifestyle, and the influence of family history of diabetes (FHD) and genetic susceptibility. Methods: The population-based study included incident LADA (n = 571), type 2 diabetes (n = 1962), and matched controls (n = 2217). A healthy lifestyle was defined by BMI < 25 kg/m2, moderate-to-high physical activity, a healthy diet, no smoking, and moderate alcohol consumption. We estimated odds ratios (OR) with 95% confidence intervals (CIs) adjusted for age, sex, education, and FHD. Results: Compared to a poor/moderate lifestyle, a healthy lifestyle was associated with a reduced risk of LADA (OR 0.51, CI 0.34–0.77) and type 2 diabetes (OR 0.09, CI 0.05–0.15). A healthy lifestyle conferred a reduced risk irrespective of FHD and high-risk HLA genotypes. Having a BMI < 25 kg/m2 conferred the largest risk reduction for both LADA (OR 0.54, CI 0.43–0.66) and type 2 diabetes (OR 0.12, CI 0.10–0.15) out of the individual items. Conclusion: People with a healthy lifestyle, especially a healthy body weight, have a reduced risk of LADA including those with genetic susceptibility to diabetes.

Department/s

  • Genomics, Diabetes and Endocrinology
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • Diabetic Complications

Publishing year

2021

Language

English

Publication/Series

Diabetes Research and Clinical Practice

Volume

174

Document type

Journal article

Publisher

Elsevier

Topic

  • Endocrinology and Diabetes

Keywords

  • Autoimmune diabetes
  • LADA
  • Lifestyle
  • Type 2 diabetes
  • ANDIS
  • diabetes

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology
  • Diabetic Complications

ISBN/ISSN/Other

  • ISSN: 0168-8227