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Leif Groop

Publications

Retrieved from Lund University's publications database

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Publications

Retrieved from Lund University's publications database

2019
- 1-Hour Post-OGTT Glucose Improves the Early Prediction of Type 2 Diabetes by Clinical and Metabolic Markers
  Gopal Peddinti, Michael Bergman, Tiinamaija Tuomi, Leif Groop
  (2019) The Journal of clinical endocrinology and metabolism
  Journal article
- A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes : results from an exome-wide association study of albuminuria
  Tarunveer S. Ahluwalia, Christina Alexandra Schulz, Johannes Waage, Tea Skaaby, Niina Sandholm, et al.
  (2019) Diabetologia
  Journal article
- Association of IRS1 genetic variants with glucose control and insulin resistance in type 2 diabetic patients from Bosnia and Herzegovina
  Lejla Mahmutovic, Tamer Bego, Maria Sterner, Gabriella Gremsperger, Emma Ahlqvist, et al.
  (2019) Drug Metabolism and Personalized Therapy
  Journal article
- DOLORisk : Study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain [version 2; referees: 2 approved]
  Mathilde M.V. Pascal, Andreas C. Themistocleous, Ralf Baron, Andreas Binder, Didier Bouhassira, et al.
  (2019) Wellcome Open Research
  Journal article
- Genotypes of HLA, TCF7L2, and FTO as potential modifiers of the association between sweetened beverage consumption and risk of LADA and type 2 diabetes
  Josefin E. Löfvenborg, Emma Ahlqvist, Lars Alfredsson, Tomas Andersson, Mozhgan Dorkhan, et al.
  (2019) European Journal of Nutrition
  Journal article
- Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control
  , Samuela Pollack, Leif Groop, Emma Ahlqvist, Valeriya Lyssenko, et al.
  (2019) Diabetes
  Journal article
- Precision medicine in Type 2 Diabetes
  Rashmi B Prasad, Leif Groop
  (2019) Journal of Internal Medicine
  Journal article review
- Serum kidney injury molecule 1 and β₂-microglobulin perform as well as larger biomarker panels for prediction of rapid decline in renal function in type 2 diabetes
  , Marco Colombo, Helen C. Looker, Bassam Farran, Sibylle Hess, et al.
  (2019) Diabetologia
  Journal article
- The associations of daylight and melatonin receptor 1B gene rs10830963 variant with glycemic traits : the prospective PPP-Botnia study
  Kadri Haljas, Liisa Hakaste, Jari Lahti, Bo Isomaa, Leif Groop, et al.
  (2019) Annals of Medicine
  Journal article
- The functional impact of G protein-coupled receptor 142 (Gpr142) on pancreatic β-cell in rodent
  Israa Mohammad Al-Amily, Pontus Dunér, Leif Groop, Albert Salehi
  (2019) Pflugers Archiv European Journal of Physiology
  Journal article
2018
- A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes
  Natalie R van Zuydam, Emma Ahlqvist, Claes Ladenvall, Peter Almgren, Christina-Alexandra Schulz, et al.
  (2018) Diabetes
  Journal article
- A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4) gene with severe diabetic retinopathy in type 2 diabetes
  , , Weihua Meng, Kaanan P. Shah, Samuela Pollack, et al.
  (2018) Acta Ophthalmologica
  Journal article
- A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes
  , Makiko Taira, Minako Imamura, Atsushi Takahashi, Yoichiro Kamatani, et al.
  (2018) PLoS ONE
  Journal article
- Activation of imidazoline receptor I₂, and improved pancreatic β-cell function in human islets
  Stefan Amisten, Pontus Duner, Olof Asplund, Israa Mohammed Al-Amily, Leif Groop, et al.
  (2018) Journal of Diabetes and its Complications1992-01-01+01:00
  Journal article
- Association between genetic risk variants and glucose intolerance during pregnancy in north Indian women
  Geeti Arora, Peter Almgren, Charlotte Brøns, Richa G Thaman, Allan Vaag, et al.
  (2018) BMC Medical Genomics
  Journal article
- Bivariate genome-wide association study of depressive symptoms with type 2 diabetes and quantitative glycemic traits
  Kadri Haljas, Azmeraw T. Amare, Behrooz Z. Alizadeh, Yi Hsiang Hsu, Thomas Mosley, et al.
  (2018) Psychosomatic Medicine
  Journal article
- Coffee consumption, genetic susceptibility and risk of latent autoimmune diabetes in adults : A population-based case-control study
  B. Rasouli, E. Ahlqvist, L. Alfredsson, T. Andersson, P. O. Carlsson, et al.
  (2018) Diabetes and Metabolism
  Journal article
- Controllability in an islet specific regulatory network identifies the transcriptional factor NFATC4, which regulates Type 2 Diabetes associated genes
  Amitabh Sharma, Arda Halu, Julius L. Decano, Megha Padi, Yang-yu Liu, et al.
  (2018) npj Systems Biology and Applications
  Journal article
- Development and validation of a path length calculation for carotid-femoral pulse wave velocity measurement : A TASCFORCE, SUMMIT, and caerphilly collaborative venture
  Jonathan R. Weir-McCall, Liam Brown, Jennifer Summersgill, Piotr Talarczyk, Michael Bonnici-Mallia, et al.
  (2018) Hypertension
  Journal article
- Discovering human diabetes-risk gene function with genetics and physiological assays
  Heshan Peiris, Sangbin Park, Shreya Louis, Xueying Gu, Jonathan Y. Lam, et al.
  (2018) Nature Communications
  Journal article
- Effects of GIP on regional blood flow during normoglycemia and hyperglycemia in anesthetized rats
  Xiang Gao, Andreas Lindqvist, Monica Sandberg, Leif Groop, Nils Wierup, et al.
  (2018) Physiological Reports
  Journal article
- Family history of diabetes and its relationship with insulin secretion and insulin sensitivity in Iraqi immigrants and native Swedes : a population-based cohort study
  Louise Bennet, Paul W. Franks, Bengt Zöller, Leif Groop
  (2018) Acta Diabetologica
  Journal article
- Genetic determinants of glucose levels in pregnancy : Genetic risk scores analysis and GWAS in the Norwegian STORK cohort
  Gunn Helen Moen, Marissa LeBlanc, Christine Sommer, Rashmi B. Prasad, Tove Lekva, et al.
  (2018) European journal of endocrinology
  Journal article
- Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes
  Viktoria Gusarova, Colm O'Dushlaine, Tanya M Teslovich, Peter N Benotti, Tooraj Mirshahi, et al.
  (2018) Nature Communications
  Journal article
- Genetics of Diabetes and Diabetic Complications
  Rashmi Prasad, Emma Ahlqvist, Leif Groop
  (2018) Endocrinology
  Book chapter
- Genome-wide meta-analysis identifies novel determinants of circulating serum progranulin
  Anke Tönjes, Markus Scholz, Jacqueline Krüger, Kerstin Krause, Dorit Schleinitz, et al.
  (2018) Human Molecular Genetics
  Journal article
- HAPT2D : high accuracy of prediction of T2D with a model combining basic and advanced data depending on availability
  Barbara Di Camillo, Liisa Hakaste, Francesco Sambo, Rafael Gabriel, Jasmina Kravic, et al.
  (2018) European journal of endocrinology
  Journal article
- Haplotype Sharing Provides Insights into Fine-Scale Population History and Disease in Finland
  Alicia R Martin, Konrad J Karczewski, Sini Kerminen, Mitja I Kurki, Antti-Pekka Sarin, et al.
  (2018) American Journal of Human Genetics
  Journal article
- Heterogeneity of diabetes - An Indian perspective
  Rashmi B Prasad, Emma Ahlqvist, Leif Groop
  (2018) Diabetes & metabolic syndrome
  Journal article
- Lessons learned from the 1-hour post-load glucose level during OGTT : Current screening recommendations for dysglycaemia should be revised
  Michael Bergman, Ram Jagannathan, Martin Buysschaert, Manan Pareek, Michael H. Olsen, et al.
  (2018) Diabetes/Metabolism Research and Reviews
  Journal article
- Melatonin receptor 1B gene rs10830963 polymorphism, depressive symptoms and glycaemic traits
  Kadri Haljas, Jari Lahti, Tiinamaija Tuomi, Bo Isomaa, Johan G. Eriksson, et al.
  (2018) Annals of Medicine
  Journal article
- N¹-methylnicotinamide is a signalling molecule produced in skeletal muscle coordinating energy metabolism
  Kristoffer Ström, David Morales-Alamo, Filip Ottosson, Anna Edlund, Line Hjort, et al.
  (2018) Scientific Reports
  Journal article
- Novel diabetes subgroups – Authors' reply
  Emma Ahlqvist, Rashmi B. Prasad, Tiinamaija Tuomi, Anders Rosengren, Leif Groop
  (2018) The Lancet Diabetes and Endocrinology
  Journal article (letter)
- Novel subgroups of adult-onset diabetes and their association with outcomes : A data-driven cluster analysis of six variables
  Emma Ahlqvist, Petter Storm, Annemari Käräjämäki, Mats Martinell, Mozhgan Dorkhan, et al.
  (2018) The Lancet Diabetes and Endocrinology
  Journal article
- Obstructive sleep apnoea and the risk for coronary heart disease and type 2 diabetes : A longitudinal population-based study in Finland
  Satu Strausz, Aki S. Havulinna, Tiinamaija Tuomi, Adel Bachour, Leif Groop, et al.
  (2018) BMJ Open
  Journal article
- Overweight, obesity and the risk of LADA : results from a Swedish case–control study and the Norwegian HUNT Study
  Rebecka Hjort, Emma Ahlqvist, Per Ola Carlsson, Valdemar Grill, Leif Groop, et al.
  (2018) Diabetologia
  Journal article
- Petition to replace current OGTT criteria for diagnosing prediabetes with the 1-hour post-load plasma glucose ≥ 155 mg/dl (8.6 mmol/L)
  Michael Bergman, Melania Manco, Giorgio Sesti, Rachel Dankner, Manan Pareek, et al.
  (2018) Diabetes Research and Clinical Practice
  Journal article review
- Predictors of responses to clinic-based childhood obesity care
  Emilia Hagman, Lior Hecht, Limor Marko, Henny Azmanov, Leif Groop, et al.
  (2018) Pediatric Diabetes
  Journal article
- Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes article
  Anubha Mahajan, Jennifer Wessel, Sara M Willems, Wei Zhao, Neil R Robertson, et al.
  (2018) Nature Genetics
  Journal article
- Role of osteopontin and its regulation in pancreatic islet
  Mengyin Cai, Pradeep Bompada, Albert Salehi, Juan R. Acosta, Rashmi B. Prasad, et al.
  (2018) Biochemical and Biophysical Research Communications
  Journal article
- Silencing of the FTO gene inhibits insulin secretion : An in vitro study using GRINCH cells
  Jalal Taneera, Rashmi B Prasad, Sarah Dhaiban, Abdul Khader Mohammed, Leena Haataja, et al.
  (2018) Molecular and Cellular Endocrinology
  Journal article
- Turning vice into virtue : Using Batch-Effects to Detect Errors in Large Genomic Datasets
  Fabrizio Mafessoni, Rashmi B Prasad, Leif Groop, Ola Hansson, Kay Prüfer
  (2018) Genome Biology and Evolution
  Journal article
2017
- A TRPV1-to-secretagogin regulatory axis controls pancreatic β-cell survival by modulating protein turnover
  Katarzyna Malenczyk, Fatima Girach, Edit Szodorai, Petter Storm, Åsa Segerstolpe, et al.
  (2017) EMBO Journal
  Journal article
- A low-frequency inactivating AKT2 variant enriched in the finnish population is associated with fasting insulin levels and type 2 diabetes risk
  Alisa Manning, Claes Ladenvall, Peter Nilsson, Tibor V. Varga, Paul Franks, et al.
  (2017) Diabetes
  Journal article
- An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans
  Robert A. Scott, Laura J Scott, Reedik Mägi, Letizia Marullo, Kyle J Gaulton, et al.
  (2017) Diabetes
  Journal article
- Aortic diameter at age 65 in men with newly diagnosed type 2 diabetes
  Soumia Taimour, Moncef Zarrouk, Jan Holst, Anders H. Rosengren, Leif Groop, et al.
  (2017) Scandinavian Cardiovascular Journal1997-01-01+01:00
  Journal article
- Automated pathway and reaction prediction facilitates in silico identification of unknown metabolites in human cohort studies
  Jan D. Quell, Werner Römisch-Margl, Marco Colombo, Jan Krumsiek, Anne M. Evans, et al.
  (2017) Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
  Journal article
- Bariatric surgery enhances splanchnic vascular responses in patients with type 2 diabetes
  Henri Honka, Jukka Koffert, Saila Kauhanen, Jarmo Teuho, Saija Hurme, et al.
  (2017) Diabetes
  Journal article
- Branched-chain amino acids are associated with odd-chain fatty acids in normoglycaemic individuals
  M. Al-Majdoub, N. Geidenstam, A. Ali, M. Ridderstråle, P. Storm, et al.
  (2017) Diabetes & Metabolism1996-01-01+01:00
  Journal article (letter)
- Continuous and simultaneous determination of venous blood metabolites
  Anneli Andersson, Qun Chen, Leif Groop, Leif Bülow, Bin Xie
  (2017) Talanta
  Journal article
- Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
  Jason Flannick, Christian Fuchsberger, Anubha Mahajan, Tanya M Teslovich, Vineeta Agarwala, et al.
  (2017) Scientific Data
  Journal article
- Differentiation of diabetes by pathophysiology, natural history, and prognosis
  Jay S Skyler, George L. Bakris, Ezio Bonifacio, Tamara Darsow, Robert H. Eckel, et al.
  (2017) Diabetes
  Journal article review
- Early metabolic markers identify potential targets for the prevention of type 2 diabetes
  Gopal Peddinti, Jeff Cobb, Loic Yengo, Philippe Froguel, Jasmina Kravic, et al.
  (2017) Diabetologia
  Journal article
- Education immigration and income as risk factors for hemoglobin a1c >70 mmol/mol when diagnosed with type 2 diabetes or latent autoimmune diabetes in adult : A population-based cohort study
  Mats Martinell, Ronnie Pingel, Johan Hallqvist, Mozhgan Dorkhan, Leif Groop, et al.
  (2017) BMJ Open Diabetes Research and Care
  Journal article
- Effects of meal and incretins in the regulation of splanchnic blood flow
  Jukka Koffert, Henri Honka, Jarmo Teuho, Saila Kauhanen, Saija Hurme, et al.
  (2017) Endocrine Connections
  Journal article
- Epigenetic modifications and gestational diabetes : A Systematic review of published literature
  Gunn Helen Moen, Christine Sommer, Rashmi B. Prasad, Line Sletner, Leif Groop, et al.
  (2017) European Journal of Endocrinology1994-01-01+01:00
  Journal article review
- Exome-wide association study of plasma lipids in >300,000 individuals
  Dajiang J Liu, Gina M. Peloso, Haojie Yu, Adam S. Butterworth, Anubha Mahajan, et al.
  (2017) Nature Genetics
  Journal article
- Family history of type 1 and type 2 diabetes and risk of latent autoimmune diabetes in adults (LADA)
  Rebecka Hjort, L Alfredsson, T. Andersson, P. O. Carlsson, V Grill, et al.
  (2017) Diabetes & Metabolism1996-01-01+01:00
  Journal article
- Functional investigations of HNF1A identify rare variants as risk factors for type 2 diabetes in the general population
  Laeya Abdoli Najmi, Ingvild Aukrust, Jason Flannick, Janne Molnes, Noel Burtt, et al.
  (2017) Diabetes
  Journal article
- Gastric bypass in the pig increases GIP levels and decreases active GLP-1 levels
  Andreas Lindqvist, Mikael Ekelund, Stefan Pierzynowski, Leif Groop, Jan Hedenbro, et al.
  (2017) Peptides
  Journal article
- Genetic Architecture of Type 2 Diabetes
  Rashmi B. Prasad, Leif Groop
  (2017)
  Book chapter
- Genetic determinants of circulating GIP and GLP-1 concentrations
  Peter Almgren, Andreas Lindqvist, Ulrika Krus, Liisa H. Hakaste, Emilia Ottosson Laakso, et al.
  (2017) JCI Insight
  Journal article
- Glucose-induced Changes in Gene Expression in Human Pancreatic Islets - Causes or Consequences of Chronic Hyperglycemia
  Emilia Ottosson-Laakso, Ulrika Krus, Petter Storm, Rashmi B Prasad, Nikolay Oskolkov, et al.
  (2017) Diabetes
  Journal article
- Glucotoxicity-induced upregulation of lincRNA GAS5 in the pancreatic islets of type 2 diabetes donors and in Goto-Kakizaki rats
  J. L. S. Esguerra, J. Ofori, M. Nagao, J. Fadista, L. Groop, et al.
  (2017) Diabetologia
  Conference paper: abstract
- Heterozygous RFX6 protein truncating variants are associated with MODY with reduced penetrance
  Kashyap A. Patel, Jarno Kettunen, Markku Laakso, Alena Stančáková, Thomas W. Laver, et al.
  (2017) Nature Communications
  Journal article
- Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks
  Ildem Akerman, Zhidong Tu, Anthony Beucher, Delphine M Y Rolando, Claire Sauty-Colace, et al.
  (2017) Cell Metabolism
  Journal article
- Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis
  Eleanor Wheeler, Aaron Leong, Ching-Ti Liu, Marie-France Hivert, Rona J. Strawbridge, et al.
  (2017) PLoS Medicine
  Journal article
- Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD
  Panu K. Luukkonen, You Zhou, P. A. Nidhina Haridas, Om P. Dwivedi, Tuulia Hyötyläinen, et al.
  (2017) Journal of Hepatology
  Journal article
- Insulin secretion and action in North Indian women during pregnancy
  G. P. Arora, P Almgren, R. G. Thaman, A. Pal, Leif Groop, et al.
  (2017) Diabetic medicine : a journal of the British Diabetic Association
  Journal article
- LoFtool : a gene intolerance score based on loss-of-function variants in 60 706 individuals
  João Fadista, Nikolay Oskolkov, Ola Hansson, Leif Groop
  (2017) Bioinformatics1998-01-01+01:00
  Journal article
- Metabolite profiling of LADA challenges the view of a metabolically distinct subtype
  Mahmoud Al-Majdoub, Arslan Ali, Petter Storm, Anders H. Rosengren, Leif Groop, et al.
  (2017) Diabetes
  Journal article
- New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals
  Aldi T. Kraja, James P. Cook, Helen R. Warren, Praveen Surendran, Chunyu Liu, et al.
  (2017) Circulation: Cardiovascular Genetics
  Journal article
- Nonsuppressed glucagon after glucose challenge as a potential predictor for glucose tolerance
  Róbert Wagner, Liisa H. Hakaste, Emma Ahlqvist, Martin Heni, Jürgen Machann, et al.
  (2017) Diabetes
  Journal article
- Roux-en-Y gastric bypass versus calorie restriction: support for surgery as the direct contributor to aloncltered responses of insulin and incretins to a mixed meal
  JOHAN BERGGREN, Andreas Lindqvist, Jan Hedenbro, Leif Groop, Nils Wierup
  (2017) Surgery for Obesity and Related Diseases
  Journal article
- Serious life events and the risk of latent autoimmune diabetes in adults (LADA) and Type 2 diabetes
  B. Rasouli, T. Andersson, P.-O. Carlsson, R. Hjort, J E Löfvenborg, et al.
  (2017) Diabetic Medicine
  Journal article
- The impact of Roux-en-Y gastric bypass surgery on normal metabolism in a porcine model
  Andreas Lindqvist, Mikael Ekelund, Eliana Garcia-Vaz, Marcus Ståhlman, Stefan Pierzynowski, et al.
  (2017) PLoS ONE
  Journal article
- The rs7903146 variant in the tcf7l2 gene increases the risk of prediabetes/type 2 diabetes in obese adolescents by impairing b-cell function and hepatic insulin sensitivity
  Catrina Cropano, Nicola Santoro, Leif Groop, Chiara Dalla Man, Claudio Cobelli, et al.
  (2017) Diabetes Care
  Journal article
2016
- A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes
  Heshan Peiris, Michael D. Duffield, Joao Fadista, Claire F. Jessup, Vinder Kashmir, et al.
  (2016) PLoS Genetics
  Journal article
- A Variant of GJD2, Encoding for Connexin 36, Alters the Function of Insulin Producing β-Cells.
  Valentina Cigliola, Celine Populaire, Ciro L Pierri, Samuel Deutsch, Jacques-Antoine Haefliger, et al.
  (2016) PLoS ONE
  Journal article
- A genome-wide mQTL analysis in human adipose tissue identifies genetic variants associated with DNA methylation, gene expression and metabolic traits
  Petr Volkov, Anders H. Olsson, Linn Gillberg, Sine W. Jørgensen, Charlotte Brøns, et al.
  (2016) PLoS ONE
  Journal article
- A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
  Janina S. Ried, Janina M. Jeff, Audrey Y. Chu, Jennifer L. Bragg-Gresham, Jenny Van Dongen, et al.
  (2016) Nature Communications
  Journal article
- A reference panel of 64,976 haplotypes for genotype imputation
  Shane McCarthy, Sayantan Das, Warren Kretzschmar, Olivier Delaneau, Andrew R. Wood, et al.
  (2016) Nature Genetics
  Journal article
- Adhesion G protein-coupled receptor G1 (ADGRG1/GPR56) and pancreatic β-cell function
  Pontus Dunér, Israa Mohammed, Arvind Soni, Olof Asplund, Fatemeh Safi, et al.
  (2016) Journal of Clinical Endocrinology and Metabolism
  Journal article
- Atrial Natriuretic Peptide in the high normal range is associated with lower prevalence of insulin resistance.
  Amra Jujic, Peter Nilsson, Margaretha Persson, Jens Juul Holst, Signe Sørensen Torekov, et al.
  (2016) The Journal of clinical endocrinology and metabolism
  Journal article
- Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes
  Karl Bacos, Linn Gillberg, Petr Volkov, Anders H Olsson, Torben Hansen, et al.
  (2016) Nature Communications
  Journal article
- CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion
  Mia Abels, Matteo Riva, Hedvig Bennet, Emma Ahlqvist, Oleg Dyachok, et al.
  (2016) Diabetologia
  Journal article
- DNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk
  Tasnim Dayeh, Tiinamaija Tuomi, Peter Almgren, Alexander Perfilyev, Per Anders Jansson, et al.
  (2016) Epigenetics
  Journal article
- Epigenetic regulation of glucose-stimulated osteopontin (OPN) expression in diabetic kidney.
  Mengyin Cai, Bompada Pradeep, David Grubich Atac, Markku Laakso, Leif Groop, et al.
  (2016) Biochemical and Biophysical Research Communications
  Journal article
- Epigenetic regulation of the thioredoxin-interacting protein (TXNIP) gene by hyperglycemia in kidney.
  Yang De Marinis, Mengyin Cai, Bompada Pradeep, David Grubich Atac, Olga Kotova, et al.
  (2016) Kidney International
  Journal article
- Excess maternal transmission of variants in the THADA gene to offspring with type 2 diabetes
  Rashmi B. Prasad, Anna Lessmark, Peter Almgren, Györgyi Kovacs, Ola Hansson, et al.
  (2016) Diabetologia
  Journal article
- Genome-wide association study of the modified stumvoll insulin sensitivity index identifies BCL2 and FAM19A2 as novel insulin sensitivity loci
  Geoffrey A. Walford, Stefan Gustafsson, Denis Rybin, Alena Stancáková, Han Chen, et al.
  (2016) Diabetes
  Journal article
- Glucose-Dependent Insulinotropic Polypeptide (GIP) Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.
  Lisa Berglund, Valeriya Lyssenko, Claes Ladenvall, Olga Kotova, Andreas Edsfeldt, et al.
  (2016) Diabetes
  Journal article
- HMGB1 binds to the rs7903146 locus in TCF7L2 in human pancreatic islets.
  Yuedan Zhou, Nikolay Oskolkov, Liliya Shcherbina, Joyce Ratti, Kian-Hong Kock, et al.
  (2016) Molecular and Cellular Endocrinology
  Journal article
- Histone acetylation of glucose-induced thioredoxin-interacting protein gene expression in pancreatic islets
  Bompada Sai Pradeep Chandra Bompada, David Atac, Cheng Luan, Robin Andersson, Judit Domènech Omella, et al.
  (2016) International Journal of Biochemistry and Cell Biology
  Journal article
- Impact of the tcf7l2 genotype on risk of hypoglycaemia and glucagon secretion during hypoglycaemia
  Peter L. Kristensen, Ulrik Pedersen-Bjergaard, Rikke Due-Andersen, Thomas Høi-Hansen, Lise Grimmeshave, et al.
  (2016) Endocrine Connections
  Journal article
- Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes
  Tiinamaija Tuomi, Cecilia L F Nagorny, Pratibha Singh, Hedvig Bennet, Qian Yu, et al.
  (2016) Cell Metabolism
  Journal article
- Influence of Familial Renal Glycosuria Due to Mutations in the SLC5A2 Gene on Changes in Glucose Tolerance over Time.
  Emilia Ottosson Laakso, Tiinamaija Tuomi, Björn Forsén, Monika Gullström, Per-Henrik Groop, et al.
  (2016) PLoS ONE
  Journal article
- Interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity
  Martin Heni, Stephanie Kullmann, Emma Ahlqvist, Robert Wagner, Fausto Machicao, et al.
  (2016) Diabetologia
  Journal article
- MafA-Controlled Nicotinic Receptor Expression Is Essential for Insulin Secretion and Is Impaired in Patients with Type 2 Diabetes.
  Elvira Ganic, Tania Singh, Cheng Luan, Joao Fadista, Jenny Johansson, et al.
  (2016) Cell Reports
  Journal article
- New approaches beyond genetics : towards precision medicine in diabetes
  Leif Groop
  (2016) Diabetologia
  Journal article (comment)
- Prevalence and risk factors for diabetic retinopathy at diagnosis (DRAD) in patients recently diagnosed with type 2 diabetes (T2D) or latent autoimmune diabetes in the adult (LADA)
  Mats Martinell, Mozhgan Dorkhan, Jan Stålhammar, Petter Storm, Leif Groop, et al.
  (2016) Journal of Diabetes and its Complications1992-01-01+01:00
  Journal article
- Single-Cell Sequencing of Human Pancreatic Islets—New Kids on the Block
  Rashmi B. Prasad, Leif Groop
  (2016) Cell Metabolism
  Journal article
- Smoking and the risk of LADA : Results from a Swedish population-based case-control study
  Bahareh Rasouli, Tomas Andersson, Per Ola Carlsson, Valdemar Grill, Leif Groop, et al.
  (2016) Diabetes Care
  Journal article
- Sweetened beverage intake and risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes
  Josefin E. Löfvenborg, Tomas Andersson, Per Ola Carlsson, Mozhgan Dorkhan, Leif Groop, et al.
  (2016) European Journal of Endocrinology1994-01-01+01:00
  Journal article
- The (in)famous GWAS P-value threshold revisited and updated for low-frequency variants.
  Joao Fadista, Alisa K Manning, Jose C Florez, Leif Groop
  (2016) European Journal of Human Genetics
  Journal article
- The genetic architecture of type 2 diabetes
  , , Christian Fuchsberger, Tibor V. Varga, Claes Ladenvall, et al.
  (2016) Nature
  Journal article
- Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
  Praveen Surendran, Fotios Drenos, Robin Young, Helen Warren, James P. Cook, et al.
  (2016) Nature Genetics
  Journal article
- Transcription factor 7-like 2 (TCF7L2)
  Struan F A Grant, Leif Groop
  (2016)
  Book chapter
- α-Hydroxybutyric acid is a selective metabolite biomarker of impaired glucose tolerance
  Jeff Cobb, Andrea Eckhart, Alison Motsinger-Reif, Bernadette Carr, Leif Groop, et al.
  (2016) Diabetes Care
  Journal article
2015
- A Bayesian Network analysis of the probabilistic relations between risk factors in the predisposition to type 2 diabetes
  Francesco Sambo, Barbara Di Camillo, Alberto Franzin, Andrea Facchinetti, Liisa Hakaste, et al.
  (2015) Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
  Conference paper
- A Bayesian Network for Probabilistic Reasoning and Imputation of Missing Risk Factors in Type 2 Diabetes
  Francesco Sambo, Andrea Facchinetti, Liisa Hakaste, Jasmina Kravic, Barbara Di Camillo, et al.
  (2015)
  Conference paper
- A Common Variant in the MTNR1B Gene Is Associated with Increased Risk of Impaired Fasting Glucose (IFG) in Youth with Obesity
  Chao Zheng, Chiara Dalla Man, Claudio Cobelli, Leif Groop, Hongyu Zhao, et al.
  (2015) Obesity
  Journal article
- A novel atlas of gene expression in human skeletal muscle reveals molecular changes associated with aging.
  Jing Su, Carl Ekman, Nikolay Oskolkov, Leo Lahti, Kristoffer Ström, et al.
  (2015) Skeletal Muscle
  Journal article
- Age- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors.
  Tove Fall, Sara Hägg, Alexander Ploner, Reedik Mägi, Krista Fischer, et al.
  (2015) Diabetes
  Journal article
- Biomarkers of rapid chronic kidney disease progression in type 2 diabetes.
  Helen C Looker, Marco Colombo, Sibylle Hess, Mary J Brosnan, Bassam Farran, et al.
  (2015) Kidney International
  Journal article
- Country of birth modifies the association of fatty liver index with insulin action in Middle Eastern immigrants to Sweden.
  Louise Bennet, Leif Groop, Paul Franks
  (2015) Diabetes Research and Clinical Practice
  Journal article
- Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation.
  Momoko Horikoshi, Reedik Mӓgi, Martijn van de Bunt, Ida Surakka, Antti-Pekka Sarin, et al.
  (2015) PLoS Genetics
  Journal article
- Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
  Kyle J Gaulton, Teresa Ferreira, Yeji Lee, Anne Raimondo, Reedik Mägi, et al.
  (2015) Nature Genetics
  Journal article
- Genetic studies of body mass index yield new insights for obesity biology.
  Adam E Locke, Bratati Kahali, Sonja I Berndt, Anne E Justice, Tune H Pers, et al.
  (2015) Nature
  Journal article
- Genetically Determined Height and Coronary Artery Disease
  C. P. Nelson, S. E. Hamby, D. Saleheen, J. C. Hopewell, L. Zeng, et al.
  (2015) New England Journal of Medicine
  Journal article
- Genetics and neonatal diabetes: towards precision medicine.
  Leif Groop
  (2015) The Lancet
  Journal article (comment)
- Genetics of type 2 diabetes : It matters from which parent we inherit the risk
  Valeriya Lyssenko, Leif Groop, Rashmi B. Prasad
  (2015) Review of Diabetic Studies
  Journal article review
- Genetics of type 2 diabetes-pitfalls and possibilities.
  Rashmi Prasad, Leif Groop
  (2015) Genes
  Journal article review
- Harmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research.
  Ola Spjuth, Maria Krestyaninova, Janna Hastings, Huei-Yi Shen, Jani Heikkinen, et al.
  (2015) European Journal of Human Genetics
  Journal article
- Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus.
  Anubha Mahajan, Xueling Sim, Hui Jin Ng, Alisa Manning, Manuel A Rivas, et al.
  (2015) PLoS Genetics
  Journal article
- Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene
  Joshua W. Knowles, Weijia Xie, Zhongyang Zhang, Indumathi Chennemsetty, Themistocles L. Assimes, et al.
  (2015) Journal of Clinical Investigation
  Journal article
- Identification of novel genes for glucose metabolism based upon expression pattern in human islets and effect on insulin secretion and glycemia.
  Jalal Taneera, Joao Fadista, Emma Ahlqvist, David Grubich Atac, Emilia Ottosson Laakso, et al.
  (2015) Human Molecular Genetics
  Journal article
- Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood.
  Tina Rönn, Petr Volkov, Linn Gillberg, Milana Kokosar, Alexander Perfilyev, et al.
  (2015) Human Molecular Genetics
  Journal article
- Less pronounced response to exercise in healthy relatives to type 2 diabetics compared to controls.
  Carl Ekman, Targ Elgzyri, Kristoffer Ström, Peter Almgren, Hemang Parikh, et al.
  (2015) Journal of Applied Physiology
  Journal article
- Low birthweight is associated with an increased risk of LADA and type 2 diabetes: results from a Swedish case-control study
  Rebecka Hjort, Lars Alfredsson, Per-Ola Carlsson, Leif Groop, Mats Martinell, et al.
  (2015) Diabetologia
  Journal article
- Modelling of OGTT curve identifies 1 h plasma glucose level as a strong predictor of incident type 2 diabetes: results from two prospective cohorts
  Akram Alyass, Peter Almgren, Mikael Åkerlund, Jonathan Dushoff, Bo Isomaa, et al.
  (2015) Diabetologia
  Journal article
- Mucosal glucagon-like peptide-1 and gastric inhibitory polypeptide cell numbers in the super-obese human foregut after gastric bypass.
  Bent J Nergård, Andreas Lindqvist, Hjörtur G Gislason, Leif Groop, Mikael Ekelund, et al.
  (2015) Surgery for Obesity and Related Diseases
  Journal article
- New genetic loci link adipose and insulin biology to body fat distribution.
  Dmitry Shungin, Thomas W Winkler, Damien C Croteau-Chonka, Teresa Ferreira, Adam E Locke, et al.
  (2015) Nature
  Journal article
- Prevalence and Risk Factors of Gestational Diabetes in Punjab, North India - Results from a Population Screening Program.
  Geeti Arora, Richa G Thaman, Rashmi Prasad, Peter Almgren, Charlotte Brøns, et al.
  (2015) European Journal of Endocrinology1994-01-01+01:00
  Journal article
- Protein biomarkers for the prediction of cardiovascular disease in type 2 diabetes
  Helen C. Looker, Marco Colombo, Felix Agakov, Tanja Zeller, Leif Groop, et al.
  (2015) Diabetologia
  Journal article
- Short- and Long-Term Hormonal and Metabolic Consequences of Reversing Gastric Bypass to Normal Anatomy in a Type 2 Diabetes Patient.
  Nils Wierup, Andreas Lindqvist, Peter Spégel, Leif Groop, Jan Hedenbro, et al.
  (2015) Obesity Surgery
  Journal article
- The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
  Thomas W Winkler, Anne E Justice, Mariaelisa Graff, Llilda Barata, Mary F Feitosa, et al.
  (2015) PLoS Genetics
  Journal article
- The genetics of diabetic complications.
  Emma Ahlqvist, Natalie R van Zuydam, Leif Groop, Mark I McCarthy
  (2015) Nature Reviews Nephrology
  Journal article review
- The impact of low-frequency and rare variants on lipid levels.
  Ida Surakka, Momoko Horikoshi, Reedik Mägi, Antti-Pekka Sarin, Anubha Mahajan, et al.
  (2015) Nature Genetics
  Journal article
- Type 2 diabetes mellitus
  Ralph A. DeFronzo, Ele Ferrannini, Leif Groop, Robert R. Henry, William H. Herman, et al.
  (2015) Nature Reviews Disease Primers
  Journal article
- Variation in Glucose Homeostasis Traits Associated With P2RX7 Polymorphisms in Mice and Humans
  Jennifer N. Todd, Wenny Poon, Valeriya Lyssenko, Leif Groop, Brendan Nichols, et al.
  (2015) Journal of Clinical Endocrinology and Metabolism
  Journal article
- Vigorous Physical Activity may be Important for the Insulin Sensitivity in Immigrants From the Middle East and Native Swedes.
  Daniel Arvidsson, Ulf Lindblad, Jan Sundquist, Kristina Sundquist, Leif Groop, et al.
  (2015) Journal of Physical Activity & Health
  Journal article
2014
- A Central Role for GRB10 in Regulation of Islet Function in Man.
  Inga Prokopenko, Wenny Poon, Reedik Mägi, Rashmi Prasad, S Albert Salehi, et al.
  (2014) PLoS Genetics
  Journal article
- A Novel Test for Recessive Contributions to Complex Diseases Implicates Bardet-Biedl Syndrome Gene BBS10 in Idiopathic Type 2 Diabetes and Obesity
  Elaine T. Lim, Yangfan P. Liu, Yingleong Chan, Tiinamaija Tuomi, AnnMari Karajamaki, et al.
  (2014) American Journal of Human Genetics
  Journal article
- ASSOCIATION OF BTG2, CYR61, ZFP36, AND SCD GENE POLYMORPHISMS WITH GRAVES' DISEASE AND OPHTHALMOPATHY.
  Tereza Planck, Bushra Shahida, Marketa Sjögren, Leif Groop, Bengt Hallengren, et al.
  (2014) Thyroid
  Journal article
- Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes.
  Siddhartha Jaiswal, Pierre Fontanillas, Jason Flannick, Alisa Manning, Peter V Grauman, et al.
  (2014) New England Journal of Medicine
  Journal article
- Alcohol and the risk for LADA: results based on the Swedish ESTRID study.
  Bahareh Rasouli, Tomas Andersson, Per-Ola Carlsson, Mozhgan Dorkhan, Valdemar Grill, et al.
  (2014) European Journal of Endocrinology1994-01-01+01:00
  Journal article
- Can genetics improve precision of therapy in diabetes?
  Leif Groop, Petter Storm, Anders Rosengren
  (2014) Trends in Endocrinology and Metabolism
  Journal article (comment)
- Carl-David Agardh, 1946-2013.
  Leif Groop, Åke Lernmark, Jan Nilsson
  (2014) Diabetologia
  Journal article
- Chromosome x-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage compensation.
  Taru Tukiainen, Matti Pirinen, Antti-Pekka Sarin, Claes Ladenvall, Johannes Kettunen, et al.
  (2014) PLoS Genetics
  Journal article
- Co-occurrence of Risk Alleles in or Near Genes Modulating Insulin Secretion Predisposes Obese Youth to Prediabetes
  Cosimo Giannini, Chiara Dalla Man, Leif Groop, Claudio Cobelli, Hongyu Zhao, et al.
  (2014) Diabetes Care
  Journal article
- Coffee consumption and the risk of latent autoimmune diabetes in adults-results from a Swedish case-control study
  J. E. Lofvenborg, T. Andersson, P. -O. Carlsson, M. Dorkhan, Leif Groop, et al.
  (2014) Diabetic Medicine
  Journal article
- Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independently of obesity.
  Robert A Scott, Tove Fall, Dorota Pasko, Adam Barker, Stephen J Sharp, et al.
  (2014) Diabetes
  Journal article
- Defining the role of common variation in the genomic and biological architecture of adult human height.
  Andrew R Wood, Tonu Esko, Jian Yang, Sailaja Vedantam, Tune H Pers, et al.
  (2014) Nature Genetics
  Journal article
- Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population.
  Elaine T Lim, Peter Würtz, Aki S Havulinna, Priit Palta, Taru Tukiainen, et al.
  (2014) PLoS Genetics
  Journal article
- Downregulation of Type II Diabetes Mellitus and Maturity Onset Diabetes of Young Pathways in Human Pancreatic Islets from Hyperglycemic Donors.
  Jalal Taneera, Petter Storm, Leif Groop
  (2014) Journal of Diabetes Research
  Journal article
- Ethnic differences in the contribution of insulin action and secretion to type 2 diabetes in immigrants from the Middle East compared to native Swedes.
  Louise Bennet, Leif Groop, Paul Franks
  (2014) Diabetes Research and Clinical Practice
  Journal article
- Ethnicity is an independent risk indicator when estimating diabetes risk with FINDRISC scores: A cross sectional study comparing immigrants from the Middle East and native Swedes.
  Louise Bennet, Leif Groop, Ulf Lindblad, Carl-David Agardh, Paul Franks
  (2014) Primary Care Diabetes
  Journal article
- Expression of Phosphofructokinase in Skeletal Muscle Is Influenced by Genetic Variation and Associated With Insulin Sensitivity
  Sarah Keildson, Joao Fadista, Claes Ladenvall, Asa K. Hedman, Targ Elgzyri, et al.
  (2014) Diabetes
  Journal article
- Extensive changes in the transcriptional profile of human adipose tissue including genes involved in oxidative phosphorylation after a six months exercise intervention.
  Tina Rönn, Petr Volkov, Åsa Tornberg, Targ Elgzyri, Ola Hansson, et al.
  (2014) Acta Physiologica2006-01-01+01:002013-01-01+01:00
  Journal article
- Fatty fish consumption and risk of latent autoimmune diabetes in adults.
  J E Löfvenborg, T Andersson, P-O Carlsson, Mozhgan Dorkhan, Leif Groop, et al.
  (2014) Nutrition & diabetes
  Journal article
- Gastric bypass improves ss-cell function and increases β-cell mass in a porcine model.
  Andreas Lindqvist, Peter Spégel, Mikael Ekelund, Eliana Garcia Vaz, Stefan Pierzynowski, et al.
  (2014) Diabetes
  Journal article
- Gene-Lifestyle Interaction and Type 2 Diabetes: The EPIC InterAct Case-Cohort Study.
  Claudia Langenberg, Stephen J Sharp, Paul Franks, Robert A Scott, Panos Deloukas, et al.
  (2014) PLoS Medicine
  Journal article
- Genome Wide Meta-analysis Highlights the Role of Genetic Variation in RARRES2 in the Regulation of Circulating Serum Chemerin.
  Anke Tönjes, Markus Scholz, Jana Breitfeld, Carola Marzi, Harald Grallert, et al.
  (2014) PLoS Genetics
  Journal article
- Genome-wide association study of urinary albumin excretion rate in patients with type 1 diabetes
  Niina Sandholm, Carol Forsblom, Ville-Petteri Makinen, Amy Jayne McKnight, Anne-May Osterholm, et al.
  (2014) Diabetologia
  Journal article
- Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
  Anubha Mahajan, Min Jin Go, Weihua Zhang, Jennifer E. Below, Kyle J. Gaulton, et al.
  (2014) Nature Genetics
  Journal article
- Genotype-based treatment of type 2 diabetes with an α2A-adrenergic receptor antagonist.
  Yunzhao Tang, Annika Axelsson, Peter Spégel, Lotta Andersson, Hindrik Mulder, et al.
  (2014) Science Translational Medicine
  Journal article
- Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism.
  Joao Fadista, Petter Vikman, Emilia Ottosson Laakso, Ines Mollet, Jonathan Esguerra, et al.
  (2014) Proceedings of the National Academy of Sciences
  Journal article
- Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis.
  Kaixin Zhou, Louise Donnelly, Jian Yang, Miaoxin Li, Harshal Deshmukh, et al.
  (2014) The Lancet Diabetes & Endocrinology
  Journal article
- Leveraging cross-species transcription factor binding site patterns: from diabetes risk Loci to disease mechanisms.
  Melina Claussnitzer, Simon N Dankel, Bernward Klocke, Harald Grallert, Viktoria Glunk, et al.
  (2014) Cell
  Journal article
- Loss-of-function mutations in SLC30A8 protect against type 2 diabetes.
  Jason Flannick, Gudmar Thorleifsson, Nicola L Beer, Suzanne B R Jacobs, Niels Grarup, et al.
  (2014) Nature Genetics
  Journal article
- Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.
  Iris Postmus, Stella Trompet, Harshal A Deshmukh, Michael R Barnes, Xiaohui Li, et al.
  (2014) Nature Communications
  Journal article
- Sleep duration and insulin resistance in individuals without type 2 diabetes: The PPP-Botnia Study
  Antti-Jussi Pyykkonen, Bo Isomaa, Anu-Katriina Pesonen, Johan G. Eriksson, Leif Groop, et al.
  (2014) Annals of Medicine
  Journal article
- TCF7L2 is a master regulator of insulin production and processing.
  Yuedan Zhou, Soo-Young Park, Jing Su, Kathleen Bailey, Emilia Ottosson Laakso, et al.
  (2014) Human Molecular Genetics
  Journal article
- The diabetes susceptibility gene clec16a regulates mitophagy.
  Scott A Soleimanpour, Aditi Gupta, Marina Bakay, Alana M Ferrari, David N Groff, et al.
  (2014) Cell
  Journal article
- The many faces of diabetes: a disease with increasing heterogeneity
  Tiinamaija Tuomi, Nicola Santoro, Sonia Caprio, Mengyin Cai, Jianping Weng, et al.
  (2014) The Lancet
  Journal article review
- Type 2 diabetes susceptibility gene variants predispose to adult-onset autoimmune diabetes
  Mette Andersen, Maria Sterner, Tom Forsen, Annemari Karajamaki, Olov Rolandsson, et al.
  (2014) Diabetologia
  Journal article
- Tyypin 2 diabetes--perinnöllinen kohtalo vai hyvinvointiyhteiskunnan rangaistus?
  Leif Groop
  (2014) Duodecim
  Journal article review
- Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol.
  Leslie A Lange, Youna Hu, He Zhang, Chenyi Xue, Ellen M Schmidt, et al.
  (2014) American Journal of Human Genetics
  Journal article
2013
- A link between GIP and osteopontin in adipose tissue and insulin resistance.
  Emma Ahlqvist, Peter Osmark, Tiina Kuulasmaa, Kasper Pilgaard, Bilal Omar, et al.
  (2013) Diabetes
  Journal article
- A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue.
  Tina Rönn, Petr Volkov, Cajsa Davegårdh, Tasnim Dayeh, Elin Hall, et al.
  (2013) PLoS Genetics
  Journal article
- Age at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk
  Judith S. Brand, Yvonne T. van der Schouw, N. Charlotte Onland-Moret, Stephen J. Sharp, Ken K. Ong, et al.
  (2013) Diabetes Care
  Journal article
- Alterations in bile acid synthesis in carriers of HNF1α mutations.
  Ella Ekholm, Ralf Nilsson, Leif Groop, Camilla Pramfalk
  (2013) Journal of Internal Medicine1989-01-01+01:00
  Journal article
- Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes
  Jason Flannick, Nicola L. Beer, Alexander G. Bick, Vineeta Agarwala, Janne Molnes, et al.
  (2013) Nature Genetics
  Journal article
- Common variants associated with plasma triglycerides and risk for coronary artery disease
  Ron Do, Cristen J. Willer, Ellen M. Schmidt, Sebanti Sengupta, Chi Gao, et al.
  (2013) Nature Genetics
  Journal article
- Discovery and refinement of loci associated with lipid levels
  Cristen J. Willer, Ellen M. Schmidt, Sebanti Sengupta, Gina M. Peloso, Stefan Gustafsson, et al.
  (2013) Nature Genetics
  Journal article
- Early Metabolic Markers of the Development of Dysglycemia and Type 2 Diabetes and Their Physiological Significance
  Ele Ferrannini, Andrea Natali, Stefania Camastra, Monica Nannipieri, Andrea Mari, et al.
  (2013) Diabetes
  Journal article
- Effect of Common Genetic Variants Associated with Type 2 Diabetes and Glycemic Traits on α- and β-cell Function and Insulin Action in Man.
  Anna Jonsson, Claes Ladenvall, Tarunveer Singh Ahluwalia, Jasmina Kravic, Ulrika Krus, et al.
  (2013) Diabetes
  Journal article
- Effects of ingestion routes on hormonal and metabolic profiles in gastric-bypassed humans
  Andreas Lindqvist, Mikael Ekelund, Hindrik Mulder, Peter Spégel, Leif Groop, et al.
  (2013) Journal of Clinical Endocrinology and Metabolism
  Journal article
- Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes
  A. Albrechtsen, N. Grarup, Y. Li, T. Sparso, G. Tian, et al.
  (2013) Diabetologia
  Journal article
- Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes.
  Jalal Taneera, Joao Fadista, Emma Ahlqvist, Mengze Zhang, Nils Wierup, et al.
  (2013) Molecular and Cellular Endocrinology
  Journal article
- Genetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes
  Weijia Xie, Andrew R. Wood, Valeriya Lyssenko, Michael N. Weedon, Joshua W. Knowles, et al.
  (2013) Diabetes
  Journal article
- Genetics of diabetes - Are we missing the genes or the disease?
  Leif Groop, Flemming Pociot
  (2013) Molecular and Cellular Endocrinology
  Journal article
- Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
  Sonja I. Berndt, Stefan Gustafsson, Reedik Maegi, Andrea Ganna, Eleanor Wheeler, et al.
  (2013) Nature Genetics
  Journal article
- Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders
  Marcel den Hoed, Mark Eijgelsheim, Tonu Esko, Bianca J. J. M. Brundel, David S. Peal, et al.
  (2013) Nature Genetics
  Journal article
- Insights Into the Molecular Mechanism for Type 2 Diabetes Susceptibility at the KCNQ1 Locus From Temporal Changes in Imprinting Status in Human Islets
  Mary E. Travers, Deborah J. G. Mackay, Marloes Dekker Nitert, Andrew P. Morris, Cecilia M. Lindgren, et al.
  (2013) Diabetes
  Journal article
- Large-scale association analysis identifies new risk loci for coronary artery disease
  Panos Deloukas, Stavroula Kanoni, Christina Willenborg, Martin Farrall, Themistocles L. Assimes, et al.
  (2013) Nature Genetics
  Journal article
- Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits
  Joshua C. Randall, Thomas W. Winkler, Zoltan Kutalik, Sonja I. Berndt, Anne U. Jackson, et al.
  (2013) PLoS Genetics
  Journal article
- THOC5 : A novel gene involved in HDL-cholesterol metabolism
  Maria Keller, Dorit Schleinitz, Julia Förster, Anke Tönjes, Yvonne Böttcher, et al.
  (2013) Journal of Lipid Research
  Journal article
- The CTRB1/2 Locus Affects Diabetes Susceptibility and Treatment via the Incretin Pathway
  Leen M. 't Hart, Andreas Fritsche, Giel Nijpels, Nienke van Leeuwen, Louise A. Donnelly, et al.
  (2013) Diabetes
  Journal article
- The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis
  Tove Fall, Sara Hagg, Reedik Maegi, Alexander Ploner, Krista Fischer, et al.
  (2013) PLoS Medicine
  Journal article
2012
- A Single Nucleotide Polymorphism Associates With the Response of Muscle ATP Synthesis to Long-Term Exercise Training in Relatives of Type 2 Diabetic Humans
  Gertrud Kacerovsky-Bielesz, Michaela Kacerovsky, Marek Chmelik, Michaela Farukuoye, Charlotte Ling, et al.
  (2012) Diabetes Care
  Journal article
- A common variant upstream of the PAX6 gene influences islet function in man.
  Emma Ahlqvist, Fabiola Turrini, Stefan Lang, Jalal Taneera, Yuedan Zhou, et al.
  (2012) Diabetologia
  Journal article
- A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
  Alisa K. Manning, Marie-France Hivert, Robert A. Scott, Jonna L. Grimsby, Nabila Bouatia-Naji, et al.
  (2012) Nature Genetics
  Journal article
- A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets.
  Jalal Taneera, Stefan Lang, Amitabh Sharma, Joao Fadista, Yuedan Zhou, et al.
  (2012) Cell Metabolism
  Journal article
- Analysis of case-control association studies with known risk variants
  Noah Zaitlen, Bogdan Pasaniuc, Nick Patterson, Samuela Pollack, Benjamin Voight, et al.
  (2012) Bioinformatics1998-01-01+01:00
  Journal article
- Association between depressive symptoms and metabolic syndrome is not explained by antidepressant medication: Results from the PPP-Botnia Study
  Antti-Jussi Pyykkonen, Katri Raikkonen, Tiinamaija Tuomi, Johan G. Eriksson, Leif Groop, et al.
  (2012) Annals of Medicine
  Journal article
- Association of variants in HLA-DQA1-DQB1, PTPN22, INS, and CTLA4 with GAD autoantibodies and insulin secretion in nondiabetic adults of the Botnia Prospective Study
  Mette K. Andersen, Virve Lundgren, Bo Isomaa, Leif Groop, Tiinamaija Tuomi
  (2012) European Journal of Endocrinology1994-01-01+01:00
  Journal article
- Codon 72 polymorphism (rs1042522) of TP53 is associated with changes in diastolic blood pressure over time
  Erwin Reiling, Valeriya Lyssenko, Jolanda M. A. Boer, Sandra Imholz, W. Monique M. Verschuren, et al.
  (2012) European Journal of Human Genetics
  Journal article
- Common variant in the HMGA2 gene increases susceptibility to nephropathy in patients with type 2 diabetes.
  Sami Alkayyali, M Lajer, H Deshmukh, Emma Ahlqvist, H Colhoun, et al.
  (2012) Diabetologia
  Journal article
- Differential gene expression in adipose tissue from obese human subjects during weight loss and weight maintenance.
  Lovisa Johansson, Anders Danielsson, Hemang Parikh, Maria Klintenberg, Fredrik Norström, et al.
  (2012) The American journal of clinical nutrition
  Journal article
- Effect of a common variant of the PCSK2 gene on reduced insulin secretion.
  Anna Jonsson, B Isomaa, Tiinamaija Tuomi, Jonas Eriksson, Leif Groop, et al.
  (2012) Diabetologia
  Journal article
- FTO genotype is associated with phenotypic variability of body mass index
  Jian Yang, Ruth J. F. Loos, Joseph E. Powell, Sarah E. Medland, Elizabeth K. Speliotes, et al.
  (2012) Nature
  Journal article
- First-Degree Relatives of Type 2 Diabetic Patients Have Reduced Expression of Genes Involved in Fatty Acid Metabolism in Skeletal Muscle.
  Targ Elgzyri, Hemang Parikh, Yuedan Zhou, Marloes Dekker Nitert, Tina Rönn, et al.
  (2012) Journal of Clinical Endocrinology and Metabolism
  Journal article
- Genetic Variation in the Glucose-Dependent Insulinotropic Polypeptide Receptor Modifies the Association between Carbohydrate and Fat Intake and Risk of Type 2 Diabetes in the Malmo Diet and Cancer Cohort.
  Emily Sonestedt, Valeriya Lyssenko, Ulrika Ericson, Bo Gullberg, Elisabet Wirfält, et al.
  (2012) The Journal of clinical endocrinology and metabolism
  Journal article
- Genetic prediction of postpartum diabetes in women with gestational diabetes mellitus
  Magnus Ekelund, Nael Shaat, Peter Almgren, Eva Anderberg, Mona Landin-Olsson, et al.
  (2012) Diabetes Research and Clinical Practice
  Journal article
- Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Degree Relatives of Patients With Type 2 Diabetes.
  Marloes Dekker Nitert, Tasnim Dayeh, Peter Volkov, Targ Elgzyri, Elin Hall, et al.
  (2012) Diabetes
  Journal article
- Informed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies
  Noah Zaitlen, Sara Lindstroem, Bogdan Pasaniuc, Marilyn Cornelis, Giulio Genovese, et al.
  (2012) PLoS Genetics
  Journal article
- Intraorbital deiodinase type 2 expression is downregulated in chronic phase of Graves' ophthalmopathy.
  Tereza Planck, Hemang Parikh, Leif Groop, Bengt Hallengren, Mikael Lantz
  (2012) Clinical Endocrinology
  Journal article (letter)
- Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
  Andrew P. Morris, Benjamin F. Voight, Tanya M. Teslovich, Teresa Ferreira, Ayellet V. Segre, et al.
  (2012) Nature Genetics
  Journal article
- Metabolite Profiling Reveals Normal Metabolic Control in Carriers of Mutations in the Glucokinase Gene (MODY2).
  Peter Spégel, Ella Ekholm, Tiinamaija Tuomi, Leif Groop, Hindrik Mulder, et al.
  (2012) Diabetes
  Journal article
- New Susceptibility Loci Associated with Kidney Disease in Type 1 Diabetes
  Niina Sandholm, Rany M. Salem, Amy Jayne McKnight, Eoin P. Brennan, Carol Forsblom, et al.
  (2012) PLoS Genetics
  Journal article
- No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels
  Robert A. Scott, Audrey Y. Chu, Niels Grarup, Alisa K. Manning, Marie-France Hivert, et al.
  (2012) Diabetes
  Journal article
- Physical activity reduces the risk of incident type 2 diabetes in general and in abdominally lean and obese men and women: the EPIC-InterAct Study
  U. Ekelund, L. Palla, S. Brage, Paul Franks, T. Peters, et al.
  (2012) Diabetologia
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- Reduced Insulin Exocytosis in Human Pancreatic β-cells With Gene Variants Linked to Type 2 Diabetes.
  Anders Rosengren, Matthias Braun, Taman Mahdi, Sofia A Andersson, Mary E Travers, et al.
  (2012) Diabetes
  Journal article
- Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes.
  Sofia A Andersson, Anders H Olsson, Jonathan L S Esguerra, Emilia Heimann, Claes Ladenvall, et al.
  (2012) Molecular and Cellular Endocrinology
  Journal article
- Regulation of the pro-inflammatory cytokine osteopontin by GIP in adipocytes - A role for the transcription factor NFAT and phosphodiesterase 3B.
  Bilal Omar, Elin Banke, Emilia Guiguis, Lina Kesson, Vincent Manganiello, et al.
  (2012) Biochemical and Biophysical Research Communications
  Journal article
- SNP in the genome-wide association study hotspot on chromosome 9p21 confers susceptibility to diabetic nephropathy in type 1 diabetes
  E. Fagerholm, Emma Ahlqvist, C. Forsblom, N. Sandholm, A. Syreeni, et al.
  (2012) Diabetologia
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- Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.
  Taman Mahdi, Sonja Hänzelmann, S Albert Salehi, Sarheed Jabar Muhammed, Thomas Reinbothe, et al.
  (2012) Cell Metabolism
  Journal article
- Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases
  John R. B. Perry, Benjamin F. Voight, Loic Yengo, Najaf Amin, Josee Dupuis, et al.
  (2012) PLoS Genetics
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- Subjective Sleep Complaints Are Associated With Insulin Resistance in Individuals Without Diabetes The PPP-Botnia Study
  Antti-Jussi Pyykkonen, Bo Isomaa, Anu-Katriina Pesonen, Johan G. Eriksson, Leif Groop, et al.
  (2012) Diabetes Care
  Journal article
- Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway.
  Yuedan Zhou, Enming Zhang, Christine Berggreen, Xingjun Jing, Peter Osmark, et al.
  (2012) Human Molecular Genetics
  Journal article
- Telomere length in blood and skeletal muscle in relation to measures of glycaemia and insulinaemia.
  Shafqat Ahmad, A Heraclides, Q Sun, Targ Elgzyri, Tina Rönn, et al.
  (2012) Diabetic medicine : a journal of the British Diabetic Association
  Journal article
- The Triglyceride Content in Skeletal Muscle Is Associated with Hepatic But Not Peripheral Insulin Resistance in Elderly Twins.
  Louise Groth Grunnet, Esa Laurila, Ola Hansson, Peter Almgren, Leif Groop, et al.
  (2012) The Journal of clinical endocrinology and metabolism
  Journal article
- Validation of a multi-marker model for the prediction of incident type 2 diabetes mellitus: Combined results of the Inter99 and Botnia studies.
  Valeriya Lyssenko, Torben Jørgensen, Robert W Gerwien, Torben Hansen, Michael W Rowe, et al.
  (2012) Diabetes & Vascular Disease Research
  Journal article
- Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents
  Nicola Santoro, Clarence K. Zhang, Hongyu Zhao, Andrew J. Pakstis, Grace Kim, et al.
  (2012) Hepatology
  Journal article
- Worse glycaemic control in LADA patients than in those with type 2 diabetes, despite a longer time on insulin therapy.
  Caroline Andersen, Louise Bennet, L Nyström, Ulf Lindblad, Eero Lindholm, et al.
  (2012) Diabetologia
  Journal article
- Zinc Transporter 8 Autoantibodies and Their Association With SLC30A8 and HLA-DQ Genes Differ Between Immigrant and Swedish Patients With Newly Diagnosed Type 1 Diabetes in the Better Diabetes Diagnosis Study.
  Ahmed Delli, Fariba Vaziri Sani, Bengt Lindblad, Helena Larsson, Annelie Carlsson, et al.
  (2012) Diabetes
  Journal article
- γ-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes.
  Jalal Taneera, Z Jin, Yuesheng Jin, Sarheed Jabar Muhammed, Enming Zhang, et al.
  (2012) Diabetologia
  Journal article
2011
- A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes.
  Thomas Koeck, Anders H Olsson, Marloes Dekker Nitert, Vladimir Sharoyko, Claes Ladenvall, et al.
  (2011) Cell Metabolism
  Journal article
- A common variant near the PRL gene is associated with increased adiposity in males
  Louise Nilsson, Anders H Olsson, Bo Isomaa, Leif Groop, Hakan Billig, et al.
  (2011) Molecular Genetics and Metabolism
  Journal article
- A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes
  G. Thanabalasingham, N. Shah, M. Vaxillaire, T. Hansen, T. Tuomi, et al.
  (2011) Diabetologia
  Journal article
- Association between parental history of diabetes and type 2 diabetes genetic risk scores in the PPP-Botnia and Framingham Offspring Studies
  Jason L. Vassy, Peter Shrader, Anna Jonsson, Caroline S. Fox, Valeriya Lyssenko, et al.
  (2011) Diabetes Research and Clinical Practice
  Journal article
- Common variants in CNDP1 and CNDP2, and risk of nephropathy in type 2 diabetes.
  Tarun Ahluwalia, Eero Lindholm, Leif Groop
  (2011) Diabetologia
  Journal article
- Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction
  Jessica Shea, Vineeta Agarwala, Anthony A. Philippakis, Jared Maguire, Eric Banks, et al.
  (2011) Nature Genetics
  Journal article
- Depressive Symptoms, Antidepressant Medication Use, and Insulin Resistance The PPP-Botnia Study
  Antti-Jussi Pyykkonen, Katri Raikkonen, Tiinamaija Tuomi, Johan G. Eriksson, Leif Groop, et al.
  (2011) Diabetes Care
  Journal article
- Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study
  C. Langenberg, S. Sharp, N. G. Forouhi, Paul Franks, M. B. Schulze, et al.
  (2011) Diabetologia
  Journal article
- Exercise capacity in relation to body fat distribution and muscle fibre distribution in elderly male subjects with impaired glucose tolerance, type 2 diabetes and matched controls.
  Åsa Tornberg, Targ Elgzyri, Karl-Fredrik Eriksson, Leif Groop, Ola Thorsson, et al.
  (2011) Diabetes Research and Clinical Practice
  Journal article
- FTO, Type 2 Diabetes, and Weight Gain Throughout Adult Life A Meta-Analysis of 41,504 Subjects From the Scandinavian HUNT, MDC, and MPP Studies
  Jens K. Hertel, Stefan Johansson, Emily Sonestedt, Anna Jonsson, Rolv T. Lie, et al.
  (2011) Diabetes
  Journal article
- Facilitation of information exhange between genetic research, primary health care and decision makers using a regional diabetes register DIREVA (Diabetes Register Vaasa)
  Tom Forsén, Kaj Lahti, J Eriksson, Tiinamaija Tuomi, Bo Isomaa, et al.
  (2011)
  Conference paper
- Gene Expression in Graves' Ophthalmopathy and Arm Lymphedema: Similarities and Differences.
  Tereza Planck, Hemang Parikh, Håkan Brorson, Tuve Mårtensson, Peter Åsman, et al.
  (2011) Thyroid
  Journal article
- Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
  Tuomas O. Kilpelainen, M. Carola Zillikens, Alena Stancakova, Francis M. Finucane, Janina S. Ried, et al.
  (2011) Nature Genetics
  Journal article
- Genetics of Type 2 Diabetes.
  Emma Ahlqvist, Tarunveer Singh Ahluwalia, Leif Groop
  (2011) Clinical Chemistry
  Journal article
- Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes
  Rona J. Strawbridge, Josee Dupuis, Inga Prokopenko, Adam Barker, Emma Ahlqvist, et al.
  (2011) Diabetes
  Journal article
- Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure
  Louise V. Wain, Germaine C. Verwoert, Paul F. O'Reilly, Gang Shi, Toby Johnson, et al.
  (2011) Nature Genetics
  Journal article
- Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study.
  Peter Almgren, M Lehtovirta, B Isomaa, L Sarelin, M R Taskinen, et al.
  (2011) Diabetologia
  Journal article
- High prevalence of type 2 diabetes in Iraqi and Swedish residents in a deprived Swedish neighbourhood - a population based study
  Louise Bennet, Sven-Erik Johansson, Carl-David Agardh, Leif Groop, Jan Sundquist, et al.
  (2011) BMC Public Health
  Journal article
- Insulin Reduces Neuronal Excitability by Turning on GABA(A) Channels that Generate Tonic Current
  Zhe Jin, Yang Jin, Suresh Kumar-Mendu, Eva Degerman, Leif Groop, et al.
  (2011) PLoS ONE
  Journal article
- Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets.
  Beatrice Yang, Tasnim Dayeh, C L Kirkpatrick, Jalal Taneera, Rajesh Kumar, et al.
  (2011) Diabetologia
  Journal article
- LifeGene-a large prospective population-based study of global relevance
  Catarina Almqvist, Hans-Olov Adami, Paul Franks, Leif Groop, Erik Ingelsson, et al.
  (2011) European Journal of Epidemiology
  Journal article
- Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children
  Tuomas O. Kilpelaeinen, Lu Qi, Soren Brage, Stephen J. Sharp, Emily Sonestedt, et al.
  (2011) PLoS Medicine
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- Pleiotropic Effects of GIP on Islet Function Involve Osteopontin
  Valeriya Lyssenko, Lena Eliasson, Olga Kotova, Kasper Pilgaard, Nils Wierup, et al.
  (2011) Diabetes
  Journal article
- Power in the Phenotypic Extremes: A Simulation Study of Power in Discovery and Replication of Rare Variants
  Lin T. Guey, Jasmina Kravic, Olle Melander, Noel P. Burtt, Jason M. Laramie, et al.
  (2011) Genetic Epidemiology
  Journal article
- Relation between cycling exercise capacity, fiber-type composition, and lower extremity muscle strength and muscle endurance.
  Åsa Tornberg, Anna Maria Drake, Ola Hansson, Targ Elgzyri, Karl-Fredrik Eriksson, et al.
  (2011) Journal of strength and conditioning research / National Strength & Conditioning Association
  Journal article
- Survival of rat pancreatic islets is partly controlled by a TCF7L2-p53-p53INP1 dependent pathway
  Y. Zhou, Enming Zhang, C. Berggreen, Xingjun Jing, P. Osmark, et al.
  (2011) Diabetologia
  Journal article
- The Genetic Structure of the Swedish Population
  Keith Humphreys, Alexander Grankvist, Monica Leu, Per Hall, Jianjun Liu, et al.
  (2011) PLoS ONE
  Journal article
- The expression of myosin heavy chain (MHC) genes in human skeletal muscle is related to metabolic characteristics involved in the pathogenesis of type 2 diabetes.
  Anders H Olsson, Tina Rönn, Tarq Elgzyri, Ola Hansson, Karl-Fredrik Eriksson, et al.
  (2011) Molecular Genetics and Metabolism
  Journal article
- Two common genetic variants near nuclear encoded OXPHOS genes are associated with insulin secretion in vivo.
  Anders H Olsson, Tina Rönn, Claes Ladenvall, Hemang Parikh, Bo Isomaa, et al.
  (2011) European Journal of Endocrinology1994-01-01+01:00
  Journal article
- Two-Step Approach for the Prediction of Future Type 2 Diabetes Risk
  Muhammad A. Abdul-Ghani, Tamam Abdul-Ghani, Michael P. Stern, Jasmina Karavic, Tiinamaija Tuomi, et al.
  (2011) Diabetes Care
  Journal article
- Upper Body Muscle Strength and Endurance in Relation to Peak Exercise Capacity During Cycling in Healthy Sedentary Male Subjects.
  Åsa Tornberg, Anna Maria Drake, Targ Elzyri, Karl-Fredrik Eriksson, Karin Ringsberg, et al.
  (2011) Journal of strength and conditioning research / National Strength & Conditioning Association
  Journal article
- Uromodulin gene variant is associated with type 2 diabetic nephropathy.
  Tarunveer S Ahluwalia, Eero Lindholm, Leif Groop, Olle Melander
  (2011) Journal of Hypertension
  Journal article
2010
- A common variant in the PAX6 gene influences islet function in man
  Emma Ahlqvist, Fabiola Turrini, Stefan Lang, Targ Elgzyri, Yuedan Zhou, et al.
  (2010) Diabetologia
  Conference paper: abstract
- A family history of diabetes is associated with reduced physical fitness in the Prevalence, Prediction and Prevention of Diabetes (PPP)-Botnia study
  B. Isomaa, B. Forsen, K. Lahti, N. Holmstrom, J. Waden, et al.
  (2010) Diabetologia
  Journal article
- A mRNA marker for glycolytic muscle fibres may be used to determine fibre type composition in human skeletal muscle
  Anders H Olsson, Targ Elgzyri, Esa Laurila, Leif Groop, Ola Hansson, et al.
  (2010) Diabetologia
  Conference paper: abstract
- An empirical index of insulin sensitivity from short IVGTT: validation against the minimal model and glucose clamp indices in patients with different clinical characteristics
  A. Tura, S. Sbrignadello, E. Succurro, Leif Groop, G. Sesti, et al.
  (2010) Diabetologia
  Journal article
- An investigation of serum concentration of apoM as a potential MODY3 marker using a novel ELISA.
  Camilla Cervin, Olof Axler, Johan Holmkvist, Peter Almgren, E Rantala, et al.
  (2010) Journal of Internal Medicine1989-01-01+01:00
  Journal article
- Analysis of TBC1D4 in patients with severe insulin resistance
  S. Dash, C. Langenberg, K. A. Fawcett, R. K. Semple, S. Romeo, et al.
  (2010) Diabetologia
  Journal article (letter)
- Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
  Elizabeth K. Speliotes, Cristen J. Willer, Sonja I. Berndt, Keri L. Monda, Gudmar Thorleifsson, et al.
  (2010) Nature Genetics
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- Biological, clinical and population relevance of 95 loci for blood lipids
  Tanya M. Teslovich, Kiran Musunuru, Albert V. Smith, Andrew C. Edmondson, Ioannis M. Stylianou, et al.
  (2010) Nature
  Journal article
- Brain natriuretic peptide is related to diastolic dysfunction whereas urinary albumin excretion rate is related to left ventricular mass in asymptomatic type 2 diabetes patients
  Martin Magnusson, Stefan Jovinge, Kambiz Shahgaldi, Bo Israelsson, Leif Groop, et al.
  (2010) Cardiovascular Diabetology
  Journal article
- Common Inherited Variation in Mitochondrial Genes Is Not Enriched for Associations with Type 2 Diabetes or Related Glycemic Traits
  Ayellet V. Segre, Leif Groop, Vamsi K. Mootha, Mark J. Daly, David Altshuler
  (2010) PLoS Genetics
  Journal article
- Deoxyribonucleic Acid Methylation and Gene Expression of PPARGC1A in Human Muscle Is Influenced by High-Fat Overfeeding in a Birth-Weight-Dependent Manner.
  Charlotte Brøns, Stine Jacobsen, Emma E Nilsson, Tina Rönn, Christine B Jensen, et al.
  (2010) The Journal of clinical endocrinology and metabolism
  Journal article
- Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans
  Erik Ingelsson, Claudia Langenberg, Marie-France Hivert, Inga Prokopenko, Valeriya Lyssenko, et al.
  (2010)
  Conference paper
- Differences in associations between HSD11B1 gene expression and metabolic parameters in subjects with and without impaired glucose homeostasis
  C. Karlsson, M. Jernas, B. Olsson, T. Lystig, A. Gummesson, et al.
  (2010) Diabetes Research and Clinical Practice
  Journal article
- Effect of variants in the RORA gene on risk of type 2 diabetes
  Anna Jonsson, Sami Alkayyali, B. Isomaa, T. Tuomi, Leif Groop, et al.
  (2010) Diabetologia
  Conference paper: abstract
- Evidence that BMI and type 2 diabetes share only a minor fraction of genetic variance: a follow-up study of 23,585 monozygotic and dizygotic twins from the Finnish Twin Cohort Study
  M. Lehtovirta, K. H. Pietilainen, E. Levalahti, K. Heikkila, Leif Groop, et al.
  (2010) Diabetologia
  Journal article
- GAD Antibody Positivity Predicts Type 2 Diabetes in an Adult Population
  Virve M. Lundgren, Bo Isomaa, Valeriya Lyssenko, Esa Laurila, Pasi Korhonen, et al.
  (2010) Diabetes
  Journal article
- Genetic association analysis of LARS2 with type 2 diabetes
  E. Reiling, B. Jafar-Mohammadi, E. van't Riet, M. N. Weedon, J. V. van Vliet-Ostaptchouk, et al.
  (2010) Diabetologia
  Journal article
- Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes
  John R. B. Perry, Michael N. Weedon, Claudia Langenberg, Anne U. Jackson, Valeriya Lyssenko, et al.
  (2010) Human Molecular Genetics
  Journal article
- Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
  Richa Saxena, Marie-France Hivert, Claudia Langenberg, Toshiko Tanaka, James S. Pankow, et al.
  (2010) Nature Genetics
  Journal article
- Genetics of type 2 diabetes -Are we getting any closer?
  Leif Groop
  (2010) Endocrine Journal
  Conference paper: abstract
- Genome wide association analysis for free fatty acid levels in DGI
  Ivana Stojkovic, C. Saloranta, Peter Almgren, Valeriya Lyssenko, E. Laurila, et al.
  (2010) Diabetologia
  Conference paper: abstract
- Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution
  Cecilia M. Lindgren, Iris M. Heid, Joshua C. Randall, Claudia Lamina, Valgerdur Steinthorsdottir, et al.
  (2010) PLoS Genetics
  Journal article
- Genome-wide meta-analyses identify multiple loci associated with smoking behavior
  Helena Furberg, YunJung Kim, Jennifer Dackor, Eric Boerwinkle, Nora Franceschini, et al.
  (2010) Nature Genetics
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- Hundreds of variants clustered in genomic loci and biological pathways affect human height
  Hana Lango Allen, Karol Estrada, Guillaume Lettre, Sonja I. Berndt, Michael N. Weedon, et al.
  (2010) Nature
  Journal article
- Impact of exercise intensity and duration on insulin sensitivity in women with T2D.
  Åsa Tornberg, Forouzan Glans, Karl-Fredrik Eriksson, Anna Maria Drake, Leif Groop, et al.
  (2010) European Journal of Internal Medicine
  Journal article
- Individualizing Therapies in Type 2 Diabetes Mellitus Based on Patient Characteristics: What We Know and What We Need to Know.
  Robert Smith, David M Nathan, Silva A Arslanian, Leif Groop, Robert A Rizza, et al.
  (2010) The Journal of clinical endocrinology and metabolism
  Journal article
- Influence of novel genetic loci affecting glucose and insulin levels during OGTT on islet function in man
  Tarun Ahluwalia, Claes Ladenvall, Anna Jonsson, Jasmina Kravic, Esa Laurila, et al.
  (2010) Diabetologia
  Conference paper: abstract
- Investigation of Type 2 Diabetes Risk Alleles Support CDKN2A/B, CDKAL1, and TCF7L2 As Susceptibility Genes in a Han Chinese Cohort
  Jie Wen, Tina Rönn, Anders H Olsson, Zhen Yang, Bin Lu, et al.
  (2010) PLoS ONE
  Journal article
- Latent Autoimmune Diabetes in Adults Differs Genetically From Classical Type 1 Diabetes Diagnosed After the Age of 35 Years
  Mette K. Andersen, Virve Lundgren, Joni A. Turunen, Carol Forsblom, Bo Isomaa, et al.
  (2010) Diabetes Care
  Journal article
- Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
  Iris M. Heid, Anne U. Jackson, Joshua C. Randall, Thomas W. Winkler, Lu Qi, et al.
  (2010) Nature Genetics
  Journal article
- Minimal Contribution of Fasting Hyperglycemia to the Incidence of Type 2 Diabetes in Subjects With Normal 2-h Plasma Glucose
  Muhammad A. Abdul-Ghani, Michael P. Stern, Valeriya Lyssenko, Tiinamaija Tuomi, Leif Groop, et al.
  (2010) Diabetes Care
  Journal article
- New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
  Josee Dupuis, Claudia Langenberg, Inga Prokopenko, Richa Saxena, Nicole Soranzo, et al.
  (2010) Nature Genetics
  Journal article
- NordicDB: a Nordic pool and portal for genome-wide control data
  Monica Leu, Keith Humphreys, Ida Surakka, Emil Rehnberg, Juha Muilu, et al.
  (2010) European Journal of Human Genetics
  Journal article
- Open chromatin and diabetes risk.
  Leif Groop
  (2010) Nature Genetics
  Journal article
- Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes.
  Anders Rosengren, Ramunas Jokubka, Damon Tojjar, Charlotte Granhall, Ola Hansson, et al.
  (2010) Science (New York, N.Y.)
  Journal article
- Plasma copeptin and the risk of diabetes mellitus.
  Sofia Enhörning, Thomas J Wang, Peter Nilsson, Peter Almgren, Bo Hedblad, et al.
  (2010) Circulation
  Journal article
- Polymorphisms in α- And β-adrenergic receptor genes, hypertension, and obstructive sleep apnea : The skaraborg sleep study
  Kristina Bengtsson Boström, Jan Hedner, Ludger Grote, Olle Melander, Fredrik Von Wowern, et al.
  (2010) International Journal of Hypertension
  Journal article
- Prediction of postpartum diabetes in women with gestational diabetes mellitus
  M. Ekelund, Nael Shaat, Peter Almgren, Leif Groop, Kerstin Berntorp
  (2010) Diabetologia
  Journal article
- Resistance to exercise-induced changes in the global DNA methylation pattern of skeletal muscle in individuals with a family history of type 2 diabetes
  Marloes Dekker Nitert, Tasnim Dayeh, Stefan Lang, Targ Elgzyri, Yang De Marinis, et al.
  (2010) Diabetologia
  Conference paper: abstract
- Risk genotypes, allele-specific expression and methylation status in human islets at the KCNQ1 type 2 diabetes-susceptibility locus
  M. E. Travers, Marloes Dekker Nitert, D. J. G. Mackay, C. M. Lindgren, Leif Groop, et al.
  (2010) Diabetologia
  Conference paper: abstract
- Stressful Life Events and the Metabolic Syndrome - The Prevalence, Prediction and Prevention of Diabetes (PPP)-Botnia Study
  Antti-Jussi Pyykkonen, Katri Raikkonen, Tiinamaija Tuomi, Johan G. Eriksson, Leif Groop, et al.
  (2010) Diabetes Care
  Journal article
- TCF7L2-conferred apoptosis in pancreatic beta cells involves the p53 pathway
  Yuedan Zhou, Enming Zhang, Erik Renström, Leif Groop, Ola Hansson
  (2010) Diabetologia
  Conference paper: abstract
- The Association of Mitochondrial Content with Prevalent and Incident Type 2 Diabetes.
  Erwin Reiling, Charlotte Ling, André G Uitterlinden, Esther Van't Riet, Laura M C Welschen, et al.
  (2010) The Journal of clinical endocrinology and metabolism
  Journal article
- The shape of plasma glucose concentration curve during OGTT predicts future risk of type 2 diabetes
  Muhammad A. Abdul-Ghani, Valeriya Lyssenko, Tiinamaija Tuomi, Ralph A. DeFronzo, Leif Groop
  (2010) Diabetes/Metabolism Research Reviews
  Journal article
- Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
  Benjamin F. Voight, Laura J. Scott, Valgerdur Steinthorsdottir, Andrew P. Morris, Christian Dina, et al.
  (2010) Nature Genetics
  Journal article
2009
- A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals.
  Tina Rönn, J Wen, Z Yang, B Lu, Y Du, et al.
  (2009) Diabetologia
  Journal article
- A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans
  A. Kotronen, L. E. Johansson, L. M. Johansson, C. Roos, J. Westerbacka, et al.
  (2009) Diabetologia
  Journal article
- A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion.
  Anna Jonsson, Bo Isomaa, Tiinamaija Tuomi, Jalal Taneera, S Albert Salehi, et al.
  (2009) Diabetes
  Journal article
- Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults.
  A Jonsson, F Renström, Valeriya Lyssenko, E Brito, B Isomaa, et al.
  (2009) Diabetologia
  Journal article
- Calpain-10 expression is elevated in pancreatic islets from patients with type 2 diabetes.
  Charlotte Ling, Leif Groop, Silvia Del Guerra, Roberto Lupi
  (2009) PLoS ONE
  Journal article
- Clinical Risk Factors, DNA Variants, and the Development of Type 2 Diabetes THE AUTHORS REPLY
  Valeriya Lyssenko, Peter Nilsson, Leif Groop
  (2009) New England Journal of Medicine
  Journal article (letter)
- Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.
  Valeriya Lyssenko, Cecilia Nagorny, Michael R Erdos, Nils Wierup, Anna Jonsson, et al.
  (2009) Nature Genetics
  Journal article
- Common variants at 30 loci contribute to polygenic dyslipidemia
  Sekar Kathiresan, Cristen J. Willer, Gina M. Peloso, Serkalem Demissie, Kiran Musunuru, et al.
  (2009) Nature Genetics
  Journal article
- Control of ACAT2 Liver Expression by HNF4{alpha}. Lesson From MODY1 Patients.
  C Pramfalk, E Karlsson, Leif Groop, L L Rudel, B Angelin, et al.
  (2009) Arteriosclerosis, Thrombosis and Vascular Biology
  Journal article
- Disruption of TFB1M impairs insulin secretion in beta cells
  Thomas Köck, Marloes Dekker Nitert, A Olsson, Olga Kotova, Jelena Stamenkovic, et al.
  (2009) Diabetologia
  Conference paper: abstract
- Effect of pioglitazone versus insulin glargine on cardiac size, function, and measures of fluid retention in patients with type 2 diabetes
  Mozhgan Dorkhan, Magnus Dencker, Martin Stagmo, Leif Groop
  (2009) Cardiovascular Diabetology
  Journal article
- Effects of six months of moderate resistance-versus endurance-training on muscle ATP synthesis in first-degree relatives of patients with type 2 diabetes
  G. Kacerovsky-Bielesz, M. Chmelik, Charlotte Ling, R. Pokan, J. Szendroedi, et al.
  (2009) Diabetologia
  Conference paper: abstract
- Epigenetics: A Molecular Link Between Environmental Factors and Type 2 Diabetes
  Charlotte Ling, Leif Groop
  (2009) Diabetes
  Journal article review
- Evaluation of chloride channel-3 as a potential target for TCF7L2-dependent impairment of insulin secretion
  Xingjun Jing, Yuedan Zhou, Peter Osmark, Stefan Lang, Leif Groop, et al.
  (2009) Diabetologia
  Conference paper: abstract
- Evaluation of the effects of exercise on insulin sensitivity in Arabian and Swedish women with type 2 diabetes.
  Forouzan Glans, Karl-Fredrik Eriksson, Åsa Tornberg, Ola Thorsson, Per Wollmer, et al.
  (2009) Diabetes Research and Clinical Practice
  Journal article
- Fasting Versus Postload Plasma Glucose Concentration and the Risk for Future Type 2 Diabetes Results from the Botnia Study
  Muhammad A. Abdul-Ghani, Valeriya Lyssenko, Tiinamaija Tuomi, Ralph A. DeFronzo, Leif Groop
  (2009) Diabetes Care
  Journal article
- Functional Variant Disrupts Insulin Induction of USF1 Mechanism for USF1-Associated Dyslipidemias
  Jussi Naukkarinen, Emma Nilsson, Heikki A. Koistinen, Sanni Soderlund, Valeriya Lyssenko, et al.
  (2009) Circulation: Cardiovascular Genetics
  Journal article
- Genetic basis of beta-cell dysfunction in man.
  Leif Groop, Valeriya Lyssenko
  (2009) Diabetes, Obesity and Metabolism
  Journal article
- Genetic dissection of type 2 diabetes.
  Martin Ridderstråle, Leif Groop
  (2009) Molecular and Cellular Endocrinology
  Journal article
- Genetic variation in ATP5O is associated with skeletal muscle ATP50 mRNA expression and glucose uptake in young twins.
  Tina Rönn, Pernille Poulsen, Tiinamaija Tuomi, Bo Isomaa, Leif Groop, et al.
  (2009) PLoS ONE
  Journal article
- Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs
  Anke Toenjes, Moritz Koriath, Dorit Schleinitz, Kerstin Dietrich, Yvonne Boettcher, et al.
  (2009) Human Molecular Genetics
  Journal article
- Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts
  Anna Kotronen, Hannele Yki-Jarvinen, Anna Aminoff, Robert Bergholm, Kirsi H. Pietilainen, et al.
  (2009) European Journal of Endocrinology1994-01-01+01:00
  Journal article
- Genetics of type 2 diabetes. On overview.
  Leif Groop, Valeriya Lyssenko
  (2009) Endocrinologia y Nutricion
  Journal article
- Genome-wide association study for type 2 diabetes: clinical applications.
  Valeriya Lyssenko, Leif Groop
  (2009) Current Opinion in Lipidology
  Journal article
- Genome-wide association study identifies eight loci associated with blood pressure
  Christopher Newton-Cheh, Toby Johnson, Vesela Gateva, Martin D. Tobin, Murielle Bochud, et al.
  (2009) Nature Genetics
  Journal article
- Hyperactivity in adrenergic signalling via alpha2A receptors contributes to human type 2 diabetes
  Anders Rosengren, Ramunas Jokubka, Damon Tojjar, Charlotte Granhall, Jonatan Tuncel, et al.
  (2009) Diabetologia
  Conference paper: abstract
- Impaired Mitochondrial Function and Insulin Resistance of Skeletal Muscle in Mitochondrial Diabetes
  Julia Szendroedi, Albrecht Ingo Schmid, Martin Meyerspeer, Camilla Cervin, Michaela Kacerovsky, et al.
  (2009)
  Conference paper
- Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes
  N. Pulizzi, Valeriya Lyssenko, Anna Jonsson, C. Osmond, M. Laakso, et al.
  (2009) Diabetologia
  Journal article
- Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant-174GC with circulating glucose levels, interleukin-6 levels, and body mass index
  Cornelia Huth, Thomas Illig, Christian Herder, Christian Gieger, Harald Grallert, et al.
  (2009) Annals of Medicine
  Journal article
- Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene.
  Hindrik Mulder, Cecilia Nagorny, Valeriya Lyssenko, Leif Groop
  (2009) Diabetologia
  Journal article
- Novel Genetic Loci Implicated in Fasting Glucose Homeostasis and Their Impact on Related Metabolic Traits
  Josee Dupuis, Claudia Langenberg, Inga Prokopenko, Richa Saxena, Nicole Soranzo, et al.
  (2009) Genetic Epidemiology
  Conference paper: abstract
- Prediction of Non-Alcoholic Fatty Liver Disease and Liver Fat Using Metabolic and Genetic Factors
  Anna Kotronen, Markku Peltonen, Antti Hakkarainen, Ksenia Sevastianova, Robert Bergholm, et al.
  (2009) Gastroenterology
  Journal article
- Previously Associated Type 2 Diabetes Variants May Interact With Physical Activity to Modify the Risk of Impaired Glucose Regulation and Type 2 Diabetes A Study of 16,003 Swedish Adults
  Ema C. Brito, Valeriya Lyssenko, Frida Renstrom, Göran Berglund, Peter Nilsson, et al.
  (2009) Diabetes
  Journal article
- Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus
  Hemang Parikh, Valeriya Lyssenko, Leif Groop
  (2009) BMC Medical Genomics
  Journal article
- Regulation and Function of FTO mRNA Expression in Human Skeletal Muscle and Subcutaneous Adipose Tissue
  Louise G. Grunnet, Emma Nilsson, Charlotte Ling, Torben Hansen, Oluf Pedersen, et al.
  (2009) Diabetes
  Journal article
- Short-Term Exercise Training Does Not Stimulate Skeletal Muscle ATP Synthesis in Relatives of Humans With Type 2 Diabetes
  Gertrud Kacerovsky-Bielesz, Marek Chmelik, Charlotte Ling, Rochus Pokan, Julia Szendroedi, et al.
  (2009) Diabetes
  Journal article
- Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
  Cristen J. Willer, Elizabeth K. Speliotes, Ruth J. F. Loos, Shengxu Li, Cecilia M. Lindgren, et al.
  (2009) Nature Genetics
  Journal article
- The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men
  K. Pilgaard, C. B. Jensen, J. H. Schou, Valeriya Lyssenko, L. Wegner, et al.
  (2009) Diabetologia
  Journal article
- The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects
  Helene Choquet, Christine Cavalcanti-Proenca, Cecile Lecoeur, Christian Dina, Stephane Cauchi, et al.
  (2009) Human Molecular Genetics
  Journal article
- The diabetes risk score outperforms fasting plasma glucose and glucose tolerance tests: combined results from the Inter99 and Botnia Studies
  M. P. McKenna, Valeriya Lyssenko, M. Rowe, R. Gerwien, J. Kolberg, et al.
  (2009) Diabetologia
  Conference paper: abstract
- The impact of differential splicing of TCF7L2 on target gene expression in human islet of Langerhans
  Yuedan Zhou, Stefan Lang, Jalal Taneera, Erik Renström, Leif Groop, et al.
  (2009) Diabetologia
  Conference paper: abstract
- Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion.
  Siri Malmgren, David Nicholls, Jalal Taneera, Karl Bacos, Thomas Koeck, et al.
  (2009) Journal of Biological Chemistry
  Journal article
- Tissue-specific alternative splicing of TCF7L2
  Ludmila Prokunina-Olsson, Cullan Welch, Ola Hansson, Neeta Adhikari, Laura J. Scott, et al.
  (2009) Human Molecular Genetics
  Journal article
- Underlying Genetic Models of Inheritance in Established Type 2 Diabetes Associations
  Georgia Salanti, Lorraine Southam, David Altshuler, Kristin Ardlie, Ines Barroso, et al.
  (2009) American Journal of Epidemiology
  Journal article review
- Unique splicing pattern of the TCF7L2 gene in human pancreatic islets.
  Peter Osmark, Ola Hansson, Anna Jonsson, Tina Rönn, Leif Groop, et al.
  (2009) Diabetologia
  Journal article
- Variants in MTNR1B influence fasting glucose levels
  Inga Prokopenko, Claudia Langenberg, Jose C. Florez, Richa Saxena, Nicole Soranzo, et al.
  (2009) Nature Genetics
  Journal article
2008
- A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population
  Caroline Brorsson, Regine Bergholdt, Marketa Sjögren, Stefanie Eising, Karina Meden Sorensen, et al.
  (2008) Molecular Genetics and Metabolism
  Journal article
- Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle.
  Tina Rönn, P Poulsen, Ola Hansson, Johan Holmkvist, Peter Almgren, et al.
  (2008) Diabetologia
  Journal article
- Assessment of exercise capacity in women with type 2 diabetes.
  Åsa Tornberg, Forouzan Glans, Karl-Fredrik Eriksson, Leif Groop, Ola Thorsson, et al.
  (2008) Clinical Physiology and Functional Imaging2002-01-01+01:00
  Journal article
- Association between LTA, TNF and AGER polymorphisms and late diabetic complications.
  Eero Lindholm, Ekaterine Bakhtadze, Corrado Cilio, Elisabet Agardh, Leif Groop, et al.
  (2008) PLoS ONE
  Journal article
- C/EBP{alpha} in adipose tissue regulates genes in lipid and glucose metabolism and a genetic variation in C/EBP{alpha} is associated with serum levels of triglycerides.
  Louise E Olofsson, Marju Orho-Melander, Lena William-Olsson, Kajsa Sjöholm, Lars Sjöström, et al.
  (2008) Journal of Clinical Endocrinology and Metabolism
  Journal article
- Can complement factors 5 and 8 and transthyretin be used as biomarkers for MODY 1 (HNF4A-MODY) and MODY 3 (HNF1A-MODY)?
  Ella Ekholm, Nael Shaat, Leif Groop
  (2008) Diabetic medicine : a journal of the British Diabetic Association
  Journal article
- Clinical risk factors, DNA variants, and the development of type 2 diabetes.
  Valeriya Lyssenko, Anna Jonsson, Peter Almgren, Nicolo Pulizzi, Bo Isomaa, et al.
  (2008) New England Journal of Medicine
  Journal article
- Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes
  Johan Holmkvist, Peter Almgren, Valeriya Lyssenko, Cecilia M Lindgren, Karl-Fredrik Eriksson, et al.
  (2008) Diabetes
  Journal article
- Common variants in or around the JAZF1, CDKN2A/2B, CDKAL1 and WFS1 genes discriminate between autoimmune and non-autoimmune diabetes
  Ekaterine Bakhtadze, Eero Lindholm, Valeriya Lyssenko, H. J. Arnkvist, J. Bolinder, et al.
  (2008) Diabetologia
  Conference paper: abstract
- Common variants in the TCF7L2 gene help to differentiate autoimmune from non-autoimmune diabetes in young (15-34 years) but not in middle-aged (40-59 years) diabetic patients.
  Ekaterine Bakhtadze, Camilla Cervin, Eero Lindholm, Henrik Borg, P Nilsson, et al.
  (2008) Diabetologia
  Journal article
- Common variants near MC4R are associated with fat mass, weight and risk of obesity
  Ruth J. F. Loos, Cecilia M. Lindgren, Shengxu Li, Eleanor Wheeler, Jing Hua Zhao, et al.
  (2008) Nature Genetics
  Journal article
- Differences in effects of insulin glargine or pioglitazone added to oral anti-diabetic therapy in patients with type 2 diabetes What to add-Insulin glargine or pioglitazone?
  Mozhgan Dorkhan, Anders Frid, Leif Groop
  (2008) Diabetes Research and Clinical Practice
  Journal article
- Discerning the ancestry of European Americans in genetic association studies
  Alkes L. Price, Johannah Butler, Nick Patterson, Cristian Capelli, Vincenzo L. Pascali, et al.
  (2008) PLoS Genetics
  Journal article
- Effect of exercise on gene transcript profiles in skeletal muscle of individuals with and without a family history of diabetes
  Ola Hansson, Targ Elgzyri, Hemang Parikh, Karl-Fredrik Eriksson, Leif Groop
  (2008) Diabetologia
  Conference paper: abstract
- Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion.
  Charlotte Ling, S Del Guerra, R Lupi, Tina Rönn, Charlotte Granhall, et al.
  (2008) Diabetologia
  Journal article
- Expression of the transcription factor 7-like 2 gene (TCF7L2) in human adipocytes is down regulated by insulin.
  Maja Ahlzén, Lovisa E Johansson, Camilla Cervin, Hans Tornqvist, Leif Groop, et al.
  (2008) Biochemical and Biophysical Research Communications
  Journal article
- Genes and type 2 diabetes mellitus.
  Leif Groop, Valeriya Lyssenko
  (2008) Current Diabetes Reports
  Journal article
- Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study)
  J K Hertel, S Johansson, H Raeder, K Midthjell, Valeriya Lyssenko, et al.
  (2008) Diabetologia
  Journal article
- Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes
  Camilla Cervin, Valeriya Lyssenko, Ekaterine Bakhtadze, Eero Lindholm, Peter Nilsson, et al.
  (2008) Diabetes
  Journal article
- Genetic variation in ATP5O is associated with mRNA expression in human skeletal muscle and in vivo glucose uptake
  Tina Rönn, P. Poulsen, Leif Groop, A. Vaag, Charlotte Ling
  (2008) Diabetologia
  Conference paper: abstract
- Identification of ten loci associated with height highlights new biological pathways in human growth
  Guillaume Lettre, Anne U. Jackson, Christian Gieger, Fredrick R. Schumacher, Sonja I. Berndt, et al.
  (2008) Nature Genetics
  Journal article
- Immigrants from the Middle-East have a different form of Type 2 diabetes compared with Swedish patients.
  Forouzan Glans, Targ Elgzyri, Nael Shaat, Eero Lindholm, Jan Apelqvist, et al.
  (2008) Diabetic medicine : a journal of the British Diabetic Association
  Journal article
- Independent introduction of two lactase-persistence alleles into human populations reflects different history of adaptation to milk culture
  Nabil Sabri Enattah, Tine G. K. Jensen, Mette Nielsen, Rikke Lewinski, Mikko Kuokkanen, et al.
  (2008) American Journal of Human Genetics
  Journal article
- Independent measures of insulin secretion and insulin sensitivity during the same test: the glucagon-insulin tolerance test.
  Mozhgan Dorkhan, Devjit Tripathy, G Malm, H Asgharian, Tiinamaija Tuomi, et al.
  (2008) Journal of Internal Medicine1989-01-01+01:00
  Journal article
- Interactions between genes and birth size for development of type 2 diabetes
  Nicolo Pulizzi, Valeriya Lyssenko, Anna Jonsson, C. Osmond, E. Kajantie, et al.
  (2008) Diabetologia
  Conference paper: abstract
- Is there a unifying genetic factor predisposing to the metabolic syndrome?
  Marketa Sjögren, Marju Orho-Melander, Anna Jonsson, Margareta Svensson, Göran Berglund, et al.
  (2008) Diabetologia
  Conference paper: abstract
- Large-scale association study between two coding LRP5 gene polymorphisms and bone phenotypes and fractures in men
  E Grundberg, EM Lau, M Lorentzson, Magnus Karlsson, Anna H Holmberg, et al.
  (2008) Osteoporosis International
  Journal article
- Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
  Eleftheria Zeggini, Laura J. Scott, Richa Saxena, Benjamin F. Voight, Jonathan L. Marchini, et al.
  (2008) Nature Genetics
  Journal article
- Metabolic effects of novel type 2 diabetes genes in a population aged 18-75 years
  Anna Jonsson, B. Isomaa, Tiinamaija Tuomi, Valeriya Lyssenko, Leif Groop
  (2008) Diabetologia
  Conference paper: abstract
- New insights into impaired muscle glycogen synthesis.
  Leif Groop, Marju Orho-Melander
  (2008) PLoS Medicine
  Journal article (letter)
- PGC-1 alpha and PGC-1 beta are related to markers for fibre type composition in human skeletal muscle
  Anders H Olsson, Tina Rönn, A. Vaag, Leif Groop, P. Poulsen, et al.
  (2008) Diabetologia
  Conference paper: abstract
- Polymorphism associated with cholesterol and risk of cardiovascular events
  Sekar Kathiresan, Olle Melander, Dragi Anevski, Candace Guiducci, Noël Burtt, et al.
  (2008) New England Journal of Medicine
  Journal article
- Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
  Sekar Kathiresan, Olle Melander, Candace Guiducci, Aarti Surti, Noel P Burtt, et al.
  (2008) Nature Genetics
  Journal article
- Strategies for Conditional Two-Locus Nonparametric Linkage Analysis.
  Lars Ängquist, Ola Hössjer, Leif Groop
  (2008) Human Heredity
  Journal article
- The Pro12Ala polymorphism of the PPAR-gamma2 gene affects associations of fish intake and marine n-3 fatty acids with glucose metabolism
  SK Ylonen, I Salminen, Valeriya Lyssenko, SM Virtanen, Leif Groop, et al.
  (2008) European Journal of Clinical Nutrition
  Journal article
- The search for putative unifying genetic factors for components of the metabolic syndrome.
  Marketa Sjögren, Valeriya Lyssenko, Anna Jonsson, Göran Berglund, Peter Nilsson, et al.
  (2008) Diabetologia
  Journal article
- Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus
  Kazuki Yasuda, Kazuaki Miyake, Yukio Horikawa, Kazuo Hara, Haruhiko Osawa, et al.
  (2008) Nature Genetics
  Journal article
- Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.
  Wei-Min Chen, Michael R Erdos, Anne U Jackson, Richa Saxena, Serena Sanna, et al.
  (2008) Journal of Clinical Investigation
  Journal article
2007
- A common variant of HMGA2 is associated with adult and childhood height in the general population
  Michael N. Weedon, Guillaume Lettre, Rachel M. Freathy, Cecilia M. Lindgren, Benjamin F. Voight, et al.
  (2007) Nature Genetics
  Journal article
- A variant in the transcription factor 7-like 2 (TCF7L2) gene is associated with an increased risk of gestational diabetes mellitus.
  Nael Shaat, Åke Lernmark, Ella Ekholm, Sten Ivarsson, Hemang Parikh, et al.
  (2007) Diabetologia
  Journal article
- Associating mitochondrial DNA variation with complex traits - Reply to Elson et al.
  Richa Saxena, Paul I. W. de Bakker, Leif Groop, Mark J. Daly, David Altshuler
  (2007) American Journal of Human Genetics
  Journal article (letter)
- Association of microsatellite polymorphisms of the human 14q13.2 region with type 2 diabetes mellitus in latvian and finnish populations
  T. Sjakste, M. Kalis, I. Poudziunas, V. Pirags, M. Lazdins, et al.
  (2007) Annals of Human Genetics
  Journal article
- Association studies of BMI and type 2 diabetes in the neuropeptide y pathway - A possible role for NPY2R as a candidate gene for type 2 diabetes in men
  Catarina D. Campbell, Helen N. Lyon, James Nemesh, Jared A. Drake, Tiinamaija Tuomi, et al.
  (2007) Diabetes
  Journal article
- Association testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetes
  J. C. Florez, Marketa Sjögren, C. M. Agapakis, N. P. Burtt, Peter Almgren, et al.
  (2007) Diabetologia
  Journal article
- COX-2 and SCD, markers of inflammation and adipogenesis, are related to disease activity in Graves' ophthalmopathy
  Tereza Planck, Annika de Capretz, Hemang Parikh, Christofer Frenander, Peter Åsman, et al.
  (2007) Thyroid
  Journal article
- Evidence of still-ongoing convergence evolution of the lactase persistence T-13910 alleles in humans
  Nabil Sabri Enattah, Aimee Trudeau, Ville Pimenoff, Luigi Maiuri, Salvatore Auricchio, et al.
  (2007) American Journal of Human Genetics
  Journal article
- From fused toes in mice to human obesity
  Leif Groop
  (2007) Nature Genetics
  Journal article (comment)
- Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle
  Charlotte Ling, Pernille Poulsen, Stina Simonsson, Tina Rönn, Johan Holmkvist, et al.
  (2007) Journal of Clinical Investigation
  Journal article
- Genetics of gestational diabetes mellitus.
  Nael Shaat, Leif Groop
  (2007) Current Medicinal Chemistry
  Journal article review
- Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
  Richa Saxena, Benjamin F. Voight, Valeriya Lyssenko, Noel P. Burtt, Paul I. W. de Bakker, et al.
  (2007) Science
  Journal article
- Impact of the peroxisome proliferator activated receptor-gamma coactivator-1 beta (PGC-1 beta) Ala203Pro polymorphism on in vivo metabolism, PGC-1 beta expression and fibre type composition in human skeletal muscle
  Charlotte Ling, L. Wegner, G. Andersen, Peter Almgren, T. Hansen, et al.
  (2007) Diabetologia
  Journal article
- Interaction between the angiotensin-converting enzyme gene insertion/deletion polymorphism and obstructive sleep apnoea as a mechanism for hypertension.
  Kristina Bengtsson Boström, Jan Hedner, Olle Melander, Ludger Grote, Bo Gullberg, et al.
  (2007) Journal of Hypertension
  Journal article
- MODY--en autosomalt dominant form av diabetes. Diagnos via gentestning ger bättre behandling
  Ella Ekholm, Leif Groop
  (2007) Läkartidningen
  Journal article
- Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.
  Valeriya Lyssenko, Roberto Lupi, Piero Marchetti, Silvia Del Guerra, Marju Orho-Melander, et al.
  (2007) Journal of Clinical Investigation
  Journal article
- Polymorphisms in the gene encoding the voltage-dependent Ca(2+) channel Ca (V)2.3 (CACNA1E) are associated with type 2 diabetes and impaired insulin secretion
  Johan Holmkvist, Damon Tojjar, Peter Almgren, Valeriya Lyssenko, C M Lindgren, et al.
  (2007) Diabetologia
  Journal article
- Regulation of skeletal muscle PPAR delta mRNA expression in twins
  Emma Nilsson, Pernille Poulsen, Marketa Sjögren, Charlotte Ling, Martin Ridderstråle, et al.
  (2007) Journal of Physiology
  Journal article
- Relationships of plasma adiponectin level and adiponectin receptors 1 and 2 gene expression to insulin sensitivity and glucose and fat metabolism in monozygotic and dizygotic twins.
  Heidi Storgaard, Pernille Poulsen, Charlotte Ling, Leif Groop, Allan A Vaag
  (2007) Journal of Clinical Endocrinology and Metabolism
  Journal article
- TXNIP regulates peripheral glucose metabolism in humans
  Hemang Parikh, Emma A Nilsson, William A. Chutkow, Lovisa Johansson, Heidi Storgaard, et al.
  (2007) PLoS Medicine
  Journal article
- The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts
  Helen N. Lyon, Valur Emilsson, Anke Hinney, Iris M. Heid, Jessica Lasky-Su, et al.
  (2007) PLoS Genetics
  Journal article
- The intake of potatoes and glucose metabolism in subjects at high risk for Type 2 diabetes
  S. K. Ylonen, S. M. Virtanen, Leif Groop
  (2007) Diabetic Medicine
  Journal article (letter)
- Thyrostimulin (a TSH-like Hormone) Expression in Orbital and Thyroid Tissue.
  Mikael Lantz, Tereza Planck, Annika Capretz, Emma Nilsson, Christofer Frenander, et al.
  (2007) Thyroid
  Journal article
- Tyypin 2 diabeteksen genetiikka selviamassa. Taustalla monen heikkotehoisen alttiusgeenin yhteispeli
  Leif Groop, Valeriya Lyssenko, Tiinamaija Tuomi
  (2007) Duodecim
  Journal article
- Tyypin 2 diabeteksen genetiikka selviämässä. Taustalla monen heikkotehoisen alttiusgeenin yhteispeli.
  Leif Groop, Valeriya Lyssenko, Tiinamaija Tuomi
  (2007) Duodecim
  Journal article
- Variants in the FFAR1 Gene Are Associated with Beta Cell Function
  Martins Kalis, Per Levéen, Valeriya Lyssenko, Peter Almgren, Leif Groop, et al.
  (2007) PLoS ONE
  Journal article
- Variation in GYS1 Interacts with Exercise and Gender to Predict Cardiovascular Mortality.
  Jenny Fredriksson, Dragi Anevski, Peter Almgren, Marketa Sjögren, Valeriya Lyssenko, et al.
  (2007) PLoS ONE
  Journal article
- Yksi, kaksi vai monta diabetesta?
  Markku Laakso, Leif Groop
  (2007) Duodecim
  Journal article
2006
- A dietary exchange of common bread for tailored bread of low glycaemic index and rich in dietary fibre improved insulin economy in young women with impaired glucose tolerance.
  Elin Östman, Anders Frid, Leif Groop, Inger Björck
  (2006) European Journal of Clinical Nutrition
  Journal article
- A polymorphism in the adiponectin gene influences adiponectin expression levels in visceral fat in obese subjects
  Jenny Fredriksson, Emma A Nilsson, Marju Orho-Melander, Leif Groop, Martin Ridderstråle
  (2006) International Journal of Obesity
  Journal article
- Analysis of the interleukin-1 and interleukin-6 polymorphisms in patients with chronic periodontitis. A pilot study
  H Jansson, Valeriya Lyssenko, A Gustavsson, K Hamberg, B Soderfeldt, et al.
  (2006) Swedish Dental Journal1977-01-01+01:00
  Journal article
- Association of the calpain-10 gene with type 2 diabetes in Europeans: Results of pooled and meta-analyses
  Takafumi Tsuchiya, Peter E. H. Schwarz, Laura del Bosque-Plata, M. Geoffrey Hayes, Christian Dina, et al.
  (2006) Molecular Genetics and Metabolism
  Journal article
- Authors' reply.
  Valeriya Lyssenko, Dragi Anevski, Peter Almgren, Leif Groop
  (2006) PLoS Medicine
  Journal article (letter)
- Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals
  Richa Saxena, Lauren Gianniny, Noel P. Burtt, Valeriya Lyssenko, Candace Giuducci, et al.
  (2006) Diabetes
  Journal article
- Common variants in HNF-1 alpha and risk of type 2 diabetes.
  Johan Holmkvist, C Cervin, Valeriya Lyssenko, W Winckler, Dragi Anevski, et al.
  (2006) Diabetologia
  Journal article
- Common variants in MODY genes increase the risk of gestational diabetes mellitus.
  Nael Shaat, Ella Ekholm, Åke Lernmark, Sten Ivarsson, Kristian Lynch, et al.
  (2006) Diabetologia
  Journal article
- Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity
  Helen N. Lyon, Jose C. Florez, Todd Bersaglieri, Richa Saxena, Wendy Winckler, et al.
  (2006) Diabetes
  Journal article
- Complex Relationship Between Blood Pressure and Mortality in Type 2 Diabetic Patients. A Follow-Up of the Botnia Study.
  Mats Ronnback, Bo Isomaa, Johan Fagerudd, Carol Forsblom, Per-Henrik Groop, et al.
  (2006) Hypertension
  Journal article
- Comprehensive association testing of common mitochondrial DNA variation in metabolic disease
  R Saxena, PIW de Bakker, K Singer, V Mootha, N Burtt, et al.
  (2006) American Journal of Human Genetics
  Journal article
- Genetic and nongenetic determinants of skeletal muscle glucose transporter 4 messenger ribonucleic acid levels and insulin action in twins
  H Storgaard, P Poulsen, Charlotte Ling, Leif Groop, A A Vaag
  (2006) Journal of Clinical Endocrinology and Metabolism
  Journal article
- Glycemic and non-glycemic effects of pioglitazone in triple oral therapy in patients with type 2 diabetes mellitus
  M Dorkhan, Martin Magnusson, A Frid, A Grubb, L Groop, et al.
  (2006) Journal of Internal Medicine1989-01-01+01:00
  Journal article
- HLA-DQB1 genotypes, islet antibodies and beta cell function in the classification of recent-onset diabetes among young adults in the nationwide Diabetes Incidence Study in Sweden.
  Ekaterine Bakhtadze, Henrik Borg, G Stenstrom, Per Fernlund, H Arnqvist, et al.
  (2006) Diabetologia
  Journal article
- High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people
  JC Florez, S Wiltshire, CM Agapakis, NP Burtt, PIW de Bakker, et al.
  (2006) Diabetes
  Journal article
- IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies
  Cornelia Huth, Iris M. Heid, Caren Vollmert, Christian Gieger, Harald Grallert, et al.
  (2006) Diabetes
  Journal article
- Improved prandial glucose control with lower risk of hypoglycemia with nateglinide than with glibenclamide in patients with maturity-onset diabetes of the young type 3
  T Tuomi, L Sarelin, EH Honkanen, Leif Groop, B Isomaa
  (2006) Diabetes Care
  Journal article
- Latent autoimmune diabetes in adults (LADA)-more than a name.
  Leif Groop, T Tuomi, M Rowley, P Zimmet, I Mackay
  (2006) Diabetologia
  Journal article (comment)
- Long-term beneficial effects of glipizide treatment on glucose tolerance in subjects with impaired glucose tolerance
  JG Eriksson, M Lehtovirta, B Ehrnstrom, S Salmela, Leif Groop
  (2006) Journal of Internal Medicine1989-01-01+01:00
  Journal article
- Polymorphism in the MHC2TA gene is associated with features of the metabolic syndrome and cardiovascular mortality.
  Eero Lindholm, Olle Melander, Peter Almgren, Göran Berglund, Carl-David Agardh, et al.
  (2006) PLoS ONE
  Journal article
- The -374 T/A polymorphism in the gene encoding RAGE is associated with diabetic nephropathy and retinopathy in type 1 diabetic patients.
  Eero Lindholm, Ekaterine Bakhtadze, Marketa Sjögren, Corrado Cilio, Elisabet Agardh, et al.
  (2006) Diabetologia
  Journal article
- The Kruppel-like factor 11 (KLF11) Q62R polymorphism is not associated with type 2 diabetes in 8,676 people
  Jose C. Florez, Richa Saxena, Wendy Winckler, Noel P. Burtt, Peter Almgren, et al.
  (2006) Diabetes
  Journal article
- The hormone-sensitive lipase C-60G promoter polymorphism is associated with increased waist circumference in normal-weight subjects.
  Emma A Nilsson, L Johansson, Kristoffer Ström, J Hoffstedt, Leif Groop, et al.
  (2006) International Journal of Obesity
  Journal article
- Transferability of tag SNPs in genetic association studies in multiple populations
  Paul I. W. de Bakker, Noel P. Burtt, Robert R. Graham, Candace Guiducci, Roman Yelensky, et al.
  (2006) Nature Genetics
  Journal article
- Treatment with a thiazolidinedione increases eye protrusion in a subgroup of patients with type 2 diabetes.
  Mozhgan Dorkhan, Mikael Lantz, Anders Frid, Leif Groop, Bengt Hallengren
  (2006) Clinical Endocrinology
  Journal article
- Type 2 diabetes and risk for periodontal disease: a role for dental health awareness
  H Jansson, Eero Lindholm, C Lindh, Leif Groop, G Bratthall
  (2006) Journal of Clinical Periodontology
  Journal article
- Variation in the adiponutrin gene influences its expression and associates with obesity.
  Lovisa Johansson, Johan Hoffstedt, Hemang Parikh, Emma A Nilsson, Martin Wabitsch, et al.
  (2006) Diabetes
  Journal article
2005
- A male-specific quantitative trait locus on 1p21 controlling human stature
  S Sammalisto, T Hiekkalinna, E Suviolahti, K Sood, A Metzidis, et al.
  (2005) Journal of Medical Genetics
  Journal article
- Association of common variation in the HNF1 alpha gene region with risk of type 2 diabetes
  W Winckler, N P Burtt, Johan Holmkvist, Camilla Cervin, P I W de Bakker, et al.
  (2005) Diabetes
  Journal article
- Association of the E23K polymorphism in the KCNJ11 gene with gestational diabetes mellitus.
  Nael Shaat, M Ekelund, Åke Lernmark, Sten Ivarsson, Peter Almgren, et al.
  (2005) Diabetologia
  Journal article
- Association testing of the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes in 7,883 people
  J C Florez, C M Agapakis, N P Burtt, M Sun, Peter Almgren, et al.
  (2005) Diabetes
  Journal article
- Association testing of variants in the hepatocyte nuclear factor 4 alpha gene with risk of type 2 diabetes in 7,883 people
  W Winckler, R R Graham, P I W de Bakker, M Sun, Peter Almgren, et al.
  (2005) Diabetes
  Journal article
- Calpain 10 and type 2 diabetes: are we getting closer to an explanation?
  Martin Ridderstråle, Hemang Parikh, Leif Groop
  (2005) Current Opinion in Clinical Nutrition and Metabolic Care
  Journal article
- Demonstrating stratification in a European American population
  C D Campbell, E L Ogburn, K L Lunetta, H N Lyon, M L Freedman, et al.
  (2005) Nature Genetics
  Journal article
- Dipping and variability of blood pressure and heart rate at night are heritable traits.
  Cristiano Fava, Philippe Burri, Peter Almgren, Guido Arcaro, Leif Groop, et al.
  (2005)
  Conference paper
- Genetic and Nongenetic Regulation of CAPN10 mRNA Expression in Skeletal Muscle.
  Emma A Nilsson, Pernille Poulsen, Heidi Storgaard, Peter Almgren, Charlotte Ling, et al.
  (2005) Diabetes
  Journal article
- Genetic and non-genetic determinants of skeletal muscle GLUT4 mRNA levels and insulin action in twins.
  Heidi Storgaard, Pernille Poulsen, Charlotte Ling, Leif Groop, Allan A Vaag
  (2005) Journal of Clinical Endocrinology and Metabolism
  Journal article
- Genetic prediction of future type 2 diabetes
  Valeriya Lyssenko, Peter Almgren, Dragi Anevski, Marju Orho-Melander, Marketa Sjögren, et al.
  (2005) PLoS Medicine
  Journal article
- Genetic testing for maturity onset diabetes of the young: uptake, attitudes and comparison with hereditary non-polyposis colorectal cancer
  B Liljestrom, K Aktan-Collan, B Isomaa, L Sarelin, A Uutela, et al.
  (2005) Diabetologia
  Journal article
- Haplotype construction of the FRDA gene and evaluation of its role in type II diabetes.
  Johan Holmkvist, Peter Almgren, Hemang Parikh, Marco Zucchelli, Juha Kere, et al.
  (2005) European Journal of Human Genetics
  Journal article
- Heritability of model-derived parameters of beta cell secretion during intravenous and oral glucose tolerance tests: a study of twins
  M Lehtovirta, J Kaprio, Leif Groop, M Trombetta, RC Bonadonna
  (2005) Diabetologia
  Journal article
- Insulin sensitivity in adults with growth hormone deficiency and effect of growth hormone treatment.
  Leif Groop, Mikael Segerlantz, Margareta Bramnert
  (2005) Hormone Research
  Journal article
- Nt-proANP in plasma, a marker of salt sensitivity, is reduced in type 2 diabetes patients.
  Olle Melander, E Frandsen, Martin Magnusson, Anders Grubb, Stefan Jovinge, et al.
  (2005) Journal of Internal Medicine1989-01-01+01:00
  Journal article
- Overexpression of immediate early genes in active Graves' ophthalmopathy.
  Mikael Lantz, Tereza Planck, Hemang Parikh, Christofer Frenander, Martin Ridderstråle, et al.
  (2005) Journal of Clinical Endocrinology and Metabolism
  Journal article
- Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes.
  Valeriya Lyssenko, Peter Almgren, Dragi Anevski, Roland Perfekt, Kaj Lahti, et al.
  (2005) Diabetes
  Journal article
- Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men
  N Pitteloud, VK Mootha, AA Dwyer, M Hardin, H Lee, et al.
  (2005) Diabetes Care
  Journal article
- Role of the FOXC2 -512C>T polymorphism in type 2 diabetes: possible association with the dysmetabolic syndrome.
  Emma A Nilsson, Leif Groop, Martin Ridderstråle
  (2005) International Journal of Obesity
  Journal article
2004
- Association between a polymorphism in the carboxyl ester lipase gene and serum cholesterol profile
  SH Bengtsson-Ellmark, J Nilsson, Marju Orho-Melander, K Dahlenborg, Leif Groop, et al.
  (2004) European Journal of Human Genetics
  Journal article
- Association testing in 9,000 people fails to confirm the association of the insulin receptor substrate-1 G972R polymorphism with type 2 diabetes
  JC Florez, Marketa Sjögren, N Burtt, Marju Orho-Melander, S Schayer, et al.
  (2004) Diabetes
  Journal article
- Candidate genes for type 2 diabetes.
  Hemang Parikh, Leif Groop
  (2004) Reviews in Endocrine and Metabolic Disorders
  Journal article review
- Characterization of the human skeletal muscle glycogen synthase gene (GYS1) promoter.
  Jenny Fredriksson, Martin Ridderstråle, Leif Groop, Marju Orho-Melander
  (2004) European Journal of Clinical Investigation
  Journal article
- Contribution of insulin-stimulated glucose uptake and basal hepatic insulin sensitivity to surrogate measures of insulin sensitivity.
  Devjit Tripathy, Peter Almgren, Tiinamaija Tuomi, Leif Groop
  (2004) Diabetes Care
  Journal article
- Cosegregation of MIDD and MODY in a Pedigree: Functional and Clinical Consequences.
  Camilla Cervin, Brita Liljeström, Tiinamaija Tuomi, Seija Heikkinen, Juha S Tapanainen, et al.
  (2004) Diabetes
  Journal article
- Effects of morning cortisol replacement on glucose and lipid metabolism in GH-treated subjects.
  Mikael Segerlantz, Margareta Bramnert, Ronnie Thomasson, Per Manhem, Esa Laurila, et al.
  (2004) European Journal of Endocrinology1994-01-01+01:00
  Journal article
- Elevated Plasma Levels of Nt-proBNP in Patients With Type 2 Diabetes Without Overt Cardiovascular Disease.
  Martin Magnusson, Olle Melander, Bo Israelsson, Anders Grubb, Leif Groop, et al.
  (2004) Diabetes Care
  Journal article
- Genotypic and phenotypic differences between Arabian and Scandinavian women with gestational diabetes mellitus.
  Nael Shaat, M. Ekelund, Åke Lernmark, Sten Ivarsson, A. Nilsson, et al.
  (2004) Diabetologia
  Journal article
- Haplotype Structure and Genotype-Phenotype Correlations of the Sulfonylurea Receptor and the Islet ATP-Sensitive Potassium Channel Gene Region.
  Jose C. Florez, Noël Burtt, Paul I.W. De Bakker, Peter Almgren, Tiinamaija Tuomi, et al.
  (2004) Diabetes
  Journal article
- Heritability of ambulatory and office blood pressure phenotypes in Swedish families.
  Cristiano Fava, Philippe Burri, Peter Almgren, Leif Groop, Lennart Hulthén, et al.
  (2004) Journal of Hypertension
  Journal article
- Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins.
  Charlotte Ling, Emma A Nilsson, Martin Ridderstråle, Peter Almgren, Leif Groop, et al.
  (2004) Journal of Clinical Investigation
  Journal article
- Parallel manifestation of insulin resistance and beta cell decompensation is compatible with a common defect in Type 2 diabetes.
  Devjit Tripathy, Karl-Fredrik Eriksson, Marju Orho-Melander, Jenny Fredriksson, G. Ahlqvist, et al.
  (2004) Diabetologia
  Journal article
- Putative role of polymorphisms in UCP1-3 genes for diabetic nephropathy.
  Eero Lindholm, Mia Klannemark, Elisabet Agardh, Leif Groop, Carl-David Agardh
  (2004) Journal of Diabetes and its Complications1992-01-01+01:00
  Journal article
- Statistical concerns about the GSEA procedure - Reply
  VK Mootha, MJ Daly, N Patterson, JN Hirschhorn, Leif Groop, et al.
  (2004) Nature Genetics
  Journal article (letter)
- The FOXC2 C-512T Polymorphism Is Associated with Obesity and Dyslipidemia.
  Emma A Nilsson, Peter Almgren, Johan Hoffstedt, Leif Groop, Martin Ridderstråle
  (2004) Obesity Research
  Journal article
- Variation in the calpain-10 gene is associated with elevated triglyceride levels and reduced adipose tissue messenger ribonucleic acid expression in obese Swedish subjects.
  Emma A Nilsson, Jenny Fredriksson, Leif Groop, Martin Ridderstråle
  (2004) Journal of Clinical Endocrinology and Metabolism
  Journal article
2003
- A Combination of Human Leukocyte Antigen DQB1*02 and the Tumor Necrosis Factor alpha Promoter G308A Polymorphism Predisposes to an Insulin-Deficient Phenotype in Patients with Type 2 Diabetes.
  Haiyan Li, Leif Groop, Anita Ramelius, Jianping Weng, Tiinamaija Tuomi
  (2003) Journal of Clinical Endocrinology and Metabolism
  Journal article
- A Genome-Wide Scan in Families With Maturity-Onset Diabetes of the Young: Evidence for Further Genetic Heterogeneity.
  Timothy M. Frayling, Cecilia Lindgren, Jean Claude Chevre, Stephan Menzel, Marie Wishart, et al.
  (2003) Diabetes
  Journal article
- A genome wide scan for early onset primary hypertension in Scandinavians.
  Fredrik von Wowern, Kristina Bengtsson Boström, Cecilia Lindgren, Marju Orho-Melander, Frej Fyhrquist, et al.
  (2003) Human Molecular Genetics
  Journal article
- A meta-analysis of four European genome screens (GIFT Consortium) shows evidence for a novel region on chromosome 17p11.2-q22 linked to type 2 diabetes.
  Florence Demenais, Timo Kanninen, Cecilia Lindgren, Steven Wiltshire, Stéphane Gaget, et al.
  (2003) Human Molecular Genetics
  Journal article
- Associations of dietary fiber with glucose metabolism in nondiabetic relatives of subjects with type 2 diabetes - The Botnia Dietary Study
  K Ylonen, C Saloranta, C Kronberg-Kippila, Leif Groop, A Aro, et al.
  (2003) Diabetes Care
  Journal article
- Bringing diabetes therapeutics to the big screen.
  Leif Groop
  (2003) Nature Biotechnology1996-01-01+01:00
  Journal article (letter)
- Development of New Peripheral Arterial Occlusive Disease in Patients With Type 2 Diabetes During a Mean Follow-Up of 11 Years.
  Milla Kallio, Carol Forsblom, Per-Henrik Groop, Leif Groop, Mauri Lepäntalo
  (2003) Diabetes Care
  Journal article
- Dietary intakes and plasma concentrations of carotenoid's and tocopherols in relation to glucose metabolism in subjects at high risk of type 2 diabetes: the Botnia Dietary Study
  K Ylonen, G Alfthan, Leif Groop, C Saloranta, A Aro, et al.
  (2003) American Journal of Clinical Nutrition
  Journal article
- Familiality of metabolic abnormalities is dependent upon age at onset and phenotype of the type 2 diabetic proband.
  Devjit Tripathy, Eero Lindholm, B Isomaa, C Saloranta, T Tuomi, et al.
  (2003) American Journal of Physiology: Endocrinology and Metabolism
  Journal article
- Fat feeding impairs glycogen synthase activity in mice without effects on its gene expression.
  Xudong Huang, Mona Hansson, Esa Laurila, Bo Ahrén, Leif Groop
  (2003) Metabolism, Clinical and Experimental
  Journal article
- Growth hormone replacement therapy induces insulin resistance by activating the glucose-Fatty Acid cycle.
  Margareta Bramnert, Mikael Segerlantz, Esa Laurila, Jens R Daugaard, Per Manhem, et al.
  (2003) Journal of Clinical Endocrinology and Metabolism
  Journal article
- Impaired cathepsin L gene expression in skeletal muscle is associated with type 2 diabetes.
  Xudong Huang, Allan Vaag, Emma A Nilsson, Mona Hansson, Bo Ahrén, et al.
  (2003) Diabetes
  Journal article
- Importance of obtaining independent measures of insulin secretion and insulin sensitivity during the same test - Results with the Botnia clamp
  Devjit Tripathy, Y Wessman, M Gullstrom, T Tuomi, Leif Groop
  (2003) Diabetes Care
  Journal article
- Influence of glucose and insulin on transcapillary fluid absorption from the arm during lower body negative pressure in man
  H Olsen, Leif Groop, T Lanne
  (2003) European Journal of Applied Physiology1999-01-01+01:00
  Journal article
- Inhibition of lipolysis during acute GH exposure increases insulin sensitivity in previously untreated GH-deficient adults.
  Mikael Segerlantz, Margareta Bramnert, Per Manhem, Esa Laurila, Leif Groop
  (2003) European Journal of Endocrinology1994-01-01+01:00
  Journal article
- Intrauterine hyperglycemia modifying the development of (monogenic) diabetes?
  Tiinamaija Tuomi, Leif Groop
  (2003) Diabetes Care
  Journal article (letter)
- No evidence of a relation between 11beta-hydroxysteroid dehydrogenasetype 2 activity and salt sensitivity.
  Olle Melander, Erik Frandsen, Leif Groop, Lennart Hulthén
  (2003) American Journal of Hypertension
  Journal article
- PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.
  VK Mootha, Cecilia Lindgren, Karl-Fredrik Eriksson, A Subramanian, S Sihag, et al.
  (2003) Nature Genetics
  Journal article
- Peroxisome proliferator-activated receptor-gammaPro12Ala polymorphism and the association with blood pressure in type 2 diabetes: Skaraborg Hypertension and Diabetes Project.
  Carl Johan Östgren, Ulf Lindblad, Olle Melander, Arne Melander, Leif Groop, et al.
  (2003) Journal of Hypertension
  Journal article
- Polymorphisms of the HDL receptor gene associated with HDL cholesterol levels in diabetic kindred from three populations
  JJ McCarthy, S Lewitzky, C Reeves, A Permutt, B Glaser, et al.
  (2003) Human Heredity
  Journal article
- The SLC6A14 gene shows evidence of association with obesity
  E Suviolahti, LJ Oksanen, M Ohman, RM Cantor, Martin Ridderstråle, et al.
  (2003) Journal of Clinical Investigation
  Journal article
- The insertion/deletion variation in the alpha2B-adrenoceptor does not seem to modify the risk for acute myocardial infarction, but may modify the risk for hypertension in sib-pairs from families with type 2 diabetes
  Amir Snapir, Mika Scheinin, Leif Groop, Marju Orho-Melander
  (2003) Cardiovascular Diabetology
  Journal article
- Three weeks dietary intervention with low-glycaemic index bread improved insulin economy in women with high risk of type II diabetes
  Helena Elmståhl, Anders Frid, Leif Groop, Inger Björck
  (2003)
  Conference paper
2002
- 5 ' flanking variants of resistin are associated with obesity
  JC Engert, MC Vohl, SM Williams, P Lepage, JC Loredo-Osti, et al.
  (2002) Diabetes
  Journal article
- Autoimmunity to CD38 and GAD in Type I and Type II diabetes: CD38 and HLA genotypes and clinical phenotypes
  A Antonelli, Tiinamaija Tuomi, M Nannipieri, P Fallahi, C Nesti, et al.
  (2002) Diabetologia
  Journal article
- Characterization of a naturally occurring mutation (L107I) in the HNF1 alpha (MODY3) gene.
  Camilla Cervin, Marju Orho-Melander, Martin Ridderstråle, M Lehto, Sebastian Barg, et al.
  (2002) Diabetologia
  Journal article
- Contribution of known and unknown susceptibility genes to early-onset diabetes in scandinavia: evidence for heterogeneity.
  Cecilia Lindgren, Elisabeth Widén, Tiinamaija Tuomi, Haiyan Li, Peter Almgren, et al.
  (2002) Diabetes
  Journal article
- Decreased expression of heat shock protein 72 in skeletal muscle of patients with type 2 diabetes correlates with insulin resistance
  I Kurucz, A Morva, A Vaag, Karl-Fredrik Eriksson, Xudong Huang, et al.
  (2002) Diabetes
  Journal article
- Down-regulation of insulin receptor substrates (IRS)-1 and IRS-2 and Src homologous and collagen-like protein Shc gene expression by insulin in skeletal muscle is not associated with insulin resistance or type 2 diabetes.
  Xudong Huang, Allan Vaag, Mona Hansson, Leif Groop
  (2002) Journal of Clinical Endocrinology and Metabolism
  Journal article
- FOXC2 mRNA Expression and a 5' Untranslated Region Polymorphism of the Gene Are Associated With Insulin Resistance.
  Martin Ridderstråle, Emma A Nilsson, Mia Klannemark, Anna Cederberg, Christina Kösters, et al.
  (2002) Diabetes
  Journal article
- Fallbeskrivning. Rosiglitazonbehandling gav kraftfull effekt, men fick ändå avbrytas
  Martin Ridderstråle, Leif Groop
  (2002) Läkartidningen
  Journal article
- Genomewide search for type 2 diabetes mellitus susceptibility loci in Finnish families: the Botnia study.
  C M Lindgren, M M Mahtani, E Widén, M I McCarthy, M J Daly, et al.
  (2002) American Journal of Human Genetics
  Journal article
- Glutamic acid decarboxylase antibody positivity is associated with an impaired insulin response to glucose and arginine in nondiabetic patients with autoimmune thyroiditis
  ÅsaLinda Lethagen, UB Ericsson, Bengt Hallengren, Leif Groop, Tiinamaija Tuomi
  (2002) Journal of Clinical Endocrinology and Metabolism
  Journal article
- Nateglinide Improves Early Insulin Secretion and Controls Postprandial Glucose Excursions in a Prediabetic Population.
  Carola Saloranta, Christiane Guitard, Eckhard Pecher, Pedro De Pablos-Velasco, Kaj Lahti, et al.
  (2002) Diabetes Care
  Journal article
- Onset of glucose intolerance in MODY3 Pro291fsInsC mutation carrierscoincides with pubertal years - a prospective follow-up study
  EH Honkanen, B Isomaa, L Sarelin, M Lehto, Leif Groop, et al.
  (2002) Diabetologia
  Conference paper: abstract
- Plasma ProANP(1-30) reflects salt sensitivity in subjects with heredity for hypertension
  Olle Melander, E Frandsen, Leif Groop, Lennart Hulthén
  (2002) Hypertension
  Journal article
- Polymorphism in the Calpain 10 gene influences glucose metabolism in human fat cells
  J Hoffstedt, M Ryden, P Lofgren, Marju Orho-Melander, Leif Groop, et al.
  (2002) Diabetologia
  Journal article
- Screening for MODY mutations, GAD antibodies, and type 1 diabetes--associated HLA genotypes in women with gestational diabetes mellitus.
  Jianping Weng, Magnus Ekelund, Markku Lehto, Haiyan Li, Göran Ekberg, et al.
  (2002) Diabetes Care
  Journal article
- The genetic abnormality in the beta cell determines the response to an oral glucose load
  A Stride, M Vaxillaire, T Tuomi, F Barbetti, PR Njolstad, et al.
  (2002) Diabetologia
  Journal article
- The hormone-sensitive lipase C-60G gene polymorphism is associated with abdominal obesity
  Mia Klannemark, V Large, T Osterlund, K Strom, D Langin, et al.
  (2002) Diabetologia
  Conference paper: abstract
- The prevalence of polymorphisms in the interleukin-1 gene in a group of patients with recurrent periodontal disease.
  H Jansson, A Gustafsson, K Hamberg, H Gu, G Soderholm, et al.
  (2002) Journal of Dental Research
  Conference paper: abstract
- Variants in the calpain-10 gene predispose to insulin resistance and elevated free fatty acid levels.
  Marju Orho-Melander, Mia Klannemark, Malin Svensson, Martin Ridderstråle, Cecilia Lindgren, et al.
  (2002) Diabetes
  Journal article
2001
- A gene conferring susceptibility to type 2 diabetes in conjunction with obesity is located on chromosome 18p11
  Alex Parker, Joanne Meyer, Steve Lewitzky, Jean S. Rennich, Gayun Chan, et al.
  (2001) Diabetes
  Journal article
- An automated fluorescent single strand conformation polymorphism technique for high throughput mutation screening
  Jianping Weng, Markku Lehto, Anna Berglund, Leif Groop
  (2001) Chinese Medical Journal
  Journal article
- Assessment of beta-cell function during the oral glucose tolerance test by a minimal model of insulin secretion
  A. Cretti, M. Lehtovirta, E. Bonora, B. Brunato, M.G. Zenti, et al.
  (2001) European Journal of Clinical Investigation
  Journal article
- Beta(2)-adrenergic receptor gene variation and hypertension in subjects with type 2 diabetes
  Kristina Bengtsson, Marju Orho-Melander, Olle Melander, Ulf Lindblad, Jonas Ranstam, et al.
  (2001) Hypertension
  Journal article
- Cardiovascular morbidity and mortality associated with the metabolic syndrome
  B. Isomaa, Peter Almgren, T. Tuomi, B. Forsen, K. Lahti, et al.
  (2001) Diabetes Care
  Journal article
- Characterization of the annexin I gene and evaluation of its role in type 2 diabetes
  Cecilia M. Lindgren, Anita Ramelius, Marju Orho-Melander, Peter Almgren, Leif Groop
  (2001) Diabetes
  Journal article
- Common variants in the beta2-(Gln27Glu) and beta3-(Trp64Arg)--adrenoceptor genes are associated with elevated serum NEFA concentrations and type II diabetes
  M Carlsson, Marju Orho-Melander, J Hedenbro, Leif Groop
  (2001) Diabetologia
  Journal article
- Differential phosphorylation of Janus kinase 2, Stat5A and Stat5B in response to growth hormone in primary rat adipocytes
  Martin Ridderstråle, Leif Groop
  (2001) Molecular and Cellular Endocrinology
  Journal article
- Functional consequences of mutations in the MODY4 gene (IPF1) and coexistence with MODY3 mutations
  J. Weng, W.M. Macfarlane, M. Lehto, H.F. Gu, L.M. Shepherd, et al.
  (2001) Diabetologia
  Journal article
- Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height
  J.N. Hirschhorn, Cecilia Lindgren, M.J. Daly, A. Kirby, S.F. Schaffner, et al.
  (2001) American Journal of Human Genetics
  Journal article
- Hypothalamic-pituitary-adrenal response to different tests in type 1 diabetes mellitus
  E G Almqvist, Leif Groop, P J Manhem
  (2001) Scandinavian Journal of Clinical & Laboratory Investigation
  Journal article
- Inhibition of the rise in FFA by Acipimox partially prevents GH-induced insulin resistance in GH-deficient adults
  Mikael Segerlantz, Margareta Bramnert, Per Manhem, Esa Laurila, Leif Groop
  (2001) Journal of Clinical Endocrinology and Metabolism
  Journal article
- Linkage disequilibrium at PPARG and other genes assessed with dense sets of SNPs.
  J.N. Hirschhorn, D. Altshuler, M.J. Daly, C.M. Lindgren, N.P. Burtt, et al.
  (2001) American Journal of Human Genetics
  Journal article
- Metabolic effects of metformin in patients with impaired glucose tolerance
  M Lehtovirta, B Forsen, M Gullstrom, M Haggblom, J G Eriksson, et al.
  (2001) Diabetic Medicine
  Journal article
- Metabolic impact of a family history of Type 2 diabetes. Results from a European multicentre study (EGIR)
  A Vaag, M Lehtovirta, P Thye-Ronn, Leif Groop
  (2001) Diabetic Medicine
  Journal article
- Polymorphism in the beta(1)-adrenergic receptor gene and hypertension
  Kristina Bengtsson, Olle Melander, Marju Orho-Melander, Ulf Lindblad, Jonas Ranstam, et al.
  (2001) Circulation
  Journal article
- Possible human leukocyte antigen-mediated genetic interaction between type 1 and type 2 Diabetes
  Haiyan Li, Eero Lindholm, Peter Almgren, A Gustafsson, C Forsblom, et al.
  (2001) Journal of Clinical Endocrinology and Metabolism
  Journal article
- Relationship between abdominal fat compartments and glucose and lipid metabolism in early postmenopausal women
  M Rendell, U L Hulthen, C Törnquist, Leif Groop, Ingrid Mattiasson
  (2001) Journal of Clinical Endocrinology and Metabolism
  Journal article
- SR-B1 variants associated with HDL cholesterol levels in three populations
  J J McCarthy, S Lewitzky, A Permutt, B Glaser, Leif Groop, et al.
  (2001) American Journal of Human Genetics
  Journal article
- The ACE gene I/D polymorphism is associated with higher mortality in men with hypertension and type 2 diabetes
  K Bengtsson, Ulf Lindblad, Marju Orho-Melander, Olle Melander, Jonas Ranstam, et al.
  (2001) Diabetologia
  Journal article
- The dysmetabolic syndrome
  Leif Groop, Marju Orho-Melander
  (2001) Journal of Internal Medicine1989-01-01+01:00
  Journal article
- The metabolic syndrome influences the risk of chronic complications in patients with type II diabetes
  B Isomaa, M Henricsson, Peter Almgren, T Tuomi, M R Taskinen, et al.
  (2001) Diabetologia
  Journal article
2000
- Angiotensin converting enzyme (ACE) gene polymorphism in sarcoidosis in relation to associated autoimmune diseases
  K I Papadopoulos, Olle Melander, Marju Orho-Melander, Leif Groop, M Carlsson, et al.
  (2000) Journal of Internal Medicine1989-01-01+01:00
  Journal article
- Association between a variant in the 11 beta-hydroxysteroid dehydrogenase type 2 gene and primary hypertension
  Olle Melander, Marju Orho-Melander, K Bengtsson, U Lindblad, Lennart Råstam, et al.
  (2000) Journal of Human Hypertension
  Journal article
- Genetic variants of thiazide-sensitive NaCl-cotransporter in Gitelman's syndrome and primary hypertension
  Olle Melander, Marju Orho-Melander, Kristina Bengtsson Boström, Ulf Lindblad, Lennart Råstam, et al.
  (2000) Hypertension
  Journal article
- Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
  Y Horikawa, N Oda, N J Cox, X Li, Marju Orho-Melander, et al.
  (2000) Nature Genetics
  Journal article
- Interaction between the Asn291Ser variant of the LPL gene and insulin resistance on dyslipidaemia in high risk individuals for Type 2 diabetes mellitus
  Mia Klannemark, L Suurinkeroinen, Marju Orho-Melander, Leif Groop, M R Taskinen
  (2000) Diabetic Medicine
  Journal article
- Pathogenesis of type 2 diabetes: the relative contribution of insulin resistance and impaired insulin secretion
  Leif Groop
  (2000) International journal of clinical practice. Supplement
  Journal article
- Role of the Gly460Trp polymorphism of the alpha-adducin gene in primary hypertension in Scandinavians
  Olle Melander, K Bengtsson, Marju Orho-Melander, U Lindblad, C Forsblom, et al.
  (2000) Journal of Human Hypertension
  Journal article
- The T 54 allele of the intestinal fatty acid-binding protein 2 is associated with a parental history of stroke
  Martin Carlsson, Marju Orho-Melander, Jan Hedenbro, Peter Almgren, Leif Groop
  (2000) Journal of Clinical Endocrinology and Metabolism
  Journal article
1999
- A paired-sibling analysis of the XbaI polymorphism in the muscle glycogen synthase gene
  Marju Orho-Melander, Peter Almgren, T Kanninen, C Forsblom, Leif Groop
  (1999) Diabetologia
  Journal article
- Expression of naturally occurring variants in the muscle glycogen synthase gene
  Marju Orho-Melander, H Shimomura, T Sanke, S K Rasmussen, K Nanjo, et al.
  (1999) Diabetes
  Journal article
- Polymorphism in the angiotensin converting enzyme but not in the angiotensinogen gene is associated with hypertension and type 2 diabetes: the Skaraborg Hypertension and diabetes project
  Kristina Bengtsson Boström, Marju Orho-Melander, Ulf Lindblad, Olle Melander, Erik Bøg-Hansen, et al.
  (1999) Journal of Hypertension
  Journal article

Publications

Retrieved from Lund University's publications database

Book chapter
- Genetics of Diabetes and Diabetic Complications
  Rashmi Prasad, Emma Ahlqvist, Leif Groop
  (2018) Endocrinology
- Genetic Architecture of Type 2 Diabetes
  Rashmi B. Prasad, Leif Groop
  (2017)
- Transcription factor 7-like 2 (TCF7L2)
  Struan F A Grant, Leif Groop
  (2016) , p.297-316
Conference paper
- A Bayesian Network analysis of the probabilistic relations between risk factors in the predisposition to type 2 diabetes
  Francesco Sambo, Barbara Di Camillo, Alberto Franzin, Andrea Facchinetti, Liisa Hakaste, et al.
  (2015) Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 2015 p.22-2119
- A Bayesian Network for Probabilistic Reasoning and Imputation of Missing Risk Factors in Type 2 Diabetes
  Francesco Sambo, Andrea Facchinetti, Liisa Hakaste, Jasmina Kravic, Barbara Di Camillo, et al.
  (2015) , 9105 p.172-176
- Facilitation of information exhange between genetic research, primary health care and decision makers using a regional diabetes register DIREVA (Diabetes Register Vaasa)
  Tom Forsén, Kaj Lahti, J Eriksson, Tiinamaija Tuomi, Bo Isomaa, et al.
  (2011) , 1 p.288-288
- Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans
  Erik Ingelsson, Claudia Langenberg, Marie-France Hivert, Inga Prokopenko, Valeriya Lyssenko, et al.
  (2010) , 59 p.1266-1275
- Impaired Mitochondrial Function and Insulin Resistance of Skeletal Muscle in Mitochondrial Diabetes
  Julia Szendroedi, Albrecht Ingo Schmid, Martin Meyerspeer, Camilla Cervin, Michaela Kacerovsky, et al.
  (2009) , 32 p.677-679
- Dipping and variability of blood pressure and heart rate at night are heritable traits.
  Cristiano Fava, Philippe Burri, Peter Almgren, Guido Arcaro, Leif Groop, et al.
  (2005) , 18 p.1402-1407
- Three weeks dietary intervention with low-glycaemic index bread improved insulin economy in women with high risk of type II diabetes
  Helena Elmståhl, Anders Frid, Leif Groop, Inger Björck
  (2003) , 47 p.396-396
Conference paper: abstract
- Glucotoxicity-induced upregulation of lincRNA GAS5 in the pancreatic islets of type 2 diabetes donors and in Goto-Kakizaki rats
  J. L. S. Esguerra, J. Ofori, M. Nagao, J. Fadista, L. Groop, et al.
  (2017) Diabetologia, 60 p.22-23
- Risk genotypes, allele-specific expression and methylation status in human islets at the KCNQ1 type 2 diabetes-susceptibility locus
  M. E. Travers, Marloes Dekker Nitert, D. J. G. Mackay, C. M. Lindgren, Leif Groop, et al.
  (2010) Diabetologia, 53 p.134-134
- Genetics of type 2 diabetes -Are we getting any closer?
  Leif Groop
  (2010) Endocrine Journal, 57 p.214-214
- A mRNA marker for glycolytic muscle fibres may be used to determine fibre type composition in human skeletal muscle
  Anders H Olsson, Targ Elgzyri, Esa Laurila, Leif Groop, Ola Hansson, et al.
  (2010) Diabetologia, 53 p.705-705
- TCF7L2-conferred apoptosis in pancreatic beta cells involves the p53 pathway
  Yuedan Zhou, Enming Zhang, Erik Renström, Leif Groop, Ola Hansson
  (2010) Diabetologia, 53 p.298-298
- Effect of variants in the RORA gene on risk of type 2 diabetes
  Anna Jonsson, Sami Alkayyali, B. Isomaa, T. Tuomi, Leif Groop, et al.
  (2010) Diabetologia, 53 p.304-304
- Resistance to exercise-induced changes in the global DNA methylation pattern of skeletal muscle in individuals with a family history of type 2 diabetes
  Marloes Dekker Nitert, Tasnim Dayeh, Stefan Lang, Targ Elgzyri, Yang De Marinis, et al.
  (2010) Diabetologia, 53 p.312-312
- A common variant in the PAX6 gene influences islet function in man
  Emma Ahlqvist, Fabiola Turrini, Stefan Lang, Targ Elgzyri, Yuedan Zhou, et al.
  (2010) Diabetologia, 53 p.297-297
- Influence of novel genetic loci affecting glucose and insulin levels during OGTT on islet function in man
  Tarun Ahluwalia, Claes Ladenvall, Anna Jonsson, Jasmina Kravic, Esa Laurila, et al.
  (2010) Diabetologia, 53 p.136-136
- Genome wide association analysis for free fatty acid levels in DGI
  Ivana Stojkovic, C. Saloranta, Peter Almgren, Valeriya Lyssenko, E. Laurila, et al.
  (2010) Diabetologia, 53 p.322-322
- Novel Genetic Loci Implicated in Fasting Glucose Homeostasis and Their Impact on Related Metabolic Traits
  Josee Dupuis, Claudia Langenberg, Inga Prokopenko, Richa Saxena, Nicole Soranzo, et al.
  (2009) Genetic Epidemiology, 33 p.124-124
- The diabetes risk score outperforms fasting plasma glucose and glucose tolerance tests: combined results from the Inter99 and Botnia Studies
  M. P. McKenna, Valeriya Lyssenko, M. Rowe, R. Gerwien, J. Kolberg, et al.
  (2009) Diabetologia, 52 p.7-7
- Evaluation of chloride channel-3 as a potential target for TCF7L2-dependent impairment of insulin secretion
  Xingjun Jing, Yuedan Zhou, Peter Osmark, Stefan Lang, Leif Groop, et al.
  (2009) Diabetologia, 52 p.332-332
- Disruption of TFB1M impairs insulin secretion in beta cells
  Thomas Köck, Marloes Dekker Nitert, A Olsson, Olga Kotova, Jelena Stamenkovic, et al.
  (2009) Diabetologia, 52 p.116-116
- Hyperactivity in adrenergic signalling via alpha2A receptors contributes to human type 2 diabetes
  Anders Rosengren, Ramunas Jokubka, Damon Tojjar, Charlotte Granhall, Jonatan Tuncel, et al.
  (2009) Diabetologia, 52 p.108-108
- Effects of six months of moderate resistance-versus endurance-training on muscle ATP synthesis in first-degree relatives of patients with type 2 diabetes
  G. Kacerovsky-Bielesz, M. Chmelik, Charlotte Ling, R. Pokan, J. Szendroedi, et al.
  (2009) Diabetologia, 52 p.687-687
- The impact of differential splicing of TCF7L2 on target gene expression in human islet of Langerhans
  Yuedan Zhou, Stefan Lang, Jalal Taneera, Erik Renström, Leif Groop, et al.
  (2009) Diabetologia, 52 p.78-78
- Common variants in or around the JAZF1, CDKN2A/2B, CDKAL1 and WFS1 genes discriminate between autoimmune and non-autoimmune diabetes
  Ekaterine Bakhtadze, Eero Lindholm, Valeriya Lyssenko, H. J. Arnkvist, J. Bolinder, et al.
  (2008) Diabetologia, 51 p.117-117
- Genetic variation in ATP5O is associated with mRNA expression in human skeletal muscle and in vivo glucose uptake
  Tina Rönn, P. Poulsen, Leif Groop, A. Vaag, Charlotte Ling
  (2008) Diabetologia, 51 p.132-132
- Interactions between genes and birth size for development of type 2 diabetes
  Nicolo Pulizzi, Valeriya Lyssenko, Anna Jonsson, C. Osmond, E. Kajantie, et al.
  (2008) Diabetologia, 51 p.28-28
- PGC-1 alpha and PGC-1 beta are related to markers for fibre type composition in human skeletal muscle
  Anders H Olsson, Tina Rönn, A. Vaag, Leif Groop, P. Poulsen, et al.
  (2008) Diabetologia, 51 p.130-130
- Metabolic effects of novel type 2 diabetes genes in a population aged 18-75 years
  Anna Jonsson, B. Isomaa, Tiinamaija Tuomi, Valeriya Lyssenko, Leif Groop
  (2008) Diabetologia, 51 p.31-32
- Is there a unifying genetic factor predisposing to the metabolic syndrome?
  Marketa Sjögren, Marju Orho-Melander, Anna Jonsson, Margareta Svensson, Göran Berglund, et al.
  (2008) Diabetologia, 51 p.32-33
- Effect of exercise on gene transcript profiles in skeletal muscle of individuals with and without a family history of diabetes
  Ola Hansson, Targ Elgzyri, Hemang Parikh, Karl-Fredrik Eriksson, Leif Groop
  (2008) Diabetologia, 51 p.270-270
- Onset of glucose intolerance in MODY3 Pro291fsInsC mutation carrierscoincides with pubertal years - a prospective follow-up study
  EH Honkanen, B Isomaa, L Sarelin, M Lehto, Leif Groop, et al.
  (2002) Diabetologia, 45 p.129-129
- The prevalence of polymorphisms in the interleukin-1 gene in a group of patients with recurrent periodontal disease.
  H Jansson, A Gustafsson, K Hamberg, H Gu, G Soderholm, et al.
  (2002) Journal of Dental Research, 81 p.291-291
- The hormone-sensitive lipase C-60G gene polymorphism is associated with abdominal obesity
  Mia Klannemark, V Large, T Osterlund, K Strom, D Langin, et al.
  (2002) Diabetologia, 45 p.124-124
Journal article
- The functional impact of G protein-coupled receptor 142 (Gpr142) on pancreatic β-cell in rodent
  Israa Mohammad Al-Amily, Pontus Dunér, Leif Groop, Albert Salehi
  (2019) Pflugers Archiv European Journal of Physiology
- A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes : results from an exome-wide association study of albuminuria
  Tarunveer S. Ahluwalia, Christina Alexandra Schulz, Johannes Waage, Tea Skaaby, Niina Sandholm, et al.
  (2019) Diabetologia, 62 p.292-305
- The associations of daylight and melatonin receptor 1B gene rs10830963 variant with glycemic traits : the prospective PPP-Botnia study
  Kadri Haljas, Liisa Hakaste, Jari Lahti, Bo Isomaa, Leif Groop, et al.
  (2019) Annals of Medicine
- Genotypes of HLA, TCF7L2, and FTO as potential modifiers of the association between sweetened beverage consumption and risk of LADA and type 2 diabetes
  Josefin E. Löfvenborg, Emma Ahlqvist, Lars Alfredsson, Tomas Andersson, Mozhgan Dorkhan, et al.
  (2019) European Journal of Nutrition
- Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control
  , Samuela Pollack, Leif Groop, Emma Ahlqvist, Valeriya Lyssenko, et al.
  (2019) Diabetes, 68 p.441-456
- Serum kidney injury molecule 1 and β₂-microglobulin perform as well as larger biomarker panels for prediction of rapid decline in renal function in type 2 diabetes
  , Marco Colombo, Helen C. Looker, Bassam Farran, Sibylle Hess, et al.
  (2019) Diabetologia, 62 p.156-168
- 1-Hour Post-OGTT Glucose Improves the Early Prediction of Type 2 Diabetes by Clinical and Metabolic Markers
  Gopal Peddinti, Michael Bergman, Tiinamaija Tuomi, Leif Groop
  (2019) The Journal of clinical endocrinology and metabolism, 104 p.1131-1140
- DOLORisk : Study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain [version 2; referees: 2 approved]
  Mathilde M.V. Pascal, Andreas C. Themistocleous, Ralf Baron, Andreas Binder, Didier Bouhassira, et al.
  (2019) Wellcome Open Research, 3
- Association of IRS1 genetic variants with glucose control and insulin resistance in type 2 diabetic patients from Bosnia and Herzegovina
  Lejla Mahmutovic, Tamer Bego, Maria Sterner, Gabriella Gremsperger, Emma Ahlqvist, et al.
  (2019) Drug Metabolism and Personalized Therapy
- N¹-methylnicotinamide is a signalling molecule produced in skeletal muscle coordinating energy metabolism
  Kristoffer Ström, David Morales-Alamo, Filip Ottosson, Anna Edlund, Line Hjort, et al.
  (2018) Scientific Reports, 8
- Predictors of responses to clinic-based childhood obesity care
  Emilia Hagman, Lior Hecht, Limor Marko, Henny Azmanov, Leif Groop, et al.
  (2018) Pediatric Diabetes, 19 p.1351-1356
- Melatonin receptor 1B gene rs10830963 polymorphism, depressive symptoms and glycaemic traits
  Kadri Haljas, Jari Lahti, Tiinamaija Tuomi, Bo Isomaa, Johan G. Eriksson, et al.
  (2018) Annals of Medicine
- Turning vice into virtue : Using Batch-Effects to Detect Errors in Large Genomic Datasets
  Fabrizio Mafessoni, Rashmi B Prasad, Leif Groop, Ola Hansson, Kay Prüfer
  (2018) Genome Biology and Evolution, 10 p.2697-2708
- Activation of imidazoline receptor I₂, and improved pancreatic β-cell function in human islets
  Stefan Amisten, Pontus Duner, Olof Asplund, Israa Mohammed Al-Amily, Leif Groop, et al.
  (2018) Journal of Diabetes and its Complications1992-01-01+01:00, 32 p.813-818
- Coffee consumption, genetic susceptibility and risk of latent autoimmune diabetes in adults : A population-based case-control study
  B. Rasouli, E. Ahlqvist, L. Alfredsson, T. Andersson, P. O. Carlsson, et al.
  (2018) Diabetes and Metabolism, 44 p.354-360
- Association between genetic risk variants and glucose intolerance during pregnancy in north Indian women
  Geeti Arora, Peter Almgren, Charlotte Brøns, Richa G Thaman, Allan Vaag, et al.
  (2018) BMC Medical Genomics, 11
- Heterogeneity of diabetes - An Indian perspective
  Rashmi B Prasad, Emma Ahlqvist, Leif Groop
  (2018) Diabetes & metabolic syndrome
- Controllability in an islet specific regulatory network identifies the transcriptional factor NFATC4, which regulates Type 2 Diabetes associated genes
  Amitabh Sharma, Arda Halu, Julius L. Decano, Megha Padi, Yang-yu Liu, et al.
  (2018) npj Systems Biology and Applications, 4
- A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes
  Natalie R van Zuydam, Emma Ahlqvist, Claes Ladenvall, Peter Almgren, Christina-Alexandra Schulz, et al.
  (2018) Diabetes, 67 p.1414-1427
- Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes
  Viktoria Gusarova, Colm O'Dushlaine, Tanya M Teslovich, Peter N Benotti, Tooraj Mirshahi, et al.
  (2018) Nature Communications, 9 p.1-11
- Overweight, obesity and the risk of LADA : results from a Swedish case–control study and the Norwegian HUNT Study
  Rebecka Hjort, Emma Ahlqvist, Per Ola Carlsson, Valdemar Grill, Leif Groop, et al.
  (2018) Diabetologia, 61 p.1333-1343
- Haplotype Sharing Provides Insights into Fine-Scale Population History and Disease in Finland
  Alicia R Martin, Konrad J Karczewski, Sini Kerminen, Mitja I Kurki, Antti-Pekka Sarin, et al.
  (2018) American Journal of Human Genetics, 102 p.760-775
- Novel subgroups of adult-onset diabetes and their association with outcomes : A data-driven cluster analysis of six variables
  Emma Ahlqvist, Petter Storm, Annemari Käräjämäki, Mats Martinell, Mozhgan Dorkhan, et al.
  (2018) The Lancet Diabetes and Endocrinology, 6 p.361-369
- HAPT2D : high accuracy of prediction of T2D with a model combining basic and advanced data depending on availability
  Barbara Di Camillo, Liisa Hakaste, Francesco Sambo, Rafael Gabriel, Jasmina Kravic, et al.
  (2018) European journal of endocrinology, 178 p.331-341
- Effects of GIP on regional blood flow during normoglycemia and hyperglycemia in anesthetized rats
  Xiang Gao, Andreas Lindqvist, Monica Sandberg, Leif Groop, Nils Wierup, et al.
  (2018) Physiological Reports, 6
- Lessons learned from the 1-hour post-load glucose level during OGTT : Current screening recommendations for dysglycaemia should be revised
  Michael Bergman, Ram Jagannathan, Martin Buysschaert, Manan Pareek, Michael H. Olsen, et al.
  (2018) Diabetes/Metabolism Research and Reviews, 34
- Genome-wide meta-analysis identifies novel determinants of circulating serum progranulin
  Anke Tönjes, Markus Scholz, Jacqueline Krüger, Kerstin Krause, Dorit Schleinitz, et al.
  (2018) Human Molecular Genetics, 27 p.546-558
- Obstructive sleep apnoea and the risk for coronary heart disease and type 2 diabetes : A longitudinal population-based study in Finland
  Satu Strausz, Aki S. Havulinna, Tiinamaija Tuomi, Adel Bachour, Leif Groop, et al.
  (2018) BMJ Open, 8
- Bivariate genome-wide association study of depressive symptoms with type 2 diabetes and quantitative glycemic traits
  Kadri Haljas, Azmeraw T. Amare, Behrooz Z. Alizadeh, Yi Hsiang Hsu, Thomas Mosley, et al.
  (2018) Psychosomatic Medicine, 80 p.242-251
- Role of osteopontin and its regulation in pancreatic islet
  Mengyin Cai, Pradeep Bompada, Albert Salehi, Juan R. Acosta, Rashmi B. Prasad, et al.
  (2018) Biochemical and Biophysical Research Communications, 495 p.1426-1431
- Genetic determinants of glucose levels in pregnancy : Genetic risk scores analysis and GWAS in the Norwegian STORK cohort
  Gunn Helen Moen, Marissa LeBlanc, Christine Sommer, Rashmi B. Prasad, Tove Lekva, et al.
  (2018) European journal of endocrinology, 179 p.363-372
- Family history of diabetes and its relationship with insulin secretion and insulin sensitivity in Iraqi immigrants and native Swedes : a population-based cohort study
  Louise Bennet, Paul W. Franks, Bengt Zöller, Leif Groop
  (2018) Acta Diabetologica, 55 p.233-242
- A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes
  , Makiko Taira, Minako Imamura, Atsushi Takahashi, Yoichiro Kamatani, et al.
  (2018) PLoS ONE, 13
- Silencing of the FTO gene inhibits insulin secretion : An in vitro study using GRINCH cells
  Jalal Taneera, Rashmi B Prasad, Sarah Dhaiban, Abdul Khader Mohammed, Leena Haataja, et al.
  (2018) Molecular and Cellular Endocrinology, 472 p.10-17
- Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes article
  Anubha Mahajan, Jennifer Wessel, Sara M Willems, Wei Zhao, Neil R Robertson, et al.
  (2018) Nature Genetics, 50 p.559-571
- A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4) gene with severe diabetic retinopathy in type 2 diabetes
  , , Weihua Meng, Kaanan P. Shah, Samuela Pollack, et al.
  (2018) Acta Ophthalmologica, 96 p.811-819
- Discovering human diabetes-risk gene function with genetics and physiological assays
  Heshan Peiris, Sangbin Park, Shreya Louis, Xueying Gu, Jonathan Y. Lam, et al.
  (2018) Nature Communications, 9
- Development and validation of a path length calculation for carotid-femoral pulse wave velocity measurement : A TASCFORCE, SUMMIT, and caerphilly collaborative venture
  Jonathan R. Weir-McCall, Liam Brown, Jennifer Summersgill, Piotr Talarczyk, Michael Bonnici-Mallia, et al.
  (2018) Hypertension, 71 p.937-945
- Heterozygous RFX6 protein truncating variants are associated with MODY with reduced penetrance
  Kashyap A. Patel, Jarno Kettunen, Markku Laakso, Alena Stančáková, Thomas W. Laver, et al.
  (2017) Nature Communications, 8
- Genetic determinants of circulating GIP and GLP-1 concentrations
  Peter Almgren, Andreas Lindqvist, Ulrika Krus, Liisa H. Hakaste, Emilia Ottosson Laakso, et al.
  (2017) JCI Insight, 2
- New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals
  Aldi T. Kraja, James P. Cook, Helen R. Warren, Praveen Surendran, Chunyu Liu, et al.
  (2017) Circulation: Cardiovascular Genetics, 10
- Insulin secretion and action in North Indian women during pregnancy
  G. P. Arora, P Almgren, R. G. Thaman, A. Pal, Leif Groop, et al.
  (2017) Diabetic medicine : a journal of the British Diabetic Association, 34 p.1477-1482
- Glucose-induced Changes in Gene Expression in Human Pancreatic Islets - Causes or Consequences of Chronic Hyperglycemia
  Emilia Ottosson-Laakso, Ulrika Krus, Petter Storm, Rashmi B Prasad, Nikolay Oskolkov, et al.
  (2017) Diabetes, 66 p.3013-3028
- Continuous and simultaneous determination of venous blood metabolites
  Anneli Andersson, Qun Chen, Leif Groop, Leif Bülow, Bin Xie
  (2017) Talanta, 171 p.270-274
- The rs7903146 variant in the tcf7l2 gene increases the risk of prediabetes/type 2 diabetes in obese adolescents by impairing b-cell function and hepatic insulin sensitivity
  Catrina Cropano, Nicola Santoro, Leif Groop, Chiara Dalla Man, Claudio Cobelli, et al.
  (2017) Diabetes Care, 40 p.1082-1089
- Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD
  Panu K. Luukkonen, You Zhou, P. A. Nidhina Haridas, Om P. Dwivedi, Tuulia Hyötyläinen, et al.
  (2017) Journal of Hepatology, 67 p.128-136
- A TRPV1-to-secretagogin regulatory axis controls pancreatic β-cell survival by modulating protein turnover
  Katarzyna Malenczyk, Fatima Girach, Edit Szodorai, Petter Storm, Åsa Segerstolpe, et al.
  (2017) EMBO Journal, 36 p.1993-2176
- Early metabolic markers identify potential targets for the prevention of type 2 diabetes
  Gopal Peddinti, Jeff Cobb, Loic Yengo, Philippe Froguel, Jasmina Kravic, et al.
  (2017) Diabetologia, p.1-11
- Education immigration and income as risk factors for hemoglobin a1c >70 mmol/mol when diagnosed with type 2 diabetes or latent autoimmune diabetes in adult : A population-based cohort study
  Mats Martinell, Ronnie Pingel, Johan Hallqvist, Mozhgan Dorkhan, Leif Groop, et al.
  (2017) BMJ Open Diabetes Research and Care, 5
- Nonsuppressed glucagon after glucose challenge as a potential predictor for glucose tolerance
  Róbert Wagner, Liisa H. Hakaste, Emma Ahlqvist, Martin Heni, Jürgen Machann, et al.
  (2017) Diabetes, 66 p.1373-1379
- Aortic diameter at age 65 in men with newly diagnosed type 2 diabetes
  Soumia Taimour, Moncef Zarrouk, Jan Holst, Anders H. Rosengren, Leif Groop, et al.
  (2017) Scandinavian Cardiovascular Journal1997-01-01+01:00, 51 p.202-206
- Automated pathway and reaction prediction facilitates in silico identification of unknown metabolites in human cohort studies
  Jan D. Quell, Werner Römisch-Margl, Marco Colombo, Jan Krumsiek, Anne M. Evans, et al.
  (2017) Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1071 p.58-67
- Gastric bypass in the pig increases GIP levels and decreases active GLP-1 levels
  Andreas Lindqvist, Mikael Ekelund, Stefan Pierzynowski, Leif Groop, Jan Hedenbro, et al.
  (2017) Peptides, 90 p.78-82
- Bariatric surgery enhances splanchnic vascular responses in patients with type 2 diabetes
  Henri Honka, Jukka Koffert, Saila Kauhanen, Jarmo Teuho, Saija Hurme, et al.
  (2017) Diabetes, 66 p.880-885
- Metabolite profiling of LADA challenges the view of a metabolically distinct subtype
  Mahmoud Al-Majdoub, Arslan Ali, Petter Storm, Anders H. Rosengren, Leif Groop, et al.
  (2017) Diabetes, 66 p.806-814
- The impact of Roux-en-Y gastric bypass surgery on normal metabolism in a porcine model
  Andreas Lindqvist, Mikael Ekelund, Eliana Garcia-Vaz, Marcus Ståhlman, Stefan Pierzynowski, et al.
  (2017) PLoS ONE, 12
- Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks
  Ildem Akerman, Zhidong Tu, Anthony Beucher, Delphine M Y Rolando, Claire Sauty-Colace, et al.
  (2017) Cell Metabolism, 25 p.400-411
- Functional investigations of HNF1A identify rare variants as risk factors for type 2 diabetes in the general population
  Laeya Abdoli Najmi, Ingvild Aukrust, Jason Flannick, Janne Molnes, Noel Burtt, et al.
  (2017) Diabetes, 66 p.335-346
- A low-frequency inactivating AKT2 variant enriched in the finnish population is associated with fasting insulin levels and type 2 diabetes risk
  Alisa Manning, Claes Ladenvall, Peter Nilsson, Tibor V. Varga, Paul Franks, et al.
  (2017) Diabetes, 66 p.2019-2032
- Roux-en-Y gastric bypass versus calorie restriction: support for surgery as the direct contributor to aloncltered responses of insulin and incretins to a mixed meal
  JOHAN BERGGREN, Andreas Lindqvist, Jan Hedenbro, Leif Groop, Nils Wierup
  (2017) Surgery for Obesity and Related Diseases, 13 p.234-242
- Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis
  Eleanor Wheeler, Aaron Leong, Ching-Ti Liu, Marie-France Hivert, Rona J. Strawbridge, et al.
  (2017) PLoS Medicine, 14
- Family history of type 1 and type 2 diabetes and risk of latent autoimmune diabetes in adults (LADA)
  Rebecka Hjort, L Alfredsson, T. Andersson, P. O. Carlsson, V Grill, et al.
  (2017) Diabetes & Metabolism1996-01-01+01:00, 43 p.536-542
- Effects of meal and incretins in the regulation of splanchnic blood flow
  Jukka Koffert, Henri Honka, Jarmo Teuho, Saila Kauhanen, Saija Hurme, et al.
  (2017) Endocrine Connections, 6 p.179-187
- Exome-wide association study of plasma lipids in >300,000 individuals
  Dajiang J Liu, Gina M. Peloso, Haojie Yu, Adam S. Butterworth, Anubha Mahajan, et al.
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- Genetics of type 2 diabetes. On overview.
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- Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus
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- Control of ACAT2 Liver Expression by HNF4{alpha}. Lesson From MODY1 Patients.
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- Effect of pioglitazone versus insulin glargine on cardiac size, function, and measures of fluid retention in patients with type 2 diabetes
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- Functional Variant Disrupts Insulin Induction of USF1 Mechanism for USF1-Associated Dyslipidemias
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- The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects
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- Immigrants from the Middle-East have a different form of Type 2 diabetes compared with Swedish patients.
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- Strategies for Conditional Two-Locus Nonparametric Linkage Analysis.
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- Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study)
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- Genes and type 2 diabetes mellitus.
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- A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population
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- Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes
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- C/EBP{alpha} in adipose tissue regulates genes in lipid and glucose metabolism and a genetic variation in C/EBP{alpha} is associated with serum levels of triglycerides.
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- Yksi, kaksi vai monta diabetesta?
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- Relationships of plasma adiponectin level and adiponectin receptors 1 and 2 gene expression to insulin sensitivity and glucose and fat metabolism in monozygotic and dizygotic twins.
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- Association testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetes
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- MODY--en autosomalt dominant form av diabetes. Diagnos via gentestning ger bättre behandling
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- Variants in the FFAR1 Gene Are Associated with Beta Cell Function
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- Thyrostimulin (a TSH-like Hormone) Expression in Orbital and Thyroid Tissue.
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- Association of microsatellite polymorphisms of the human 14q13.2 region with type 2 diabetes mellitus in latvian and finnish populations
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- IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies
  Cornelia Huth, Iris M. Heid, Caren Vollmert, Christian Gieger, Harald Grallert, et al.
  (2006) Diabetes, 55 p.2915-2921
- Improved prandial glucose control with lower risk of hypoglycemia with nateglinide than with glibenclamide in patients with maturity-onset diabetes of the young type 3
  T Tuomi, L Sarelin, EH Honkanen, Leif Groop, B Isomaa
  (2006) Diabetes Care, 29 p.189-194
- Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals
  Richa Saxena, Lauren Gianniny, Noel P. Burtt, Valeriya Lyssenko, Candace Giuducci, et al.
  (2006) Diabetes, 55 p.2890-2895
- Association of the calpain-10 gene with type 2 diabetes in Europeans: Results of pooled and meta-analyses
  Takafumi Tsuchiya, Peter E. H. Schwarz, Laura del Bosque-Plata, M. Geoffrey Hayes, Christian Dina, et al.
  (2006) Molecular Genetics and Metabolism, 89 p.174-184
- Comprehensive association testing of common mitochondrial DNA variation in metabolic disease
  R Saxena, PIW de Bakker, K Singer, V Mootha, N Burtt, et al.
  (2006) American Journal of Human Genetics, 79 p.54-61
- Transferability of tag SNPs in genetic association studies in multiple populations
  Paul I. W. de Bakker, Noel P. Burtt, Robert R. Graham, Candace Guiducci, Roman Yelensky, et al.
  (2006) Nature Genetics, 38 p.1298-1303
- A dietary exchange of common bread for tailored bread of low glycaemic index and rich in dietary fibre improved insulin economy in young women with impaired glucose tolerance.
  Elin Östman, Anders Frid, Leif Groop, Inger Björck
  (2006) European Journal of Clinical Nutrition, 60 p.334-341
- High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people
  JC Florez, S Wiltshire, CM Agapakis, NP Burtt, PIW de Bakker, et al.
  (2006) Diabetes, 55 p.128-135
- Long-term beneficial effects of glipizide treatment on glucose tolerance in subjects with impaired glucose tolerance
  JG Eriksson, M Lehtovirta, B Ehrnstrom, S Salmela, Leif Groop
  (2006) Journal of Internal Medicine1989-01-01+01:00, 259 p.553-560
- Treatment with a thiazolidinedione increases eye protrusion in a subgroup of patients with type 2 diabetes.
  Mozhgan Dorkhan, Mikael Lantz, Anders Frid, Leif Groop, Bengt Hallengren
  (2006) Clinical Endocrinology, 65 p.35-39
- Common variants in HNF-1 alpha and risk of type 2 diabetes.
  Johan Holmkvist, C Cervin, Valeriya Lyssenko, W Winckler, Dragi Anevski, et al.
  (2006) Diabetologia, 49 p.2882-2891
- The Kruppel-like factor 11 (KLF11) Q62R polymorphism is not associated with type 2 diabetes in 8,676 people
  Jose C. Florez, Richa Saxena, Wendy Winckler, Noel P. Burtt, Peter Almgren, et al.
  (2006) Diabetes, 55 p.3620-3624
- The -374 T/A polymorphism in the gene encoding RAGE is associated with diabetic nephropathy and retinopathy in type 1 diabetic patients.
  Eero Lindholm, Ekaterine Bakhtadze, Marketa Sjögren, Corrado Cilio, Elisabet Agardh, et al.
  (2006) Diabetologia, 49 p.2745-2755
- HLA-DQB1 genotypes, islet antibodies and beta cell function in the classification of recent-onset diabetes among young adults in the nationwide Diabetes Incidence Study in Sweden.
  Ekaterine Bakhtadze, Henrik Borg, G Stenstrom, Per Fernlund, H Arnqvist, et al.
  (2006) Diabetologia, 49 p.1785-1794
- Genetic and Nongenetic Regulation of CAPN10 mRNA Expression in Skeletal Muscle.
  Emma A Nilsson, Pernille Poulsen, Heidi Storgaard, Peter Almgren, Charlotte Ling, et al.
  (2005) Diabetes, 54 p.3015-3020
- Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes.
  Valeriya Lyssenko, Peter Almgren, Dragi Anevski, Roland Perfekt, Kaj Lahti, et al.
  (2005) Diabetes, 54 p.166-174
- Heritability of model-derived parameters of beta cell secretion during intravenous and oral glucose tolerance tests: a study of twins
  M Lehtovirta, J Kaprio, Leif Groop, M Trombetta, RC Bonadonna
  (2005) Diabetologia, 48 p.1604-1613
- Overexpression of immediate early genes in active Graves' ophthalmopathy.
  Mikael Lantz, Tereza Planck, Hemang Parikh, Christofer Frenander, Martin Ridderstråle, et al.
  (2005) Journal of Clinical Endocrinology and Metabolism, 90 p.4784-4791
- Genetic prediction of future type 2 diabetes
  Valeriya Lyssenko, Peter Almgren, Dragi Anevski, Marju Orho-Melander, Marketa Sjögren, et al.
  (2005) PLoS Medicine, 2 p.1299-1308
- Nt-proANP in plasma, a marker of salt sensitivity, is reduced in type 2 diabetes patients.
  Olle Melander, E Frandsen, Martin Magnusson, Anders Grubb, Stefan Jovinge, et al.
  (2005) Journal of Internal Medicine1989-01-01+01:00, 257 p.281-288
- A male-specific quantitative trait locus on 1p21 controlling human stature
  S Sammalisto, T Hiekkalinna, E Suviolahti, K Sood, A Metzidis, et al.
  (2005) Journal of Medical Genetics, 42 p.932-939
- Association of common variation in the HNF1 alpha gene region with risk of type 2 diabetes
  W Winckler, N P Burtt, Johan Holmkvist, Camilla Cervin, P I W de Bakker, et al.
  (2005) Diabetes, 54 p.2336-2342
- Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men
  N Pitteloud, VK Mootha, AA Dwyer, M Hardin, H Lee, et al.
  (2005) Diabetes Care, 28 p.1636-1642
- Association testing of the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes in 7,883 people
  J C Florez, C M Agapakis, N P Burtt, M Sun, Peter Almgren, et al.
  (2005) Diabetes, 54 p.1884-1891
- Demonstrating stratification in a European American population
  C D Campbell, E L Ogburn, K L Lunetta, H N Lyon, M L Freedman, et al.
  (2005) Nature Genetics, 37 p.868-872
- Role of the FOXC2 -512C>T polymorphism in type 2 diabetes: possible association with the dysmetabolic syndrome.
  Emma A Nilsson, Leif Groop, Martin Ridderstråle
  (2005) International Journal of Obesity, 29 p.268-274
- Association of the E23K polymorphism in the KCNJ11 gene with gestational diabetes mellitus.
  Nael Shaat, M Ekelund, Åke Lernmark, Sten Ivarsson, Peter Almgren, et al.
  (2005) Diabetologia, 48 p.2544-2551
- Haplotype construction of the FRDA gene and evaluation of its role in type II diabetes.
  Johan Holmkvist, Peter Almgren, Hemang Parikh, Marco Zucchelli, Juha Kere, et al.
  (2005) European Journal of Human Genetics, 13 p.849-855
- Association testing of variants in the hepatocyte nuclear factor 4 alpha gene with risk of type 2 diabetes in 7,883 people
  W Winckler, R R Graham, P I W de Bakker, M Sun, Peter Almgren, et al.
  (2005) Diabetes, 54 p.886-892
- Calpain 10 and type 2 diabetes: are we getting closer to an explanation?
  Martin Ridderstråle, Hemang Parikh, Leif Groop
  (2005) Current Opinion in Clinical Nutrition and Metabolic Care, 8 p.361-366
- Genetic and non-genetic determinants of skeletal muscle GLUT4 mRNA levels and insulin action in twins.
  Heidi Storgaard, Pernille Poulsen, Charlotte Ling, Leif Groop, Allan A Vaag
  (2005) Journal of Clinical Endocrinology and Metabolism, 91 p.8-702
- Insulin sensitivity in adults with growth hormone deficiency and effect of growth hormone treatment.
  Leif Groop, Mikael Segerlantz, Margareta Bramnert
  (2005) Hormone Research, 64 Suppl 3 p.45-50
- Genetic testing for maturity onset diabetes of the young: uptake, attitudes and comparison with hereditary non-polyposis colorectal cancer
  B Liljestrom, K Aktan-Collan, B Isomaa, L Sarelin, A Uutela, et al.
  (2005) Diabetologia, 48 p.242-250
- Contribution of insulin-stimulated glucose uptake and basal hepatic insulin sensitivity to surrogate measures of insulin sensitivity.
  Devjit Tripathy, Peter Almgren, Tiinamaija Tuomi, Leif Groop
  (2004) Diabetes Care, 27 p.2204-2210
- Variation in the calpain-10 gene is associated with elevated triglyceride levels and reduced adipose tissue messenger ribonucleic acid expression in obese Swedish subjects.
  Emma A Nilsson, Jenny Fredriksson, Leif Groop, Martin Ridderstråle
  (2004) Journal of Clinical Endocrinology and Metabolism, 89 p.3601-3605
- Cosegregation of MIDD and MODY in a Pedigree: Functional and Clinical Consequences.
  Camilla Cervin, Brita Liljeström, Tiinamaija Tuomi, Seija Heikkinen, Juha S Tapanainen, et al.
  (2004) Diabetes, 53 p.1894-1899
- Association testing in 9,000 people fails to confirm the association of the insulin receptor substrate-1 G972R polymorphism with type 2 diabetes
  JC Florez, Marketa Sjögren, N Burtt, Marju Orho-Melander, S Schayer, et al.
  (2004) Diabetes, 53 p.3313-3318
- Heritability of ambulatory and office blood pressure phenotypes in Swedish families.
  Cristiano Fava, Philippe Burri, Peter Almgren, Leif Groop, Lennart Hulthén, et al.
  (2004) Journal of Hypertension, 22 p.1717-1721
- The FOXC2 C-512T Polymorphism Is Associated with Obesity and Dyslipidemia.
  Emma A Nilsson, Peter Almgren, Johan Hoffstedt, Leif Groop, Martin Ridderstråle
  (2004) Obesity Research, 12 p.1738-1743
- Haplotype Structure and Genotype-Phenotype Correlations of the Sulfonylurea Receptor and the Islet ATP-Sensitive Potassium Channel Gene Region.
  Jose C. Florez, Noël Burtt, Paul I.W. De Bakker, Peter Almgren, Tiinamaija Tuomi, et al.
  (2004) Diabetes, 53 p.1360-1368
- Effects of morning cortisol replacement on glucose and lipid metabolism in GH-treated subjects.
  Mikael Segerlantz, Margareta Bramnert, Ronnie Thomasson, Per Manhem, Esa Laurila, et al.
  (2004) European Journal of Endocrinology1994-01-01+01:00, 151 p.701-707
- Parallel manifestation of insulin resistance and beta cell decompensation is compatible with a common defect in Type 2 diabetes.
  Devjit Tripathy, Karl-Fredrik Eriksson, Marju Orho-Melander, Jenny Fredriksson, G. Ahlqvist, et al.
  (2004) Diabetologia, 47 p.782-793
- Elevated Plasma Levels of Nt-proBNP in Patients With Type 2 Diabetes Without Overt Cardiovascular Disease.
  Martin Magnusson, Olle Melander, Bo Israelsson, Anders Grubb, Leif Groop, et al.
  (2004) Diabetes Care, 27 p.1929-1935
- Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins.
  Charlotte Ling, Emma A Nilsson, Martin Ridderstråle, Peter Almgren, Leif Groop, et al.
  (2004) Journal of Clinical Investigation, 114 p.1518-1526
- Putative role of polymorphisms in UCP1-3 genes for diabetic nephropathy.
  Eero Lindholm, Mia Klannemark, Elisabet Agardh, Leif Groop, Carl-David Agardh
  (2004) Journal of Diabetes and its Complications1992-01-01+01:00, 18 p.103-107
- Characterization of the human skeletal muscle glycogen synthase gene (GYS1) promoter.
  Jenny Fredriksson, Martin Ridderstråle, Leif Groop, Marju Orho-Melander
  (2004) European Journal of Clinical Investigation, 34 p.113-121
- Genotypic and phenotypic differences between Arabian and Scandinavian women with gestational diabetes mellitus.
  Nael Shaat, M. Ekelund, Åke Lernmark, Sten Ivarsson, A. Nilsson, et al.
  (2004) Diabetologia, 47 p.878-884
- Association between a polymorphism in the carboxyl ester lipase gene and serum cholesterol profile
  SH Bengtsson-Ellmark, J Nilsson, Marju Orho-Melander, K Dahlenborg, Leif Groop, et al.
  (2004) European Journal of Human Genetics, 12 p.627-632
- Peroxisome proliferator-activated receptor-gammaPro12Ala polymorphism and the association with blood pressure in type 2 diabetes: Skaraborg Hypertension and Diabetes Project.
  Carl Johan Östgren, Ulf Lindblad, Olle Melander, Arne Melander, Leif Groop, et al.
  (2003) Journal of Hypertension, 21 p.1657-1662
- Fat feeding impairs glycogen synthase activity in mice without effects on its gene expression.
  Xudong Huang, Mona Hansson, Esa Laurila, Bo Ahrén, Leif Groop
  (2003) Metabolism, Clinical and Experimental, 52 p.535-539
- Dietary intakes and plasma concentrations of carotenoid's and tocopherols in relation to glucose metabolism in subjects at high risk of type 2 diabetes: the Botnia Dietary Study
  K Ylonen, G Alfthan, Leif Groop, C Saloranta, A Aro, et al.
  (2003) American Journal of Clinical Nutrition, 77 p.1434-1441
- Impaired cathepsin L gene expression in skeletal muscle is associated with type 2 diabetes.
  Xudong Huang, Allan Vaag, Emma A Nilsson, Mona Hansson, Bo Ahrén, et al.
  (2003) Diabetes, 52 p.2411-2418
- A genome wide scan for early onset primary hypertension in Scandinavians.
  Fredrik von Wowern, Kristina Bengtsson Boström, Cecilia Lindgren, Marju Orho-Melander, Frej Fyhrquist, et al.
  (2003) Human Molecular Genetics, 12 p.2077-2081
- No evidence of a relation between 11beta-hydroxysteroid dehydrogenasetype 2 activity and salt sensitivity.
  Olle Melander, Erik Frandsen, Leif Groop, Lennart Hulthén
  (2003) American Journal of Hypertension, 16 p.729-733
- A meta-analysis of four European genome screens (GIFT Consortium) shows evidence for a novel region on chromosome 17p11.2-q22 linked to type 2 diabetes.
  Florence Demenais, Timo Kanninen, Cecilia Lindgren, Steven Wiltshire, Stéphane Gaget, et al.
  (2003) Human Molecular Genetics, 12 p.1865-1873
- A Combination of Human Leukocyte Antigen DQB1*02 and the Tumor Necrosis Factor alpha Promoter G308A Polymorphism Predisposes to an Insulin-Deficient Phenotype in Patients with Type 2 Diabetes.
  Haiyan Li, Leif Groop, Anita Ramelius, Jianping Weng, Tiinamaija Tuomi
  (2003) Journal of Clinical Endocrinology and Metabolism, 88 p.2767-2774
- Growth hormone replacement therapy induces insulin resistance by activating the glucose-Fatty Acid cycle.
  Margareta Bramnert, Mikael Segerlantz, Esa Laurila, Jens R Daugaard, Per Manhem, et al.
  (2003) Journal of Clinical Endocrinology and Metabolism, 88 p.1455-1463
- A Genome-Wide Scan in Families With Maturity-Onset Diabetes of the Young: Evidence for Further Genetic Heterogeneity.
  Timothy M. Frayling, Cecilia Lindgren, Jean Claude Chevre, Stephan Menzel, Marie Wishart, et al.
  (2003) Diabetes, 52 p.872-881
- Associations of dietary fiber with glucose metabolism in nondiabetic relatives of subjects with type 2 diabetes - The Botnia Dietary Study
  K Ylonen, C Saloranta, C Kronberg-Kippila, Leif Groop, A Aro, et al.
  (2003) Diabetes Care, 26 p.1979-1985
- Polymorphisms of the HDL receptor gene associated with HDL cholesterol levels in diabetic kindred from three populations
  JJ McCarthy, S Lewitzky, C Reeves, A Permutt, B Glaser, et al.
  (2003) Human Heredity, 55 p.163-170
- Importance of obtaining independent measures of insulin secretion and insulin sensitivity during the same test - Results with the Botnia clamp
  Devjit Tripathy, Y Wessman, M Gullstrom, T Tuomi, Leif Groop
  (2003) Diabetes Care, 26 p.1395-1401
- Development of New Peripheral Arterial Occlusive Disease in Patients With Type 2 Diabetes During a Mean Follow-Up of 11 Years.
  Milla Kallio, Carol Forsblom, Per-Henrik Groop, Leif Groop, Mauri Lepäntalo
  (2003) Diabetes Care, 26 p.1241-1245
- Inhibition of lipolysis during acute GH exposure increases insulin sensitivity in previously untreated GH-deficient adults.
  Mikael Segerlantz, Margareta Bramnert, Per Manhem, Esa Laurila, Leif Groop
  (2003) European Journal of Endocrinology1994-01-01+01:00, 149 p.511-519
- PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.
  VK Mootha, Cecilia Lindgren, Karl-Fredrik Eriksson, A Subramanian, S Sihag, et al.
  (2003) Nature Genetics, 34 p.267-273
- Influence of glucose and insulin on transcapillary fluid absorption from the arm during lower body negative pressure in man
  H Olsen, Leif Groop, T Lanne
  (2003) European Journal of Applied Physiology1999-01-01+01:00, 90 p.138-143
- Familiality of metabolic abnormalities is dependent upon age at onset and phenotype of the type 2 diabetic proband.
  Devjit Tripathy, Eero Lindholm, B Isomaa, C Saloranta, T Tuomi, et al.
  (2003) American Journal of Physiology: Endocrinology and Metabolism, 285 p.1297-1303
- The insertion/deletion variation in the alpha2B-adrenoceptor does not seem to modify the risk for acute myocardial infarction, but may modify the risk for hypertension in sib-pairs from families with type 2 diabetes
  Amir Snapir, Mika Scheinin, Leif Groop, Marju Orho-Melander
  (2003) Cardiovascular Diabetology, 2
- The SLC6A14 gene shows evidence of association with obesity
  E Suviolahti, LJ Oksanen, M Ohman, RM Cantor, Martin Ridderstråle, et al.
  (2003) Journal of Clinical Investigation, 112 p.1762-1772
- Fallbeskrivning. Rosiglitazonbehandling gav kraftfull effekt, men fick ändå avbrytas
  Martin Ridderstråle, Leif Groop
  (2002) Läkartidningen, 99 p.407-410
- Down-regulation of insulin receptor substrates (IRS)-1 and IRS-2 and Src homologous and collagen-like protein Shc gene expression by insulin in skeletal muscle is not associated with insulin resistance or type 2 diabetes.
  Xudong Huang, Allan Vaag, Mona Hansson, Leif Groop
  (2002) Journal of Clinical Endocrinology and Metabolism, 87 p.255-259
- Contribution of known and unknown susceptibility genes to early-onset diabetes in scandinavia: evidence for heterogeneity.
  Cecilia Lindgren, Elisabeth Widén, Tiinamaija Tuomi, Haiyan Li, Peter Almgren, et al.
  (2002) Diabetes, 51 p.1609-1617
- Nateglinide Improves Early Insulin Secretion and Controls Postprandial Glucose Excursions in a Prediabetic Population.
  Carola Saloranta, Christiane Guitard, Eckhard Pecher, Pedro De Pablos-Velasco, Kaj Lahti, et al.
  (2002) Diabetes Care, 25 p.2141-2146
- Genomewide search for type 2 diabetes mellitus susceptibility loci in Finnish families: the Botnia study.
  C M Lindgren, M M Mahtani, E Widén, M I McCarthy, M J Daly, et al.
  (2002) American Journal of Human Genetics, 70 p.509-516
- 5 ' flanking variants of resistin are associated with obesity
  JC Engert, MC Vohl, SM Williams, P Lepage, JC Loredo-Osti, et al.
  (2002) Diabetes, 51 p.1629-1634
- FOXC2 mRNA Expression and a 5' Untranslated Region Polymorphism of the Gene Are Associated With Insulin Resistance.
  Martin Ridderstråle, Emma A Nilsson, Mia Klannemark, Anna Cederberg, Christina Kösters, et al.
  (2002) Diabetes, 51 p.3554-3560
- Polymorphism in the Calpain 10 gene influences glucose metabolism in human fat cells
  J Hoffstedt, M Ryden, P Lofgren, Marju Orho-Melander, Leif Groop, et al.
  (2002) Diabetologia, 45 p.276-282
- Decreased expression of heat shock protein 72 in skeletal muscle of patients with type 2 diabetes correlates with insulin resistance
  I Kurucz, A Morva, A Vaag, Karl-Fredrik Eriksson, Xudong Huang, et al.
  (2002) Diabetes, 51 p.1102-1109
- Characterization of a naturally occurring mutation (L107I) in the HNF1 alpha (MODY3) gene.
  Camilla Cervin, Marju Orho-Melander, Martin Ridderstråle, M Lehto, Sebastian Barg, et al.
  (2002) Diabetologia, 45 p.1703-1708
- Plasma ProANP(1-30) reflects salt sensitivity in subjects with heredity for hypertension
  Olle Melander, E Frandsen, Leif Groop, Lennart Hulthén
  (2002) Hypertension, 39 p.996-999
- The genetic abnormality in the beta cell determines the response to an oral glucose load
  A Stride, M Vaxillaire, T Tuomi, F Barbetti, PR Njolstad, et al.
  (2002) Diabetologia, 45 p.427-435
- Screening for MODY mutations, GAD antibodies, and type 1 diabetes--associated HLA genotypes in women with gestational diabetes mellitus.
  Jianping Weng, Magnus Ekelund, Markku Lehto, Haiyan Li, Göran Ekberg, et al.
  (2002) Diabetes Care, 25 p.68-71
- Variants in the calpain-10 gene predispose to insulin resistance and elevated free fatty acid levels.
  Marju Orho-Melander, Mia Klannemark, Malin Svensson, Martin Ridderstråle, Cecilia Lindgren, et al.
  (2002) Diabetes, 51 p.2658-2664
- Glutamic acid decarboxylase antibody positivity is associated with an impaired insulin response to glucose and arginine in nondiabetic patients with autoimmune thyroiditis
  ÅsaLinda Lethagen, UB Ericsson, Bengt Hallengren, Leif Groop, Tiinamaija Tuomi
  (2002) Journal of Clinical Endocrinology and Metabolism, 87 p.1177-1183
- Autoimmunity to CD38 and GAD in Type I and Type II diabetes: CD38 and HLA genotypes and clinical phenotypes
  A Antonelli, Tiinamaija Tuomi, M Nannipieri, P Fallahi, C Nesti, et al.
  (2002) Diabetologia, 45 p.1298-1306
- Cardiovascular morbidity and mortality associated with the metabolic syndrome
  B. Isomaa, Peter Almgren, T. Tuomi, B. Forsen, K. Lahti, et al.
  (2001) Diabetes Care, 24 p.683-689
- Metabolic effects of metformin in patients with impaired glucose tolerance
  M Lehtovirta, B Forsen, M Gullstrom, M Haggblom, J G Eriksson, et al.
  (2001) Diabetic Medicine, 18 p.578-583
- The dysmetabolic syndrome
  Leif Groop, Marju Orho-Melander
  (2001) Journal of Internal Medicine1989-01-01+01:00, 250 p.105-120
- An automated fluorescent single strand conformation polymorphism technique for high throughput mutation screening
  Jianping Weng, Markku Lehto, Anna Berglund, Leif Groop
  (2001) Chinese Medical Journal, 114 p.1147-1150
- Relationship between abdominal fat compartments and glucose and lipid metabolism in early postmenopausal women
  M Rendell, U L Hulthen, C Törnquist, Leif Groop, Ingrid Mattiasson
  (2001) Journal of Clinical Endocrinology and Metabolism, 86 p.744-749
- Common variants in the beta2-(Gln27Glu) and beta3-(Trp64Arg)--adrenoceptor genes are associated with elevated serum NEFA concentrations and type II diabetes
  M Carlsson, Marju Orho-Melander, J Hedenbro, Leif Groop
  (2001) Diabetologia, 44 p.629-636
- Differential phosphorylation of Janus kinase 2, Stat5A and Stat5B in response to growth hormone in primary rat adipocytes
  Martin Ridderstråle, Leif Groop
  (2001) Molecular and Cellular Endocrinology, 183 p.49-54
- Hypothalamic-pituitary-adrenal response to different tests in type 1 diabetes mellitus
  E G Almqvist, Leif Groop, P J Manhem
  (2001) Scandinavian Journal of Clinical & Laboratory Investigation, 61 p.557-565
- Polymorphism in the beta(1)-adrenergic receptor gene and hypertension
  Kristina Bengtsson, Olle Melander, Marju Orho-Melander, Ulf Lindblad, Jonas Ranstam, et al.
  (2001) Circulation, 104 p.187-190
- A gene conferring susceptibility to type 2 diabetes in conjunction with obesity is located on chromosome 18p11
  Alex Parker, Joanne Meyer, Steve Lewitzky, Jean S. Rennich, Gayun Chan, et al.
  (2001) Diabetes, 50 p.675-680
- Metabolic impact of a family history of Type 2 diabetes. Results from a European multicentre study (EGIR)
  A Vaag, M Lehtovirta, P Thye-Ronn, Leif Groop
  (2001) Diabetic Medicine, 18 p.533-540
- Characterization of the annexin I gene and evaluation of its role in type 2 diabetes
  Cecilia M. Lindgren, Anita Ramelius, Marju Orho-Melander, Peter Almgren, Leif Groop
  (2001) Diabetes, 50 p.2402-2405
- SR-B1 variants associated with HDL cholesterol levels in three populations
  J J McCarthy, S Lewitzky, A Permutt, B Glaser, Leif Groop, et al.
  (2001) American Journal of Human Genetics, 69 p.383-383
- The ACE gene I/D polymorphism is associated with higher mortality in men with hypertension and type 2 diabetes
  K Bengtsson, Ulf Lindblad, Marju Orho-Melander, Olle Melander, Jonas Ranstam, et al.
  (2001) Diabetologia, 44 p.35-35
- The metabolic syndrome influences the risk of chronic complications in patients with type II diabetes
  B Isomaa, M Henricsson, Peter Almgren, T Tuomi, M R Taskinen, et al.
  (2001) Diabetologia, 44 p.1148-1154
- Assessment of beta-cell function during the oral glucose tolerance test by a minimal model of insulin secretion
  A. Cretti, M. Lehtovirta, E. Bonora, B. Brunato, M.G. Zenti, et al.
  (2001) European Journal of Clinical Investigation, 31 p.405-416
- Functional consequences of mutations in the MODY4 gene (IPF1) and coexistence with MODY3 mutations
  J. Weng, W.M. Macfarlane, M. Lehto, H.F. Gu, L.M. Shepherd, et al.
  (2001) Diabetologia, 44 p.249-258
- Inhibition of the rise in FFA by Acipimox partially prevents GH-induced insulin resistance in GH-deficient adults
  Mikael Segerlantz, Margareta Bramnert, Per Manhem, Esa Laurila, Leif Groop
  (2001) Journal of Clinical Endocrinology and Metabolism, 86 p.5813-5818
- Possible human leukocyte antigen-mediated genetic interaction between type 1 and type 2 Diabetes
  Haiyan Li, Eero Lindholm, Peter Almgren, A Gustafsson, C Forsblom, et al.
  (2001) Journal of Clinical Endocrinology and Metabolism, 86 p.574-582
- Beta(2)-adrenergic receptor gene variation and hypertension in subjects with type 2 diabetes
  Kristina Bengtsson, Marju Orho-Melander, Olle Melander, Ulf Lindblad, Jonas Ranstam, et al.
  (2001) Hypertension, 37 p.1303-1308
- Linkage disequilibrium at PPARG and other genes assessed with dense sets of SNPs.
  J.N. Hirschhorn, D. Altshuler, M.J. Daly, C.M. Lindgren, N.P. Burtt, et al.
  (2001) American Journal of Human Genetics, 69 p.522-522
- Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height
  J.N. Hirschhorn, Cecilia Lindgren, M.J. Daly, A. Kirby, S.F. Schaffner, et al.
  (2001) American Journal of Human Genetics, 69 p.106-116
- Angiotensin converting enzyme (ACE) gene polymorphism in sarcoidosis in relation to associated autoimmune diseases
  K I Papadopoulos, Olle Melander, Marju Orho-Melander, Leif Groop, M Carlsson, et al.
  (2000) Journal of Internal Medicine1989-01-01+01:00, 247 p.71-77
- The T 54 allele of the intestinal fatty acid-binding protein 2 is associated with a parental history of stroke
  Martin Carlsson, Marju Orho-Melander, Jan Hedenbro, Peter Almgren, Leif Groop
  (2000) Journal of Clinical Endocrinology and Metabolism, 85 p.2801-2804
- Role of the Gly460Trp polymorphism of the alpha-adducin gene in primary hypertension in Scandinavians
  Olle Melander, K Bengtsson, Marju Orho-Melander, U Lindblad, C Forsblom, et al.
  (2000) Journal of Human Hypertension, 14 p.43-46
- Genetic variants of thiazide-sensitive NaCl-cotransporter in Gitelman's syndrome and primary hypertension
  Olle Melander, Marju Orho-Melander, Kristina Bengtsson Boström, Ulf Lindblad, Lennart Råstam, et al.
  (2000) Hypertension, 36 p.389-394
- Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
  Y Horikawa, N Oda, N J Cox, X Li, Marju Orho-Melander, et al.
  (2000) Nature Genetics, 26 p.163-175
- Pathogenesis of type 2 diabetes: the relative contribution of insulin resistance and impaired insulin secretion
  Leif Groop
  (2000) International journal of clinical practice. Supplement, p.3-13
- Interaction between the Asn291Ser variant of the LPL gene and insulin resistance on dyslipidaemia in high risk individuals for Type 2 diabetes mellitus
  Mia Klannemark, L Suurinkeroinen, Marju Orho-Melander, Leif Groop, M R Taskinen
  (2000) Diabetic Medicine, 17 p.599-605
- Association between a variant in the 11 beta-hydroxysteroid dehydrogenase type 2 gene and primary hypertension
  Olle Melander, Marju Orho-Melander, K Bengtsson, U Lindblad, Lennart Råstam, et al.
  (2000) Journal of Human Hypertension, 14 p.819-823
- Expression of naturally occurring variants in the muscle glycogen synthase gene
  Marju Orho-Melander, H Shimomura, T Sanke, S K Rasmussen, K Nanjo, et al.
  (1999) Diabetes, 48 p.918-920
- Polymorphism in the angiotensin converting enzyme but not in the angiotensinogen gene is associated with hypertension and type 2 diabetes: the Skaraborg Hypertension and diabetes project
  Kristina Bengtsson Boström, Marju Orho-Melander, Ulf Lindblad, Olle Melander, Erik Bøg-Hansen, et al.
  (1999) Journal of Hypertension, 17 p.1569-1575
- A paired-sibling analysis of the XbaI polymorphism in the muscle glycogen synthase gene
  Marju Orho-Melander, Peter Almgren, T Kanninen, C Forsblom, Leif Groop
  (1999) Diabetologia, 42 p.1138-1145
Journal article (comment)
- New approaches beyond genetics : towards precision medicine in diabetes
  Leif Groop
  (2016) Diabetologia, 59 p.2495-2496
- Genetics and neonatal diabetes: towards precision medicine.
  Leif Groop
  (2015) The Lancet, 386 p.934-935
- Can genetics improve precision of therapy in diabetes?
  Leif Groop, Petter Storm, Anders Rosengren
  (2014) Trends in Endocrinology and Metabolism, 25 p.440-443
- From fused toes in mice to human obesity
  Leif Groop
  (2007) Nature Genetics, 39 p.706-707
- Latent autoimmune diabetes in adults (LADA)-more than a name.
  Leif Groop, T Tuomi, M Rowley, P Zimmet, I Mackay
  (2006) Diabetologia, 49 p.1996-1998
Journal article (letter)
- Novel diabetes subgroups – Authors' reply
  Emma Ahlqvist, Rashmi B. Prasad, Tiinamaija Tuomi, Anders Rosengren, Leif Groop
  (2018) The Lancet Diabetes and Endocrinology, 6 p.440-441
- Branched-chain amino acids are associated with odd-chain fatty acids in normoglycaemic individuals
  M. Al-Majdoub, N. Geidenstam, A. Ali, M. Ridderstråle, P. Storm, et al.
  (2017) Diabetes & Metabolism1996-01-01+01:00, 43 p.475-479
- Intraorbital deiodinase type 2 expression is downregulated in chronic phase of Graves' ophthalmopathy.
  Tereza Planck, Hemang Parikh, Leif Groop, Bengt Hallengren, Mikael Lantz
  (2012) Clinical Endocrinology, 77 p.487-488
- Analysis of TBC1D4 in patients with severe insulin resistance
  S. Dash, C. Langenberg, K. A. Fawcett, R. K. Semple, S. Romeo, et al.
  (2010) Diabetologia, 53 p.1239-1242
- Clinical Risk Factors, DNA Variants, and the Development of Type 2 Diabetes THE AUTHORS REPLY
  Valeriya Lyssenko, Peter Nilsson, Leif Groop
  (2009) New England Journal of Medicine, 360 p.1361-1361
- New insights into impaired muscle glycogen synthesis.
  Leif Groop, Marju Orho-Melander
  (2008) PLoS Medicine, 5 p.18-19
- The intake of potatoes and glucose metabolism in subjects at high risk for Type 2 diabetes
  S. K. Ylonen, S. M. Virtanen, Leif Groop
  (2007) Diabetic Medicine, 24 p.1049-1050
- Associating mitochondrial DNA variation with complex traits - Reply to Elson et al.
  Richa Saxena, Paul I. W. de Bakker, Leif Groop, Mark J. Daly, David Altshuler
  (2007) American Journal of Human Genetics, 80 p.382-383
- Authors' reply.
  Valeriya Lyssenko, Dragi Anevski, Peter Almgren, Leif Groop
  (2006) PLoS Medicine, 3 p.271-272
- Statistical concerns about the GSEA procedure - Reply
  VK Mootha, MJ Daly, N Patterson, JN Hirschhorn, Leif Groop, et al.
  (2004) Nature Genetics, 36 p.663-663
- Intrauterine hyperglycemia modifying the development of (monogenic) diabetes?
  Tiinamaija Tuomi, Leif Groop
  (2003) Diabetes Care, 26 p.1295-1296
- Bringing diabetes therapeutics to the big screen.
  Leif Groop
  (2003) Nature Biotechnology1996-01-01+01:00, 21 p.240-241
Journal article review
- Precision medicine in Type 2 Diabetes
  Rashmi B Prasad, Leif Groop
  (2019) Journal of Internal Medicine, 285 p.40-48
- Petition to replace current OGTT criteria for diagnosing prediabetes with the 1-hour post-load plasma glucose ≥ 155 mg/dl (8.6 mmol/L)
  Michael Bergman, Melania Manco, Giorgio Sesti, Rachel Dankner, Manan Pareek, et al.
  (2018) Diabetes Research and Clinical Practice, 146 p.18-33
- Epigenetic modifications and gestational diabetes : A Systematic review of published literature
  Gunn Helen Moen, Christine Sommer, Rashmi B. Prasad, Line Sletner, Leif Groop, et al.
  (2017) European Journal of Endocrinology1994-01-01+01:00, 176 p.247-267
- Differentiation of diabetes by pathophysiology, natural history, and prognosis
  Jay S Skyler, George L. Bakris, Ezio Bonifacio, Tamara Darsow, Robert H. Eckel, et al.
  (2017) Diabetes, 66 p.241-255
- The genetics of diabetic complications.
  Emma Ahlqvist, Natalie R van Zuydam, Leif Groop, Mark I McCarthy
  (2015) Nature Reviews Nephrology, 11 p.277-287
- Genetics of type 2 diabetes : It matters from which parent we inherit the risk
  Valeriya Lyssenko, Leif Groop, Rashmi B. Prasad
  (2015) Review of Diabetic Studies, 12 p.233-242
- Genetics of type 2 diabetes-pitfalls and possibilities.
  Rashmi Prasad, Leif Groop
  (2015) Genes, 6 p.87-123
- Tyypin 2 diabetes--perinnöllinen kohtalo vai hyvinvointiyhteiskunnan rangaistus?
  Leif Groop
  (2014) Duodecim, 130 p.2339-2346
- The many faces of diabetes: a disease with increasing heterogeneity
  Tiinamaija Tuomi, Nicola Santoro, Sonia Caprio, Mengyin Cai, Jianping Weng, et al.
  (2014) The Lancet, 383 p.1084-1094
- Underlying Genetic Models of Inheritance in Established Type 2 Diabetes Associations
  Georgia Salanti, Lorraine Southam, David Altshuler, Kristin Ardlie, Ines Barroso, et al.
  (2009) American Journal of Epidemiology, 170 p.537-545
- Epigenetics: A Molecular Link Between Environmental Factors and Type 2 Diabetes
  Charlotte Ling, Leif Groop
  (2009) Diabetes, 58 p.2718-2725
- Genetics of gestational diabetes mellitus.
  Nael Shaat, Leif Groop
  (2007) Current Medicinal Chemistry, 14 p.569-583
- Candidate genes for type 2 diabetes.
  Hemang Parikh, Leif Groop
  (2004) Reviews in Endocrine and Metabolic Disorders, 5 p.151-176

12 October 2016

Leif Groop

E-mail: leif [dot] groop [at] med [dot] lu [dot] se

Principal investigator

Genomics, Diabetes and Endocrinology

Telephone number:+46 40 39 12 02

Mobile number:+46 70 591 25 48

Service point:33

Professor

EXODIAB: Excellence in Diabetes Research in Sweden

Professor

Genomics, Diabetes and Endocrinology

Service point:33

My profile in Lund University research portal

Lund University Diabetes Centre

Excellence of diabetes research in Sweden

Leif Groop

Publications

Publications

Publications