Leif Groop
Principal investigator
Publications
Displaying of publications. Sorted by year, then title.
A multigenerational study on phenotypic consequences of the most common causal variant of HNF1A-MODY
Jarno L.T. Kettunen, Elina Rantala, Om P. Dwivedi, Bo Isomaa, Leena Sarelin, et al.
(2022) Diabetologia, 65 p.632-643
Journal articleSubgroups of patients with young-onset type 2 diabetes in India reveal insulin deficiency as a major driver
Rashmi B Prasad, Olof Asplund, Sharvari R Shukla, Rucha Wagh, Pooja Kunte, et al.
(2022) Diabetologia, 65 p.65-78
Journal articleValidation of the classification for type 2 diabetes into five subgroups : a report from the ORIGIN trial
Marie Pigeyre, Sibylle Hess, Maria F. Gomez, Olof Asplund, Leif Groop, et al.
(2022) Diabetologia, 65 p.206-215
Journal articleThe role of circulating galectin-1 in type 2 diabetes and chronic kidney disease : evidence from cross-sectional, longitudinal and Mendelian randomisation analyses
Isabel Drake, Emanuel Fryk, Lena Strindberg, Annika Lundqvist, Anders H. Rosengren, et al.
(2022) Diabetologia, 65 p.128-139
Journal articleTowards improved precision and a new classification of diabetes mellitus
Emma Ahlqvist, Rashmi B Prasad, Leif Groop
(2022) Journal of Endocrinology, 252 p.59-70
Journal article reviewLipid-Associated Variants near ANGPTL3 and LPL Show Parent-of-Origin Specific Effects on Blood Lipid Levels and Obesity
Anna Lessmark, Gad Hatem, Györgyi Kovacs, Marta Vitai, Emma Ahlqvist, et al.
(2022) Genes, 13 p.1-15
Journal articleMapping the cord blood transcriptome of pregnancies affected by early maternal anemia to identify signatures of fetal programming
Gad Hatem, Line Hjort, Olof Asplund, Daniel T R Minja, Omari Abdul Msemo, et al.
(2022) The Journal of clinical endocrinology and metabolism
Journal articleData-driven subgroups of type 2 diabetes, metabolic response, and renal risk profile after bariatric surgery : a retrospective cohort study
Violeta Raverdy, Ricardo V. Cohen, Robert Caiazzo, Helene Verkindt, Tarissa Beatrice Zanata Petry, et al.
(2022) The Lancet Diabetes and Endocrinology, 10 p.167-176
Journal articleEpigenome-Wide Histone Acetylation Changes in Peripheral Blood Mononuclear Cells in Patients with Type 2 Diabetes and Atherosclerotic Disease
Pradeep Bompada, Isabel Goncalves, Chuanyan Wu, Rui Gao, Jiangming Sun, et al.
(2021) Biomedicines, 9
Journal articleReduced expression of OXPHOS and DNA damage genes is linked to protection from microvascular complications in long-term type 1 diabetes : the PROLONG study
Türküler Özgümüş, Oksana Sulaieva, Leon Eyrich Jessen, Ruchi Jain, Henrik Falhammar, et al.
(2021) Scientific Reports, 11
Journal articleDistinct Molecular Signatures of Clinical Clusters in People with Type 2 Diabetes : an IMIRHAPSODY Study
Roderick C Slieker, Louise A Donnelly, Hugo Fitipaldi, Gerard A Bouland, Giuseppe N Giordano, et al.
(2021) Diabetes, 70 p.2683-2693
Journal articleRelationship between insulin sensitivity and gene expression in human skeletal muscle
Hemang M Parikh, Targ Elgzyri, Amra Alibegovic, Natalie Hiscock, Ola Ekström, et al.
(2021) BMC Endocrine Disorders, 21
Journal articleSCRT1 is a novel beta cell transcription factor with insulin regulatory properties
S. Chriett, A. Lindqvist, L. Shcherbina, A. Edlund, M. Abels, et al.
(2021) Molecular and Cellular Endocrinology, 521
Journal articleGlucose-Dependent Insulinotropic Peptide in the High-Normal Range Is Associated With Increased Carotid Intima-Media Thickness
Amra Jujić, Peter M Nilsson, Naeimeh Atabaki-Pasdar, Anna Dieden, Tiinamaija Tuomi, et al.
(2021) Diabetes Care, 44 p.224-230
Journal articleConsumption of red meat, genetic susceptibility, and risk of LADA and type 2 diabetes
Josefin E. Löfvenborg, Emma Ahlqvist, Lars Alfredsson, Tomas Andersson, Leif Groop, et al.
(2021) European Journal of Nutrition, 60 p.769-779
Journal articleAdult-onset type 1 diabetic patients with less severe clinical manifestation have less risk DR-DQ genotypes than childhood-onset patients
Wenqian Ren, Daizhi Yang, Ziyu Jiang, Yingxin Xian, Qianwen Huang, et al.
(2021) Diabetes/Metabolism Research and Reviews, 37
Journal articleHLA class I genes modulate disease risk and age at onset together with DR-DQ in Chinese patients with insulin-requiring type 1 diabetes
Ziyu Jiang, Wenqian Ren, Hua Liang, Jinhua Yan, Daizhi Yang, et al.
(2021) Diabetologia, 64 p.2026-2036
Journal articleReplication and cross-validation of type 2 diabetes subtypes based on clinical variables : an IMI-RHAPSODY study
Roderick C Slieker, Louise A Donnelly, Hugo Fitipaldi, Gerard A Bouland, Giuseppe N Giordano, et al.
(2021) Diabetologia, 64 p.1982-1989
Journal articleAdult-onset diabetes in Middle Eastern immigrants to Sweden : Novel subgroups and diabetic complications—The All New Diabetes in Scania cohort diabetic complications and ethnicity
Louise Bennet, Christopher Nilsson, Dina Mansour-Aly, Anders Christensson, Leif Groop, et al.
(2021) Diabetes/Metabolism Research and Reviews, 37
Journal articleCombined lifestyle factors and the risk of LADA and type 2 diabetes – Results from a Swedish population-based case-control study
Katharina Herzog, Emma Ahlqvist, Lars Alfredsson, Leif Groop, Rebecka Hjort, et al.
(2021) Diabetes Research and Clinical Practice, 174
Journal articleAssociation of Implementation of a Comprehensive Preconception-to-Pregnancy Management Plan With Pregnancy Outcomes Among Chinese Pregnant Women With Type 1 Diabetes : The CARNATION Study
Xueying Zheng, Daizhi Yang, Sihui Luo, Jinhua Yan, Xiaohui Guo, et al.
(2021) Diabetes Care, 44 p.883-892
Journal articleAccuracy of 1-Hour Plasma Glucose During the Oral Glucose Tolerance Test in Diagnosis of Type 2 Diabetes in Adults : A Meta-analysis
Vasudha Ahuja, Pasi Aronen, T. A. Pramodkumar, Helen Looker, Angela Chetrit, et al.
(2021) Diabetes Care, 44 p.1062-1069
Journal article reviewSex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
Vasiliki Lagou, Ulrika Krus, Leif Groop, Tiinamaija Tuomi, Valeriya Lyssenko, et al.
(2021) Nature Communications, 12
Journal articleRecognition of maturity-onset diabetes of the young in China
Hua Liang, Yanan Zhang, Maixinyue Li, Jinhua Yan, Daizhi Yang, et al.
(2021) Journal of Diabetes Investigation, 12 p.501-509
Journal articleNovel Reclassification of Adult Diabetes Is Useful to Distinguish Stages of β-Cell Function Linked to the Risk of Vascular Complications : The DOLCE Study From Northern Ukraine
Olena Fedotkina, Oksana Sulaieva, Turkuler Ozgumus, Liubov Cherviakova, Nadiya Khalimon, et al.
(2021) Frontiers in Genetics, 12
Journal articleGenetic factors affect the susceptibility to bacterial infections in diabetes
Johan R Simonsen, Annemari Käräjämäki, Anni A Antikainen, Iiro Toppila, Emma Ahlqvist, et al.
(2021) Scientific Reports, 11
Journal articleCohort profile : Epigenetics in Pregnancy (EPIPREG) - population-based sample of European and South Asian pregnant women with epigenome-wide DNA methylation (850k) in peripheral blood leukocytes
Nicolas Fragoso-Bargas, Julia O Opsahl, Nadezhda Kiryushchenko, Yvonne Böttcher, Sindre Lee-Ødegård, et al.
(2021) PLoS ONE, 16 p.1-15
Journal articleGenome-wide association analyses highlight etiological differences underlying newly defined subtypes of diabetes
Dina Mansour Aly, Om Prakash Dwivedi, Rashmi B Prasad, Annemari Käräjämäki, Rebecka Hjort, et al.
(2021) Nature Genetics, 53 p.1534-1542
Journal articleUrinary extracellular vesicles : Assessment of pre-analytical variables and development of a quality control with focus on transcriptomic biomarker research
Karina Barreiro, Om Prakash Dwivedi, Sami Valkonen, Per Henrik Groop, Tiinamaija Tuomi, et al.
(2021) Journal of Extracellular Vesicles, 10
Journal articleElevated circulating follistatin associates with an increased risk of type 2 diabetes
Chuanyan Wu, Yan Borné, Rui Gao, Maykel López Rodriguez, William C Roell, et al.
(2021) Nature Communications, 12 p.1-10
Journal articleGenome-Wide Association Study of Peripheral Artery Disease
Natalie R. van Zuydam, Alexander Stiby, Moustafa Abdalla, Erin Austin, Emma H. Dahlström, et al.
(2021) Circulation. Genomic and precision medicine, 14 p.002862-002862
Journal articleGenetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health
Satu Strausz, Sanni Ruotsalainen, Hanna M. Ollila, Juha Karjalainen, Tuomo Kiiskinen, et al.
(2021) European Respiratory Journal, 57 p.1-17
Journal articleDeterminants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes
J.K. Goodrich, Leif Groop, Peter M Nilsson, Tiinamaija Tuomi, M.S. Udler
(2021) Nature Communications, 12
Journal articleThe trans-ancestral genomic architecture of glycemic traits
J. Chen, Valeriya Lyssenko, Paul Franks, Sölve Elmståhl, Leif Groop, et al.
(2021) Nature Genetics, 53 p.840-860
Journal articleTIGER : The gene expression regulatory variation landscape of human pancreatic islets
Lorena Alonso, Anthony Piron, Ignasi Morán, Marta Guindo-Martínez, Sílvia Bonàs-Guarch, et al.
(2021) Cell Reports, 37
Journal articleMuscleAtlasExplorer : a web service for studying gene expression in human skeletal muscle
Olof Asplund, Johan Rung, Leif Groop, Rashmi Prasad B, Ola Hansson
(2020) Database: the journal of biological databases and curation, 2020
Journal articlePhysical Activity, Genetic Susceptibility, and the Risk of Latent Autoimmune Diabetes in Adults and Type 2 Diabetes
Rebecka Hjort, Emma Ahlqvist, Tomas Andersson, Lars Alfredsson, Per Ola Carlsson, et al.
(2020) The Journal of clinical endocrinology and metabolism, 105
Journal articleLow-cost exercise interventions improve long-term cardiometabolic health independently of a family history of type 2 diabetes : a randomized parallel group trial
Niko S Wasenius, Bo A Isomaa, Bjarne Östman, Johan Söderström, Björn Forsén, et al.
(2020) BMJ open diabetes research & care, 8
Journal articleGenetic variant effects on gene expression in human pancreatic islets and their implications for T2D
Ana Viñuela, Arushi Varshney, Martijn van de Bunt, Rashmi B Prasad, Olof Asplund, et al.
(2020) Nature Communications, 11 p.4912-4912
Journal articleEvaluating drug targets through human loss-of-function genetic variation
Eric Vallabh Minikel, Daniel G MacArthur
(2020) Nature, 581 p.459-464
Journal articleTranscript expression-aware annotation improves rare variant interpretation
Beryl B. Cummings, Daniel G MacArthur
(2020) Nature, 581 p.452-458
Journal articleA structural variation reference for medical and population genetics
Ryan Collins, Michael E Talkowski
(2020) Nature, 581 p.444-451
Journal articleThe mutational constraint spectrum quantified from variation in 141,456 humans
Konrad J. Karczewski, Daniel G MacArthur
(2020) Nature, 581 p.434-443
Journal articleGlucose-dependent insulinotropic peptide and risk of cardiovascular events and mortality : a prospective study
Amra Jujić, Naeimeh Atabaki-Pasdar, Peter M Nilsson, Peter Almgren, Liisa Hakaste, et al.
(2020) Diabetologia, 63 p.1043-1054
Journal articleHigh Prevalence of Gestational Diabetes Mellitus in Rural Tanzania-Diagnosis Mainly Based on Fasting Blood Glucose from Oral Glucose Tolerance Test
Louise Groth Grunnet, Line Hjort, Daniel Thomas Minja, Omari Abdul Msemo, Sofie Lykke Møller, et al.
(2020) International Journal of Environmental Research and Public Health, 17
Journal articleHydroxysteroid 17-β dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease
Panu K. Luukkonen, Taru Tukiainen, Anne Juuti, Henna Sammalkorpi, P. A. Nidhina Haridas, et al.
(2020) JCI Insight, 5
Journal articleGlucocorticoid induces human beta cell dysfunction by involving riborepressor GAS5 LincRNA
Jonathan L.S. Esguerra, Jones K. Ofori, Mototsugu Nagao, Yuki Shuto, Alexandros Karagiannopoulos, et al.
(2020) Molecular Metabolism, 32 p.160-167
Journal articleGenotypes of HLA, TCF7L2, and FTO as potential modifiers of the association between sweetened beverage consumption and risk of LADA and type 2 diabetes
Josefin E. Löfvenborg, Emma Ahlqvist, Lars Alfredsson, Tomas Andersson, Mozhgan Dorkhan, et al.
(2020) European Journal of Nutrition, 59 p.127-135
Journal articleLife-long impairment of glucose homeostasis upon prenatal exposure to psychostimulants
Solomiia Korchynska, Maria Krassnitzer, Katarzyna Malenczyk, Rashmi B Prasad, Evgenii O Tretiakov, et al.
(2020) EMBO Journal, 39
Journal articleAbsence of Islet Autoantibodies and Modestly Raised Glucose Values at Diabetes Diagnosis Should Lead to Testing for MODY : Lessons From a 5-Year Pediatric Swedish National Cohort Study
Annelie Carlsson, Maggie Shepherd, Sian Ellard, Michael Weedon, Åke Lernmark, et al.
(2020) Diabetes Care, 43 p.82-89
Journal articleMetabolic and Genetic Determinants of Glucose Shape After Oral Challenge in Obese Youths : A Longitudinal Study
Alfonso Galderisi, Domenico Tricò, Chiara Dalla Man, Nicola Santoro, Bridget Pierpont, et al.
(2020) The Journal of clinical endocrinology and metabolism, 105
Journal articleGenetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC
Rajashree Mishra, Mikael Åkerlund, Diana L. Cousminer, Emma Ahlqvist, Jonathan P. Bradfield, et al.
(2020) Diabetes Care, 43 p.418-425
Journal articleGhrelin suppresses insulin secretion in human islets and type 2 diabetes patients have diminished islet ghrelin cell number and lower plasma ghrelin levels
A Lindqvist, L Shcherbina, R B Prasad, M G Miskelly, M Abels, et al.
(2020) Molecular and Cellular Endocrinology, 511
Journal articleThe effect of LRRK2 loss-of-function variants in humans
Nicola Whiffin, Leif Groop, Olle Melander, Peter M. Nilsson, Daniel G MacArthur
(2020) Nature Medicine , p.869-877
Journal articleLiver nucleotide biosynthesis is linked to protection from vascular complications in individuals with long-term type 1 diabetes
Ruchi Jain, Türküler Özgümüş, Troels Mygind Jensen, Elsa du Plessis, Magdalena Keindl, et al.
(2020) Scientific Reports, 10
Journal articleDiscovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
Praveen Surendran, Cristiano Fava, Olle Melander, Marju Orho-Melander, Alaitz Poveda, et al.
(2020) Nature Genetics, 52 p.1314-1332
Journal articleSerology assessment of antibody response to SARS-CoV-2 in patients with COVID-19 by rapid IgM/IgG antibody test
Yang De Marinis, Torgny Sunnerhagen, Pradeep Bompada, Anna Bläckberg, Runtao Yang, et al.
(2020) Infection Ecology and Epidemiology, 10
Journal articleIncreased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms
Magdalena Keindl, Olena Fedotkina, Elsa du Plessis, Ruchi Jain, Brith Bergum, et al.
(2020) Frontiers in Endocrinology, 11
Journal articleSubtypes of type 2 diabetes determined from clinical parameters
Emma Ahlqvist, Rashmi B. Prasad, Leif Groop
(2020) Diabetes, 69 p.2086-2093
Journal article reviewBlood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array
Yunsung Lee, Kristine L. Haftorn, William R.P. Denault, Haakon E. Nustad, Christian M. Page, et al.
(2020) BMC Genomics, 21
Journal articleGenome-wide association analysis of type 2 diabetes in the EPIC-InterAct study
Lina Cai, Eleanor Wheeler, Nicola D. Kerrison, Jian’an Luan, Panos Deloukas, et al.
(2020) Scientific Data, 7
Journal articleGenetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus
Natalie R. van Zuydam, Leif Groop, Colin N. A. Palmer
(2020) Circulation: Genomic and Precision Medicine , p.640-648
Journal articleMetabolic Effects of Gastric Bypass Surgery : Is It All About Calories?
Katharina Herzog, Johan Berggren, Mahmoud Al Majdoub, Claudia Balderas Arroyo, Andreas Lindqvist, et al.
(2020) Diabetes, 69 p.2027-2035
Journal articleEpigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes
Sonia García-Calzón, Alexander Perfilyev, Mats Martinell, Monta Ustinova, Sebastian Kalamajski, et al.
(2020) Science Translational Medicine, 12
Journal articleCharacterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals
Nicola Whiffin, Leif Groop, C Haiman, Olle Melander, Peter M Nilsson, et al.
(2020) Nature Communications, 11
Journal articleLandscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes
Qingbo Wang, Leif Groop, C Haiman, Olle Melander, Peter M Nilsson, et al.
(2020) Nature Communications, 11
Journal articleLoss of ZnT8 function protects against diabetes by enhanced insulin secretion
Om Prakash Dwivedi, Mikko Lehtovirta, Benoit Hastoy, Vikash Chandra, Nicole A. J. Krentz, et al.
(2019) Nature Genetics , p.1-22
Journal articleClusters provide a better holistic view of type 2 diabetes than simple clinical features
Emma Ahlqvist, Tiinamaija Tuomi, Leif Groop
(2019) The Lancet Diabetes and Endocrinology, 7 p.668-669
Journal article (letter)Heterogeneity of diabetes - An Indian perspective
Rashmi B Prasad, Emma Ahlqvist, Leif Groop
(2019) Diabetes & metabolic syndrome, 13 p.3065-3067
Journal article reviewWhat do healthcare professionals need to turn risk models for type 2 diabetes into usable computerized clinical decision support systems? Lessons learned from the MOSAIC project
Giuseppe Fico, Liss Hernanzez, Jorge Cancela, Arianna Dagliati, Lucia Sacchi, et al.
(2019) BMC Medical Informatics and Decision Making, 19
Journal articleHuman pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes
Irene Miguel-Escalada, Silvia Bonàs-Guarch, Inês Cebola, Joan Ponsa-Cobas, Julen Mendieta-Esteban, et al.
(2019) Nature Genetics, 51 p.1137-1148
Journal articleFostering improved human islet research : a European perspective
Piero Marchetti, Anke M. Schulte, Lorella Marselli, Eyke Schoniger, Marco Bugliani, et al.
(2019) Diabetologia, 62 p.1514-1516
Journal article (letter)Genome editing of human pancreatic beta cell models : problems, possibilities and outlook
Diego Balboa, Rashmi B Prasad, Leif Groop, Timo Otonkoski
(2019) Diabetologia, 62 p.1329-1336
Journal article reviewFOETAL for NCD-FOetal Exposure and Epidemiological Transitions : the role of Anaemia in early Life for Non-Communicable Diseases in later life: a prospective preconception study in rural Tanzania
Line Hjort, Sofie Lykke Møller, Daniel Minja, Omari Msemo, Birgitte Bruun Nielsen, et al.
(2019) BMJ Open, 9
Journal articleRoadmap for a precision-medicine initiative in the Nordic region
Pål Rasmus Njølstad, Ole Andreas Andreassen, Søren Brunak, Anders D. Børglum, Joakim Dillner, et al.
(2019) Nature Genetics
Journal article (comment)Phenotypic and genotypic differences between Indian and Scandinavian women with gestational diabetes mellitus
Geeti P Arora, Mikael Åkerlund, Charlotte Brøns, Gunn-Helen Moen, Niko S Wasenius, et al.
(2019) Journal of Internal Medicine, 286 p.192-206
Journal articleThe Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia : design, results and future prospects
Christel M Middeldorp, Leif Groop, Rashmi Prasad, Mark I McCarthy
(2019) European Journal of Epidemiology, 34 p.279-300
Journal articleThe functional impact of G protein-coupled receptor 142 (Gpr142) on pancreatic β-cell in rodent
Israa Mohammad Al-Amily, Pontus Dunér, Leif Groop, Albert Salehi
(2019) Pflügers Archiv, 471 p.633-645
Journal articleA novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes : results from an exome-wide association study of albuminuria
Tarunveer S. Ahluwalia, Christina Alexandra Schulz, Johannes Waage, Tea Skaaby, Niina Sandholm, et al.
(2019) Diabetologia, 62 p.292-305
Journal articleThe associations of daylight and melatonin receptor 1B gene rs10830963 variant with glycemic traits : the prospective PPP-Botnia study
Kadri Haljas, Liisa Hakaste, Jari Lahti, Bo Isomaa, Leif Groop, et al.
(2019) Annals of Medicine, 51 p.58-67
Journal articlePreserving Insulin Secretion in Diabetes by Inhibiting VDAC1 Overexpression and Surface Translocation in β Cells
Enming Zhang, Israa Mohammed, Sarheed Mohammed, Cheng Luan, Olof Asplund, et al.
(2019) Cell Metabolism, 29 p.6-77
Journal articleMultiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control
Samuela Pollack, Leif Groop, Emma Ahlqvist, Valeriya Lyssenko, Elisabet Agardh, et al.
(2019) Diabetes, 68 p.441-456
Journal articleSerum kidney injury molecule 1 and β2-microglobulin perform as well as larger biomarker panels for prediction of rapid decline in renal function in type 2 diabetes
Marco Colombo, Helen C. Looker, Bassam Farran, Sibylle Hess, Leif Groop, et al.
(2019) Diabetologia, 62 p.156-168
Journal articlePrecision medicine in Type 2 Diabetes
Rashmi B Prasad, Leif Groop
(2019) Journal of Internal Medicine, 285 p.40-48
Journal article review1-Hour Post-OGTT Glucose Improves the Early Prediction of Type 2 Diabetes by Clinical and Metabolic Markers
Gopal Peddinti, Michael Bergman, Tiinamaija Tuomi, Leif Groop
(2019) The Journal of clinical endocrinology and metabolism, 104 p.1131-1140
Journal articleDOLORisk : Study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain [version 2; referees: 2 approved]
Mathilde M.V. Pascal, Andreas C. Themistocleous, Ralf Baron, Andreas Binder, Didier Bouhassira, et al.
(2019) Wellcome Open Research, 3
Journal articleAssociation of IRS1 genetic variants with glucose control and insulin resistance in type 2 diabetic patients from Bosnia and Herzegovina
Lejla Mahmutovic, Tamer Bego, Maria Sterner, Gabriella Gremsperger, Emma Ahlqvist, et al.
(2019) Drug Metabolism and Personalized Therapy, 34
Journal articleExome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls
Jason Flannick, Valeriya Lyssenko, Leif Groop, Peter Nilsson, Michael Boehnke
(2019) Nature, 570 p.71-76
Journal articleRisk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes : a 5-year follow-up study
Oana P. Zaharia, Klaus Strassburger, Alexander Strom, Gidon J. Bönhof, Yanislava Karusheva, et al.
(2019) The Lancet Diabetes and Endocrinology, 7 p.684-694
Journal articleAssociations of autozygosity with a broad range of human phenotypes
David W Clark, Rashmi B Prasad, Leif Groop, James F. Wilson
(2019) Nature Communications, 10
Journal articleInteraction Between Overweight and Genotypes of HLA, TCF7L2, and FTO in Relation to the Risk of Latent Autoimmune Diabetes in Adults and Type 2 Diabetes
Rebecka Hjort, Josefin E. Löfvenborg, Emma Ahlqvist, Lars Alfredsson, Tomas Andersson, et al.
(2019) The Journal of clinical endocrinology and metabolism, 104 p.4815-4826
Journal articleGenome-Wide association study of diabetic kidney disease highlights biology involved in glomerular basement membrane collagen
Rany M. Salem, Jennifer N. Todd, Niina Sandholm, Joanne B. Cole, Wei Min Chen, et al.
(2019) Journal of the American Society of Nephrology, 30 p.2000-2016
Journal articleEffects of TCF7L2 rs7903146 variant on metformin response in patients with type 2 diabetes
Tanja Dujic, Tamer Bego, Maja Malenica, Zelija Velija-Asimi, Emma Ahlqvist, et al.
(2019) Bosnian Journal of Basic Medical Sciences, 19 p.368-374
Journal articleN1-methylnicotinamide is a signalling molecule produced in skeletal muscle coordinating energy metabolism
Kristoffer Ström, David Morales-Alamo, Filip Ottosson, Anna Edlund, Line Hjort, et al.
(2018) Scientific Reports, 8
Journal articlePredictors of responses to clinic-based childhood obesity care
Emilia Hagman, Lior Hecht, Limor Marko, Henny Azmanov, Leif Groop, et al.
(2018) Pediatric Diabetes, 19 p.1351-1356
Journal articleFirst Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes
Diana L Cousminer, Emma Ahlqvist, Mikael Åkerlund, Olle Melander, Benjamin F Voight, et al.
(2018) Diabetes Care, 41 p.2396-2403
Journal articleMelatonin receptor 1B gene rs10830963 polymorphism, depressive symptoms and glycaemic traits
Kadri Haljas, Jari Lahti, Tiinamaija Tuomi, Bo Isomaa, Johan G. Eriksson, et al.
(2018) Annals of Medicine, 50 p.704-712
Journal articleTurning vice into virtue : Using Batch-Effects to Detect Errors in Large Genomic Datasets
Fabrizio Mafessoni, Rashmi B Prasad, Leif Groop, Ola Hansson, Kay Prüfer
(2018) Genome Biology and Evolution, 10 p.2697-2708
Journal articleCoffee consumption, genetic susceptibility and risk of latent autoimmune diabetes in adults : A population-based case-control study
B. Rasouli, E. Ahlqvist, L. Alfredsson, T. Andersson, P. O. Carlsson, et al.
(2018) Diabetes & Metabolism, 44 p.354-360
Journal articleActivation of imidazoline receptor I2, and improved pancreatic β-cell function in human islets
Stefan Amisten, Pontus Duner, Olof Asplund, Israa Mohammed Al-Amily, Leif Groop, et al.
(2018) Journal of Diabetes and its Complications, 32 p.813-818
Journal articleAssociation between genetic risk variants and glucose intolerance during pregnancy in north Indian women
Geeti Arora, Peter Almgren, Charlotte Brøns, Richa G Thaman, Allan Vaag, et al.
(2018) BMC Medical Genomics, 11
Journal articleControllability in an islet specific regulatory network identifies the transcriptional factor NFATC4, which regulates Type 2 Diabetes associated genes
Amitabh Sharma, Arda Halu, Julius L. Decano, Megha Padi, Yang-yu Liu, et al.
(2018) npj Systems Biology and Applications, 4
Journal articleA Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes
Natalie R van Zuydam, Emma Ahlqvist, Claes Ladenvall, Peter Almgren, Christina-Alexandra Schulz, et al.
(2018) Diabetes, 67 p.1414-1427
Journal articleGenetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes
Viktoria Gusarova, Colm O'Dushlaine, Tanya M Teslovich, Peter N Benotti, Tooraj Mirshahi, et al.
(2018) Nature Communications, 9 p.1-11
Journal articleOverweight, obesity and the risk of LADA : results from a Swedish case–control study and the Norwegian HUNT Study
Rebecka Hjort, Emma Ahlqvist, Per Ola Carlsson, Valdemar Grill, Leif Groop, et al.
(2018) Diabetologia, 61 p.1333-1343
Journal articleNovel diabetes subgroups – Authors' reply
Emma Ahlqvist, Rashmi B. Prasad, Tiinamaija Tuomi, Anders Rosengren, Leif Groop
(2018) The Lancet Diabetes and Endocrinology, 6 p.440-441
Journal article (letter)Haplotype Sharing Provides Insights into Fine-Scale Population History and Disease in Finland
Alicia R Martin, Konrad J Karczewski, Sini Kerminen, Mitja I Kurki, Antti-Pekka Sarin, et al.
(2018) American Journal of Human Genetics, 102 p.760-775
Journal articleNovel subgroups of adult-onset diabetes and their association with outcomes : A data-driven cluster analysis of six variables
Emma Ahlqvist, Petter Storm, Annemari Käräjämäki, Mats Martinell, Mozhgan Dorkhan, et al.
(2018) The Lancet Diabetes and Endocrinology, 6 p.361-369
Journal articleEffects of GIP on regional blood flow during normoglycemia and hyperglycemia in anesthetized rats
Xiang Gao, Andreas Lindqvist, Monica Sandberg, Leif Groop, Nils Wierup, et al.
(2018) Physiological Reports, 6
Journal articleHAPT2D : high accuracy of prediction of T2D with a model combining basic and advanced data depending on availability
Barbara Di Camillo, Liisa Hakaste, Francesco Sambo, Rafael Gabriel, Jasmina Kravic, et al.
(2018) European Journal of Endocrinology, 178 p.331-341
Journal articleLessons learned from the 1-hour post-load glucose level during OGTT : Current screening recommendations for dysglycaemia should be revised
Michael Bergman, Ram Jagannathan, Martin Buysschaert, Manan Pareek, Michael H. Olsen, et al.
(2018) Diabetes/Metabolism Research and Reviews, 34
Journal articleGenetics of Diabetes and Diabetic Complications
Rashmi Prasad, Emma Ahlqvist, Leif Groop
(2018) Endocrinology
Book chapterGenome-wide meta-analysis identifies novel determinants of circulating serum progranulin
Anke Tönjes, Markus Scholz, Jacqueline Krüger, Kerstin Krause, Dorit Schleinitz, et al.
(2018) Human Molecular Genetics, 27 p.546-558
Journal articleRefining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes article
Anubha Mahajan, Jennifer Wessel, Sara M Willems, Wei Zhao, Neil R Robertson, et al.
(2018) Nature Genetics, 50 p.559-571
Journal articleFamily history of diabetes and its relationship with insulin secretion and insulin sensitivity in Iraqi immigrants and native Swedes : a population-based cohort study
Louise Bennet, Paul W. Franks, Bengt Zöller, Leif Groop
(2018) Acta Diabetologica, 55 p.233-242
Journal articleRole of osteopontin and its regulation in pancreatic islet
Mengyin Cai, Pradeep Bompada, Albert Salehi, Juan R. Acosta, Rashmi B. Prasad, et al.
(2018) Biochemical and Biophysical Research Communications, 495 p.1426-1431
Journal articleA genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4) gene with severe diabetic retinopathy in type 2 diabetes
Weihua Meng, Kaanan P. Shah, Samuela Pollack, Iiro Toppila, Harry L. Hebert, et al.
(2018) Acta Ophthalmologica, 96 p.811-819
Journal articleObstructive sleep apnoea and the risk for coronary heart disease and type 2 diabetes : A longitudinal population-based study in Finland
Satu Strausz, Aki S. Havulinna, Tiinamaija Tuomi, Adel Bachour, Leif Groop, et al.
(2018) BMJ Open, 8
Journal articlePetition to replace current OGTT criteria for diagnosing prediabetes with the 1-hour post-load plasma glucose ≥ 155 mg/dl (8.6 mmol/L)
Michael Bergman, Melania Manco, Giorgio Sesti, Rachel Dankner, Manan Pareek, et al.
(2018) Diabetes Research and Clinical Practice, 146 p.18-33
Journal article reviewDevelopment and validation of a path length calculation for carotid-femoral pulse wave velocity measurement : A TASCFORCE, SUMMIT, and caerphilly collaborative venture
Jonathan R. Weir-McCall, Liam Brown, Jennifer Summersgill, Piotr Talarczyk, Michael Bonnici-Mallia, et al.
(2018) Hypertension, 71 p.937-945
Journal articleBivariate genome-wide association study of depressive symptoms with type 2 diabetes and quantitative glycemic traits
Kadri Haljas, Azmeraw T. Amare, Behrooz Z. Alizadeh, Yi Hsiang Hsu, Thomas Mosley, et al.
(2018) Psychosomatic Medicine, 80 p.242-251
Journal articleDiscovering human diabetes-risk gene function with genetics and physiological assays
Heshan Peiris, Sangbin Park, Shreya Louis, Xueying Gu, Jonathan Y. Lam, et al.
(2018) Nature Communications, 9
Journal articleGenetic determinants of glucose levels in pregnancy : Genetic risk scores analysis and GWAS in the Norwegian STORK cohort
Gunn Helen Moen, Marissa LeBlanc, Christine Sommer, Rashmi B. Prasad, Tove Lekva, et al.
(2018) European Journal of Endocrinology, 179 p.363-372
Journal articleA variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes
Makiko Taira, Minako Imamura, Atsushi Takahashi, Yoichiro Kamatani, Toshimasa Yamauchi, et al.
(2018) PLoS ONE, 13
Journal articleSilencing of the FTO gene inhibits insulin secretion : An in vitro study using GRINCH cells
Jalal Taneera, Rashmi B Prasad, Sarah Dhaiban, Abdul Khader Mohammed, Leena Haataja, et al.
(2018) Molecular and Cellular Endocrinology, 472 p.10-17
Journal articleLiver blood dynamics after bariatric surgery : The effects of mixed-meal test and incretin infusions
Henri Honka, Jukka Koffert, Saila Kauhanen, Nobuyuki Kudomi, Saija Hurme, et al.
(2018) Endocrine Connections, 7 p.888-896
Journal articleHeterozygous RFX6 protein truncating variants are associated with MODY with reduced penetrance
Kashyap A. Patel, Jarno Kettunen, Markku Laakso, Alena Stančáková, Thomas W. Laver, et al.
(2017) Nature Communications, 8
Journal articleGenetic determinants of circulating GIP and GLP-1 concentrations
Peter Almgren, Andreas Lindqvist, Ulrika Krus, Liisa H. Hakaste, Emilia Ottosson Laakso, et al.
(2017) JCI Insight, 2
Journal articleNew Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals
Aldi T. Kraja, James P. Cook, Helen R. Warren, Praveen Surendran, Chunyu Liu, et al.
(2017) Circulation: Cardiovascular Genetics, 10
Journal articleInsulin secretion and action in North Indian women during pregnancy
G. P. Arora, P Almgren, R. G. Thaman, A. Pal, Leif Groop, et al.
(2017) Diabetic Medicine: A journal of the British Diabetic Association, 34 p.1477-1482
Journal articleGlucose-induced Changes in Gene Expression in Human Pancreatic Islets - Causes or Consequences of Chronic Hyperglycemia
Emilia Ottosson-Laakso, Ulrika Krus, Petter Storm, Rashmi B Prasad, Nikolay Oskolkov, et al.
(2017) Diabetes, 66 p.3013-3028
Journal articleGlucotoxicity-induced upregulation of lincRNA GAS5 in the pancreatic islets of type 2 diabetes donors and in Goto-Kakizaki rats
J. L. S. Esguerra, J. Ofori, M. Nagao, J. Fadista, L. Groop, et al.
(2017) Diabetologia, 60 p.22-23
Conference paper: abstractContinuous and simultaneous determination of venous blood metabolites
Anneli Andersson, Qun Chen, Leif Groop, Leif Bülow, Bin Xie
(2017) Talanta, 171 p.270-274
Journal articleThe rs7903146 variant in the tcf7l2 gene increases the risk of prediabetes/type 2 diabetes in obese adolescents by impairing b-cell function and hepatic insulin sensitivity
Catrina Cropano, Nicola Santoro, Leif Groop, Chiara Dalla Man, Claudio Cobelli, et al.
(2017) Diabetes Care, 40 p.1082-1089
Journal articleImpaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD
Panu K. Luukkonen, You Zhou, P. A. Nidhina Haridas, Om P. Dwivedi, Tuulia Hyötyläinen, et al.
(2017) Journal of Hepatology, 67 p.128-136
Journal articleA TRPV1-to-secretagogin regulatory axis controls pancreatic β-cell survival by modulating protein turnover
Katarzyna Malenczyk, Fatima Girach, Edit Szodorai, Petter Storm, Åsa Segerstolpe, et al.
(2017) EMBO Journal, 36 p.1993-2176
Journal articleEarly metabolic markers identify potential targets for the prevention of type 2 diabetes
Gopal Peddinti, Jeff Cobb, Loic Yengo, Philippe Froguel, Jasmina Kravic, et al.
(2017) Diabetologia , p.1-11
Journal articleEducation immigration and income as risk factors for hemoglobin a1c >70 mmol/mol when diagnosed with type 2 diabetes or latent autoimmune diabetes in adult : A population-based cohort study
Mats Martinell, Ronnie Pingel, Johan Hallqvist, Mozhgan Dorkhan, Leif Groop, et al.
(2017) BMJ Open Diabetes Research and Care, 5
Journal articleNonsuppressed glucagon after glucose challenge as a potential predictor for glucose tolerance
Róbert Wagner, Liisa H. Hakaste, Emma Ahlqvist, Martin Heni, Jürgen Machann, et al.
(2017) Diabetes, 66 p.1373-1379
Journal articleEpigenetic modifications and gestational diabetes : A Systematic review of published literature
Gunn Helen Moen, Christine Sommer, Rashmi B. Prasad, Line Sletner, Leif Groop, et al.
(2017) European Journal of Endocrinology, 176 p.247-267
Journal article reviewAortic diameter at age 65 in men with newly diagnosed type 2 diabetes
Soumia Taimour, Moncef Zarrouk, Jan Holst, Anders H. Rosengren, Leif Groop, et al.
(2017) Scandinavian Cardiovascular Journal, 51 p.202-206
Journal articleAutomated pathway and reaction prediction facilitates in silico identification of unknown metabolites in human cohort studies
Jan D. Quell, Werner Römisch-Margl, Marco Colombo, Jan Krumsiek, Anne M. Evans, et al.
(2017) Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1071 p.58-67
Journal articleGastric bypass in the pig increases GIP levels and decreases active GLP-1 levels
Andreas Lindqvist, Mikael Ekelund, Stefan Pierzynowski, Leif Groop, Jan Hedenbro, et al.
(2017) Peptides, 90 p.78-82
Journal articleMetabolite profiling of LADA challenges the view of a metabolically distinct subtype
Mahmoud Al-Majdoub, Arslan Ali, Petter Storm, Anders H. Rosengren, Leif Groop, et al.
(2017) Diabetes, 66 p.806-814
Journal articleBariatric surgery enhances splanchnic vascular responses in patients with type 2 diabetes
Henri Honka, Jukka Koffert, Saila Kauhanen, Jarmo Teuho, Saija Hurme, et al.
(2017) Diabetes, 66 p.880-885
Journal articleThe impact of Roux-en-Y gastric bypass surgery on normal metabolism in a porcine model
Andreas Lindqvist, Mikael Ekelund, Eliana Garcia-Vaz, Marcus Ståhlman, Stefan Pierzynowski, et al.
(2017) PLoS ONE, 12
Journal articleHuman Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks
Ildem Akerman, Zhidong Tu, Anthony Beucher, Delphine M Y Rolando, Claire Sauty-Colace, et al.
(2017) Cell Metabolism, 25 p.400-411
Journal articleDifferentiation of diabetes by pathophysiology, natural history, and prognosis
Jay S Skyler, George L. Bakris, Ezio Bonifacio, Tamara Darsow, Robert H. Eckel, et al.
(2017) Diabetes, 66 p.241-255
Journal article reviewFunctional investigations of HNF1A identify rare variants as risk factors for type 2 diabetes in the general population
Laeya Abdoli Najmi, Ingvild Aukrust, Jason Flannick, Janne Molnes, Noel Burtt, et al.
(2017) Diabetes, 66 p.335-346
Journal articleBranched-chain amino acids are associated with odd-chain fatty acids in normoglycaemic individuals
M. Al-Majdoub, N. Geidenstam, A. Ali, M. Ridderstråle, P. Storm, et al.
(2017) Diabetes & Metabolism, 43 p.475-479
Journal article (letter)Genetic Architecture of Type 2 Diabetes
Rashmi B. Prasad, Leif Groop
(2017) Textbook of Diabetes
Book chapterRoux-en-Y gastric bypass versus calorie restriction: support for surgery as the direct contributor to aloncltered responses of insulin and incretins to a mixed meal
JOHAN BERGGREN, Andreas Lindqvist, Jan Hedenbro, Leif Groop, Nils Wierup
(2017) Surgery for Obesity and Related Diseases, 13 p.234-242
Journal articleLoFtool : a gene intolerance score based on loss-of-function variants in 60 706 individuals
João Fadista, Nikolay Oskolkov, Ola Hansson, Leif Groop
(2017) Bioinformatics, 33 p.471-474
Journal articleImpact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis
Eleanor Wheeler, Aaron Leong, Ching-Ti Liu, Marie-France Hivert, Rona J. Strawbridge, et al.
(2017) PLoS Medicine, 14
Journal articleEffects of meal and incretins in the regulation of splanchnic blood flow
Jukka Koffert, Henri Honka, Jarmo Teuho, Saila Kauhanen, Saija Hurme, et al.
(2017) Endocrine Connections, 6 p.179-187
Journal articleFamily history of type 1 and type 2 diabetes and risk of latent autoimmune diabetes in adults (LADA)
Rebecka Hjort, L Alfredsson, T. Andersson, P. O. Carlsson, V Grill, et al.
(2017) Diabetes & Metabolism, 43 p.536-542
Journal articleSerious life events and the risk of latent autoimmune diabetes in adults (LADA) and Type 2 diabetes
B. Rasouli, T. Andersson, P.-O. Carlsson, R. Hjort, J E Löfvenborg, et al.
(2017) Diabetic Medicine, 34 p.1259-1263
Journal articleData Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
Jason Flannick, Christian Fuchsberger, Anubha Mahajan, Tanya M Teslovich, Vineeta Agarwala, et al.
(2017) Scientific Data, 4
Journal articleExome-wide association study of plasma lipids in >300,000 individuals
Dajiang J Liu, Gina M. Peloso, Haojie Yu, Adam S. Butterworth, Anubha Mahajan, et al.
(2017) Nature Genetics, 49 p.1758-1766
Journal articleAn Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans
Robert A. Scott, Laura J Scott, Reedik Mägi, Letizia Marullo, Kyle J Gaulton, et al.
(2017) Diabetes, 66 p.2888-2902
Journal articleA low-frequency inactivating AKT2 variant enriched in the finnish population is associated with fasting insulin levels and type 2 diabetes risk
Alisa Manning, Claes Ladenvall, Peter Nilsson, Tibor V. Varga, Paul Franks, et al.
(2017) Diabetes, 66 p.2019-2032
Journal articleThe genetic landscape of renal complications in type 1 diabetes
Niina Sandholm, Natalie Van Zuydam, Emma Ahlqvist, Thorhildur Juliusdottir, Harshal A. Deshmukh, et al.
(2017) Journal of the American Society of Nephrology, 28 p.557-574
Journal articleHistone acetylation of glucose-induced thioredoxin-interacting protein gene expression in pancreatic islets
Bompada Sai Pradeep Chandra Bompada, David Atac, Cheng Luan, Robin Andersson, Judit Domènech Omella, et al.
(2016) International Journal of Biochemistry and Cell Biology, 81 p.82-91
Journal articleAdhesion G protein-coupled receptor G1 (ADGRG1/GPR56) and pancreatic β-cell function
Pontus Dunér, Israa Mohammed, Arvind Soni, Olof Asplund, Fatemeh Safi, et al.
(2016) Journal of Clinical Endocrinology and Metabolism, 101 p.4637-4645
Journal articleSweetened beverage intake and risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes
Josefin E. Löfvenborg, Tomas Andersson, Per Ola Carlsson, Mozhgan Dorkhan, Leif Groop, et al.
(2016) European Journal of Endocrinology, 175 p.605-614
Journal articleInteraction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity
Martin Heni, Stephanie Kullmann, Emma Ahlqvist, Robert Wagner, Fausto Machicao, et al.
(2016) Diabetologia, 59 p.2622-2631
Journal articleA principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
Janina S. Ried, Janina M. Jeff, Audrey Y. Chu, Jennifer L. Bragg-Gresham, Jenny Van Dongen, et al.
(2016) Nature Communications, 7
Journal articlePrevalence and risk factors for diabetic retinopathy at diagnosis (DRAD) in patients recently diagnosed with type 2 diabetes (T2D) or latent autoimmune diabetes in the adult (LADA)
Mats Martinell, Mozhgan Dorkhan, Jan Stålhammar, Petter Storm, Leif Groop, et al.
(2016) Journal of Diabetes and its Complications, 30 p.1456-1461
Journal articleImpact of the tcf7l2 genotype on risk of hypoglycaemia and glucagon secretion during hypoglycaemia
Peter L. Kristensen, Ulrik Pedersen-Bjergaard, Rikke Due-Andersen, Thomas Høi-Hansen, Lise Grimmeshave, et al.
(2016) Endocrine Connections, 5 p.53-60
Journal articleSingle-Cell Sequencing of Human Pancreatic Islets—New Kids on the Block
Rashmi B. Prasad, Leif Groop
(2016) Cell Metabolism, 24 p.523-524
Journal articleNew approaches beyond genetics : towards precision medicine in diabetes
Leif Groop
(2016) Diabetologia, 59 p.2495-2496
Journal article (comment)Genome-wide association study of the modified stumvoll insulin sensitivity index identifies BCL2 and FAM19A2 as novel insulin sensitivity loci
Geoffrey A. Walford, Stefan Gustafsson, Denis Rybin, Alena Stancáková, Han Chen, et al.
(2016) Diabetes, 65 p.3200-3211
Journal articleTrans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
Praveen Surendran, Fotios Drenos, Robin Young, Helen Warren, James P. Cook, et al.
(2016) Nature Genetics, 48 p.1151-1161
Journal articleA reference panel of 64,976 haplotypes for genotype imputation
Shane McCarthy, Sayantan Das, Warren Kretzschmar, Olivier Delaneau, Andrew R. Wood, et al.
(2016) Nature Genetics, 48 p.1279-1283
Journal articleExcess maternal transmission of variants in the THADA gene to offspring with type 2 diabetes
Rashmi B. Prasad, Anna Lessmark, Peter Almgren, Györgyi Kovacs, Ola Hansson, et al.
(2016) Diabetologia, 59 p.1702-1713
Journal articleDNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk
Tasnim Dayeh, Tiinamaija Tuomi, Peter Almgren, Alexander Perfilyev, Per Anders Jansson, et al.
(2016) Epigenetics, 11 p.482-488
Journal articleCART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion
Mia Abels, Matteo Riva, Hedvig Bennet, Emma Ahlqvist, Oleg Dyachok, et al.
(2016) Diabetologia, 59 p.1928-1937
Journal articleIncreased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes
Tiinamaija Tuomi, Cecilia L F Nagorny, Pratibha Singh, Hedvig Bennet, Qian Yu, et al.
(2016) Cell Metabolism, 23 p.1067-1077
Journal articleα-Hydroxybutyric acid is a selective metabolite biomarker of impaired glucose tolerance
Jeff Cobb, Andrea Eckhart, Alison Motsinger-Reif, Bernadette Carr, Leif Groop, et al.
(2016) Diabetes Care, 39 p.988-995
Journal articleA genome-wide mQTL analysis in human adipose tissue identifies genetic variants associated with DNA methylation, gene expression and metabolic traits
Petr Volkov, Anders H. Olsson, Linn Gillberg, Sine W. Jørgensen, Charlotte Brøns, et al.
(2016) PLoS ONE, 11
Journal articleA Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes
Heshan Peiris, Michael D. Duffield, Joao Fadista, Claire F. Jessup, Vinder Kashmir, et al.
(2016) PLoS Genetics, 12
Journal articleHMGB1 binds to the rs7903146 locus in TCF7L2 in human pancreatic islets.
Yuedan Zhou, Nikolay Oskolkov, Liliya Shcherbina, Joyce Ratti, Kian-Hong Kock, et al.
(2016) Molecular and Cellular Endocrinology, 430 p.138-145
Journal articleThe (in)famous GWAS P-value threshold revisited and updated for low-frequency variants.
Joao Fadista, Alisa K Manning, Jose C Florez, Leif Groop
(2016) European Journal of Human Genetics, 24 p.1202-1205
Journal articleTranscription factor 7-like 2 (TCF7L2)
Struan F A Grant, Leif Groop
(2016) The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation , p.297-316
Book chapterInfluence of Familial Renal Glycosuria Due to Mutations in the SLC5A2 Gene on Changes in Glucose Tolerance over Time.
Emilia Ottosson Laakso, Tiinamaija Tuomi, Björn Forsén, Monika Gullström, Per-Henrik Groop, et al.
(2016) PLoS ONE, 11
Journal articleA Variant of GJD2, Encoding for Connexin 36, Alters the Function of Insulin Producing β-Cells.
Valentina Cigliola, Celine Populaire, Ciro L Pierri, Samuel Deutsch, Jacques-Antoine Haefliger, et al.
(2016) PLoS ONE, 11
Journal articleGlucose-Dependent Insulinotropic Polypeptide (GIP) Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.
Lisa Berglund, Valeriya Lyssenko, Claes Ladenvall, Olga Kotova, Andreas Edsfeldt, et al.
(2016) Diabetes, 65 p.239-254
Journal articleEpigenetic regulation of glucose-stimulated osteopontin (OPN) expression in diabetic kidney.
Mengyin Cai, Bompada Pradeep, David Grubich Atac, Markku Laakso, Leif Groop, et al.
(2016) Biochemical and Biophysical Research Communications, 469 p.108-113
Journal articleEpigenetic regulation of the thioredoxin-interacting protein (TXNIP) gene by hyperglycemia in kidney.
Yang De Marinis, Mengyin Cai, Bompada Pradeep, David Grubich Atac, Olga Kotova, et al.
(2016) Kidney International, 89 p.342-353
Journal articleAtrial Natriuretic Peptide in the high normal range is associated with lower prevalence of insulin resistance.
Amra Jujic, Peter Nilsson, Margaretha Persson, Jens Juul Holst, Signe Sørensen Torekov, et al.
(2016) The Journal of clinical endocrinology and metabolism, 101 p.1372-1380
Journal articleMafA-Controlled Nicotinic Receptor Expression Is Essential for Insulin Secretion and Is Impaired in Patients with Type 2 Diabetes.
Elvira Ganic, Tania Singh, Cheng Luan, Joao Fadista, Jenny Johansson, et al.
(2016) Cell Reports, 14 p.1991-2002
Journal articleSmoking and the risk of LADA : Results from a Swedish population-based case-control study
Bahareh Rasouli, Tomas Andersson, Per Ola Carlsson, Valdemar Grill, Leif Groop, et al.
(2016) Diabetes Care, 39 p.794-800
Journal articleBlood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes
Karl Bacos, Linn Gillberg, Petr Volkov, Anders H Olsson, Torben Hansen, et al.
(2016) Nature Communications, 7
Journal articleThe genetic architecture of type 2 diabetes
Christian Fuchsberger, Tibor V. Varga, Claes Ladenvall, Jasmina Kravic, Paul Franks, et al.
(2016) Nature, 536 p.41-47
Journal articleHarmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research.
Ola Spjuth, Maria Krestyaninova, Janna Hastings, Huei-Yi Shen, Jani Heikkinen, et al.
(2015) European Journal of Human Genetics
Journal articleType 2 diabetes mellitus
Ralph A. DeFronzo, Ele Ferrannini, Leif Groop, Robert R. Henry, William H. Herman, et al.
(2015) Nature Reviews Disease Primers, 1
Journal articleIdentification and validation of N-acetyltransferase 2 as an insulin sensitivity gene
Joshua W. Knowles, Weijia Xie, Zhongyang Zhang, Indumathi Chennemsetty, Themistocles L. Assimes, et al.
(2015) Journal of Clinical Investigation, 125 p.1739-1751
Journal articleA novel atlas of gene expression in human skeletal muscle reveals molecular changes associated with aging.
Jing Su, Carl Ekman, Nikolay Oskolkov, Leo Lahti, Kristoffer Ström, et al.
(2015) Skeletal Muscle, 5
Journal articleGenetics and neonatal diabetes: towards precision medicine.
Leif Groop
(2015) The Lancet, 386 p.934-935
Journal article (comment)A Bayesian Network for Probabilistic Reasoning and Imputation of Missing Risk Factors in Type 2 Diabetes
Francesco Sambo, Andrea Facchinetti, Liisa Hakaste, Jasmina Kravic, Barbara Di Camillo, et al.
(2015) Lecture Notes in Computer Science, 9105 p.172-176
Conference paperDiscovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation.
Momoko Horikoshi, Reedik Mӓgi, Martijn van de Bunt, Ida Surakka, Antti-Pekka Sarin, et al.
(2015) PLoS Genetics, 11
Journal articleNew genetic loci link adipose and insulin biology to body fat distribution.
Dmitry Shungin, Thomas W Winkler, Damien C Croteau-Chonka, Teresa Ferreira, Adam E Locke, et al.
(2015) Nature, 518 p.187-378
Journal articleThe Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
Thomas W Winkler, Anne E Justice, Mariaelisa Graff, Llilda Barata, Mary F Feitosa, et al.
(2015) PLoS Genetics, 11
Journal articleThe impact of low-frequency and rare variants on lipid levels.
Ida Surakka, Momoko Horikoshi, Reedik Mägi, Antti-Pekka Sarin, Anubha Mahajan, et al.
(2015) Nature Genetics, 47 p.589-597
Journal articleBiomarkers of rapid chronic kidney disease progression in type 2 diabetes.
Helen C Looker, Marco Colombo, Sibylle Hess, Mary J Brosnan, Bassam Farran, et al.
(2015) Kidney International, 88 p.888-896
Journal articleIdentification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus.
Anubha Mahajan, Xueling Sim, Hui Jin Ng, Alisa Manning, Manuel A Rivas, et al.
(2015) PLoS Genetics, 11
Journal articleA Common Variant in the MTNR1B Gene Is Associated with Increased Risk of Impaired Fasting Glucose (IFG) in Youth with Obesity
Chao Zheng, Chiara Dalla Man, Claudio Cobelli, Leif Groop, Hongyu Zhao, et al.
(2015) Obesity, 23 p.1022-1029
Journal articleGenetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
Kyle J Gaulton, Teresa Ferreira, Yeji Lee, Anne Raimondo, Reedik Mägi, et al.
(2015) Nature Genetics, 47 p.1415-1415
Journal articleProtein biomarkers for the prediction of cardiovascular disease in type 2 diabetes
Helen C. Looker, Marco Colombo, Felix Agakov, Tanja Zeller, Leif Groop, et al.
(2015) Diabetologia, 58 p.1363-1371
Journal articleCountry of birth modifies the association of fatty liver index with insulin action in Middle Eastern immigrants to Sweden.
Louise Bennet, Leif Groop, Paul Franks
(2015) Diabetes Research and Clinical Practice, 110 p.66-74
Journal articleGenetic studies of body mass index yield new insights for obesity biology.
Adam E Locke, Bratati Kahali, Sonja I Berndt, Anne E Justice, Tune H Pers, et al.
(2015) Nature, 518 p.197-401
Journal articleGenetically Determined Height and Coronary Artery Disease
C. P. Nelson, S. E. Hamby, D. Saleheen, J. C. Hopewell, L. Zeng, et al.
(2015) New England Journal of Medicine, 372 p.1608-1618
Journal articleVigorous Physical Activity may be Important for the Insulin Sensitivity in Immigrants From the Middle East and Native Swedes.
Daniel Arvidsson, Ulf Lindblad, Jan Sundquist, Kristina Sundquist, Leif Groop, et al.
(2015) Journal of Physical Activity & Health, 12 p.273-281
Journal articleIdentification of novel genes for glucose metabolism based upon expression pattern in human islets and effect on insulin secretion and glycemia.
Jalal Taneera, Joao Fadista, Emma Ahlqvist, David Grubich Atac, Emilia Ottosson Laakso, et al.
(2015) Human Molecular Genetics, 24 p.1945-1955
Journal articlePrevalence and Risk Factors of Gestational Diabetes in Punjab, North India - Results from a Population Screening Program.
Geeti Arora, Richa G Thaman, Rashmi Prasad, Peter Almgren, Charlotte Brøns, et al.
(2015) European Journal of Endocrinology, 173 p.257-267
Journal articleLow birthweight is associated with an increased risk of LADA and type 2 diabetes: results from a Swedish case-control study
Rebecka Hjort, Lars Alfredsson, Per-Ola Carlsson, Leif Groop, Mats Martinell, et al.
(2015) Diabetologia, 58 p.2525-2532
Journal articleShort- and Long-Term Hormonal and Metabolic Consequences of Reversing Gastric Bypass to Normal Anatomy in a Type 2 Diabetes Patient.
Nils Wierup, Andreas Lindqvist, Peter Spégel, Leif Groop, Jan Hedenbro, et al.
(2015) Obesity Surgery, 25 p.180-185
Journal articleLess pronounced response to exercise in healthy relatives to type 2 diabetics compared to controls.
Carl Ekman, Targ Elgzyri, Kristoffer Ström, Peter Almgren, Hemang Parikh, et al.
(2015) Journal of Applied Physiology, 119 p.953-960
Journal articleModelling of OGTT curve identifies 1 h plasma glucose level as a strong predictor of incident type 2 diabetes: results from two prospective cohorts
Akram Alyass, Peter Almgren, Mikael Åkerlund, Jonathan Dushoff, Bo Isomaa, et al.
(2015) Diabetologia, 58 p.87-97
Journal articleImpact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood.
Tina Rönn, Petr Volkov, Linn Gillberg, Milana Kokosar, Alexander Perfilyev, et al.
(2015) Human Molecular Genetics, 24 p.3792-3813
Journal articleAge- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors.
Tove Fall, Sara Hägg, Alexander Ploner, Reedik Mägi, Krista Fischer, et al.
(2015) Diabetes, 64 p.1841-1852
Journal articleMucosal glucagon-like peptide-1 and gastric inhibitory polypeptide cell numbers in the super-obese human foregut after gastric bypass.
Bent J Nergård, Andreas Lindqvist, Hjörtur G Gislason, Leif Groop, Mikael Ekelund, et al.
(2015) Surgery for Obesity and Related Diseases, 11 p.1237-1246
Journal articleThe genetics of diabetic complications.
Emma Ahlqvist, Natalie R van Zuydam, Leif Groop, Mark I McCarthy
(2015) Nature Reviews Nephrology, 11 p.277-287
Journal article reviewGenetics of type 2 diabetes : It matters from which parent we inherit the risk
Valeriya Lyssenko, Leif Groop, Rashmi B. Prasad
(2015) Review of Diabetic Studies, 12 p.233-242
Journal article reviewGenetics of type 2 diabetes-pitfalls and possibilities.
Rashmi Prasad, Leif Groop
(2015) Genes, 6 p.87-123
Journal article reviewVariation in Glucose Homeostasis Traits Associated With P2RX7 Polymorphisms in Mice and Humans
Jennifer N. Todd, Wenny Poon, Valeriya Lyssenko, Leif Groop, Brendan Nichols, et al.
(2015) Journal of Clinical Endocrinology and Metabolism, 100 p.688-696
Journal articleA Bayesian Network analysis of the probabilistic relations between risk factors in the predisposition to type 2 diabetes
Francesco Sambo, Barbara Di Camillo, Alberto Franzin, Andrea Facchinetti, Liisa Hakaste, et al.
(2015) Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 2015 p.22-2119
Conference paperThe genetics of type 2 diabetes
Emma Ahlqvist, Leif Groop
(2015) International Textbook of Diabetes Mellitus , p.401-412
Book chapterGASTRIC BYPASS SURGERY HAS GREATER EFFECT THAN CALORIE RESTRICTION ON INCRETIN RELEASE AND INSULIN SECRETION ALREADY ON POSTOP. DAY 1
Johan Berggren, Andreas Lindqvist, Leif Groop, Jan Hedenbro, Nils Wierup
(2015) Obesity Surgery, 25 p.85-85
Conference paper: abstractDubbelt så hög risk för diabetes typ 2 hos svenskar födda i Irak
Louise Bennet, Leif Groop, Paul Franks, Ulf Lindblad, Daniel Arvidsson, et al.
(2015) Lakartidningen, 112 p.1-4
Journal articleExpression of Phosphofructokinase in Skeletal Muscle Is Influenced by Genetic Variation and Associated With Insulin Sensitivity
Sarah Keildson, Joao Fadista, Claes Ladenvall, Asa K. Hedman, Targ Elgzyri, et al.
(2014) Diabetes, 63 p.1154-1165
Journal articleCo-occurrence of Risk Alleles in or Near Genes Modulating Insulin Secretion Predisposes Obese Youth to Prediabetes
Cosimo Giannini, Chiara Dalla Man, Leif Groop, Claudio Cobelli, Hongyu Zhao, et al.
(2014) Diabetes Care, 37 p.475-482
Journal articleGenome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
Anubha Mahajan, Min Jin Go, Weihua Zhang, Jennifer E. Below, Kyle J. Gaulton, et al.
(2014) Nature Genetics, 46 p.234-234
Journal articleCoffee consumption and the risk of latent autoimmune diabetes in adults-results from a Swedish case-control study
J. E. Lofvenborg, T. Andersson, P. -O. Carlsson, M. Dorkhan, Leif Groop, et al.
(2014) Diabetic Medicine, 31 p.799-805
Journal articleFatty fish consumption and risk of latent autoimmune diabetes in adults.
J E Löfvenborg, T Andersson, P-O Carlsson, Mozhgan Dorkhan, Leif Groop, et al.
(2014) Nutrition & diabetes, 4 p.139-139
Journal articleGenome Wide Meta-analysis Highlights the Role of Genetic Variation in RARRES2 in the Regulation of Circulating Serum Chemerin.
Anke Tönjes, Markus Scholz, Jana Breitfeld, Carola Marzi, Harald Grallert, et al.
(2014) PLoS Genetics, 10
Journal articleASSOCIATION OF BTG2, CYR61, ZFP36, AND SCD GENE POLYMORPHISMS WITH GRAVES' DISEASE AND OPHTHALMOPATHY.
Tereza Planck, Bushra Shahida, Marketa Sjögren, Leif Groop, Bengt Hallengren, et al.
(2014) Thyroid, 24 p.1156-1161
Journal articleDistribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population.
Elaine T Lim, Peter Würtz, Aki S Havulinna, Priit Palta, Taru Tukiainen, et al.
(2014) PLoS Genetics, 10
Journal articleGenome-wide association study of urinary albumin excretion rate in patients with type 1 diabetes
Niina Sandholm, Carol Forsblom, Ville-Petteri Makinen, Amy Jayne McKnight, Anne-May Osterholm, et al.
(2014) Diabetologia, 57 p.1143-1153
Journal articleEthnic differences in the contribution of insulin action and secretion to type 2 diabetes in immigrants from the Middle East compared to native Swedes.
Louise Bennet, Leif Groop, Paul Franks
(2014) Diabetes Research and Clinical Practice, 105 p.79-87
Journal articleLeveraging cross-species transcription factor binding site patterns: from diabetes risk Loci to disease mechanisms.
Melina Claussnitzer, Simon N Dankel, Bernward Klocke, Harald Grallert, Viktoria Glunk, et al.
(2014) Cell, 156 p.343-358
Journal articleA Novel Test for Recessive Contributions to Complex Diseases Implicates Bardet-Biedl Syndrome Gene BBS10 in Idiopathic Type 2 Diabetes and Obesity
Elaine T. Lim, Yangfan P. Liu, Yingleong Chan, Tiinamaija Tuomi, AnnMari Karajamaki, et al.
(2014) American Journal of Human Genetics, 95 p.509-520
Journal articleDefining the role of common variation in the genomic and biological architecture of adult human height.
Andrew R Wood, Tonu Esko, Jian Yang, Sailaja Vedantam, Tune H Pers, et al.
(2014) Nature Genetics, 46 p.1173-1186
Journal articleGenotype-based treatment of type 2 diabetes with an α2A-adrenergic receptor antagonist.
Yunzhao Tang, Annika Axelsson, Peter Spégel, Lotta Andersson, Hindrik Mulder, et al.
(2014) Science Translational Medicine, 6 p.139-257
Journal articleSleep duration and insulin resistance in individuals without type 2 diabetes: The PPP-Botnia Study
Antti-Jussi Pyykkonen, Bo Isomaa, Anu-Katriina Pesonen, Johan G. Eriksson, Leif Groop, et al.
(2014) Annals of Medicine, 46 p.324-329
Journal articleAge-Related Clonal Hematopoiesis Associated with Adverse Outcomes.
Siddhartha Jaiswal, Pierre Fontanillas, Jason Flannick, Alisa Manning, Peter V Grauman, et al.
(2014) New England Journal of Medicine, 371 p.2488-2498
Journal articleExtensive changes in the transcriptional profile of human adipose tissue including genes involved in oxidative phosphorylation after a six months exercise intervention.
Tina Rönn, Petr Volkov, Åsa Tornberg, Targ Elgzyri, Ola Hansson, et al.
(2014) Acta Physiologica, 211 p.188-200
Journal articleCommon genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independently of obesity.
Robert A Scott, Tove Fall, Dorota Pasko, Adam Barker, Stephen J Sharp, et al.
(2014) Diabetes, 63 p.4378-4387
Journal articleCan genetics improve precision of therapy in diabetes?
Leif Groop, Petter Storm, Anders Rosengren
(2014) Trends in Endocrinology and Metabolism, 25 p.440-443
Journal article (comment)Gene-Lifestyle Interaction and Type 2 Diabetes: The EPIC InterAct Case-Cohort Study.
Claudia Langenberg, Stephen J Sharp, Paul Franks, Robert A Scott, Panos Deloukas, et al.
(2014) PLoS Medicine, 11
Journal articleChromosome x-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage compensation.
Taru Tukiainen, Matti Pirinen, Antti-Pekka Sarin, Claes Ladenvall, Johannes Kettunen, et al.
(2014) PLoS Genetics, 10
Journal articleWhole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol.
Leslie A Lange, Youna Hu, He Zhang, Chenyi Xue, Ellen M Schmidt, et al.
(2014) American Journal of Human Genetics, 94 p.233-245
Journal articleHeritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis.
Kaixin Zhou, Louise Donnelly, Jian Yang, Miaoxin Li, Harshal Deshmukh, et al.
(2014) The Lancet Diabetes & Endocrinology, 2 p.481-487
Journal articleEthnicity is an independent risk indicator when estimating diabetes risk with FINDRISC scores: A cross sectional study comparing immigrants from the Middle East and native Swedes.
Louise Bennet, Leif Groop, Ulf Lindblad, Carl-David Agardh, Paul Franks
(2014) Primary Care Diabetes, 8 p.231-238
Journal articleThe many faces of diabetes: a disease with increasing heterogeneity
Tiinamaija Tuomi, Nicola Santoro, Sonia Caprio, Mengyin Cai, Jianping Weng, et al.
(2014) The Lancet, 383 p.1084-1094
Journal article reviewTCF7L2 is a master regulator of insulin production and processing.
Yuedan Zhou, Soo-Young Park, Jing Su, Kathleen Bailey, Emilia Ottosson Laakso, et al.
(2014) Human Molecular Genetics, 23 p.6419-6431
Journal articleGlobal genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism.
Joao Fadista, Petter Vikman, Emilia Ottosson Laakso, Ines Mollet, Jonathan Esguerra, et al.
(2014) Proceedings of the National Academy of Sciences, 111 p.13924-13929
Journal articleA Central Role for GRB10 in Regulation of Islet Function in Man.
Inga Prokopenko, Wenny Poon, Reedik Mägi, Rashmi Prasad, S Albert Salehi, et al.
(2014) PLoS Genetics, 10
Journal articleThe diabetes susceptibility gene clec16a regulates mitophagy.
Scott A Soleimanpour, Aditi Gupta, Marina Bakay, Alana M Ferrari, David N Groff, et al.
(2014) Cell, 157 p.1577-1590
Journal articleAlcohol and the risk for LADA: results based on the Swedish ESTRID study.
Bahareh Rasouli, Tomas Andersson, Per-Ola Carlsson, Mozhgan Dorkhan, Valdemar Grill, et al.
(2014) European Journal of Endocrinology, 171 p.535-543
Journal articleType 2 diabetes susceptibility gene variants predispose to adult-onset autoimmune diabetes
Mette Andersen, Maria Sterner, Tom Forsen, Annemari Karajamaki, Olov Rolandsson, et al.
(2014) Diabetologia, 57 p.1859-1868
Journal articleLoss-of-function mutations in SLC30A8 protect against type 2 diabetes.
Jason Flannick, Gudmar Thorleifsson, Nicola L Beer, Suzanne B R Jacobs, Niels Grarup, et al.
(2014) Nature Genetics, 46 p.357-357
Journal articleGastric bypass improves ss-cell function and increases β-cell mass in a porcine model.
Andreas Lindqvist, Peter Spégel, Mikael Ekelund, Eliana Garcia Vaz, Stefan Pierzynowski, et al.
(2014) Diabetes, 63 p.1665-1671
Journal articleDownregulation of Type II Diabetes Mellitus and Maturity Onset Diabetes of Young Pathways in Human Pancreatic Islets from Hyperglycemic Donors.
Jalal Taneera, Petter Storm, Leif Groop
(2014) Journal of Diabetes Research, 2014
Journal articleTyypin 2 diabetes--perinnöllinen kohtalo vai hyvinvointiyhteiskunnan rangaistus?
Leif Groop
(2014) Duodecim, 130 p.2339-2346
Journal article reviewCarl-David Agardh, 1946-2013.
Leif Groop, Åke Lernmark, Jan Nilsson
(2014) Diabetologia
Journal articlePharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.
Iris Postmus, Stella Trompet, Harshal A Deshmukh, Michael R Barnes, Xiaohui Li, et al.
(2014) Nature Communications, 5
Journal articleTHOC5 : A novel gene involved in HDL-cholesterol metabolism
Maria Keller, Dorit Schleinitz, Julia Förster, Anke Tönjes, Yvonne Böttcher, et al.
(2013) Journal of Lipid Research, 54 p.3170-3176
Journal articleGenetics of diabetes - Are we missing the genes or the disease?
Leif Groop, Flemming Pociot
(2013) Molecular and Cellular Endocrinology
Journal articleAge at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk
Judith S. Brand, Yvonne T. van der Schouw, N. Charlotte Onland-Moret, Stephen J. Sharp, Ken K. Ong, et al.
(2013) Diabetes Care, 36 p.1012-1019
Journal articleLarge-scale association analysis identifies new risk loci for coronary artery disease
Panos Deloukas, Stavroula Kanoni, Christina Willenborg, Martin Farrall, Themistocles L. Assimes, et al.
(2013) Nature Genetics, 45 p.25-33
Journal articleGenome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Sonja I. Berndt, Stefan Gustafsson, Reedik Maegi, Andrea Ganna, Eleanor Wheeler, et al.
(2013) Nature Genetics, 45 p.501-512
Journal articleDiscovery and refinement of loci associated with lipid levels
Cristen J. Willer, Ellen M. Schmidt, Sebanti Sengupta, Gina M. Peloso, Stefan Gustafsson, et al.
(2013) Nature Genetics, 45 p.1274-1274
Journal articleEarly Metabolic Markers of the Development of Dysglycemia and Type 2 Diabetes and Their Physiological Significance
Ele Ferrannini, Andrea Natali, Stefania Camastra, Monica Nannipieri, Andrea Mari, et al.
(2013) Diabetes, 62 p.1730-1737
Journal articleThe CTRB1/2 Locus Affects Diabetes Susceptibility and Treatment via the Incretin Pathway
Leen M. 't Hart, Andreas Fritsche, Giel Nijpels, Nienke van Leeuwen, Louise A. Donnelly, et al.
(2013) Diabetes, 62 p.3275-3281
Journal articleCommon variants associated with plasma triglycerides and risk for coronary artery disease
Ron Do, Cristen J. Willer, Ellen M. Schmidt, Sebanti Sengupta, Chi Gao, et al.
(2013) Nature Genetics, 45 p.1345-1345
Journal articleGenetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes
Weijia Xie, Andrew R. Wood, Valeriya Lyssenko, Michael N. Weedon, Joshua W. Knowles, et al.
(2013) Diabetes, 62 p.2141-2150
Journal articleIdentification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders
Marcel den Hoed, Mark Eijgelsheim, Tonu Esko, Bianca J. J. M. Brundel, David S. Peal, et al.
(2013) Nature Genetics, 45 p.621-631
Journal articleAssessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes
Jason Flannick, Nicola L. Beer, Alexander G. Bick, Vineeta Agarwala, Janne Molnes, et al.
(2013) Nature Genetics, 45 p.1380-1380
Journal articleInsights Into the Molecular Mechanism for Type 2 Diabetes Susceptibility at the KCNQ1 Locus From Temporal Changes in Imprinting Status in Human Islets
Mary E. Travers, Deborah J. G. Mackay, Marloes Dekker Nitert, Andrew P. Morris, Cecilia M. Lindgren, et al.
(2013) Diabetes, 62 p.987-992
Journal articleExpression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes.
Jalal Taneera, Joao Fadista, Emma Ahlqvist, Mengze Zhang, Nils Wierup, et al.
(2013) Molecular and Cellular Endocrinology, 375 p.35-42
Journal articleThe Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis
Tove Fall, Sara Hagg, Reedik Maegi, Alexander Ploner, Krista Fischer, et al.
(2013) PLoS Medicine, 10
Journal articleA link between GIP and osteopontin in adipose tissue and insulin resistance.
Emma Ahlqvist, Peter Osmark, Tiina Kuulasmaa, Kasper Pilgaard, Bilal Omar, et al.
(2013) Diabetes, 62 p.2088-2094
Journal articleSex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits
Joshua C. Randall, Thomas W. Winkler, Zoltan Kutalik, Sonja I. Berndt, Anne U. Jackson, et al.
(2013) PLoS Genetics, 9
Journal articleEffects of ingestion routes on hormonal and metabolic profiles in gastric-bypassed humans
Andreas Lindqvist, Mikael Ekelund, Hindrik Mulder, Peter Spégel, Leif Groop, et al.
(2013) Journal of Clinical Endocrinology and Metabolism, 98 p.856-861
Journal articleAlterations in bile acid synthesis in carriers of HNF1α mutations.
Ella Ekholm, Ralf Nilsson, Leif Groop, Camilla Pramfalk
(2013) Journal of Internal Medicine, 274 p.263-272
Journal articleA six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue.
Tina Rönn, Petr Volkov, Cajsa Davegårdh, Tasnim Dayeh, Elin Hall, et al.
(2013) PLoS Genetics, 9
Journal articleEffect of Common Genetic Variants Associated with Type 2 Diabetes and Glycemic Traits on α- and β-cell Function and Insulin Action in Man.
Anna Jonsson, Claes Ladenvall, Tarunveer Singh Ahluwalia, Jasmina Kravic, Ulrika Krus, et al.
(2013) Diabetes, 62 p.2978-2983
Journal articleExome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes
A. Albrechtsen, N. Grarup, Y. Li, T. Sparso, G. Tian, et al.
(2013) Diabetologia, 56 p.298-310
Journal articleMetabolite Profiling Reveals Normal Metabolic Control in Carriers of Mutations in the Glucokinase Gene (MODY2).
Peter Spégel, Ella Ekholm, Tiinamaija Tuomi, Leif Groop, Hindrik Mulder, et al.
(2012) Diabetes
Journal articleCommon variant in the HMGA2 gene increases susceptibility to nephropathy in patients with type 2 diabetes.
Sami Alkayyali, M Lajer, H Deshmukh, Emma Ahlqvist, H Colhoun, et al.
(2012) Diabetologia
Journal articleThe Triglyceride Content in Skeletal Muscle Is Associated with Hepatic But Not Peripheral Insulin Resistance in Elderly Twins.
Louise Groth Grunnet, Esa Laurila, Ola Hansson, Peter Almgren, Leif Groop, et al.
(2012) The Journal of clinical endocrinology and metabolism
Journal articleImpact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Degree Relatives of Patients With Type 2 Diabetes.
Marloes Dekker Nitert, Tasnim Dayeh, Peter Volkov, Targ Elgzyri, Elin Hall, et al.
(2012) Diabetes
Journal articleEffect of a common variant of the PCSK2 gene on reduced insulin secretion.
Anna Jonsson, B Isomaa, Tiinamaija Tuomi, Jonas Eriksson, Leif Groop, et al.
(2012) Diabetologia
Journal articleA Single Nucleotide Polymorphism Associates With the Response of Muscle ATP Synthesis to Long-Term Exercise Training in Relatives of Type 2 Diabetic Humans
Gertrud Kacerovsky-Bielesz, Michaela Kacerovsky, Marek Chmelik, Michaela Farukuoye, Charlotte Ling, et al.
(2012) Diabetes Care, 35 p.350-357
Journal articleLarge-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Andrew P. Morris, Benjamin F. Voight, Tanya M. Teslovich, Teresa Ferreira, Ayellet V. Segre, et al.
(2012) Nature Genetics, 44 p.981-981
Journal articleSubjective Sleep Complaints Are Associated With Insulin Resistance in Individuals Without Diabetes The PPP-Botnia Study
Antti-Jussi Pyykkonen, Bo Isomaa, Anu-Katriina Pesonen, Johan G. Eriksson, Leif Groop, et al.
(2012) Diabetes Care, 35 p.2271-2278
Journal articleRegulation of the pro-inflammatory cytokine osteopontin by GIP in adipocytes - A role for the transcription factor NFAT and phosphodiesterase 3B.
Bilal Omar, Elin Banke, Emilia Guiguis, Lina Kesson, Vincent Manganiello, et al.
(2012) Biochemical and Biophysical Research Communications, 425 p.812-817
Journal articleZinc Transporter 8 Autoantibodies and Their Association With SLC30A8 and HLA-DQ Genes Differ Between Immigrant and Swedish Patients With Newly Diagnosed Type 1 Diabetes in the Better Diabetes Diagnosis Study.
Ahmed Delli, Fariba Vaziri Sani, Bengt Lindblad, Helena Larsson, Annelie Carlsson, et al.
(2012) Diabetes, 61 p.2556-2564
Journal articleNo Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels
Robert A. Scott, Audrey Y. Chu, Niels Grarup, Alisa K. Manning, Marie-France Hivert, et al.
(2012) Diabetes, 61 p.1291-1296
Journal articleA genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
Alisa K. Manning, Marie-France Hivert, Robert A. Scott, Jonna L. Grimsby, Nabila Bouatia-Naji, et al.
(2012) Nature Genetics, 44 p.81-659
Journal articleAssociation of variants in HLA-DQA1-DQB1, PTPN22, INS, and CTLA4 with GAD autoantibodies and insulin secretion in nondiabetic adults of the Botnia Prospective Study
Mette K. Andersen, Virve Lundgren, Bo Isomaa, Leif Groop, Tiinamaija Tuomi
(2012) European Journal of Endocrinology, 167 p.27-33
Journal articleFirst-Degree Relatives of Type 2 Diabetic Patients Have Reduced Expression of Genes Involved in Fatty Acid Metabolism in Skeletal Muscle.
Targ Elgzyri, Hemang Parikh, Yuedan Zhou, Marloes Dekker Nitert, Tina Rönn, et al.
(2012) Journal of Clinical Endocrinology and Metabolism, 97 p.1332-1337
Journal articleSNP in the genome-wide association study hotspot on chromosome 9p21 confers susceptibility to diabetic nephropathy in type 1 diabetes
E. Fagerholm, Emma Ahlqvist, C. Forsblom, N. Sandholm, A. Syreeni, et al.
(2012) Diabetologia, 55 p.2386-2393
Journal articleAnalysis of case-control association studies with known risk variants
Noah Zaitlen, Bogdan Pasaniuc, Nick Patterson, Samuela Pollack, Benjamin Voight, et al.
(2012) Bioinformatics, 28 p.1729-1737
Journal articleStratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases
John R. B. Perry, Benjamin F. Voight, Loic Yengo, Najaf Amin, Josee Dupuis, et al.
(2012) PLoS Genetics, 8
Journal articleγ-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes.
Jalal Taneera, Z Jin, Yuesheng Jin, Sarheed Jabar Muhammed, Enming Zhang, et al.
(2012) Diabetologia, 55 p.1985-1994
Journal articleInformed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies
Noah Zaitlen, Sara Lindstroem, Bogdan Pasaniuc, Marilyn Cornelis, Giulio Genovese, et al.
(2012) PLoS Genetics, 8
Journal articleAssociation between depressive symptoms and metabolic syndrome is not explained by antidepressant medication: Results from the PPP-Botnia Study
Antti-Jussi Pyykkonen, Katri Raikkonen, Tiinamaija Tuomi, Johan G. Eriksson, Leif Groop, et al.
(2012) Annals of Medicine, 44 p.279-288
Journal articlePhysical activity reduces the risk of incident type 2 diabetes in general and in abdominally lean and obese men and women: the EPIC-InterAct Study
U. Ekelund, L. Palla, S. Brage, Paul Franks, T. Peters, et al.
(2012) Diabetologia, 55 p.1944-1952
Journal articleFTO genotype is associated with phenotypic variability of body mass index
Jian Yang, Ruth J. F. Loos, Joseph E. Powell, Sarah E. Medland, Elizabeth K. Speliotes, et al.
(2012) Nature, 490 p.267-272
Journal articleNew Susceptibility Loci Associated with Kidney Disease in Type 1 Diabetes
Niina Sandholm, Rany M. Salem, Amy Jayne McKnight, Eoin P. Brennan, Carol Forsblom, et al.
(2012) PLoS Genetics, 8
Journal articleReduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes.
Sofia A Andersson, Anders H Olsson, Jonathan L S Esguerra, Emilia Heimann, Claes Ladenvall, et al.
(2012) Molecular and Cellular Endocrinology, 364 p.36-45
Journal articleCodon 72 polymorphism (rs1042522) of TP53 is associated with changes in diastolic blood pressure over time
Erwin Reiling, Valeriya Lyssenko, Jolanda M. A. Boer, Sandra Imholz, W. Monique M. Verschuren, et al.
(2012) European Journal of Human Genetics, 20 p.696-700
Journal articleSecreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.
Taman Mahdi, Sonja Hänzelmann, S Albert Salehi, Sarheed Jabar Muhammed, Thomas Reinbothe, et al.
(2012) Cell Metabolism, 16 p.625-633
Journal articleReduced Insulin Exocytosis in Human Pancreatic β-cells With Gene Variants Linked to Type 2 Diabetes.
Anders Rosengren, Matthias Braun, Taman Mahdi, Sofia A Andersson, Mary E Travers, et al.
(2012) Diabetes, 61 p.1726-1733
Journal articleGenetic prediction of postpartum diabetes in women with gestational diabetes mellitus
Magnus Ekelund, Nael Shaat, Peter Almgren, Eva Anderberg, Mona Landin-Olsson, et al.
(2012) Diabetes Research and Clinical Practice, 97 p.394-398
Journal articleIntraorbital deiodinase type 2 expression is downregulated in chronic phase of Graves' ophthalmopathy.
Tereza Planck, Hemang Parikh, Leif Groop, Bengt Hallengren, Mikael Lantz
(2012) Clinical Endocrinology, 77 p.487-488
Journal article (letter)Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway.
Yuedan Zhou, Enming Zhang, Christine Berggreen, Xingjun Jing, Peter Osmark, et al.
(2012) Human Molecular Genetics, 21 p.196-207
Journal articleDifferential gene expression in adipose tissue from obese human subjects during weight loss and weight maintenance.
Lovisa Johansson, Anders Danielsson, Hemang Parikh, Maria Klintenberg, Fredrik Norström, et al.
(2012) The American journal of clinical nutrition, 96 p.196-207
Journal articleTelomere length in blood and skeletal muscle in relation to measures of glycaemia and insulinaemia.
Shafqat Ahmad, A Heraclides, Q Sun, Targ Elgzyri, Tina Rönn, et al.
(2012) Diabetic medicine : a journal of the British Diabetic Association, 29 p.377-381
Journal articleA systems genetics approach identifies genes and pathways for type 2 diabetes in human islets.
Jalal Taneera, Stefan Lang, Amitabh Sharma, Joao Fadista, Yuedan Zhou, et al.
(2012) Cell Metabolism, 16 p.122-134
Journal articleA common variant upstream of the PAX6 gene influences islet function in man.
Emma Ahlqvist, Fabiola Turrini, Stefan Lang, Jalal Taneera, Yuedan Zhou, et al.
(2012) Diabetologia, 55 p.94-104
Journal articleWorse glycaemic control in LADA patients than in those with type 2 diabetes, despite a longer time on insulin therapy.
Caroline Andersen, Louise Bennet, L Nyström, Ulf Lindblad, Eero Lindholm, et al.
(2012) Diabetologia
Journal articleValidation of a multi-marker model for the prediction of incident type 2 diabetes mellitus: Combined results of the Inter99 and Botnia studies.
Valeriya Lyssenko, Torben Jørgensen, Robert W Gerwien, Torben Hansen, Michael W Rowe, et al.
(2012) Diabetes & Vascular Disease Research, 9 p.59-67
Journal articleGenetic Variation in the Glucose-Dependent Insulinotropic Polypeptide Receptor Modifies the Association between Carbohydrate and Fat Intake and Risk of Type 2 Diabetes in the Malmo Diet and Cancer Cohort.
Emily Sonestedt, Valeriya Lyssenko, Ulrika Ericson, Bo Gullberg, Elisabet Wirfält, et al.
(2012) The Journal of clinical endocrinology and metabolism, 97 p.810-818
Journal articleVariant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents
Nicola Santoro, Clarence K. Zhang, Hongyu Zhao, Andrew J. Pakstis, Grace Kim, et al.
(2012) Hepatology, 55 p.781-789
Journal articleSurvival of rat pancreatic islets is partly controlled by a TCF7L2-p53-p53INP1 dependent pathway
Y. Zhou, Enming Zhang, C. Berggreen, Xingjun Jing, P. Osmark, et al.
(2011) Diabetologia, 54 p.64-65
Journal articleThe Genetic Structure of the Swedish Population
Keith Humphreys, Alexander Grankvist, Monica Leu, Per Hall, Jianjun Liu, et al.
(2011) PLoS ONE, 6
Journal articleGenome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes
Rona J. Strawbridge, Josee Dupuis, Inga Prokopenko, Adam Barker, Emma Ahlqvist, et al.
(2011) Diabetes, 60 p.2624-2634
Journal articleComparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction
Jessica Shea, Vineeta Agarwala, Anthony A. Philippakis, Jared Maguire, Eric Banks, et al.
(2011) Nature Genetics, 43 p.114-801
Journal articleGenome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure
Louise V. Wain, Germaine C. Verwoert, Paul F. O'Reilly, Gang Shi, Toby Johnson, et al.
(2011) Nature Genetics, 43 p.122-1005
Journal articleTwo-Step Approach for the Prediction of Future Type 2 Diabetes Risk
Muhammad A. Abdul-Ghani, Tamam Abdul-Ghani, Michael P. Stern, Jasmina Karavic, Tiinamaija Tuomi, et al.
(2011) Diabetes Care, 34 p.2108-2112
Journal articleFTO, Type 2 Diabetes, and Weight Gain Throughout Adult Life A Meta-Analysis of 41,504 Subjects From the Scandinavian HUNT, MDC, and MPP Studies
Jens K. Hertel, Stefan Johansson, Emily Sonestedt, Anna Jonsson, Rolv T. Lie, et al.
(2011) Diabetes, 60 p.1637-1644
Journal articleDepressive Symptoms, Antidepressant Medication Use, and Insulin Resistance The PPP-Botnia Study
Antti-Jussi Pyykkonen, Katri Raikkonen, Tiinamaija Tuomi, Johan G. Eriksson, Leif Groop, et al.
(2011) Diabetes Care, 34 p.2545-2547
Journal articleInsulin Reduces Neuronal Excitability by Turning on GABA(A) Channels that Generate Tonic Current
Zhe Jin, Yang Jin, Suresh Kumar-Mendu, Eva Degerman, Leif Groop, et al.
(2011) PLoS ONE, 6
Journal articleHigh prevalence of type 2 diabetes in Iraqi and Swedish residents in a deprived Swedish neighbourhood - a population based study
Louise Bennet, Sven-Erik Johansson, Carl-David Agardh, Leif Groop, Jan Sundquist, et al.
(2011) BMC Public Health, 11
Journal articleGenetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
Tuomas O. Kilpelainen, M. Carola Zillikens, Alena Stancakova, Francis M. Finucane, Janina S. Ried, et al.
(2011) Nature Genetics, 43 p.58-753
Journal articleA large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes
G. Thanabalasingham, N. Shah, M. Vaxillaire, T. Hansen, T. Tuomi, et al.
(2011) Diabetologia, 54 p.2801-2810
Journal articlePhysical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children
Tuomas O. Kilpelaeinen, Lu Qi, Soren Brage, Stephen J. Sharp, Emily Sonestedt, et al.
(2011) PLoS Medicine, 8
Journal articleAssociation between parental history of diabetes and type 2 diabetes genetic risk scores in the PPP-Botnia and Framingham Offspring Studies
Jason L. Vassy, Peter Shrader, Anna Jonsson, Caroline S. Fox, Valeriya Lyssenko, et al.
(2011) Diabetes Research and Clinical Practice, 93 p.76-79
Journal articlePower in the Phenotypic Extremes: A Simulation Study of Power in Discovery and Replication of Rare Variants
Lin T. Guey, Jasmina Kravic, Olle Melander, Noel P. Burtt, Jason M. Laramie, et al.
(2011) Genetic Epidemiology, 35 p.236-246
Journal articleLifeGene-a large prospective population-based study of global relevance
Catarina Almqvist, Hans-Olov Adami, Paul Franks, Leif Groop, Erik Ingelsson, et al.
(2011) European Journal of Epidemiology, 26 p.67-77
Journal articleTwo common genetic variants near nuclear encoded OXPHOS genes are associated with insulin secretion in vivo.
Anders H Olsson, Tina Rönn, Claes Ladenvall, Hemang Parikh, Bo Isomaa, et al.
(2011) European Journal of Endocrinology, 164 p.765-771
Journal articleA common variant near the PRL gene is associated with increased adiposity in males
Louise Nilsson, Anders H Olsson, Bo Isomaa, Leif Groop, Hakan Billig, et al.
(2011) Molecular Genetics and Metabolism, 102 p.78-81
Journal articleDesign and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study
C. Langenberg, S. Sharp, N. G. Forouhi, Paul Franks, M. B. Schulze, et al.
(2011) Diabetologia, 54 p.2272-2282
Journal articleCommon variants in CNDP1 and CNDP2, and risk of nephropathy in type 2 diabetes.
Tarun Ahluwalia, Eero Lindholm, Leif Groop
(2011) Diabetologia, 54 p.2295-2302
Journal articleUromodulin gene variant is associated with type 2 diabetic nephropathy.
Tarunveer S Ahluwalia, Eero Lindholm, Leif Groop, Olle Melander
(2011) Journal of Hypertension, 29 p.1731-1734
Journal articleInsulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets.
Beatrice Yang, Tasnim Dayeh, C L Kirkpatrick, Jalal Taneera, Rajesh Kumar, et al.
(2011) Diabetologia, Dec p.360-367
Journal articleGene Expression in Graves' Ophthalmopathy and Arm Lymphedema: Similarities and Differences.
Tereza Planck, Hemang Parikh, Håkan Brorson, Tuve Mårtensson, Peter Åsman, et al.
(2011) Thyroid, 21 p.663-674
Journal articleExercise capacity in relation to body fat distribution and muscle fibre distribution in elderly male subjects with impaired glucose tolerance, type 2 diabetes and matched controls.
Åsa Tornberg, Targ Elgzyri, Karl-Fredrik Eriksson, Leif Groop, Ola Thorsson, et al.
(2011) Diabetes Research and Clinical Practice, 94 p.57-63
Journal articleUpper Body Muscle Strength and Endurance in Relation to Peak Exercise Capacity During Cycling in Healthy Sedentary Male Subjects.
Åsa Tornberg, Anna Maria Drake, Targ Elzyri, Karl-Fredrik Eriksson, Karin Ringsberg, et al.
(2011) Journal of Strength and Conditioning Research, 25 p.1413-1417
Journal articleRelation between cycling exercise capacity, fiber-type composition, and lower extremity muscle strength and muscle endurance.
Åsa Tornberg, Anna Maria Drake, Ola Hansson, Targ Elgzyri, Karl-Fredrik Eriksson, et al.
(2011) Journal of Strength and Conditioning Research, 25 p.16-22
Journal articleHeritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study.
Peter Almgren, M Lehtovirta, B Isomaa, L Sarelin, M R Taskinen, et al.
(2011) Diabetologia, 54 p.2811-2819
Journal articleThe expression of myosin heavy chain (MHC) genes in human skeletal muscle is related to metabolic characteristics involved in the pathogenesis of type 2 diabetes.
Anders H Olsson, Tina Rönn, Tarq Elgzyri, Ola Hansson, Karl-Fredrik Eriksson, et al.
(2011) Molecular Genetics and Metabolism, 103 p.275-281
Journal articleGenetics of Type 2 Diabetes.
Emma Ahlqvist, Tarunveer Singh Ahluwalia, Leif Groop
(2011) Clinical Chemistry, 57 p.241-254
Journal article reviewA common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes.
Thomas Koeck, Anders H Olsson, Marloes Dekker Nitert, Vladimir Sharoyko, Claes Ladenvall, et al.
(2011) Cell Metabolism, 13 p.80-91
Journal articleFacilitation of information exhange between genetic research, primary health care and decision makers using a regional diabetes register DIREVA (Diabetes Register Vaasa)
Tom Forsén, Kaj Lahti, J Eriksson, Tiinamaija Tuomi, Bo Isomaa, et al.
(2011) IMSCI 2011 - 5th International Multi-Conference on Society, Cybernetics and Informatics, Proceedings, 1 p.288-288
Conference paperPleiotropic Effects of GIP on Islet Function Involve Osteopontin
Valeriya Lyssenko, Lena Eliasson, Olga Kotova, Kasper Pilgaard, Nils Wierup, et al.
(2011) Diabetes, 60 p.2424-2433
Journal articleGenetics of type 2 diabetes
Emma Ahlqvist, Tarunveer Singh Ahluwalia, Leif Groop
(2011) Clinical Chemistry, 57 p.241-254
Journal article reviewPolymorphisms in α- And β-adrenergic receptor genes, hypertension, and obstructive sleep apnea : The skaraborg sleep study
Kristina Bengtsson Boström, Jan Hedner, Ludger Grote, Olle Melander, Fredrik Von Wowern, et al.
(2010) International Journal of Hypertension, 2010
Journal articleInvestigation of Type 2 Diabetes Risk Alleles Support CDKN2A/B, CDKAL1, and TCF7L2 As Susceptibility Genes in a Han Chinese Cohort
Jie Wen, Tina Rönn, Anders H Olsson, Zhen Yang, Bin Lu, et al.
(2010) PLoS ONE, 5
Journal articleGAD Antibody Positivity Predicts Type 2 Diabetes in an Adult Population
Virve M. Lundgren, Bo Isomaa, Valeriya Lyssenko, Esa Laurila, Pasi Korhonen, et al.
(2010) Diabetes, 59 p.416-422
Journal articleMinimal Contribution of Fasting Hyperglycemia to the Incidence of Type 2 Diabetes in Subjects With Normal 2-h Plasma Glucose
Muhammad A. Abdul-Ghani, Michael P. Stern, Valeriya Lyssenko, Tiinamaija Tuomi, Leif Groop, et al.
(2010) Diabetes Care, 33 p.557-561
Journal articleBrain natriuretic peptide is related to diastolic dysfunction whereas urinary albumin excretion rate is related to left ventricular mass in asymptomatic type 2 diabetes patients
Martin Magnusson, Stefan Jovinge, Kambiz Shahgaldi, Bo Israelsson, Leif Groop, et al.
(2010) Cardiovascular Diabetology, 9
Journal articleGenetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
Richa Saxena, Marie-France Hivert, Claudia Langenberg, Toshiko Tanaka, James S. Pankow, et al.
(2010) Nature Genetics, 42 p.75-142
Journal articleAssociation analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Elizabeth K. Speliotes, Cristen J. Willer, Sonja I. Berndt, Keri L. Monda, Gudmar Thorleifsson, et al.
(2010) Nature Genetics, 42 p.53-937
Journal articleDetailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans
Erik Ingelsson, Claudia Langenberg, Marie-France Hivert, Inga Prokopenko, Valeriya Lyssenko, et al.
(2010) Diabetes, 59 p.1266-1275
Conference paperMeta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Iris M. Heid, Anne U. Jackson, Joshua C. Randall, Thomas W. Winkler, Lu Qi, et al.
(2010) Nature Genetics, 42 p.160-949
Journal articleGenome-wide meta-analyses identify multiple loci associated with smoking behavior
Helena Furberg, YunJung Kim, Jennifer Dackor, Eric Boerwinkle, Nora Franceschini, et al.
(2010) Nature Genetics, 42 p.134-441
Journal articleStressful Life Events and the Metabolic Syndrome - The Prevalence, Prediction and Prevention of Diabetes (PPP)-Botnia Study
Antti-Jussi Pyykkonen, Katri Raikkonen, Tiinamaija Tuomi, Johan G. Eriksson, Leif Groop, et al.
(2010) Diabetes Care, 33 p.378-384
Journal articleTwelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Benjamin F. Voight, Laura J. Scott, Valgerdur Steinthorsdottir, Andrew P. Morris, Christian Dina, et al.
(2010) Nature Genetics, 42 p.155-579
Journal articleTCF7L2-conferred apoptosis in pancreatic beta cells involves the p53 pathway
Yuedan Zhou, Enming Zhang, Erik Renström, Leif Groop, Ola Hansson
(2010) Diabetologia, 53 p.298-298
Conference paper: abstractDifferences in associations between HSD11B1 gene expression and metabolic parameters in subjects with and without impaired glucose homeostasis
C. Karlsson, M. Jernas, B. Olsson, T. Lystig, A. Gummesson, et al.
(2010) Diabetes Research and Clinical Practice, 88 p.252-258
Journal articleNordicDB: a Nordic pool and portal for genome-wide control data
Monica Leu, Keith Humphreys, Ida Surakka, Emil Rehnberg, Juha Muilu, et al.
(2010) European Journal of Human Genetics, 18 p.1322-1326
Journal articleAn empirical index of insulin sensitivity from short IVGTT: validation against the minimal model and glucose clamp indices in patients with different clinical characteristics
A. Tura, S. Sbrignadello, E. Succurro, Leif Groop, G. Sesti, et al.
(2010) Diabetologia, 53 p.144-152
Journal articleHundreds of variants clustered in genomic loci and biological pathways affect human height
Hana Lango Allen, Karol Estrada, Guillaume Lettre, Sonja I. Berndt, Michael N. Weedon, et al.
(2010) Nature, 467 p.832-838
Journal articleAnalysis of TBC1D4 in patients with severe insulin resistance
S. Dash, C. Langenberg, K. A. Fawcett, R. K. Semple, S. Romeo, et al.
(2010) Diabetologia, 53 p.1239-1242
Journal article (letter)The shape of plasma glucose concentration curve during OGTT predicts future risk of type 2 diabetes
Muhammad A. Abdul-Ghani, Valeriya Lyssenko, Tiinamaija Tuomi, Ralph A. DeFronzo, Leif Groop
(2010) Diabetes/Metabolism Research & Reviews, 26 p.280-286
Journal articleA mRNA marker for glycolytic muscle fibres may be used to determine fibre type composition in human skeletal muscle
Anders H Olsson, Targ Elgzyri, Esa Laurila, Leif Groop, Ola Hansson, et al.
(2010) Diabetologia, 53 p.705-705
Conference paper: abstractA family history of diabetes is associated with reduced physical fitness in the Prevalence, Prediction and Prevention of Diabetes (PPP)-Botnia study
B. Isomaa, B. Forsen, K. Lahti, N. Holmstrom, J. Waden, et al.
(2010) Diabetologia, 53 p.1709-1713
Journal articleInfluence of novel genetic loci affecting glucose and insulin levels during OGTT on islet function in man
Tarun Ahluwalia, Claes Ladenvall, Anna Jonsson, Jasmina Kravic, Esa Laurila, et al.
(2010) Diabetologia, 53 p.136-136
Conference paper: abstractEvidence that BMI and type 2 diabetes share only a minor fraction of genetic variance: a follow-up study of 23,585 monozygotic and dizygotic twins from the Finnish Twin Cohort Study
M. Lehtovirta, K. H. Pietilainen, E. Levalahti, K. Heikkila, Leif Groop, et al.
(2010) Diabetologia, 53 p.1314-1321
Journal articleCommon Inherited Variation in Mitochondrial Genes Is Not Enriched for Associations with Type 2 Diabetes or Related Glycemic Traits
Ayellet V. Segre, Leif Groop, Vamsi K. Mootha, Mark J. Daly, David Altshuler
(2010) PLoS Genetics, 6
Journal articlePrediction of postpartum diabetes in women with gestational diabetes mellitus
M. Ekelund, Nael Shaat, Peter Almgren, Leif Groop, Kerstin Berntorp
(2010) Diabetologia, 53 p.452-457
Journal articleResistance to exercise-induced changes in the global DNA methylation pattern of skeletal muscle in individuals with a family history of type 2 diabetes
Marloes Dekker Nitert, Tasnim Dayeh, Stefan Lang, Targ Elgzyri, Yang De Marinis, et al.
(2010) Diabetologia, 53 p.312-312
Conference paper: abstractGenetic association analysis of LARS2 with type 2 diabetes
E. Reiling, B. Jafar-Mohammadi, E. van't Riet, M. N. Weedon, J. V. van Vliet-Ostaptchouk, et al.
(2010) Diabetologia, 53 p.103-110
Journal articleEffect of variants in the RORA gene on risk of type 2 diabetes
Anna Jonsson, Sami Alkayyali, B. Isomaa, T. Tuomi, Leif Groop, et al.
(2010) Diabetologia, 53 p.304-304
Conference paper: abstractRisk genotypes, allele-specific expression and methylation status in human islets at the KCNQ1 type 2 diabetes-susceptibility locus
M. E. Travers, Marloes Dekker Nitert, D. J. G. Mackay, C. M. Lindgren, Leif Groop, et al.
(2010) Diabetologia, 53 p.134-134
Conference paper: abstractA common variant in the PAX6 gene influences islet function in man
Emma Ahlqvist, Fabiola Turrini, Stefan Lang, Targ Elgzyri, Yuedan Zhou, et al.
(2010) Diabetologia, 53 p.297-297
Conference paper: abstractGenetics of type 2 diabetes -Are we getting any closer?
Leif Groop
(2010) Endocrine Journal, 57 p.214-214
Conference paper: abstractGenome wide association analysis for free fatty acid levels in DGI
Ivana Stojkovic, C. Saloranta, Peter Almgren, Valeriya Lyssenko, E. Laurila, et al.
(2010) Diabetologia, 53 p.322-322
Conference paper: abstractBiological, clinical and population relevance of 95 loci for blood lipids
Tanya M. Teslovich, Kiran Musunuru, Albert V. Smith, Andrew C. Edmondson, Ioannis M. Stylianou, et al.
(2010) Nature, 466 p.707-713
Journal articleGenome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution
Cecilia M. Lindgren, Iris M. Heid, Joshua C. Randall, Claudia Lamina, Valgerdur Steinthorsdottir, et al.
(2010) PLoS Genetics, 5
Journal articleGenetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes
John R. B. Perry, Michael N. Weedon, Claudia Langenberg, Anne U. Jackson, Valeriya Lyssenko, et al.
(2010) Human Molecular Genetics, 19 p.535-544
Journal articleAn investigation of serum concentration of apoM as a potential MODY3 marker using a novel ELISA.
Camilla Cervin, Olof Axler, Johan Holmkvist, Peter Almgren, E Rantala, et al.
(2010) Journal of Internal Medicine, 267 p.316-321
Journal articleIndividualizing Therapies in Type 2 Diabetes Mellitus Based on Patient Characteristics: What We Know and What We Need to Know.
Robert Smith, David M Nathan, Silva A Arslanian, Leif Groop, Robert A Rizza, et al.
(2010) The Journal of clinical endocrinology and metabolism, Apr 7 p.1566-1574
Journal articleOverexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes.
Anders Rosengren, Ramunas Jokubka, Damon Tojjar, Charlotte Granhall, Ola Hansson, et al.
(2010) Science (New York, N.Y.), 327 p.217-220
Journal articleDeoxyribonucleic Acid Methylation and Gene Expression of PPARGC1A in Human Muscle Is Influenced by High-Fat Overfeeding in a Birth-Weight-Dependent Manner.
Charlotte Brøns, Stine Jacobsen, Emma E Nilsson, Tina Rönn, Christine B Jensen, et al.
(2010) The Journal of clinical endocrinology and metabolism, 95 p.3048-3056
Journal articleThe Association of Mitochondrial Content with Prevalent and Incident Type 2 Diabetes.
Erwin Reiling, Charlotte Ling, André G Uitterlinden, Esther Van't Riet, Laura M C Welschen, et al.
(2010) The Journal of clinical endocrinology and metabolism, 95 p.1909-1915
Journal articlePlasma copeptin and the risk of diabetes mellitus.
Sofia Enhörning, Thomas J Wang, Peter Nilsson, Peter Almgren, Bo Hedblad, et al.
(2010) Circulation, 121 p.51-2102
Journal articleImpact of exercise intensity and duration on insulin sensitivity in women with T2D.
Åsa Tornberg, Forouzan Glans, Karl-Fredrik Eriksson, Anna Maria Drake, Leif Groop, et al.
(2010) European Journal of Internal Medicine, 21 p.404-408
Journal articleNew genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Josee Dupuis, Claudia Langenberg, Inga Prokopenko, Richa Saxena, Nicole Soranzo, et al.
(2010) Nature Genetics, 42 p.32-105
Journal articleLatent Autoimmune Diabetes in Adults Differs Genetically From Classical Type 1 Diabetes Diagnosed After the Age of 35 Years
Mette K. Andersen, Virve Lundgren, Joni A. Turunen, Carol Forsblom, Bo Isomaa, et al.
(2010) Diabetes Care, 33 p.2062-2064
Journal articleSix new loci associated with body mass index highlight a neuronal influence on body weight regulation
Cristen J. Willer, Elizabeth K. Speliotes, Ruth J. F. Loos, Shengxu Li, Cecilia M. Lindgren, et al.
(2009) Nature Genetics, 41 p.25-34
Journal articleGenome-wide association study identifies eight loci associated with blood pressure
Christopher Newton-Cheh, Toby Johnson, Vesela Gateva, Martin D. Tobin, Murielle Bochud, et al.
(2009) Nature Genetics, 41 p.666-676
Journal articleImpaired Mitochondrial Function and Insulin Resistance of Skeletal Muscle in Mitochondrial Diabetes
Julia Szendroedi, Albrecht Ingo Schmid, Martin Meyerspeer, Camilla Cervin, Michaela Kacerovsky, et al.
(2009) Diabetes Care, 32 p.677-679
Conference paperEpigenetics: A Molecular Link Between Environmental Factors and Type 2 Diabetes
Charlotte Ling, Leif Groop
(2009) Diabetes, 58 p.2718-2725
Journal article reviewVariants in MTNR1B influence fasting glucose levels
Inga Prokopenko, Claudia Langenberg, Jose C. Florez, Richa Saxena, Nicole Soranzo, et al.
(2009) Nature Genetics, 41 p.77-81
Journal articleFunctional Variant Disrupts Insulin Induction of USF1 Mechanism for USF1-Associated Dyslipidemias
Jussi Naukkarinen, Emma Nilsson, Heikki A. Koistinen, Sanni Soderlund, Valeriya Lyssenko, et al.
(2009) Circulation: Cardiovascular Genetics, 2 p.245-522
Journal articleGenetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs
Anke Toenjes, Moritz Koriath, Dorit Schleinitz, Kerstin Dietrich, Yvonne Boettcher, et al.
(2009) Human Molecular Genetics, 18 p.4662-4668
Journal articleUnderlying Genetic Models of Inheritance in Established Type 2 Diabetes Associations
Georgia Salanti, Lorraine Southam, David Altshuler, Kristin Ardlie, Ines Barroso, et al.
(2009) American Journal of Epidemiology, 170 p.537-545
Journal article reviewEvaluation of chloride channel-3 as a potential target for TCF7L2-dependent impairment of insulin secretion
Xingjun Jing, Yuedan Zhou, Peter Osmark, Stefan Lang, Leif Groop, et al.
(2009) Diabetologia, 52 p.332-332
Conference paper: abstractThe diabetes risk score outperforms fasting plasma glucose and glucose tolerance tests: combined results from the Inter99 and Botnia Studies
M. P. McKenna, Valeriya Lyssenko, M. Rowe, R. Gerwien, J. Kolberg, et al.
(2009) Diabetologia, 52 p.7-7
Conference paper: abstractGenetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts
Anna Kotronen, Hannele Yki-Jarvinen, Anna Aminoff, Robert Bergholm, Kirsi H. Pietilainen, et al.
(2009) European Journal of Endocrinology, 160 p.593-602
Journal articleEffects of six months of moderate resistance-versus endurance-training on muscle ATP synthesis in first-degree relatives of patients with type 2 diabetes
G. Kacerovsky-Bielesz, M. Chmelik, Charlotte Ling, R. Pokan, J. Szendroedi, et al.
(2009) Diabetologia, 52 p.687-687
Conference paper: abstractThe T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects
Helene Choquet, Christine Cavalcanti-Proenca, Cecile Lecoeur, Christian Dina, Stephane Cauchi, et al.
(2009) Human Molecular Genetics, 18 p.2495-2501
Journal articleControl of ACAT2 Liver Expression by HNF4{alpha}. Lesson From MODY1 Patients.
C Pramfalk, E Karlsson, Leif Groop, L L Rudel, B Angelin, et al.
(2009) Arteriosclerosis, Thrombosis and Vascular Biology, 29 p.1235-1241
Journal articleThe impact of differential splicing of TCF7L2 on target gene expression in human islet of Langerhans
Yuedan Zhou, Stefan Lang, Jalal Taneera, Erik Renström, Leif Groop, et al.
(2009) Diabetologia, 52 p.78-78
Conference paper: abstractA variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion.
Anna Jonsson, Bo Isomaa, Tiinamaija Tuomi, Jalal Taneera, S Albert Salehi, et al.
(2009) Diabetes, 58 p.2409-2413
Journal articleRegulation and Function of FTO mRNA Expression in Human Skeletal Muscle and Subcutaneous Adipose Tissue
Louise G. Grunnet, Emma Nilsson, Charlotte Ling, Torben Hansen, Oluf Pedersen, et al.
(2009) Diabetes, 58 p.2402-2408
Journal articlePreviously Associated Type 2 Diabetes Variants May Interact With Physical Activity to Modify the Risk of Impaired Glucose Regulation and Type 2 Diabetes A Study of 16,003 Swedish Adults
Ema C. Brito, Valeriya Lyssenko, Frida Renstrom, Göran Berglund, Peter Nilsson, et al.
(2009) Diabetes, 58 p.1411-1418
Journal articleFasting Versus Postload Plasma Glucose Concentration and the Risk for Future Type 2 Diabetes Results from the Botnia Study
Muhammad A. Abdul-Ghani, Valeriya Lyssenko, Tiinamaija Tuomi, Ralph A. DeFronzo, Leif Groop
(2009) Diabetes Care, 32 p.281-286
Journal articleEffect of pioglitazone versus insulin glargine on cardiac size, function, and measures of fluid retention in patients with type 2 diabetes
Mozhgan Dorkhan, Magnus Dencker, Martin Stagmo, Leif Groop
(2009) Cardiovascular Diabetology, 8
Journal articleGenome-wide association study for type 2 diabetes: clinical applications.
Valeriya Lyssenko, Leif Groop
(2009) Current Opinion in Lipidology, 20 p.87-91
Journal articleCommon variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.
Valeriya Lyssenko, Cecilia Nagorny, Michael R Erdos, Nils Wierup, Anna Jonsson, et al.
(2009) Nature Genetics, 41 p.82-88
Journal articleTight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion.
Siri Malmgren, David Nicholls, Jalal Taneera, Karl Bacos, Thomas Koeck, et al.
(2009) Journal of Biological Chemistry, 284 p.32395-32404
Journal articleGenetic variation in ATP5O is associated with skeletal muscle ATP50 mRNA expression and glucose uptake in young twins.
Tina Rönn, Pernille Poulsen, Tiinamaija Tuomi, Bo Isomaa, Leif Groop, et al.
(2009) PLoS ONE, 4
Journal articleCalpain-10 expression is elevated in pancreatic islets from patients with type 2 diabetes.
Charlotte Ling, Leif Groop, Silvia Del Guerra, Roberto Lupi
(2009) PLoS ONE, 4
Journal articleGenetic basis of beta-cell dysfunction in man.
Leif Groop, Valeriya Lyssenko
(2009) Diabetes, Obesity and Metabolism, 11 Suppl 4 p.149-158
Journal articleA common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals.
Tina Rönn, J Wen, Z Yang, B Lu, Y Du, et al.
(2009) Diabetologia, Feb 25 p.830-833
Journal articleUnique splicing pattern of the TCF7L2 gene in human pancreatic islets.
Peter Osmark, Ola Hansson, Anna Jonsson, Tina Rönn, Leif Groop, et al.
(2009) Diabetologia, 52 p.850-854
Journal articleGenetics of type 2 diabetes. On overview.
Leif Groop, Valeriya Lyssenko
(2009) Endocrinologia y Nutricion, 56 Suppl 4 p.34-37
Journal articleMelatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene.
Hindrik Mulder, Cecilia Nagorny, Valeriya Lyssenko, Leif Groop
(2009) Diabetologia, 52 p.1240-1249
Journal articleAssessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults.
A Jonsson, F Renström, Valeriya Lyssenko, E Brito, B Isomaa, et al.
(2009) Diabetologia, 52 p.1334-1338
Journal articleEvaluation of the effects of exercise on insulin sensitivity in Arabian and Swedish women with type 2 diabetes.
Forouzan Glans, Karl-Fredrik Eriksson, Åsa Tornberg, Ola Thorsson, Per Wollmer, et al.
(2009) Diabetes Research and Clinical Practice, 85 p.69-74
Journal articleJoint analysis of individual participants' data from 17 studies on the association of the IL6 variant-174GC with circulating glucose levels, interleukin-6 levels, and body mass index
Cornelia Huth, Thomas Illig, Christian Herder, Christian Gieger, Harald Grallert, et al.
(2009) Annals of Medicine, 41 p.128-138
Journal articleInteraction between prenatal growth and high-risk genotypes in the development of type 2 diabetes
N. Pulizzi, Valeriya Lyssenko, Anna Jonsson, C. Osmond, M. Laakso, et al.
(2009) Diabetologia, 52 p.825-829
Journal articleNovel Genetic Loci Implicated in Fasting Glucose Homeostasis and Their Impact on Related Metabolic Traits
Josee Dupuis, Claudia Langenberg, Inga Prokopenko, Richa Saxena, Nicole Soranzo, et al.
(2009) Genetic Epidemiology, 33 p.124-124
Conference paper: abstractDisruption of TFB1M impairs insulin secretion in beta cells
Thomas Köck, Marloes Dekker Nitert, A Olsson, Olga Kotova, Jelena Stamenkovic, et al.
(2009) Diabetologia, 52 p.116-116
Conference paper: abstractPrediction of Non-Alcoholic Fatty Liver Disease and Liver Fat Using Metabolic and Genetic Factors
Anna Kotronen, Markku Peltonen, Antti Hakkarainen, Ksenia Sevastianova, Robert Bergholm, et al.
(2009) Gastroenterology, 137 p.865-872
Journal articleClinical Risk Factors, DNA Variants, and the Development of Type 2 Diabetes THE AUTHORS REPLY
Valeriya Lyssenko, Peter Nilsson, Leif Groop
(2009) New England Journal of Medicine, 360 p.1361-1361
Journal article (letter)Genetic dissection of type 2 diabetes.
Martin Ridderstråle, Leif Groop
(2009) Molecular and Cellular Endocrinology, 2008 p.10-17
Journal articleHyperactivity in adrenergic signalling via alpha2A receptors contributes to human type 2 diabetes
Anders Rosengren, Ramunas Jokubka, Damon Tojjar, Charlotte Granhall, Jonatan Tuncel, et al.
(2009) Diabetologia, 52 p.108-108
Conference paper: abstractTissue-specific alternative splicing of TCF7L2
Ludmila Prokunina-Olsson, Cullan Welch, Ola Hansson, Neeta Adhikari, Laura J. Scott, et al.
(2009) Human Molecular Genetics, 18 p.3795-3804
Journal articleA common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans
A. Kotronen, L. E. Johansson, L. M. Johansson, C. Roos, J. Westerbacka, et al.
(2009) Diabetologia, 52 p.1056-1060
Journal articleThe T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men
K. Pilgaard, C. B. Jensen, J. H. Schou, Valeriya Lyssenko, L. Wegner, et al.
(2009) Diabetologia, 52 p.1298-1307
Journal articleCommon variants at 30 loci contribute to polygenic dyslipidemia
Sekar Kathiresan, Cristen J. Willer, Gina M. Peloso, Serkalem Demissie, Kiran Musunuru, et al.
(2009) Nature Genetics, 41 p.56-65
Journal articleShort-Term Exercise Training Does Not Stimulate Skeletal Muscle ATP Synthesis in Relatives of Humans With Type 2 Diabetes
Gertrud Kacerovsky-Bielesz, Marek Chmelik, Charlotte Ling, Rochus Pokan, Julia Szendroedi, et al.
(2009) Diabetes, 58 p.1333-1341
Journal articlePrioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus
Hemang Parikh, Valeriya Lyssenko, Leif Groop
(2009) BMC Medical Genomics, 2
Journal articleMeta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Eleftheria Zeggini, Laura J. Scott, Richa Saxena, Benjamin F. Voight, Jonathan L. Marchini, et al.
(2008) Nature Genetics, 40 p.638-645
Journal articleIdentification of ten loci associated with height highlights new biological pathways in human growth
Guillaume Lettre, Anne U. Jackson, Christian Gieger, Fredrick R. Schumacher, Sonja I. Berndt, et al.
(2008) Nature Genetics, 40 p.584-591
Journal articleC/EBP{alpha} in adipose tissue regulates genes in lipid and glucose metabolism and a genetic variation in C/EBP{alpha} is associated with serum levels of triglycerides.
Louise E Olofsson, Marju Orho-Melander, Lena William-Olsson, Kajsa Sjöholm, Lars Sjöström, et al.
(2008) Journal of Clinical Endocrinology and Metabolism, 93 p.4880-4886
Journal articleSix new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
Sekar Kathiresan, Olle Melander, Candace Guiducci, Aarti Surti, Noel P Burtt, et al.
(2008) Nature Genetics, 40 p.189-197
Journal articleGenetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study)
J K Hertel, S Johansson, H Raeder, K Midthjell, Valeriya Lyssenko, et al.
(2008) Diabetologia, 51 p.971-977
Journal articleInteractions between genes and birth size for development of type 2 diabetes
Nicolo Pulizzi, Valeriya Lyssenko, Anna Jonsson, C. Osmond, E. Kajantie, et al.
(2008) Diabetologia, 51 p.28-28
Conference paper: abstractGenetic variation in ATP5O is associated with mRNA expression in human skeletal muscle and in vivo glucose uptake
Tina Rönn, P. Poulsen, Leif Groop, A. Vaag, Charlotte Ling
(2008) Diabetologia, 51 p.132-132
Conference paper: abstractMetabolic effects of novel type 2 diabetes genes in a population aged 18-75 years
Anna Jonsson, B. Isomaa, Tiinamaija Tuomi, Valeriya Lyssenko, Leif Groop
(2008) Diabetologia, 51 p.31-32
Conference paper: abstractCommon variants in the TCF7L2 gene help to differentiate autoimmune from non-autoimmune diabetes in young (15-34 years) but not in middle-aged (40-59 years) diabetic patients.
Ekaterine Bakhtadze, Camilla Cervin, Eero Lindholm, Henrik Borg, P Nilsson, et al.
(2008) Diabetologia, 51 p.2224-2232
Journal articlePGC-1 alpha and PGC-1 beta are related to markers for fibre type composition in human skeletal muscle
Anders H Olsson, Tina Rönn, A. Vaag, Leif Groop, P. Poulsen, et al.
(2008) Diabetologia, 51 p.130-130
Conference paper: abstractGenetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes
Camilla Cervin, Valeriya Lyssenko, Ekaterine Bakhtadze, Eero Lindholm, Peter Nilsson, et al.
(2008) Diabetes, 57 p.1433-1437
Journal articleIndependent introduction of two lactase-persistence alleles into human populations reflects different history of adaptation to milk culture
Nabil Sabri Enattah, Tine G. K. Jensen, Mette Nielsen, Rikke Lewinski, Mikko Kuokkanen, et al.
(2008) American Journal of Human Genetics, 82 p.57-72
Journal articleA non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population
Caroline Brorsson, Regine Bergholdt, Marketa Sjögren, Stefanie Eising, Karina Meden Sorensen, et al.
(2008) Molecular Genetics and Metabolism, 94 p.386-388
Journal articlePolymorphism associated with cholesterol and risk of cardiovascular events
Sekar Kathiresan, Olle Melander, Dragi Anevski, Candace Guiducci, Noël Burtt, et al.
(2008) New England Journal of Medicine, 358 p.1240-1249
Journal articleIs there a unifying genetic factor predisposing to the metabolic syndrome?
Marketa Sjögren, Marju Orho-Melander, Anna Jonsson, Margareta Svensson, Göran Berglund, et al.
(2008) Diabetologia, 51 p.32-33
Conference paper: abstractDiscerning the ancestry of European Americans in genetic association studies
Alkes L. Price, Johannah Butler, Nick Patterson, Cristian Capelli, Vincenzo L. Pascali, et al.
(2008) PLoS Genetics, 4
Journal articleThe Pro12Ala polymorphism of the PPAR-gamma2 gene affects associations of fish intake and marine n-3 fatty acids with glucose metabolism
SK Ylonen, I Salminen, Valeriya Lyssenko, SM Virtanen, Leif Groop, et al.
(2008) European Journal of Clinical Nutrition, 62 p.1432-1439
Journal articleCommon variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes
Johan Holmkvist, Peter Almgren, Valeriya Lyssenko, Cecilia M Lindgren, Karl-Fredrik Eriksson, et al.
(2008) Diabetes, 57 p.1738-1744
Journal articleLarge-scale association study between two coding LRP5 gene polymorphisms and bone phenotypes and fractures in men
E Grundberg, EM Lau, M Lorentzson, Magnus Karlsson, Anna H Holmberg, et al.
(2008) Osteoporosis International, 19 p.829-837
Journal articleAge influences DNA methylation and gene expression of COX7A1 in human skeletal muscle.
Tina Rönn, P Poulsen, Ola Hansson, Johan Holmkvist, Peter Almgren, et al.
(2008) Diabetologia, 51 p.1159-1168
Journal articleThe search for putative unifying genetic factors for components of the metabolic syndrome.
Marketa Sjögren, Valeriya Lyssenko, Anna Jonsson, Göran Berglund, Peter Nilsson, et al.
(2008) Diabetologia, 51 p.2242-2251
Journal articleAssessment of exercise capacity in women with type 2 diabetes.
Åsa Tornberg, Forouzan Glans, Karl-Fredrik Eriksson, Leif Groop, Ola Thorsson, et al.
(2008) Clinical Physiology and Functional Imaging, 28 p.294-298
Journal articleDifferences in effects of insulin glargine or pioglitazone added to oral anti-diabetic therapy in patients with type 2 diabetes What to add-Insulin glargine or pioglitazone?
Mozhgan Dorkhan, Anders Frid, Leif Groop
(2008) Diabetes Research and Clinical Practice, 82 p.340-345
Journal articleVariations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.
Wei-Min Chen, Michael R Erdos, Anne U Jackson, Richa Saxena, Serena Sanna, et al.
(2008) Journal of Clinical Investigation, Jun 2 p.2620-2628
Journal articleGenes and type 2 diabetes mellitus.
Leif Groop, Valeriya Lyssenko
(2008) Current Diabetes Reports, 8 p.192-197
Journal articleAssociation between LTA, TNF and AGER polymorphisms and late diabetic complications.
Eero Lindholm, Ekaterine Bakhtadze, Corrado Cilio, Elisabet Agardh, Leif Groop, et al.
(2008) PLoS ONE, 3
Journal articleCan complement factors 5 and 8 and transthyretin be used as biomarkers for MODY 1 (HNF4A-MODY) and MODY 3 (HNF1A-MODY)?
Ella Ekholm, Nael Shaat, Leif Groop
(2008) Diabetic medicine : a journal of the British Diabetic Association, May 29 p.788-791
Journal articleIndependent measures of insulin secretion and insulin sensitivity during the same test: the glucagon-insulin tolerance test.
Mozhgan Dorkhan, Devjit Tripathy, G Malm, H Asgharian, Tiinamaija Tuomi, et al.
(2008) Journal of Internal Medicine, 264 p.62-71
Journal articleImmigrants from the Middle-East have a different form of Type 2 diabetes compared with Swedish patients.
Forouzan Glans, Targ Elgzyri, Nael Shaat, Eero Lindholm, Jan Apelqvist, et al.
(2008) Diabetic medicine : a journal of the British Diabetic Association, 25 p.303-307
Journal articleExpression of the transcription factor 7-like 2 gene (TCF7L2) in human adipocytes is down regulated by insulin.
Maja Ahlzén, Lovisa E Johansson, Camilla Cervin, Hans Tornqvist, Leif Groop, et al.
(2008) Biochemical and Biophysical Research Communications, 370 p.49-52
Journal articleEpigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion.
Charlotte Ling, S Del Guerra, R Lupi, Tina Rönn, Charlotte Granhall, et al.
(2008) Diabetologia, 51 p.615-622
Journal articleNew insights into impaired muscle glycogen synthesis.
Leif Groop, Marju Orho-Melander
(2008) PLoS Medicine, 5 p.18-19
Journal article (letter)Strategies for Conditional Two-Locus Nonparametric Linkage Analysis.
Lars Ängquist, Ola Hössjer, Leif Groop
(2008) Human Heredity, 66 p.138-156
Journal articleClinical risk factors, DNA variants, and the development of type 2 diabetes.
Valeriya Lyssenko, Anna Jonsson, Peter Almgren, Nicolo Pulizzi, Bo Isomaa, et al.
(2008) New England Journal of Medicine, 359 p.2220-2232
Journal articleCommon variants near MC4R are associated with fat mass, weight and risk of obesity
Ruth J. F. Loos, Cecilia M. Lindgren, Shengxu Li, Eleanor Wheeler, Jing Hua Zhao, et al.
(2008) Nature Genetics, 40 p.768-775
Journal articleCommon variants in or around the JAZF1, CDKN2A/2B, CDKAL1 and WFS1 genes discriminate between autoimmune and non-autoimmune diabetes
Ekaterine Bakhtadze, Eero Lindholm, Valeriya Lyssenko, H. J. Arnkvist, J. Bolinder, et al.
(2008) Diabetologia, 51 p.117-117
Conference paper: abstractEffect of exercise on gene transcript profiles in skeletal muscle of individuals with and without a family history of diabetes
Ola Hansson, Targ Elgzyri, Hemang Parikh, Karl-Fredrik Eriksson, Leif Groop
(2008) Diabetologia, 51 p.270-270
Conference paper: abstractVariants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus
Kazuki Yasuda, Kazuaki Miyake, Yukio Horikawa, Kazuo Hara, Haruhiko Osawa, et al.
(2008) Nature Genetics, 40 p.1092-1097
Journal articleTyypin 2 diabeteksen genetiikka selviamassa. Taustalla monen heikkotehoisen alttiusgeenin yhteispeli
Leif Groop, Valeriya Lyssenko, Tiinamaija Tuomi
(2007) Duodecim, 123 p.1449-1449
Journal articleAssociating mitochondrial DNA variation with complex traits - Reply to Elson et al.
Richa Saxena, Paul I. W. de Bakker, Leif Groop, Mark J. Daly, David Altshuler
(2007) American Journal of Human Genetics, 80 p.382-383
Journal article (letter)The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts
Helen N. Lyon, Valur Emilsson, Anke Hinney, Iris M. Heid, Jessica Lasky-Su, et al.
(2007) PLoS Genetics, 3
Journal articleImpact of the peroxisome proliferator activated receptor-gamma coactivator-1 beta (PGC-1 beta) Ala203Pro polymorphism on in vivo metabolism, PGC-1 beta expression and fibre type composition in human skeletal muscle
Charlotte Ling, L. Wegner, G. Andersen, Peter Almgren, T. Hansen, et al.
(2007) Diabetologia, 50 p.1615-1620
Journal articleCOX-2 and SCD, markers of inflammation and adipogenesis, are related to disease activity in Graves' ophthalmopathy
Tereza Planck, Annika de Capretz, Hemang Parikh, Christofer Frenander, Peter Åsman, et al.
(2007) Thyroid, 17 p.511-517
Journal articleA variant in the transcription factor 7-like 2 (TCF7L2) gene is associated with an increased risk of gestational diabetes mellitus.
Nael Shaat, Åke Lernmark, Ella Ekholm, Sten Ivarsson, Hemang Parikh, et al.
(2007) Diabetologia, 50 p.972-979
Journal articleEvidence of still-ongoing convergence evolution of the lactase persistence T-13910 alleles in humans
Nabil Sabri Enattah, Aimee Trudeau, Ville Pimenoff, Luigi Maiuri, Salvatore Auricchio, et al.
(2007) American Journal of Human Genetics, 81 p.615-625
Journal articleVariation in GYS1 Interacts with Exercise and Gender to Predict Cardiovascular Mortality.
Jenny Fredriksson, Dragi Anevski, Peter Almgren, Marketa Sjögren, Valeriya Lyssenko, et al.
(2007) PLoS ONE, 2 p.285-285
Journal articleFrom fused toes in mice to human obesity
Leif Groop
(2007) Nature Genetics, 39 p.706-707
Journal article (comment)Interaction between the angiotensin-converting enzyme gene insertion/deletion polymorphism and obstructive sleep apnoea as a mechanism for hypertension.
Kristina Bengtsson Boström, Jan Hedner, Olle Melander, Ludger Grote, Bo Gullberg, et al.
(2007) Journal of Hypertension, 25 p.779-783
Journal articleGenetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle
Charlotte Ling, Pernille Poulsen, Stina Simonsson, Tina Rönn, Johan Holmkvist, et al.
(2007) Journal of Clinical Investigation, 117 p.3427-3435
Journal articleVariants in the FFAR1 Gene Are Associated with Beta Cell Function
Martins Kalis, Per Levéen, Valeriya Lyssenko, Peter Almgren, Leif Groop, et al.
(2007) PLoS ONE, 2
Journal articleAssociation studies of BMI and type 2 diabetes in the neuropeptide y pathway - A possible role for NPY2R as a candidate gene for type 2 diabetes in men
Catarina D. Campbell, Helen N. Lyon, James Nemesh, Jared A. Drake, Tiinamaija Tuomi, et al.
(2007) Diabetes, 56 p.1460-1467
Journal articleMechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.
Valeriya Lyssenko, Roberto Lupi, Piero Marchetti, Silvia Del Guerra, Marju Orho-Melander, et al.
(2007) Journal of Clinical Investigation, 117 p.2155-2163
Journal articleRelationships of plasma adiponectin level and adiponectin receptors 1 and 2 gene expression to insulin sensitivity and glucose and fat metabolism in monozygotic and dizygotic twins.
Heidi Storgaard, Pernille Poulsen, Charlotte Ling, Leif Groop, Allan A Vaag
(2007) Journal of Clinical Endocrinology and Metabolism, 92 p.2835-2839
Journal articleThe intake of potatoes and glucose metabolism in subjects at high risk for Type 2 diabetes
S. K. Ylonen, S. M. Virtanen, Leif Groop
(2007) Diabetic Medicine, 24 p.1049-1050
Journal article (letter)Tyypin 2 diabeteksen genetiikka selviämässä. Taustalla monen heikkotehoisen alttiusgeenin yhteispeli.
Leif Groop, Valeriya Lyssenko, Tiinamaija Tuomi
(2007) Duodecim, 123 p.55-1449
Journal articleYksi, kaksi vai monta diabetesta?
Markku Laakso, Leif Groop
(2007) Duodecim, 123 p.1427-1427
Journal articleGenetics of gestational diabetes mellitus.
Nael Shaat, Leif Groop
(2007) Current Medicinal Chemistry, 14 p.569-583
Journal article reviewThyrostimulin (a TSH-like Hormone) Expression in Orbital and Thyroid Tissue.
Mikael Lantz, Tereza Planck, Annika Capretz, Emma Nilsson, Christofer Frenander, et al.
(2007) Thyroid, 17 p.113-118
Journal articleRegulation of skeletal muscle PPAR delta mRNA expression in twins
Emma Nilsson, Pernille Poulsen, Marketa Sjögren, Charlotte Ling, Martin Ridderstråle, et al.
(2007) Journal of Physiology, 584 p.1011-1017
Journal articleGenome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
Richa Saxena, Benjamin F. Voight, Valeriya Lyssenko, Noel P. Burtt, Paul I. W. de Bakker, et al.
(2007) Science, 316 p.1331-1336
Journal articleA common variant of HMGA2 is associated with adult and childhood height in the general population
Michael N. Weedon, Guillaume Lettre, Rachel M. Freathy, Cecilia M. Lindgren, Benjamin F. Voight, et al.
(2007) Nature Genetics, 39 p.1245-1250
Journal articleMODY--en autosomalt dominant form av diabetes. Diagnos via gentestning ger bättre behandling
Ella Ekholm, Leif Groop
(2007) Läkartidningen, 104 p.2600-2602
Journal articleAssociation of microsatellite polymorphisms of the human 14q13.2 region with type 2 diabetes mellitus in latvian and finnish populations
T. Sjakste, M. Kalis, I. Poudziunas, V. Pirags, M. Lazdins, et al.
(2007) Annals of Human Genetics, 71 p.772-776
Journal articleTXNIP regulates peripheral glucose metabolism in humans
Hemang Parikh, Emma A Nilsson, William A. Chutkow, Lovisa Johansson, Heidi Storgaard, et al.
(2007) PLoS Medicine, 4 p.868-879
Journal articlePolymorphisms in the gene encoding the voltage-dependent Ca(2+) channel Ca (V)2.3 (CACNA1E) are associated with type 2 diabetes and impaired insulin secretion
Johan Holmkvist, Damon Tojjar, Peter Almgren, Valeriya Lyssenko, C M Lindgren, et al.
(2007) Diabetologia, 50 p.2467-2475
Journal articleAssociation testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetes
J. C. Florez, Marketa Sjögren, C. M. Agapakis, N. P. Burtt, Peter Almgren, et al.
(2007) Diabetologia, 50 p.1209-1217
Journal articleGlycemic and non-glycemic effects of pioglitazone in triple oral therapy in patients with type 2 diabetes mellitus
M Dorkhan, Martin Magnusson, A Frid, A Grubb, L Groop, et al.
(2006) Journal of Internal Medicine, 260 p.125-133
Journal articleHLA-DQB1 genotypes, islet antibodies and beta cell function in the classification of recent-onset diabetes among young adults in the nationwide Diabetes Incidence Study in Sweden.
Ekaterine Bakhtadze, Henrik Borg, G Stenstrom, Per Fernlund, H Arnqvist, et al.
(2006) Diabetologia, 49 p.1785-1794
Journal articleComplex Relationship Between Blood Pressure and Mortality in Type 2 Diabetic Patients. A Follow-Up of the Botnia Study.
Mats Ronnback, Bo Isomaa, Johan Fagerudd, Carol Forsblom, Per-Henrik Groop, et al.
(2006) Hypertension, 47 p.168-173
Journal articleAssociation of the calpain-10 gene with type 2 diabetes in Europeans: Results of pooled and meta-analyses
Takafumi Tsuchiya, Peter E. H. Schwarz, Laura del Bosque-Plata, M. Geoffrey Hayes, Christian Dina, et al.
(2006) Molecular Genetics and Metabolism, 89 p.174-184
Journal articleComprehensive association testing of common mitochondrial DNA variation in metabolic disease
R Saxena, PIW de Bakker, K Singer, V Mootha, N Burtt, et al.
(2006) American Journal of Human Genetics, 79 p.54-61
Journal articleThe -374 T/A polymorphism in the gene encoding RAGE is associated with diabetic nephropathy and retinopathy in type 1 diabetic patients.
Eero Lindholm, Ekaterine Bakhtadze, Marketa Sjögren, Corrado Cilio, Elisabet Agardh, et al.
(2006) Diabetologia, 49 p.2745-2755
Journal articleLatent autoimmune diabetes in adults (LADA)-more than a name.
Leif Groop, T Tuomi, M Rowley, P Zimmet, I Mackay
(2006) Diabetologia, 49 p.1996-1998
Journal article (comment)Treatment with a thiazolidinedione increases eye protrusion in a subgroup of patients with type 2 diabetes.
Mozhgan Dorkhan, Mikael Lantz, Anders Frid, Leif Groop, Bengt Hallengren
(2006) Clinical Endocrinology, 65 p.35-39
Journal articleCommon variants in MODY genes increase the risk of gestational diabetes mellitus.
Nael Shaat, Ella Ekholm, Åke Lernmark, Sten Ivarsson, Kristian Lynch, et al.
(2006) Diabetologia, 49 p.1545-1551
Journal articleLong-term beneficial effects of glipizide treatment on glucose tolerance in subjects with impaired glucose tolerance
JG Eriksson, M Lehtovirta, B Ehrnstrom, S Salmela, Leif Groop
(2006) Journal of Internal Medicine, 259 p.553-560
Journal articleHigh-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people
JC Florez, S Wiltshire, CM Agapakis, NP Burtt, PIW de Bakker, et al.
(2006) Diabetes, 55 p.128-135
Journal articlePolymorphism in the MHC2TA gene is associated with features of the metabolic syndrome and cardiovascular mortality.
Eero Lindholm, Olle Melander, Peter Almgren, Göran Berglund, Carl-David Agardh, et al.
(2006) PLoS ONE, 1
Journal articleVariation in the adiponutrin gene influences its expression and associates with obesity.
Lovisa Johansson, Johan Hoffstedt, Hemang Parikh, Emma A Nilsson, Martin Wabitsch, et al.
(2006) Diabetes, 55 p.826-833
Journal articleTransferability of tag SNPs in genetic association studies in multiple populations
Paul I. W. de Bakker, Noel P. Burtt, Robert R. Graham, Candace Guiducci, Roman Yelensky, et al.
(2006) Nature Genetics, 38 p.1298-1303
Journal articleAnalysis of the interleukin-1 and interleukin-6 polymorphisms in patients with chronic periodontitis. A pilot study
H Jansson, Valeriya Lyssenko, A Gustavsson, K Hamberg, B Soderfeldt, et al.
(2006) Swedish Dental Journal, 30 p.17-23
Journal articleThe Kruppel-like factor 11 (KLF11) Q62R polymorphism is not associated with type 2 diabetes in 8,676 people
Jose C. Florez, Richa Saxena, Wendy Winckler, Noel P. Burtt, Peter Almgren, et al.
(2006) Diabetes, 55 p.3620-3624
Journal articleA dietary exchange of common bread for tailored bread of low glycaemic index and rich in dietary fibre improved insulin economy in young women with impaired glucose tolerance.
Elin Östman, Anders Frid, Leif Groop, Inger Björck
(2006) European Journal of Clinical Nutrition, 60 p.334-341
Journal articleCommon variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity
Helen N. Lyon, Jose C. Florez, Todd Bersaglieri, Richa Saxena, Wendy Winckler, et al.
(2006) Diabetes, 55 p.3180-3184
Journal articleCommon single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals
Richa Saxena, Lauren Gianniny, Noel P. Burtt, Valeriya Lyssenko, Candace Giuducci, et al.
(2006) Diabetes, 55 p.2890-2895
Journal articleGenetic and nongenetic determinants of skeletal muscle glucose transporter 4 messenger ribonucleic acid levels and insulin action in twins
H Storgaard, P Poulsen, Charlotte Ling, Leif Groop, A A Vaag
(2006) Journal of Clinical Endocrinology and Metabolism, 91 p.702-708
Journal articleType 2 diabetes and risk for periodontal disease: a role for dental health awareness
H Jansson, Eero Lindholm, C Lindh, Leif Groop, G Bratthall
(2006) Journal of Clinical Periodontology, 33 p.408-414
Journal articleImproved prandial glucose control with lower risk of hypoglycemia with nateglinide than with glibenclamide in patients with maturity-onset diabetes of the young type 3
T Tuomi, L Sarelin, EH Honkanen, Leif Groop, B Isomaa
(2006) Diabetes Care, 29 p.189-194
Journal articleIL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies
Cornelia Huth, Iris M. Heid, Caren Vollmert, Christian Gieger, Harald Grallert, et al.
(2006) Diabetes, 55 p.2915-2921
Journal articleCommon variants in HNF-1 alpha and risk of type 2 diabetes.
Johan Holmkvist, C Cervin, Valeriya Lyssenko, W Winckler, Dragi Anevski, et al.
(2006) Diabetologia, 49 p.2882-2891
Journal articleAuthors' reply.
Valeriya Lyssenko, Dragi Anevski, Peter Almgren, Leif Groop
(2006) PLoS Medicine, 3 p.271-272
Journal article (letter)A polymorphism in the adiponectin gene influences adiponectin expression levels in visceral fat in obese subjects
Jenny Fredriksson, Emma A Nilsson, Marju Orho-Melander, Leif Groop, Martin Ridderstråle
(2006) International Journal of Obesity, 30 p.226-232
Journal articleThe hormone-sensitive lipase C-60G promoter polymorphism is associated with increased waist circumference in normal-weight subjects.
Emma A Nilsson, L Johansson, Kristoffer Ström, J Hoffstedt, Leif Groop, et al.
(2006) International Journal of Obesity, 30 p.1442-1448
Journal articleGenetic prediction of future type 2 diabetes
Valeriya Lyssenko, Peter Almgren, Dragi Anevski, Marju Orho-Melander, Marketa Sjögren, et al.
(2005) PLoS Medicine, 2 p.1299-1308
Journal articleGenetic testing for maturity onset diabetes of the young: uptake, attitudes and comparison with hereditary non-polyposis colorectal cancer
B Liljestrom, K Aktan-Collan, B Isomaa, L Sarelin, A Uutela, et al.
(2005) Diabetologia, 48 p.242-250
Journal articleHaplotype construction of the FRDA gene and evaluation of its role in type II diabetes.
Johan Holmkvist, Peter Almgren, Hemang Parikh, Marco Zucchelli, Juha Kere, et al.
(2005) European Journal of Human Genetics, 13 p.849-855
Journal articleDipping and variability of blood pressure and heart rate at night are heritable traits.
Cristiano Fava, Philippe Burri, Peter Almgren, Guido Arcaro, Leif Groop, et al.
(2005) American Journal of Hypertension, 18 p.1402-1407
Conference paperHeritability of model-derived parameters of beta cell secretion during intravenous and oral glucose tolerance tests: a study of twins
M Lehtovirta, J Kaprio, Leif Groop, M Trombetta, RC Bonadonna
(2005) Diabetologia, 48 p.1604-1613
Journal articleDemonstrating stratification in a European American population
C D Campbell, E L Ogburn, K L Lunetta, H N Lyon, M L Freedman, et al.
(2005) Nature Genetics, 37 p.868-872
Journal articleOverexpression of immediate early genes in active Graves' ophthalmopathy.
Mikael Lantz, Tereza Planck, Hemang Parikh, Christofer Frenander, Martin Ridderstråle, et al.
(2005) Journal of Clinical Endocrinology and Metabolism, 90 p.4784-4791
Journal articleInsulin sensitivity in adults with growth hormone deficiency and effect of growth hormone treatment.
Leif Groop, Mikael Segerlantz, Margareta Bramnert
(2005) Hormone Research, 64 p.45-50
Journal articleCalpain 10 and type 2 diabetes: are we getting closer to an explanation?
Martin Ridderstråle, Hemang Parikh, Leif Groop
(2005) Current Opinion in Clinical Nutrition and Metabolic Care, 8 p.361-366
Journal articleAssociation of common variation in the HNF1 alpha gene region with risk of type 2 diabetes
W Winckler, N P Burtt, Johan Holmkvist, Camilla Cervin, P I W de Bakker, et al.
(2005) Diabetes, 54 p.2336-2342
Journal articleGenetic and Nongenetic Regulation of CAPN10 mRNA Expression in Skeletal Muscle.
Emma A Nilsson, Pernille Poulsen, Heidi Storgaard, Peter Almgren, Charlotte Ling, et al.
(2005) Diabetes, 54 p.3015-3020
Journal articleAssociation testing of variants in the hepatocyte nuclear factor 4 alpha gene with risk of type 2 diabetes in 7,883 people
W Winckler, R R Graham, P I W de Bakker, M Sun, Peter Almgren, et al.
(2005) Diabetes, 54 p.886-892
Journal articleNt-proANP in plasma, a marker of salt sensitivity, is reduced in type 2 diabetes patients.
Olle Melander, E Frandsen, Martin Magnusson, Anders Grubb, Stefan Jovinge, et al.
(2005) Journal of Internal Medicine, 257 p.281-288
Journal articlePredictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes.
Valeriya Lyssenko, Peter Almgren, Dragi Anevski, Roland Perfekt, Kaj Lahti, et al.
(2005) Diabetes, 54 p.166-174
Journal articleGenetic and non-genetic determinants of skeletal muscle GLUT4 mRNA levels and insulin action in twins.
Heidi Storgaard, Pernille Poulsen, Charlotte Ling, Leif Groop, Allan A Vaag
(2005) Journal of Clinical Endocrinology and Metabolism, 91 p.8-702
Journal articleAssociation testing of the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes in 7,883 people
J C Florez, C M Agapakis, N P Burtt, M Sun, Peter Almgren, et al.
(2005) Diabetes, 54 p.1884-1891
Journal articleA male-specific quantitative trait locus on 1p21 controlling human stature
S Sammalisto, T Hiekkalinna, E Suviolahti, K Sood, A Metzidis, et al.
(2005) Journal of Medical Genetics, 42 p.932-939
Journal articleRelationship between testosterone levels, insulin sensitivity, and mitochondrial function in men
N Pitteloud, VK Mootha, AA Dwyer, M Hardin, H Lee, et al.
(2005) Diabetes Care, 28 p.1636-1642
Journal articleRole of the FOXC2 -512C>T polymorphism in type 2 diabetes: possible association with the dysmetabolic syndrome.
Emma A Nilsson, Leif Groop, Martin Ridderstråle
(2005) International Journal of Obesity, 29 p.268-274
Journal articleAssociation of the E23K polymorphism in the KCNJ11 gene with gestational diabetes mellitus.
Nael Shaat, M Ekelund, Åke Lernmark, Sten Ivarsson, Peter Almgren, et al.
(2005) Diabetologia, 48 p.2544-2551
Journal articleParallel manifestation of insulin resistance and beta cell decompensation is compatible with a common defect in Type 2 diabetes.
Devjit Tripathy, Karl-Fredrik Eriksson, Marju Orho-Melander, Jenny Fredriksson, G. Ahlqvist, et al.
(2004) Diabetologia, 47 p.782-793
Journal articlePutative role of polymorphisms in UCP1-3 genes for diabetic nephropathy.
Eero Lindholm, Mia Klannemark, Elisabet Agardh, Leif Groop, Carl-David Agardh
(2004) Journal of Diabetes and its Complications, 18 p.103-107
Journal articleVariation in the calpain-10 gene is associated with elevated triglyceride levels and reduced adipose tissue messenger ribonucleic acid expression in obese Swedish subjects.
Emma A Nilsson, Jenny Fredriksson, Leif Groop, Martin Ridderstråle
(2004) Journal of Clinical Endocrinology and Metabolism, 89 p.3601-3605
Journal articleAssociation testing in 9,000 people fails to confirm the association of the insulin receptor substrate-1 G972R polymorphism with type 2 diabetes
JC Florez, Marketa Sjögren, N Burtt, Marju Orho-Melander, S Schayer, et al.
(2004) Diabetes, 53 p.3313-3318
Journal articleThe FOXC2 C-512T Polymorphism Is Associated with Obesity and Dyslipidemia.
Emma A Nilsson, Peter Almgren, Johan Hoffstedt, Leif Groop, Martin Ridderstråle
(2004) Obesity Research, 12 p.1738-1743
Journal articleCosegregation of MIDD and MODY in a Pedigree: Functional and Clinical Consequences.
Camilla Cervin, Brita Liljeström, Tiinamaija Tuomi, Seija Heikkinen, Juha S Tapanainen, et al.
(2004) Diabetes, 53 p.1894-1899
Journal articleHaplotype Structure and Genotype-Phenotype Correlations of the Sulfonylurea Receptor and the Islet ATP-Sensitive Potassium Channel Gene Region.
Jose C. Florez, Noël Burtt, Paul I.W. De Bakker, Peter Almgren, Tiinamaija Tuomi, et al.
(2004) Diabetes, 53 p.1360-1368
Journal articleContribution of insulin-stimulated glucose uptake and basal hepatic insulin sensitivity to surrogate measures of insulin sensitivity.
Devjit Tripathy, Peter Almgren, Tiinamaija Tuomi, Leif Groop
(2004) Diabetes Care, 27 p.2204-2210
Journal articleElevated Plasma Levels of Nt-proBNP in Patients With Type 2 Diabetes Without Overt Cardiovascular Disease.
Martin Magnusson, Olle Melander, Bo Israelsson, Anders Grubb, Leif Groop, et al.
(2004) Diabetes Care, 27 p.1929-1935
Journal articleStatistical concerns about the GSEA procedure - Reply
VK Mootha, MJ Daly, N Patterson, JN Hirschhorn, Leif Groop, et al.
(2004) Nature Genetics, 36 p.663-663
Journal article (letter)Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins.
Charlotte Ling, Emma A Nilsson, Martin Ridderstråle, Peter Almgren, Leif Groop, et al.
(2004) Journal of Clinical Investigation, 114 p.1518-1526
Journal articleHeritability of ambulatory and office blood pressure phenotypes in Swedish families.
Cristiano Fava, Philippe Burri, Peter Almgren, Leif Groop, Lennart Hulthén, et al.
(2004) Journal of Hypertension, 22 p.1717-1721
Journal articleAssociation between a polymorphism in the carboxyl ester lipase gene and serum cholesterol profile
SH Bengtsson-Ellmark, J Nilsson, Marju Orho-Melander, K Dahlenborg, Leif Groop, et al.
(2004) European Journal of Human Genetics, 12 p.627-632
Journal articleGenotypic and phenotypic differences between Arabian and Scandinavian women with gestational diabetes mellitus.
Nael Shaat, M. Ekelund, Åke Lernmark, Sten Ivarsson, A. Nilsson, et al.
(2004) Diabetologia, 47 p.878-884
Journal articleCharacterization of the human skeletal muscle glycogen synthase gene (GYS1) promoter.
Jenny Fredriksson, Martin Ridderstråle, Leif Groop, Marju Orho-Melander
(2004) European Journal of Clinical Investigation, 34 p.113-121
Journal articleEffects of morning cortisol replacement on glucose and lipid metabolism in GH-treated subjects.
Mikael Segerlantz, Margareta Bramnert, Ronnie Thomasson, Per Manhem, Esa Laurila, et al.
(2004) European Journal of Endocrinology, 151 p.701-707
Journal articleCandidate genes for type 2 diabetes.
Hemang Parikh, Leif Groop
(2004) Reviews in Endocrine and Metabolic Disorders, 5 p.151-176
Journal article reviewA meta-analysis of four European genome screens (GIFT Consortium) shows evidence for a novel region on chromosome 17p11.2-q22 linked to type 2 diabetes.
Florence Demenais, Timo Kanninen, Cecilia Lindgren, Steven Wiltshire, Stéphane Gaget, et al.
(2003) Human Molecular Genetics, 12 p.1865-1873
Journal articleInhibition of lipolysis during acute GH exposure increases insulin sensitivity in previously untreated GH-deficient adults.
Mikael Segerlantz, Margareta Bramnert, Per Manhem, Esa Laurila, Leif Groop, et al.
(2003) European Journal of Endocrinology, 149 p.511-519
Journal articleGrowth hormone replacement therapy induces insulin resistance by activating the glucose-Fatty Acid cycle.
Margareta Bramnert, Mikael Segerlantz, Esa Laurila, Jens R Daugaard, Per Manhem, et al.
(2003) Journal of Clinical Endocrinology and Metabolism, 88 p.1455-1463
Journal articleIntrauterine hyperglycemia modifying the development of (monogenic) diabetes?
Tiinamaija Tuomi, Leif Groop
(2003) Diabetes Care, 26 p.1295-1296
Journal article (letter)Peroxisome proliferator-activated receptor-gammaPro12Ala polymorphism and the association with blood pressure in type 2 diabetes: Skaraborg Hypertension and Diabetes Project.
Carl Johan Östgren, Ulf Lindblad, Olle Melander, Arne Melander, Leif Groop, et al.
(2003) Journal of Hypertension, 21 p.1657-1662
Journal articleAssociations of dietary fiber with glucose metabolism in nondiabetic relatives of subjects with type 2 diabetes - The Botnia Dietary Study
K Ylonen, C Saloranta, C Kronberg-Kippila, Leif Groop, A Aro, et al.
(2003) Diabetes Care, 26 p.1979-1985
Journal articleBringing diabetes therapeutics to the big screen.
Leif Groop
(2003) Nature Biotechnology, 21 p.240-241
Journal article (letter)Dietary intakes and plasma concentrations of carotenoid's and tocopherols in relation to glucose metabolism in subjects at high risk of type 2 diabetes: the Botnia Dietary Study
K Ylonen, G Alfthan, Leif Groop, C Saloranta, A Aro, et al.
(2003) American Journal of Clinical Nutrition, 77 p.1434-1441
Journal articleThe SLC6A14 gene shows evidence of association with obesity
E Suviolahti, LJ Oksanen, M Ohman, RM Cantor, Martin Ridderstråle, et al.
(2003) Journal of Clinical Investigation, 112 p.1762-1772
Journal articleFamiliality of metabolic abnormalities is dependent upon age at onset and phenotype of the type 2 diabetic proband.
Devjit Tripathy, Eero Lindholm, B Isomaa, C Saloranta, T Tuomi, et al.
(2003) American Journal of Physiology: Endocrinology and Metabolism, 285 p.1297-1303
Journal articleDevelopment of New Peripheral Arterial Occlusive Disease in Patients With Type 2 Diabetes During a Mean Follow-Up of 11 Years.
Milla Kallio, Carol Forsblom, Per-Henrik Groop, Leif Groop, Mauri Lepäntalo
(2003) Diabetes Care, 26 p.1241-1245
Journal articleThe insertion/deletion variation in the alpha2B-adrenoceptor does not seem to modify the risk for acute myocardial infarction, but may modify the risk for hypertension in sib-pairs from families with type 2 diabetes
Amir Snapir, Mika Scheinin, Leif Groop, Marju Orho-Melander
(2003) Cardiovascular Diabetology, 2
Journal articlePGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.
VK Mootha, Cecilia Lindgren, Karl-Fredrik Eriksson, A Subramanian, S Sihag, et al.
(2003) Nature Genetics, 34 p.267-273
Journal articleThree weeks dietary intervention with low-glycaemic index bread improved insulin economy in women with high risk of type II diabetes
Helena Elmståhl, Anders Frid, Leif Groop, Inger Björck
(2003) Annals of Nutrition & Metabolism., 47 p.396-396
Conference paperA Combination of Human Leukocyte Antigen DQB1*02 and the Tumor Necrosis Factor alpha Promoter G308A Polymorphism Predisposes to an Insulin-Deficient Phenotype in Patients with Type 2 Diabetes.
Haiyan Li, Leif Groop, Anita Ramelius, Jianping Weng, Tiinamaija Tuomi
(2003) Journal of Clinical Endocrinology and Metabolism, 88 p.2767-2774
Journal articleImpaired cathepsin L gene expression in skeletal muscle is associated with type 2 diabetes.
Xudong Huang, Allan Vaag, Emma A Nilsson, Mona Hansson, Bo Ahrén, et al.
(2003) Diabetes, 52 p.2411-2418
Journal articleImportance of obtaining independent measures of insulin secretion and insulin sensitivity during the same test - Results with the Botnia clamp
Devjit Tripathy, Y Wessman, M Gullstrom, T Tuomi, Leif Groop
(2003) Diabetes Care, 26 p.1395-1401
Journal articleFat feeding impairs glycogen synthase activity in mice without effects on its gene expression.
Xudong Huang, Mona Hansson, Esa Laurila, Bo Ahrén, Leif Groop
(2003) Metabolism, Clinical and Experimental, 52 p.535-539
Journal articleA Genome-Wide Scan in Families With Maturity-Onset Diabetes of the Young: Evidence for Further Genetic Heterogeneity.
Timothy M. Frayling, Cecilia Lindgren, Jean Claude Chevre, Stephan Menzel, Marie Wishart, et al.
(2003) Diabetes, 52 p.872-881
Journal articlePolymorphisms of the HDL receptor gene associated with HDL cholesterol levels in diabetic kindred from three populations
JJ McCarthy, S Lewitzky, C Reeves, A Permutt, B Glaser, et al.
(2003) Human Heredity, 55 p.163-170
Journal articleNo evidence of a relation between 11beta-hydroxysteroid dehydrogenasetype 2 activity and salt sensitivity.
Olle Melander, Erik Frandsen, Leif Groop, Lennart Hulthén
(2003) American Journal of Hypertension, 16 p.729-733
Journal articleInfluence of glucose and insulin on transcapillary fluid absorption from the arm during lower body negative pressure in man
H Olsen, Leif Groop, T Lanne
(2003) European Journal of Applied Physiology, 90 p.138-143
Journal articleA genome wide scan for early onset primary hypertension in Scandinavians.
Fredrik von Wowern, Kristina Bengtsson Boström, Cecilia Lindgren, Marju Orho-Melander, Frej Fyhrquist, et al.
(2003) Human Molecular Genetics, 12 p.2077-2081
Journal articlePolymorphism in the Calpain 10 gene influences glucose metabolism in human fat cells
J Hoffstedt, M Ryden, P Lofgren, Marju Orho-Melander, Leif Groop, et al.
(2002) Diabetologia, 45 p.276-282
Journal articleThe genetic abnormality in the beta cell determines the response to an oral glucose load
A Stride, M Vaxillaire, T Tuomi, F Barbetti, PR Njolstad, et al.
(2002) Diabetologia, 45 p.427-435
Journal articleAutoimmunity to CD38 and GAD in Type I and Type II diabetes: CD38 and HLA genotypes and clinical phenotypes
A Antonelli, Tiinamaija Tuomi, M Nannipieri, P Fallahi, C Nesti, et al.
(2002) Diabetologia, 45 p.1298-1306
Journal articleThe prevalence of polymorphisms in the interleukin-1 gene in a group of patients with recurrent periodontal disease.
H Jansson, A Gustafsson, K Hamberg, H Gu, G Soderholm, et al.
(2002) Journal of Dental Research, 81 p.291-291
Conference paper: abstractNateglinide Improves Early Insulin Secretion and Controls Postprandial Glucose Excursions in a Prediabetic Population.
Carola Saloranta, Christiane Guitard, Eckhard Pecher, Pedro De Pablos-Velasco, Kaj Lahti, et al.
(2002) Diabetes Care, 25 p.2141-2146
Journal articleScreening for MODY mutations, GAD antibodies, and type 1 diabetes--associated HLA genotypes in women with gestational diabetes mellitus.
Jianping Weng, Magnus Ekelund, Markku Lehto, Haiyan Li, Göran Ekberg, et al.
(2002) Diabetes Care, 25 p.68-71
Journal articleFallbeskrivning. Rosiglitazonbehandling gav kraftfull effekt, men fick ändå avbrytas
Martin Ridderstråle, Leif Groop
(2002) Läkartidningen, 99 p.407-410
Journal articleVariants in the calpain-10 gene predispose to insulin resistance and elevated free fatty acid levels.
Marju Orho-Melander, Mia Klannemark, Malin Svensson, Martin Ridderstråle, Cecilia Lindgren, et al.
(2002) Diabetes, 51 p.2658-2664
Journal articleDown-regulation of insulin receptor substrates (IRS)-1 and IRS-2 and Src homologous and collagen-like protein Shc gene expression by insulin in skeletal muscle is not associated with insulin resistance or type 2 diabetes.
Xudong Huang, Allan Vaag, Mona Hansson, Leif Groop
(2002) Journal of Clinical Endocrinology and Metabolism, 87 p.255-259
Journal articleDecreased expression of heat shock protein 72 in skeletal muscle of patients with type 2 diabetes correlates with insulin resistance
I Kurucz, A Morva, A Vaag, Karl-Fredrik Eriksson, Xudong Huang, et al.
(2002) Diabetes, 51 p.1102-1109
Journal articleGlutamic acid decarboxylase antibody positivity is associated with an impaired insulin response to glucose and arginine in nondiabetic patients with autoimmune thyroiditis
ÅsaLinda Lethagen, UB Ericsson, Bengt Hallengren, Leif Groop, Tiinamaija Tuomi
(2002) Journal of Clinical Endocrinology and Metabolism, 87 p.1177-1183
Journal articleFOXC2 mRNA Expression and a 5' Untranslated Region Polymorphism of the Gene Are Associated With Insulin Resistance.
Martin Ridderstråle, Emma A Nilsson, Mia Klannemark, Anna Cederberg, Christina Kösters, et al.
(2002) Diabetes, 51 p.3554-3560
Journal articleContribution of known and unknown susceptibility genes to early-onset diabetes in scandinavia: evidence for heterogeneity.
Cecilia Lindgren, Elisabeth Widén, Tiinamaija Tuomi, Haiyan Li, Peter Almgren, et al.
(2002) Diabetes, 51 p.1609-1617
Journal article5 ' flanking variants of resistin are associated with obesity
JC Engert, MC Vohl, SM Williams, P Lepage, JC Loredo-Osti, et al.
(2002) Diabetes, 51 p.1629-1634
Journal articleGenomewide search for type 2 diabetes mellitus susceptibility loci in Finnish families: the Botnia study.
C M Lindgren, M M Mahtani, E Widén, M I McCarthy, M J Daly, et al.
(2002) American Journal of Human Genetics, 70 p.509-516
Journal articleThe hormone-sensitive lipase C-60G gene polymorphism is associated with abdominal obesity
Mia Klannemark, V Large, T Osterlund, K Strom, D Langin, et al.
(2002) Diabetologia, 45 p.124-124
Conference paper: abstractCharacterization of a naturally occurring mutation (L107I) in the HNF1 alpha (MODY3) gene.
Camilla Cervin, Marju Orho-Melander, Martin Ridderstråle, M Lehto, Sebastian Barg, et al.
(2002) Diabetologia, 45 p.1703-1708
Journal articlePlasma ProANP(1-30) reflects salt sensitivity in subjects with heredity for hypertension
Olle Melander, E Frandsen, Leif Groop, Lennart Hulthén
(2002) Hypertension, 39 p.996-999
Journal articleOnset of glucose intolerance in MODY3 Pro291fsInsC mutation carrierscoincides with pubertal years - a prospective follow-up study
EH Honkanen, B Isomaa, L Sarelin, M Lehto, Leif Groop, et al.
(2002) Diabetologia, 45 p.129-129
Conference paper: abstractCommon variants in the beta2-(Gln27Glu) and beta3-(Trp64Arg)--adrenoceptor genes are associated with elevated serum NEFA concentrations and type II diabetes
M Carlsson, Marju Orho-Melander, J Hedenbro, Leif Groop
(2001) Diabetologia, 44 p.629-636
Journal articleThe ACE gene I/D polymorphism is associated with higher mortality in men with hypertension and type 2 diabetes
K Bengtsson, Ulf Lindblad, Marju Orho-Melander, Olle Melander, Jonas Ranstam, et al.
(2001) Diabetologia, 44 p.35-35
Journal articleSR-B1 variants associated with HDL cholesterol levels in three populations
J J McCarthy, S Lewitzky, A Permutt, B Glaser, Leif Groop, et al.
(2001) American Journal of Human Genetics, 69 p.383-383
Journal articleThe metabolic syndrome influences the risk of chronic complications in patients with type II diabetes
B Isomaa, M Henricsson, Peter Almgren, T Tuomi, M R Taskinen, et al.
(2001) Diabetologia, 44 p.1148-1154
Journal articleBeta(2)-adrenergic receptor gene variation and hypertension in subjects with type 2 diabetes
Kristina Bengtsson, Marju Orho-Melander, Olle Melander, Ulf Lindblad, Jonas Ranstam, et al.
(2001) Hypertension, 37 p.1303-1308
Journal articleFunctional consequences of mutations in the MODY4 gene (IPF1) and coexistence with MODY3 mutations
J. Weng, W.M. Macfarlane, M. Lehto, H.F. Gu, L.M. Shepherd, et al.
(2001) Diabetologia, 44 p.249-258
Journal articleCharacterization of the annexin I gene and evaluation of its role in type 2 diabetes
Cecilia M. Lindgren, Anita Ramelius, Marju Orho-Melander, Peter Almgren, Leif Groop
(2001) Diabetes, 50 p.2402-2405
Journal articleMetabolic impact of a family history of Type 2 diabetes. Results from a European multicentre study (EGIR)
A Vaag, M Lehtovirta, P Thye-Ronn, Leif Groop
(2001) Diabetic Medicine, 18 p.533-540
Journal articleLinkage disequilibrium at PPARG and other genes assessed with dense sets of SNPs.
J.N. Hirschhorn, D. Altshuler, M.J. Daly, C.M. Lindgren, N.P. Burtt, et al.
(2001) American Journal of Human Genetics, 69 p.522-522
Journal articlePossible human leukocyte antigen-mediated genetic interaction between type 1 and type 2 Diabetes
Haiyan Li, Eero Lindholm, Peter Almgren, A Gustafsson, C Forsblom, et al.
(2001) Journal of Clinical Endocrinology and Metabolism, 86 p.574-582
Journal articleMetabolic effects of metformin in patients with impaired glucose tolerance
M Lehtovirta, B Forsen, M Gullstrom, M Haggblom, J G Eriksson, et al.
(2001) Diabetic Medicine, 18 p.578-583
Journal articleRelationship between abdominal fat compartments and glucose and lipid metabolism in early postmenopausal women
M Rendell, U L Hulthen, C Törnquist, Leif Groop, Ingrid Mattiasson
(2001) Journal of Clinical Endocrinology and Metabolism, 86 p.744-749
Journal articleA gene conferring susceptibility to type 2 diabetes in conjunction with obesity is located on chromosome 18p11
Alex Parker, Joanne Meyer, Steve Lewitzky, Jean S. Rennich, Gayun Chan, et al.
(2001) Diabetes, 50 p.675-680
Journal articleHypothalamic-pituitary-adrenal response to different tests in type 1 diabetes mellitus
E G Almqvist, Leif Groop, P J Manhem
(2001) Scandinavian Journal of Clinical & Laboratory Investigation, 61 p.557-565
Journal articleThe dysmetabolic syndrome
Leif Groop, Marju Orho-Melander
(2001) Journal of Internal Medicine, 250 p.105-120
Journal articleInhibition of the rise in FFA by Acipimox partially prevents GH-induced insulin resistance in GH-deficient adults
Mikael Segerlantz, Margareta Bramnert, Per Manhem, Esa Laurila, Leif Groop
(2001) Journal of Clinical Endocrinology and Metabolism, 86 p.5813-5818
Journal articleCardiovascular morbidity and mortality associated with the metabolic syndrome
B. Isomaa, Peter Almgren, T. Tuomi, B. Forsen, K. Lahti, et al.
(2001) Diabetes Care, 24 p.683-689
Journal articlePolymorphism in the beta(1)-adrenergic receptor gene and hypertension
Kristina Bengtsson, Olle Melander, Marju Orho-Melander, Ulf Lindblad, Jonas Ranstam, et al.
(2001) Circulation, 104 p.187-190
Journal articleAn automated fluorescent single strand conformation polymorphism technique for high throughput mutation screening
Jianping Weng, Markku Lehto, Anna Berglund, Leif Groop
(2001) Chinese Medical Journal, 114 p.1147-1150
Journal articleAssessment of beta-cell function during the oral glucose tolerance test by a minimal model of insulin secretion
A. Cretti, M. Lehtovirta, E. Bonora, B. Brunato, M.G. Zenti, et al.
(2001) European Journal of Clinical Investigation, 31 p.405-416
Journal articleDifferential phosphorylation of Janus kinase 2, Stat5A and Stat5B in response to growth hormone in primary rat adipocytes
Martin Ridderstråle, Leif Groop
(2001) Molecular and Cellular Endocrinology, 183 p.49-54
Journal articleGenomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height
J.N. Hirschhorn, Cecilia Lindgren, M.J. Daly, A. Kirby, S.F. Schaffner, et al.
(2001) American Journal of Human Genetics, 69 p.106-116
Journal articleGenetic variants of thiazide-sensitive NaCl-cotransporter in Gitelman's syndrome and primary hypertension
Olle Melander, Marju Orho-Melander, Kristina Bengtsson Boström, Ulf Lindblad, Lennart Råstam, et al.
(2000) Hypertension, 36 p.389-394
Journal articleInteraction between the Asn291Ser variant of the LPL gene and insulin resistance on dyslipidaemia in high risk individuals for Type 2 diabetes mellitus
Mia Klannemark, L Suurinkeroinen, Marju Orho-Melander, Leif Groop, M R Taskinen
(2000) Diabetic Medicine, 17 p.599-605
Journal articleAngiotensin converting enzyme (ACE) gene polymorphism in sarcoidosis in relation to associated autoimmune diseases
K I Papadopoulos, Olle Melander, Marju Orho-Melander, Leif Groop, M Carlsson, et al.
(2000) Journal of Internal Medicine, 247 p.71-77
Journal articlePathogenesis of type 2 diabetes: the relative contribution of insulin resistance and impaired insulin secretion
Leif Groop
(2000) International journal of clinical practice. Supplement , p.3-13
Journal articleGenetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
Y Horikawa, N Oda, N J Cox, X Li, Marju Orho-Melander, et al.
(2000) Nature Genetics, 26 p.163-175
Journal articleThe T 54 allele of the intestinal fatty acid-binding protein 2 is associated with a parental history of stroke
Martin Carlsson, Marju Orho-Melander, Jan Hedenbro, Peter Almgren, Leif Groop
(2000) Journal of Clinical Endocrinology and Metabolism, 85 p.2801-2804
Journal articleAssociation between a variant in the 11 beta-hydroxysteroid dehydrogenase type 2 gene and primary hypertension
Olle Melander, Marju Orho-Melander, K Bengtsson, U Lindblad, Lennart Råstam, et al.
(2000) Journal of Human Hypertension, 14 p.819-823
Journal articleRole of the Gly460Trp polymorphism of the alpha-adducin gene in primary hypertension in Scandinavians
Olle Melander, K Bengtsson, Marju Orho-Melander, U Lindblad, C Forsblom, et al.
(2000) Journal of Human Hypertension, 14 p.43-46
Journal articleThe role of sulphonylurea in combination therapy assessed in a trial of sulphonylurea withdrawal. Scandinavian Insulin-Sulphonylurea Study Group Research Team
L Landstedt-Hallin, P Arner, P E Lins, J Bolinder, H Olsen, et al.
(1999) Diabetic Medicine: A journal of the British Diabetic Association, 16 p.34-827
Journal articlePolymorphism in the angiotensin converting enzyme but not in the angiotensinogen gene is associated with hypertension and type 2 diabetes: the Skaraborg Hypertension and diabetes project
Kristina Bengtsson Boström, Marju Orho-Melander, Ulf Lindblad, Olle Melander, Erik Bøg-Hansen, et al.
(1999) Journal of Hypertension, 17 p.1569-1575
Journal articleExpression of naturally occurring variants in the muscle glycogen synthase gene
Marju Orho-Melander, H Shimomura, T Sanke, S K Rasmussen, K Nanjo, et al.
(1999) Diabetes, 48 p.918-920
Journal articleA paired-sibling analysis of the XbaI polymorphism in the muscle glycogen synthase gene
Marju Orho-Melander, Peter Almgren, T Kanninen, C Forsblom, Leif Groop
(1999) Diabetologia, 42 p.1138-1145
Journal articleMortality in diabetic patients participating in an ophthalmological control and screening programme
M. Henricsson, A. Nilsson, A. Heijl, L. Janzon, L. Groop
(1997) Diabetic Medicine, 14 p.576-583
Journal articleProgression of retinopathy is related to glycaemic control even in patients with mild diabetes mellitus
Marianne Henricsson, Leif Groop, Anders Heijl
(1996) Acta Ophthalmologica Scandinavica, 74 p.528-532
Journal articlePrevalence of diabetic retinopathy in relation to age at onset of the diabetes, treatment, duration and glycemic control
Marianne Henricsson, Anders Nilsson, Leif Groop, Anders Heijl, Lars Janzon
(1996) Acta Ophthalmologica Scandinavica, 74 p.523-527
Journal article