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Kerstin Berntorp

Kerstin Berntorp

Adjunct professor

Kerstin Berntorp

Progression of retinopathy in insulin-treated type 2 diabetic patients.

Author

  • Marianne Henricsson
  • Kerstin Berntorp
  • Per Fernlund
  • Göran Sundkvist

Summary, in English

OBJECTIVE—To study the progression of retinopathy 3 years after initiation of insulin therapy.



RESEARCH DESIGN AND METHODS—In a prospective, observational case-control study, 42 type 2 diabetic patients were examined at baseline and 1, 3, 6, 12, 24, and 36 months after change to insulin therapy. Retinopathy was graded based on fundus photographs using the Wisconsin scale; HbA1c and IGF-1 were measured.



RESULTS—During the observation period of 3 years, 26 patients progressed in the retinopathy scale; 11 patients progressed at least three levels. After 3 years of insulin therapy, HbA1c and IGF-1 were significantly lower than at baseline. Progression of retinopathy greater than or equal to three levels was related to high IGF-1 levels.



CONCLUSIONS—A relationship was found between high IGF-1 levels at 3 years and progression of retinopathy in type 2 diabetic patients.

Department/s

  • Ophthalmology (Malmö)
  • Genomics, Diabetes and Endocrinology
  • Clinical Chemistry, Malmö
  • Department of Clinical Sciences, Malmö

Publishing year

2002

Language

English

Pages

381-385

Publication/Series

Diabetes Care

Volume

25

Issue

2

Document type

Journal article

Publisher

American Diabetes Association

Topic

  • Endocrinology and Diabetes

Keywords

  • Treatment Outcome
  • Non-U.S. Gov't
  • Support
  • Prospective Studies
  • Middle Age
  • Non-Insulin-Dependent: physiopathology
  • Diabetic Retinopathy: physiopathology
  • Disease Progression
  • Logistic Models
  • Insulin: administration & dosage
  • Hypoglycemic Agents: administration & dosage
  • Human
  • Follow-Up Studies
  • Male
  • Female
  • Non-Insulin-Dependent: drug therapy
  • Diabetes Mellitus
  • Non-Insulin-Dependent: complications
  • Aged
  • Case-Control Studies

Status

Published

Research group

  • Ophthalmology (Malmö)
  • Genomics, Diabetes and Endocrinology
  • Clinical Chemistry, Malmö

ISBN/ISSN/Other

  • ISSN: 1935-5548