
Kerstin Berntorp
Adjunct professor

Pregnancy to postpartum transition of serum metabolites in women with gestational diabetes
Author
Summary, in English
Context Gestational diabetes is commonly linked to development of type 2 diabetes mellitus (T2DM). There is a need to characterize metabolic changes associated with gestational diabetes in order to find novel biomarkers for T2DM. Objective To find potential pathophysiological mechanisms and markers for progression from gestational diabetes mellitus to T2DM by studying the metabolic transition from pregnancy to postpartum. Design The metabolic transition profile from pregnancy to postpartum was characterized in 56 women by mass spectrometry-based metabolomics; 11 women had gestational diabetes mellitus, 24 had normal glucose tolerance, and 21 were normoglycaemic but at increased risk for gestational diabetes mellitus. Fasting serum samples collected during trimester 3 (gestational week 32 ± 0.6) and postpartum (10.5 ± 0.4 months) were compared in diagnosis-specific multivariate models (orthogonal partial least squares analysis). Clinical measurements (e.g., insulin, glucose, lipid levels) were compared and models of insulin sensitivity and resistance were calculated for the same time period. Results Women with gestational diabetes had significantly increased postpartum levels of the branched-chain amino acids (BCAAs) leucine, isoleucine, and valine, and their circulating lipids did not return to normal levels after pregnancy. The increase in BCAAs occurred postpartum since the BCAAs did not differ during pregnancy, as compared to normoglycemic women. Conclusions Postpartum levels of specific BCAAs, notably valine, are related to gestational diabetes during pregnancy.
Department/s
- Genomics, Diabetes and Endocrinology
Publishing year
2017-07-01
Language
English
Pages
27-36
Publication/Series
Metabolism: Clinical and Experimental
Volume
72
Full text
- Available as PDF - 481 kB
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Document type
Journal article
Publisher
Elsevier
Topic
- Endocrinology and Diabetes
Keywords
- Branched-chain amino acids
- Gestational diabetes mellitus
- Metabolomics
- Multivariate statistics
- Type 2 diabetes mellitus
Status
Published
Research group
- Genomics, Diabetes and Endocrinology
ISBN/ISSN/Other
- ISSN: 0026-0495