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Kerstin Berntorp

Kerstin Berntorp

Adjunct professor

Kerstin Berntorp

Pregnancy to postpartum transition of serum metabolites in women with gestational diabetes

Author

  • Elin Chorell
  • Ulrika Andersson Hall
  • Carolina Gustavsson
  • Kerstin Berntorp
  • Jatta Puhkala
  • Riitta Luoto
  • Tommy Olsson
  • Agneta Holmäng

Summary, in English

Context Gestational diabetes is commonly linked to development of type 2 diabetes mellitus (T2DM). There is a need to characterize metabolic changes associated with gestational diabetes in order to find novel biomarkers for T2DM. Objective To find potential pathophysiological mechanisms and markers for progression from gestational diabetes mellitus to T2DM by studying the metabolic transition from pregnancy to postpartum. Design The metabolic transition profile from pregnancy to postpartum was characterized in 56 women by mass spectrometry-based metabolomics; 11 women had gestational diabetes mellitus, 24 had normal glucose tolerance, and 21 were normoglycaemic but at increased risk for gestational diabetes mellitus. Fasting serum samples collected during trimester 3 (gestational week 32 ± 0.6) and postpartum (10.5 ± 0.4 months) were compared in diagnosis-specific multivariate models (orthogonal partial least squares analysis). Clinical measurements (e.g., insulin, glucose, lipid levels) were compared and models of insulin sensitivity and resistance were calculated for the same time period. Results Women with gestational diabetes had significantly increased postpartum levels of the branched-chain amino acids (BCAAs) leucine, isoleucine, and valine, and their circulating lipids did not return to normal levels after pregnancy. The increase in BCAAs occurred postpartum since the BCAAs did not differ during pregnancy, as compared to normoglycemic women. Conclusions Postpartum levels of specific BCAAs, notably valine, are related to gestational diabetes during pregnancy.

Department/s

  • Genomics, Diabetes and Endocrinology

Publishing year

2017-07-01

Language

English

Pages

27-36

Publication/Series

Metabolism: Clinical and Experimental

Volume

72

Document type

Journal article

Publisher

Elsevier

Topic

  • Endocrinology and Diabetes

Keywords

  • Branched-chain amino acids
  • Gestational diabetes mellitus
  • Metabolomics
  • Multivariate statistics
  • Type 2 diabetes mellitus

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 0026-0495