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Kerstin Berntorp

Kerstin Berntorp

Adjunct professor

Kerstin Berntorp

Progression of retinopathy after improved metabolic control in type 2 diabetic patients. Relation to IGF-1 and hemostatic variables


  • Marianne Henricsson
  • Kerstin Berntorp
  • Erik Berntorp
  • Per Fernlund
  • Göran Sundkvist

Summary, in English

OBJECTIVE: To determine the impact of improved glycemic control on the development and progression of retinopathy after the institution of insulin therapy in patients with type 2 diabetes and to assess the relation to IGF-1 and hemostatic variables. RESEARCH DESIGN AND METHODS: In a prospective observational study, 45 type 2 diabetic patients were examined at baseline and 1, 3, 6, 12, and 24 months after change to insulin therapy. Retinopathy was graded on fundus photographs using the Wisconsin scale; HbA1c, IGF-1, and hemostatic variables were measured. RESULTS: During the observation period of 2 years, 23 patients progressed in the retinopathy scale; 8 progressed > or = 3 levels. After 2 years of insulin treatment, HbA1c and IGF-1 were significantly lower than at baseline, whereas the hemostatic variables had not changed significantly. Progression of retinopathy > or = 3 levels was related to the degree of HbA1c reduction, the duration of diabetes, a higher prothrombin fragment 1 + 2 levels (F1 + 2), but not to other hemostatic variables or IGF-1. The relative risk for progression > or = 3 levels was 2.6 when HbA1c had been reduced > or = 3 percent units (95% CI 1.1-6.1). CONCLUSIONS: The magnitude of improvement of HbA1c by the institution of insulin treatment over a 2-year period may be associated with progression of retinopathy in patients with type 2 diabetes.


  • Department of Clinical Sciences, Malmö
  • Genomics, Diabetes and Endocrinology
  • Clinical Coagulation, Malmö
  • Clinical Chemistry, Malmö

Publishing year







Diabetes Care





Document type

Journal article


American Diabetes Association


  • Endocrinology and Diabetes



Research group

  • Genomics, Diabetes and Endocrinology
  • Clinical Coagulation, Malmö
  • Clinical Chemistry, Malmö


  • ISSN: 1935-5548