
Kerstin Berntorp
Adjunct professor

Screening for MODY mutations, GAD antibodies, and type 1 diabetes--associated HLA genotypes in women with gestational diabetes mellitus.
Author
Summary, in English
OBJECTIVE: To investigate whether genetic susceptibility to type 1 diabetes or maturity-onset diabetes of the young (MODY) increases susceptibility to gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS: We studied mutations in MODY1-4 genes, the presence of GAD antibodies, and HLA DQB1 risk genotypes in 66 Swedish women with GDM and a family history of diabetes. An oral glucose tolerance test was repeated in 46 women at 1 year postpartum. RESULTS: There was no increase in type 1 diabetes-associated HLA-DQB1 alleles or GAD antibodies when compared with a group of type 2 diabetic patients (n = 82) or healthy control subjects (n = 86). Mutations in known MODY genes were identified in 3 of the 66 subjects (1 MODY2, 1 MODY3, and 1 MODY4). Of the 46 GDM subjects, 2 had diabetes (4%) and 17 had impaired glucose tolerance (IGT) (37%) at 1 year postpartum. Of the two subjects who developed manifest diabetes, one carried a MODY3 mutation (A203H in the hepatocyte nuclear factor-1alpha gene). There was no increase in high-risk HLA alleles or GAD antibodies in the women who had manifest diabetes or IGT at 1 year postpartum. CONCLUSIONS: MODY mutations but not autoimmunity contribute to GDM in Swedish women with a family history of diabetes and increase the risk of subsequent diabetes.
Department/s
- Department of Clinical Sciences, Malmö
- Obstetrics and Gynaecology (Lund)
- Genomics, Diabetes and Endocrinology
Publishing year
2002
Language
English
Pages
68-71
Publication/Series
Diabetes Care
Volume
25
Issue
1
Links
Document type
Journal article
Publisher
American Diabetes Association
Topic
- Endocrinology and Diabetes
Keywords
- Diabetes Mellitus Non-Insulin-Dependent : genetics
- Diabetes Gestational : genetics : immunology
- Female
- Support Non-U.S. Gov't
- Sweden
- Risk Assessment
- Pregnancy
- Patient Selection
- Mutation
- Middle Age
- Human
- HLA Antigens : genetics
- HLA-DQ Antigens : genetics
- Genotype
- Glucose Intolerance : genetics : immunology
- Adult
- Diabetes Mellitus Insulin-Dependent : genetics : immunology
Status
Published
Research group
- Genomics, Diabetes and Endocrinology
ISBN/ISSN/Other
- ISSN: 1935-5548