
Kerstin Berntorp
Adjunct professor

High androgen levels protect against hypothyroidism
Author
Summary, in English
Introduction: Hypothyroidism is a common disorder, appearing mainly in women although less frequently found in women with polycystic ovary syndrome (PCOS). The objective was to test the hypothesis that hyperandrogenism might protect against hypothyroidism. Material and methods: The data from three prospective follow-up studies (up to 21 years) and one register study were compared: women with PCOS (Rotterdam criteria), n = 25, women with Turner syndrome, n = 217, a random population sample of women, n = 315, and men, n = 95 (the WHO MONICA study). Findings were to be verified or rejected in all females, n = 553 716, from the same region. The proportion of hypothyroidism was calculated and thyroid peroxidase antibodies (TPO) in serum were measured. Results: Hypothyroidism at >50 years of age was found in 8% of women with PCOS, 4% in men (PCOS vs. men; ns), 43% of women with Turner syndrome, irrespective of karyotype (p < 0.001 vs. PCOS), and in 17% of postmenopausal women in the population (p < 0.01 vs. PCOS). Elevated TPO were similar in PCOS and women and men in the population but higher in Turner syndrome. Hypothyroidism increased with age in all groups except PCOS women and men. In the register study, hypothyroidism was less common in women with PCOS >25 years (5.5%) than in women without PCOS (6.8%) from the same region (p < 0.01). Conclusions: Hypothyroidism was less frequently seen in women with PCOS and in men compared with women in the general population and among women with Turner syndrome. This was not explained by altered autoimmunity or the Y-chromosome. Androgens seem to protect against hypothyroidism.
Department/s
- Genomics, Diabetes and Endocrinology
Publishing year
2017-01-01
Language
English
Pages
39-46
Publication/Series
Acta Obstetricia et Gynecologica Scandinavica
Volume
96
Issue
1
Document type
Journal article
Publisher
Wiley-Blackwell
Topic
- Obstetrics, Gynecology and Reproductive Medicine
Keywords
- Androgens
- hypothyroidism
- polycystic ovary syndrome
- Turner syndrome
Status
Published
Research group
- Genomics, Diabetes and Endocrinology
ISBN/ISSN/Other
- ISSN: 0001-6349