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Karl-Fredrik Eriksson

Associate professor

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Evaluation of the effects of exercise on insulin sensitivity in Arabian and Swedish women with type 2 diabetes.

Author

  • Forouzan Glans
  • Karl-Fredrik Eriksson
  • Åsa Tornberg
  • Ola Thorsson
  • Per Wollmer
  • Leif Groop

Summary, in English

AIMS: The purpose of this study was to evaluate the effects of exercise on cardio-respiratory fitness and insulin sensitivity in sedentary, overweight Arabian and Swedish women with type 2 diabetes. METHODS: Eighteen Arabian and 14 Swedish women participated in a supervised 6-month resistance training and aerobic program of moderate intensity. Insulin sensitivity and VO(2max) were measured at entry to the study and after 3 and 6 months training. RESULTS: After 6 months exercise, insulin sensitivity (M-value) increased (2.7+/-1.4mgkg(-1)min(-1) vs. 3.4+/-2mgkg(-1)min(-1), p<0.05) in all patients and accounted for by an increase in non-oxidative glucose metabolism (0.3+/-1.1mgkg(-1)min(-1) vs. 1.5+/-1.5mgkg(-1)min(-1), p<0.005) with no significant difference between the ethnic groups. Notably, significant improvement in HbA1c was only seen in the Swedish patients who achieved greater exercise intensity (73.3+/-4.8% vs. 63.3+/-5.2% of maximum heart rate, p<0.005). No changes were observed regarding VO(2max) or lipid profile in either group. CONCLUSIONS: Although a 6-month exercise intervention of moderate intensity in Arabian and Swedish patients with type 2 diabetes can improve insulin sensitivity it is hampered by the metabolic inflexibility of switching between oxidation of glucose or fat.

Department/s

  • Genomics, Diabetes and Endocrinology
  • Vascular Diseases - Clinical Research
  • Human Movement: health and rehabilitation
  • Clinical Physiology, Malmö

Publishing year

2009

Language

English

Pages

69-74

Publication/Series

Diabetes Research and Clinical Practice

Volume

85

Document type

Journal article

Publisher

Elsevier

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology
  • Vascular Diseases - Clinical Research
  • Physiotherapy
  • Clinical Physiology, Malmö

ISBN/ISSN/Other

  • ISSN: 1872-8227