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Karl-Fredrik Eriksson

Associate professor

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PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.


  • VK Mootha
  • Cecilia Lindgren
  • Karl-Fredrik Eriksson
  • A Subramanian
  • S Sihag
  • J Lehar
  • P Puigserver
  • Emma A Nilsson
  • Martin Ridderstråle
  • Esa Laurila
  • N Houstis
  • MJ Daly
  • N Patterson
  • JP Mesirov
  • TR Golub
  • P Tamayo
  • B Spiegelman
  • ES Lander
  • JN Hirschhorn
  • D Altshuler
  • Leif Groop

Summary, in English

DNA microarrays can be used to identify gene expression changes characteristic of human disease. This is challenging, however, when relevant differences are subtle at the level of individual genes. We introduce an analytical strategy, Gene Set Enrichment Analysis, designed to detect modest but coordinate changes in the expression of groups of functionally related genes. Using this approach, we identify a set of genes involved in oxidative phosphorylation whose expression is coordinately decreased in human diabetic muscle. Expression of these genes is high at sites of insulin-mediated glucose disposal, activated by PGC-1alpha and correlated with total-body aerobic capacity. Our results associate this gene set with clinically important variation in human metabolism and illustrate the value of pathway relationships in the analysis of genomic profiling experiments.


  • Department of Clinical Sciences, Malmö
  • Vascular Diseases - Clinical Research
  • Genomics, Diabetes and Endocrinology
  • Diabetes - Clinical Obesity

Publishing year







Nature Genetics





Document type

Journal article


Nature Publishing Group


  • Endocrinology and Diabetes
  • Clinical Medicine
  • Nutrition and Dietetics
  • Cardiac and Cardiovascular Systems



Research group

  • Vascular Diseases - Clinical Research
  • Genomics, Diabetes and Endocrinology
  • Diabetes - Clinical Obesity


  • ISSN: 1546-1718