Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Default user image.

Karl-Fredrik Eriksson

Associate professor

Default user image.

A prospective study of orthostatic blood pressure in diabetic patients

Author

  • M. De Kanter
  • B. Lilja
  • S. Elmståhl
  • K. F. Eriksson
  • G. Sundkvist

Summary, in English

To clarify whether orthostatic blood pressure is affected by the type of diabetes, cardiac autonomic neuropathy, and the duration of diabetes, orthostatic blood pressure (passive 90°tilt) was evaluated in 102 patients with insulin dependent diabetes mellitus (IDDM), 51 patients with non-insulin dependent diabetes mellitus (NIDDM), and in 238 control subjects in a first study followed up after 8 to 17 years. The heart rate reaction during deep breathing (E/I ratio) and to tilt (acceleration and brake indices) assessed cardiac autonomic function. In the first study, the lowest systolic blood pressure (LSBP) and the lowest diastolic blood pressure (LDBP) after tilt were significantly lower in IDDM patients compared with NIDDM patients (p < 0.001 for LSBP and p < 0.05 for LDBP) and controls (p < 0.001). LDBP was, however, also significantly lower (p < 0.05) in NIDDM patients than in controls. Hence, although most severe in IDDM, LDBP was disturbed in both types of diabetes. In IDDM, a low E/I ratio was associated with disturbed orthostatic blood pressure. At follow-up examinations, orthostatic blood pressure deteriorated in NIDDM but not in IDDM patients. In conclusion, LSBP and LDBP were impaired in IDDM patients compared with NIDDM and control subjects; however, LDBP was also impaired in NIDDM patients compared with controls. When the duration of diabetes increased, orthostatic blood pressure deteriorated in NIDDM but not in IDDM patients.

Department/s

  • Geriatrics
  • Geriatric Medicine
  • Vascular Diseases - Clinical Research
  • Department of Clinical Sciences, Malmö

Publishing year

1998-11-20

Language

English

Pages

189-193

Publication/Series

Clinical Autonomic Research

Volume

8

Issue

4

Document type

Journal article

Publisher

Springer

Topic

  • Cardiac and Cardiovascular Systems
  • Anesthesiology and Intensive Care

Keywords

  • Autonomic neuropathy
  • IDDM
  • NIDDM
  • Orthostatic blood pressure
  • Postural hypotension

Status

Published

Research group

  • Geriatrics
  • Geriatric Medicine
  • Vascular Diseases - Clinical Research

ISBN/ISSN/Other

  • ISSN: 0959-9851