
Karin Filipsson
Research project participant

Glycogen metabolism in the glucose-sensing and supply-driven β-cell
Author
Summary, in English
Glycogen metabolism in β-cells may affect downstream metabolic pathways controlling insulin release. We examined glycogen metabolism in human islets and in the rodent-derived INS-1 832/13 β-cells and found them to express the same isoforms of key enzymes required for glycogen metabolism. Our findings indicate that glycogenesis is insulin-independent but influenced by extracellular glucose concentrations. Levels of glycogen synthase decrease with increasing glucose concentrations, paralleling accumulation of glycogen. We did not find cAMP-elicited glycogenolysis and insulin secretion to be causally related. In conclusion, our results reveal regulated glycogen metabolism in human islets and insulin-secreting cells. Whether glycogen metabolism affects insulin secretion under physiological conditions remains to be determined.
Department/s
- Diabetes - Molecular Metabolism
- Centre for Analysis and Synthesis
- EXODIAB: Excellence of Diabetes Research in Sweden
Publishing year
2016-12-01
Language
English
Pages
4242-4251
Publication/Series
FEBS Letters
Volume
590
Issue
23
Document type
Journal article (letter)
Publisher
Wiley-Blackwell
Topic
- Cell and Molecular Biology
Keywords
- human islets
- INS-1 832/13
- insulin secretion
Status
Published
Research group
- Diabetes - Molecular Metabolism
ISBN/ISSN/Other
- ISSN: 0014-5793