Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Default user image.

Karin Filipsson

Research project participant

Default user image.

Glycogen metabolism in the glucose-sensing and supply-driven β-cell

Author

  • Lotta E. Andersson
  • Lisa M. Nicholas
  • Karin Filipsson
  • Jiangming Sun
  • Anya Medina Benavente
  • Mahmoud Al-Majdoub
  • Malin Fex
  • Hindrik Mulder
  • Peter Spégel

Summary, in English

Glycogen metabolism in β-cells may affect downstream metabolic pathways controlling insulin release. We examined glycogen metabolism in human islets and in the rodent-derived INS-1 832/13 β-cells and found them to express the same isoforms of key enzymes required for glycogen metabolism. Our findings indicate that glycogenesis is insulin-independent but influenced by extracellular glucose concentrations. Levels of glycogen synthase decrease with increasing glucose concentrations, paralleling accumulation of glycogen. We did not find cAMP-elicited glycogenolysis and insulin secretion to be causally related. In conclusion, our results reveal regulated glycogen metabolism in human islets and insulin-secreting cells. Whether glycogen metabolism affects insulin secretion under physiological conditions remains to be determined.

Department/s

  • Diabetes - Molecular Metabolism
  • Centre for Analysis and Synthesis
  • EXODIAB: Excellence in Diabetes Research in Sweden

Publishing year

2016-12-01

Language

English

Pages

4242-4251

Publication/Series

FEBS Letters

Volume

590

Issue

23

Document type

Journal article (letter)

Publisher

Wiley-Blackwell

Topic

  • Cell and Molecular Biology

Keywords

  • human islets
  • INS-1 832/13
  • insulin secretion

Status

Published

Research group

  • Diabetes - Molecular Metabolism

ISBN/ISSN/Other

  • ISSN: 0014-5793