Jonathan Esguerra
Affiliated researcher
Jonathan Esguerra started as LUDC postdoc (2009) within the group and continued as a senior associate researcher. He concurrently serves as lead of LUDC´s Bioinformatics Unit since 2017. He studied molecular biology and biotechnology at University of the Philippines (1993), and obtained Master´s in Bioinformatics at Chalmers Technical University (2001) and later on, PhD in Microbiology with focus on functional genomics from University of Gothenburg (2008). His current research interest is on RNA-based therapeutics and diagnostics in metabolic diseases.
Publications
Displaying of publications. Sorted by year, then title.
Human pancreatic islet miRNA-mRNA networks of altered miRNAs due to glycemic status
Alexandros Karagiannopoulos, Jonathan LS Esguerra, Morten Pedersen, Anna Wendt, Rashmi Prasad, et al.
(2022) iScience, 25
Journal articleRibosomal biogenesis regulator DIMT1 controls β-cell protein synthesis, mitochondrial function, and insulin secretion
Gaurav Verma, Alexander Bowen, Sevda Gheibi, Alexander Hamilton, Sowndarya Muthukumar, et al.
(2022) The Journal of biological chemistry, 298
Journal articleHuman Islet MicroRNA-200c Is Elevated in Type 2 Diabetes and Targets the Transcription Factor ETV5 to Reduce Insulin Secretion
Jones Ofori, Alexandros Karagiannopoulos, Mototsugu Nagao, Efraim Westholm, Shaima Ramadan, et al.
(2022) Diabetes, 71 p.275-284
Journal articleGenetic regulation of RNA splicing in human pancreatic islets
Goutham Atla, Silvia Bonàs-Guarch, Mirabai Cuenca-Ardura, Anthony Beucher, Daniel J. M. Crouch, et al.
(2022) Genome Biology, 23 p.1-28
Journal articleReplication study reveals miR-483-5p as an important target in prevention of cardiometabolic disease
Widet Gallo, Filip Ottosson, Cecilia Kennbäck, Amra Jujic, Jonathan LS Esguerra, et al.
(2021) BMC Cardiovascular Disorders, 21
Journal articleDiagnostic potential of miR-483 family for IGF-II producing non-islet cell tumor hypoglycemia
Mototsugu Nagao, Izumi Fukuda, Akira Asai, Jonathan L.S. Esguerra, Naomi Hizuka, et al.
(2021) European Journal of Endocrinology, 184 p.41-49
Journal articleTranscriptional analysis of islets of Langerhans from organ donors of different ages
Peter Seiron, Anton Stenwall, Anders Hedin, Louise Granlund, Jonathan Lou S. Esguerra, et al.
(2021) PLoS ONE, 16
Journal articleDifferential DNA Methylation and Expression of miRNAs in Adipose Tissue From Twin Pairs Discordant for Type 2 Diabetes
Emma Nilsson, Magdalena Vavakova, Alexander Perfilyev, Johanna Säll, Per-Anders Jansson, et al.
(2021) Diabetes, 70 p.2402-2418
Journal articleTIGER : The gene expression regulatory variation landscape of human pancreatic islets
Lorena Alonso, Anthony Piron, Ignasi Morán, Marta Guindo-Martínez, Sílvia Bonàs-Guarch, et al.
(2021) Cell Reports, 37
Journal articlePotential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells
Mototsugu Nagao, Jonathan L S Esguerra, Akira Asai, Jones K Ofori, Anna Edlund, et al.
(2020) Diabetes, 69 p.1193-1205
Journal articleSelectively Bred Diabetes Models : GK Rats, NSY Mice, and ON Mice
Mototsugu Nagao, Jonathan Lou S Esguerra, Anna Wendt, Akira Asai, Hitoshi Sugihara, et al.
(2020) Methods in molecular biology (Clifton, N.J.), 2128 p.25-54
Book chapterGlucocorticoid induces human beta cell dysfunction by involving riborepressor GAS5 LincRNA
Jonathan L.S. Esguerra, Jones K. Ofori, Mototsugu Nagao, Yuki Shuto, Alexandros Karagiannopoulos, et al.
(2020) Molecular Metabolism, 32 p.160-167
Journal articleA circular RNA generated from an intron of the insulin gene controls insulin secretion
Lisa Stoll, Adriana Rodríguez-Trejo, Claudiane Guay, Flora Brozzi, Mustafa Bilal Bayazit, et al.
(2020) Nature Communications, 11
Journal articleMicroRNA networks in pancreatic islet cells : Normal function and type 2 diabetes
Lena Eliasson, Jonathan L.S. Esguerra
(2020) Diabetes, 69 p.804-812
Journal articleIn Vivo Silencing of MicroRNA-132 Reduces Blood Glucose and Improves Insulin Secretion
Roel Bijkerk, Jonathan L S Esguerra, Johanne H Ellenbroek, Yu Wah Au, Maaike A J Hanegraaf, et al.
(2019) Nucleic acid therapeutics, 29 p.67-72
Journal articleDefective exocytosis and processing of insulin in a cystic fibrosis mouse model
Anna Edlund, Mohammad Barghouth, Michael Huhn, Mia Abels, Jonathan Esguerra, et al.
(2019) Journal of Endocrinology, 241 p.45-57
Journal articleIslet microRNAs in health and type-2 diabetes
Anna Wendt, Jonathan LS Esguerra, Lena Eliasson
(2018) Current Opinion in Pharmacology, 43 p.46-52
Journal article reviewmiR-483-5p associates with obesity and insulin resistance and independently associates with new onset diabetes mellitus and cardiovascular disease
Widet Gallo, Jonathan Lou S. Esguerra, Lena Eliasson, Olle Melander
(2018) PLoS ONE, 13
Journal articleMicroRNAs in islet hormone secretion
Jonathan L.S. Esguerra, Mototsugu Nagao, Jones K. Ofori, Anna Wendt, Lena Eliasson
(2018) Diabetes, Obesity and Metabolism, 20 p.11-19
Journal article reviewMiR-335 overexpression impairs insulin secretion through defective priming of insulin vesicles
Vishal A. Salunkhe, Jones K. Ofori, Nikhil R. Gandasi, Sofia A. Salö, Sofia Hansson, et al.
(2017) Physiological Reports, 5
Journal articleGlucotoxicity-induced upregulation of lincRNA GAS5 in the pancreatic islets of type 2 diabetes donors and in Goto-Kakizaki rats
J. L. S. Esguerra, J. Ofori, M. Nagao, J. Fadista, L. Groop, et al.
(2017) Diabetologia, 60 p.22-23
Conference paper: abstractReduced insulin secretion in a diet-induced glucose intolerance susceptible mouse model is coupled with increased CD36 and triglycerides in the beta cells
A. Asai, M. Nagao, T. Tsuduki, T. Miyazawa, J. L. S. Esguerra, et al.
(2017) , p.61-61
Conference paper: abstractCD36 is increased in human islets from obese type 2 diabetes donors, and affects beta cell function by the modulation of exocytotic proteins and insulin content
M. Nagao, J. L. S. Esguerra, J. K. Ofori, A. Wendt, A. Asai, et al.
(2017) Diabetologia, 60 p.185-186
Conference paper: abstractIdentification of islet-enriched long non-coding RNAs contributing to β-cell failure in type 2 diabetes
Anna Motterle, Sonia Gattesco, Marie Line Peyot, Jonathan Lou S. Esguerra, Ana Ruiz-Gomez, et al.
(2017) Molecular Metabolism, 6 p.1407-1418
Journal articleConfluence does not affect the expression of miR-375 and its direct targets in rat and human insulin-secreting cell lines
Jones K Ofori, Helena A Malm, Ines G Mollet, Lena Eliasson, Jonathan Lou S Esguerra
(2017) PeerJ, 5
Journal articleElevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell
Jones K. Ofori, Vishal A. Salunkhe, Annika Bagge, Neelanjan Vishnu, Mototsugu Nagao, et al.
(2017) Scientific Reports, 7
Journal articleEndogenous beta-cell CART regulates insulin secretion and transcription of beta-cell genes
L Shcherbina, A Edlund, J L S Esguerra, M Abels, Y Zhou, et al.
(2017) Molecular and Cellular Endocrinology, 447 p.52-60
Journal articleNeuron-enriched RNA-binding Proteins Regulate Pancreatic Beta Cell Function and Survival
Jon Agraves Juan-Mateu, Tatiana H Rech, Olatz Villate, Esther Lizarraga-Mollinedo, Anna Wendt, et al.
(2017) Journal of Biological Chemistry, 292 p.3466-3480
Journal articleWhole-genome Bisulfite Sequencing of Human Pancreatic Islets Reveals Novel Differentially Methylated Regions in Type 2 Diabetes Pathogenesis
Petr Volkov, Karl Bacos, Jones K Ofori, Jonathan Lou S Esguerra, Lena Eliasson, et al.
(2017) Diabetes, 66 p.1074-1085
Journal articleLessons from basic pancreatic beta cell research in type-2 diabetes and vascular complications
Lena Eliasson, Jonathan Lou S. Esguerra, Anna Wendt
(2017) Diabetology International, 8 p.139-152
Journal article reviewDual Effect of Rosuvastatin on Glucose Homeostasis Through Improved Insulin Sensitivity and Reduced Insulin Secretion
Vishal A. Salunkhe, Ines Mollet, Jones K. Ofori, Helena A. Malm, Jonathan L S Esguerra, et al.
(2016) EBioMedicine, 10 p.185-194
Journal articleTranscriptional regulation of the miR-212/miR-132 cluster in insulin-secreting β-cells by cAMP-regulated transcriptional co-activator 1 and salt-inducible kinases.
Helena Malm, Ines Mollet, Christine Berggreen, Marju Orho-Melander, Jonathan Esguerra, et al.
(2016) Molecular and Cellular Endocrinology, 424 p.23-33
Journal articleCD46 Activation Regulates miR-150-Mediated Control of GLUT1 Expression and Cytokine Secretion in Human CD4+ T Cells.
Ben King, Jonathan Esguerra, Ewelina Golec, Lena Eliasson, Claudia Kemper, et al.
(2016) Journal of immunology, 196 p.1636-1645
Journal articleMiR-335 regulates exocytotic proteins and affects glucose-stimulated insulin secretion through decreased Ca2+-dependent exocytosis in beta cells
V.A. Salunkhe, J. Ofori, N.R. Gandasi, S.A. Salö, A. Wendt, et al.
(2015) Diabetologia, 58 p.128-128
Conference paper: abstractModulation of microRNA-375 expression alters voltage-gated Na(+) channel properties and exocytosis in insulin-secreting cells.
Vishal Ashok Salunkhe, Jonathan Esguerra, Jones Ofori, Ines Mollet, Matthias Braun, et al.
(2015) Acta Physiologica, 213 p.882-892
Journal articleMicroRNA-7a regulates pancreatic beta cell function
Mathieu Latreille, Jean Hausser, Ina Stuetzer, Quan Zhang, Benoit Hastoy, et al.
(2014) Journal of Clinical Investigation, 124 p.2722-2735
Journal articleSex differences in the genome-wide DNA methylation pattern and impact on gene expression, microRNA levels and insulin secretion in human pancreatic islets
Elin Hall, Petr Volkov, Tasnim Dayeh, Jonathan Esguerra, Sofia Salo, et al.
(2014) GenomeBiology, 15
Journal articleGlobal genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism.
Joao Fadista, Petter Vikman, Emilia Ottosson Laakso, Ines Mollet, Jonathan Esguerra, et al.
(2014) Proceedings of the National Academy of Sciences, 111 p.13924-13929
Journal articleNova1 is a master regulator of alternative splicing in pancreatic beta cells.
Olatz Villate, Jean-Valery Turatsinze, Loriana G Mascali, Fabio A Grieco, Tatiane C Nogueira, et al.
(2014) Nucleic Acids Research, 42 p.11818-11830
Journal articleRole of non-coding RNAs in pancreatic beta-cell development and physiology.
Lena Eliasson, Jonathan Esguerra
(2014) Acta Physiologica, 211 p.273-284
Journal article reviewArgonaute2 Mediates Compensatory Expansion of the Pancreatic β Cell.
Sudhir G Tattikota, Thomas Rathjen, Sarah J McAnulty, Hans-Hermann Wessels, Ildem Akerman, et al.
(2014) Cell Metabolism, 19 p.122-134
Journal articleFunctional implications of long non-coding RNAs in the pancreatic islets of Langerhans.
Jonathan Esguerra, Lena Eliasson
(2014) Frontiers in Genetics, 5 p.1-9
Journal article reviewCFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells.
Anna Edlund, Jonathan Esguerra, Anna Wendt, Malin Flodström-Tullberg, Lena Eliasson
(2014) BMC Medicine, 12
Journal articleRegulation of Pancreatic Beta Cell Stimulus-Secretion Coupling by microRNAs.
Jonathan Esguerra, Ines Mollet, Vishal Ashok Salunkhe, Anna Wendt, Lena Eliasson
(2014) Genes, 5 p.1018-1031
Journal article reviewCD46 costimulation leads to enhanced T cell activation and microrna expression
Benjamin C. King, Jonathan Esguerra, Munazza Qayyum, Lena Eliasson, Claudia Kemper, et al.
(2012) Immunobiology, 217 p.1148-1149
Conference paper: abstractSecreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.
Taman Mahdi, Sonja Hänzelmann, S Albert Salehi, Sarheed Jabar Muhammed, Thomas Reinbothe, et al.
(2012) Cell Metabolism, 16 p.625-633
Journal articleA systems genetics approach identifies genes and pathways for type 2 diabetes in human islets.
Jalal Taneera, Stefan Lang, Amitabh Sharma, Joao Fadista, Yuedan Zhou, et al.
(2012) Cell Metabolism, 16 p.122-134
Journal articleDifferences in islet-enriched miRNAs in healthy and glucose intolerant human subjects.
Caroline Bolmeson, Jonathan Esguerra, S Albert Salehi, Dina Speidel, Lena Eliasson, et al.
(2011) Biochemical and Biophysical Research Communications, Dec p.16-22
Journal articleDifferential Glucose-Regulation of MicroRNAs in Pancreatic Islets of Non-Obese Type 2 Diabetes Model Goto-Kakizaki Rat.
Jonathan Esguerra, Caroline Bolmeson, Corrado Cilio, Lena Eliasson
(2011) PLoS ONE, 6
Journal articleBeta-cell specific deletion of dicer1 leads to defective insulin secretion and diabetes mellitus.
Martins Kalis, Caroline Bolmeson, Jonathan Esguerra, Shashank Gupta, Anna Edlund, et al.
(2011) PLoS ONE, 6
Journal articleMicroRNA differences in human islets and glucose-sensitive tissues
Caroline Bolmeson, Jonathan Esguerra, Dina Speidel, Lena Eliasson, Corrado Cilio
(2010) Diabetologia, 53 p.527-527
Conference paper: abstractPredicted targets of co-expressed microRNAs in pancreatic islets of GK rats are enriched for genes involved in regulation of beta cell mass and glucose-stimulated insulin secretion
Jonathan Esguerra, Caroline Bolmeson, Corrado Cilio, Lena Eliasson
(2009) Diabetologia, 52 p.391-391
Conference paper: abstractFunctional importance of individual rRNA 2'-O-ribose methylations revealed by high-resolution phenotyping
Jonathan Esguerra, J. Warringer, A. Blomberg
(2008) RNA, 14 p.56-649
Journal article