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John Molvin

Physician

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Proteins linked to atherosclerosis and cell proliferation are associated with the shrunken pore syndrome in heart failure patients

Author

  • Liana Xhakollari
  • Amra Jujic
  • John Molvin
  • Peter Nilsson
  • Hannes Holm
  • Erasmus Bachus
  • Margret Leosdottir
  • Anders Grubb
  • Anders Christensson
  • Martin Magnusson

Summary, in English

PURPOSE: The "Shrunken pore syndrome" (SPS) is characterized by a difference in renal filtration between cystatin C and creatinine, resulting in a low eGFRcystatinC /eGFRcreatinine -ratio. Studies have demonstrated a high risk for cardiovascular morbidity and mortality for patients with SPS. In this discovery study, we explored associations between SPS and proteins implicated in cardiovascular disease and inflammation in patients with heart failure.

EXPERIMENTAL DESIGN: Plasma samples from 300 individuals in HARVEST-Malmö trial hospitalized for the diagnosis of heart failure (mean age 74.9±11.5 years; 30.0% female), were analyzed with a proximity extension assay consisting of 92 proteins. A Bonferroni-corrected p-value of 0.05/92 = 5.4 × 10-4 was considered significant in the initial age and sex-adjusted analyses. Presence of SPS was defined as eGFRcystatinC ≤60% of eGFRcreatinine .

RESULTS: SPS presented with significant associations (p < 5.4 × 10-4 ) in age and sex-adjusted logistic regressions with elevated levels of six proteins; scavenger receptor cysteine rich type 1 protein M130, tumor necrosis factor receptor 1, tumor necrosis factor receptor 2, osteoprotegerin, interleukin-2 receptor subunit alpha, and tyrosine-protein kinase receptor UFO. All proteins remained associated (p < 0.05) with SPS after multivariate adjustments.

CONCLUSIONS AND CLINICAL RELEVANCE: In heart failure patients, SPS was associated with proteins linked to atherosclerosis and cell proliferation. This article is protected by copyright. All rights reserved.

Department/s

  • Internal Medicine - Epidemiology
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • Cardiovascular Research - Hypertension
  • EpiHealth: Epidemiology for Health
  • Cystatin C, renal disease, amyloidosis and antibiotics
  • WCMM-Wallenberg Centre for Molecular Medicine

Publishing year

2021-03-07

Language

English

Publication/Series

Proteomics Clinical Applications

Volume

15

Issue

4

Document type

Journal article

Publisher

John Wiley and Sons

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Internal Medicine - Epidemiology
  • Cardiovascular Research - Hypertension
  • Cystatin C, renal disease, amyloidosis and antibiotics

ISBN/ISSN/Other

  • ISSN: 1862-8354