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ludc web

Joao Duarte

Principal investigator

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Animal Models of Metabolic Disorders in the Study of Neurodegenerative Diseases : An Overview

Author

  • Andreza Fabro de Bem
  • Rachel Krolow
  • Hémelin Resende Farias
  • Victória Linden de Rezende
  • Daniel Pens Gelain
  • José Cláudio Fonseca Moreira
  • João Miguel das Neves Duarte
  • Jade de Oliveira

Summary, in English

The incidence of metabolic disorders, as well as of neurodegenerative diseases—mainly the sporadic forms of Alzheimer’s and Parkinson’s disease—are increasing worldwide. Notably, obesity, diabetes, and hypercholesterolemia have been indicated as early risk factors for sporadic forms of Alzheimer’s and Parkinson’s disease. These conditions share a range of molecular and cellular features, including protein aggregation, oxidative stress, neuroinflammation, and blood-brain barrier dysfunction, all of which contribute to neuronal death and cognitive impairment. Rodent models of obesity, diabetes, and hypercholesterolemia exhibit all the hallmarks of these degenerative diseases, and represent an interesting approach to the study of the phenotypic features and pathogenic mechanisms of neurodegenerative disorders. We review the main pathological aspects of Alzheimer’s and Parkinson’s disease as summarized in rodent models of obesity, diabetes, and hypercholesterolemia.

Department/s

  • WCMM-Wallenberg Centre for Molecular Medicine
  • Diabetes and Brain Function
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2021

Language

English

Publication/Series

Frontiers in Neuroscience

Volume

14

Document type

Journal article review

Publisher

Frontiers Media S. A.

Topic

  • Neurosciences

Keywords

  • Alzheimer’s disease
  • diabetes
  • hypercholesterolemia
  • neurodegeneration
  • obesity
  • Parkinson’s disease
  • rodent models

Status

Published

Research group

  • Diabetes and Brain Function

ISBN/ISSN/Other

  • ISSN: 1662-4548