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ludc web

Joao Duarte

Principal investigator

ludc web

Mitochondria and the Brain : Bioenergetics and Beyond

Author

  • Pascale Belenguer
  • João M.N. Duarte
  • Patrícia F. Schuck
  • Gustavo C. Ferreira

Summary, in English

The view of mitochondria acting solely as a powerhouse of the cell is no longer accurate. Besides cell bioenergetics, primary targets of mitochondrial studies include their interplay with essential processes within the cell, including redox and calcium homeostasis, and apoptosis. Recent studies evidence the dynamic behavior of mitochondria, continuously moving, fusing, and dividing, and the interaction of these events with cellular degeneration and plasticity in neural cells. Our review summarizes novel data and technologies that are developed and applied to the identification and clarification of the mitochondrial role in neural plasticity using both cultured cells and in vivo approaches. The complete understanding and modulation of such mechanisms may represent a novel and promising therapeutic approach for treatment of diseases affecting central and peripheral nervous system.

Department/s

  • WCMM-Wallenberg Centre for Molecular Medicine
  • Diabetes and Brain Function
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2019-06-01

Language

English

Pages

219-238

Publication/Series

Neurotoxicity Research

Volume

36

Issue

2

Document type

Journal article

Publisher

Springer

Topic

  • Neurosciences

Keywords

  • Brain metabolism
  • Mitochondria
  • MRS
  • Neurogenesis

Status

Published

Research group

  • Diabetes and Brain Function

ISBN/ISSN/Other

  • ISSN: 1029-8428