
Joao Duarte
Principal investigator

Brain Metabolism Alterations in Type 2 Diabetes : What Did We Learn From Diet-Induced Diabetes Models?
Author
Summary, in English
Type 2 diabetes (T2D) is a metabolic disease with impact on brain function through mechanisms that include glucose toxicity, vascular damage and blood–brain barrier (BBB) impairments, mitochondrial dysfunction, oxidative stress, brain insulin resistance, synaptic failure, neuroinflammation, and gliosis. Rodent models have been developed for investigating T2D, and have contributed to our understanding of mechanisms involved in T2D-induced brain dysfunction. Namely, mice or rats exposed to diabetogenic diets that are rich in fat and/or sugar have been widely used since they develop memory impairment, especially in tasks that depend on hippocampal processing. Here we summarize main findings on brain energy metabolism alterations underlying dysfunction of neuronal and glial cells promoted by diet-induced metabolic syndrome that progresses to a T2D phenotype.
Department/s
- EXODIAB: Excellence of Diabetes Research in Sweden
- Diabetes and Brain Function
- WCMM-Wallenberg Centre for Molecular Medicine
Publishing year
2020
Language
English
Publication/Series
Frontiers in Neuroscience
Volume
14
Document type
Journal article review
Publisher
Frontiers Media S. A.
Topic
- Neurosciences
Keywords
- brain metabolism
- diet-induced obesity
- glucose
- high-fat
- insulin resistance
- sucrose
Status
Published
Research group
- Diabetes and Brain Function
ISBN/ISSN/Other
- ISSN: 1662-4548