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ludc web

Joao Duarte

Principal investigator

ludc web

Brain Metabolism Alterations in Type 2 Diabetes : What Did We Learn From Diet-Induced Diabetes Models?

Author

  • Alba M. Garcia-Serrano
  • João M.N. Duarte

Summary, in English

Type 2 diabetes (T2D) is a metabolic disease with impact on brain function through mechanisms that include glucose toxicity, vascular damage and blood–brain barrier (BBB) impairments, mitochondrial dysfunction, oxidative stress, brain insulin resistance, synaptic failure, neuroinflammation, and gliosis. Rodent models have been developed for investigating T2D, and have contributed to our understanding of mechanisms involved in T2D-induced brain dysfunction. Namely, mice or rats exposed to diabetogenic diets that are rich in fat and/or sugar have been widely used since they develop memory impairment, especially in tasks that depend on hippocampal processing. Here we summarize main findings on brain energy metabolism alterations underlying dysfunction of neuronal and glial cells promoted by diet-induced metabolic syndrome that progresses to a T2D phenotype.

Department/s

  • EXODIAB: Excellence of Diabetes Research in Sweden
  • Diabetes and Brain Function
  • WCMM-Wallenberg Centre for Molecular Medicine

Publishing year

2020

Language

English

Publication/Series

Frontiers in Neuroscience

Volume

14

Document type

Journal article review

Publisher

Frontiers Media S. A.

Topic

  • Neurosciences

Keywords

  • brain metabolism
  • diet-induced obesity
  • glucose
  • high-fat
  • insulin resistance
  • sucrose

Status

Published

Research group

  • Diabetes and Brain Function

ISBN/ISSN/Other

  • ISSN: 1662-4548