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ludc web

Joao Duarte

Research team manager

ludc web

The neurochemical profile quantified by in vivo 1H NMR spectroscopy

Author

  • João M N Duarte
  • Hongxia Lei
  • Vladimír Mlynárik
  • Rolf Gruetter

Summary, in English

Proton NMR spectroscopy is emerging from translational and preclinical neuroscience research as an important tool for evidence based diagnosis and therapy monitoring. It provides biomarkers that offer fingerprints of neurological disorders even in cases where a lesion is not yet observed in MR images. The collection of molecules used as cerebral biomarkers that are detectable by (1)H NMR spectroscopy define the so-called "neurochemical profile". The non-invasive quality of this technique makes it suitable not only for diagnostic purposes but also for therapy monitoring paralleling an eventual neuroprotection. The application of (1)H NMR spectroscopy in basic and translational neuroscience research is discussed here.

Publishing year

2012-06

Language

English

Pages

342-362

Publication/Series

NeuroImage

Volume

61

Issue

2

Document type

Journal article

Publisher

Elsevier

Keywords

  • Animals
  • Blood-Brain Barrier
  • Brain
  • Brain Chemistry
  • Brain Neoplasms
  • Cell Proliferation
  • Electromagnetic Fields
  • Humans
  • Magnetic Resonance Spectroscopy
  • Membrane Lipids
  • Nervous System Diseases
  • Neurotransmitter Agents
  • Species Specificity
  • Translational Medical Research
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

Status

Published

ISBN/ISSN/Other

  • ISSN: 1095-9572