The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

ludc web

Joao Duarte

Research team manager

ludc web

Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotocin-induced diabetic rats

Author

  • João M N Duarte
  • Célia Nogueira
  • Ken Mackie
  • Catarina R Oliveira
  • Rodrigo A Cunha
  • Attila Köfalvi

Summary, in English

In the hippocampus, impaired neurophysiology, compromised neurogenesis, and eventually apoptosis accompany cognitive deficits in insulinopenic (type-1) diabetes (T1D). The underlying pathological mechanisms remain to be defined. The hippocampus has a high density of the cannabinoid type 1 receptor (CB(1)R), which has been shown to control several brain functions affected by diabetes, such as synaptic plasticity, glucose utilisation, memory consolidation and cognition, and maturation and survival of hippocampal neurons. However, the role of this receptor has not been investigated yet in diabetic encephalopathy. We report now that in the streptozotocin animal model of T1D, the hippocampal densities of CB(1)R protein and of specific CB(1)R binding sites are significantly increased both in the nerve terminals and in total membranes (changes between 13% and 38%), whereas CB(1)R mRNA expression is decreased by 25%, suggesting that CB(1)Rs might play a role in diabetic encephalopathy.

Publishing year

2007-03

Language

English

Pages

479-484

Publication/Series

Experimental Neurology

Volume

204

Issue

1

Document type

Journal article

Publisher

Elsevier

Topic

  • Neurosciences
  • Endocrinology and Diabetes

Keywords

  • Animals
  • Binding Sites
  • Diabetes Mellitus, Experimental/metabolism
  • Hippocampus/metabolism
  • Male
  • Membranes/metabolism
  • Nerve Endings/metabolism
  • RNA, Messenger/metabolism
  • Rats
  • Rats, Wistar
  • Receptor, Cannabinoid, CB1/genetics

Status

Published

ISBN/ISSN/Other

  • ISSN: 0014-4886