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ludc web

Joao Duarte

Principal investigator

ludc web

Metabolic disturbances in diseases with neurological involvement

Author

  • João M N Duarte
  • Patrícia F Schuck
  • Gary L Wenk
  • Gustavo C Ferreira

Summary, in English

Degeneration of specific neuronal populations and progressive nervous system dysfunction characterize neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. These findings are also reported in inherited diseases such as phenylketonuria and glutaric aciduria type I. The involvement of mitochondrial dysfunction in these diseases was reported, elicited by genetic alterations, exogenous toxins or buildup of toxic metabolites. In this review we shall discuss some metabolic alterations related to the pathophysiology of diseases with neurological involvement and aging process. These findings may help identifying early disease biomarkers and lead to more effective therapies to improve the quality of life of the patients affected by these devastating illnesses.

Publishing year

2014-08

Language

English

Pages

55-238

Publication/Series

Aging and Disease

Volume

5

Issue

4

Document type

Journal article

Publisher

Buck Institute for Age Research

Keywords

  • Journal Article
  • Review

Status

Published

ISBN/ISSN/Other

  • ISSN: 2152-5250