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ludc web

Joao Duarte

Principal investigator

ludc web

Longitudinal neurochemical modifications in the aging mouse brain measured in vivo by 1H magnetic resonance spectroscopy

Author

  • João M N Duarte
  • Kim Q Do
  • Rolf Gruetter

Summary, in English

Alterations to brain homeostasis during development are reflected in the neurochemical profile determined noninvasively by (1)H magnetic resonance spectroscopy. We determined longitudinal biochemical modifications in the cortex, hippocampus, and striatum of C57BL/6 mice aged between 3 and 24 months . The regional neurochemical profile evolution indicated that aging induces general modifications of neurotransmission processes (reduced GABA and glutamate), primary energy metabolism (altered glucose, alanine, and lactate) and turnover of lipid membranes (modification of choline-containing compounds and phosphorylethanolamine), which are all probably involved in the frequently observed age-related cognitive decline. Interestingly, the neurochemical profile was different in male and female mice, particularly in the levels of taurine that may be under the control of estrogen receptors. These neurochemical profiles constitute the basal concentrations in cortex, hippocampus, and striatum of healthy aging male and female mice.

Publishing year

2014-07

Language

English

Pages

8-1660

Publication/Series

Neurobiology of Aging

Volume

35

Issue

7

Document type

Journal article

Publisher

Elsevier

Keywords

  • Aging
  • Alanine
  • Animals
  • Cerebral Cortex
  • Cognition
  • Corpus Striatum
  • Energy Metabolism
  • Ethanolamines
  • Female
  • Glucose
  • Glutamic Acid
  • Hippocampus
  • Hydrogen
  • Lactates
  • Magnetic Resonance Spectroscopy
  • Male
  • Membrane Lipids
  • Mice
  • Mice, Inbred C57BL
  • Receptors, Estrogen
  • Sex Characteristics
  • Synaptic Transmission
  • gamma-Aminobutyric Acid

Status

Published

ISBN/ISSN/Other

  • ISSN: 1558-1497