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Joana Dias

Joana Alves Dias

Assistant researcher

Joana Dias

Inflammatory potential of diet and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition

Author

  • Marta Solans
  • Yolanda Benavente
  • Marc Saez
  • Antonio Agudo
  • Paula Jakszyn
  • Sabine Naudin
  • Fatemeh Saberi Hosnijeh
  • Marc Gunter
  • Inge Huybrechts
  • Pietro Ferrari
  • Caroline Besson
  • Yahya Mahamat-Saleh
  • Marie Christine Boutron-Ruault
  • Tilman Kühn
  • Rudolf Kaaks
  • Heiner Boeing
  • Cristina Lasheras
  • Maria Jose Sánchez
  • Pilar Amiano
  • María Dolores Chirlaque
  • Eva Ardanaz
  • Julie A. Schmidt
  • Paolo Vineis
  • Elio Riboli
  • Antonia Trichopoulou
  • Anna Karakatsani
  • Elisavet Valanou
  • Giovanna Masala
  • Claudia Agnoli
  • Rosario Tumino
  • Carlotta Sacerdote
  • Amalia Mattiello
  • Guri Skeie
  • Elisabete Weiderpass
  • Mats Jerkeman
  • Joana Alves Dias
  • Florentin Späth
  • Lena Maria Nilsson
  • Christina C. Dahm
  • Kim Overvad
  • Kristina Elin Nielsen Petersen
  • Anne Tjønneland
  • Silvia de Sanjose
  • Roel Vermeulen
  • Alexandra Nieters
  • Delphine Casabonne

Summary, in English

Introduction: Chronic inflammation plays a critical role in lymphomagenesis and several dietary factors seem to be involved its regulation. The aim of the current study was to assess the association between the inflammatory potential of the diet and the risk of lymphoma and its subtypes in the European Investigation into Cancer and Nutrition (EPIC) study. Methods: The analysis included 476,160 subjects with an average follow-up of 13.9 years, during which 3,136 lymphomas (135 Hodgkin lymphoma (HL), 2606 non-Hodgkin lymphoma (NHL) and 395 NOS) were identified. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated using 28 dietary components and their corresponding inflammatory weights. The association between the ISD and lymphoma risk was estimated by hazard ratios (HR) and 95% confidence intervals (CI) calculated by multivariable Cox regression models adjusted for potential confounders. Results: The ISD was not associated with overall lymphoma risk. Among lymphoma subtypes, a positive association between the ISD and mature B-cell NHL (HR for a 1-SD increase: 1.07 (95% CI 1.01; 1.14), p trend = 0.03) was observed. No statistically significant association was found among other subtypes. However, albeit with smaller number of cases, a suggestive association was observed for HL (HR for a 1-SD increase = 1.22 (95% CI 0.94; 1.57), p trend 0.13). Conclusions: Our findings suggested that a high ISD score, reflecting a pro-inflammatory diet, was modestly positively associated with the risk of B-cell lymphoma subtypes. Further large prospective studies on low-grade inflammation induced by diet are warranted to confirm these findings.

Department/s

  • Nutrition Epidemiology
  • EpiHealth: Epidemiology for Health
  • LUCC - Lund University Cancer Centre

Publishing year

2020-03

Language

English

Pages

813-823

Publication/Series

European Journal of Nutrition

Volume

59

Issue

2

Document type

Journal article

Publisher

Springer

Topic

  • Nutrition and Dietetics
  • Cancer and Oncology

Keywords

  • Chronic inflammation
  • Inflammatory score of the diet
  • Lymphoma
  • Nutrition
  • Prospective studies

Status

Published

Research group

  • Nutrition Epidemiology

ISBN/ISSN/Other

  • ISSN: 1436-6207