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Jens Lagerstedt

Associate professor

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Single injections of apoA-I acutely improve in vivo glucose tolerance in insulin-resistant mice.

Author

  • Karin Stenkula
  • Maria Lindahl
  • Jitka Petrlova
  • Jonathan Dalla-Riva
  • Olga Göransson
  • Sam Cushman
  • Ewa Krupinska
  • Helena Jones
  • Jens Lagerstedt

Summary, in English

Apolipoprotein A-I (apoA-I), the main protein constituent of HDL, has a central role in the reverse cholesterol-transport pathway, which together with the anti-inflammatory properties of apoA-I/HDL provide cardioprotection. Recent findings of direct stimulation of glucose uptake in muscle by apoA-I/HDL suggest that altered apoA-I and HDL functionality may be a contributing factor to the development of diabetes. We have studied the in vivo effects of short treatments with human apoA-I in a high-fat diet fed mouse model. In addition to native apoA-I, we investigated the effects of the cardioprotective Milano variant (Arg173Cys).

Department/s

  • EXODIAB: Excellence in Diabetes Research in Sweden
  • Medical Protein Science
  • Department of Experimental Medical Science
  • Genomics, Diabetes and Endocrinology
  • Molecular Endocrinology

Publishing year

2014

Language

English

Pages

797-800

Publication/Series

Diabetologia

Volume

57

Issue

4

Document type

Journal article

Publisher

Springer

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Medical Protein Science
  • Genomics, Diabetes and Endocrinology
  • Molecular Endocrinology

ISBN/ISSN/Other

  • ISSN: 1432-0428