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Jens Lagerstedt

Associate professor

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Superantigen activates the gp130 receptor on adipocytes resulting in altered adipocyte metabolism.

Author

  • Elin Banke
  • Karin Rödström
  • Mikael Ekelund
  • Jonathan Dalla-Riva
  • Jens Lagerstedt
  • Staffan Nilsson
  • Eva Degerman
  • Karin Lindkvist
  • Bo Nilson

Summary, in English

The bacteria Staphylococcus aureus is part of the normal bacterial flora and produces a repertoire of enterotoxins which can cause food poisoning and toxic shock and might contribute to the pathogenesis of inflammatory diseases. These enterotoxins directly cross-link the T cell receptor with MHC class II, activating large amounts of T cells and are therefore called superantigens. It was recently discovered that the superantigen SEA binds to the cytokine receptor gp130. As obesity and type 2 diabetes are highly associated with inflammation of the adipose tissue and gp130 has been shown to play an important role in adipocytes, we wanted to investigate the effect of SEA on adipocyte signaling and function.

Department/s

  • Insulin Signal Transduction
  • Medical Structural Biology
  • Surgery (Lund)
  • Medical Protein Science
  • Division of Medical Microbiology
  • EXODIAB: Excellence in Diabetes Research in Sweden

Publishing year

2014

Language

English

Pages

831-840

Publication/Series

Metabolism, Clinical and Experimental

Volume

63

Issue

6

Document type

Journal article

Publisher

Elsevier

Topic

  • Cell and Molecular Biology

Status

Published

Research group

  • Insulin Signal Transduction
  • Medical Structural Biology
  • Medical Protein Science

ISBN/ISSN/Other

  • ISSN: 1532-8600