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Jan Nilsson

Professor

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High disaccharide intake associates with atherogenic lipoprotein profile.

Author

  • Emily Sonestedt
  • Elisabet Wirfält
  • Peter Wallström
  • Bo Gullberg
  • Isabel Drake
  • Joanna Hlebowicz
  • Gunilla Nordin Fredrikson
  • Bo Hedblad
  • Jan Nilsson
  • Ronald M Krauss
  • Marju Orho-Melander

Summary, in English

Increased plasma concentrations of small LDL particles denote an atherogenic lipoprotein phenotype (ALP) that is correlated with increased circulating TAG and reduced HDL-cholesterol. Principal component analyses of subfraction concentrations have previously been used in the Swedish population-based Malmö Diet and Cancer (MDC) cohort to identify three independent components, one pattern representing the ALP. The aim of the present study was to examine the associations between macronutrient intakes and the principal component representing the ALP. We examined 4301 healthy subjects (46-68 years old, 60 % women) at baseline in the MDC cohort. Dietary data were collected using a modified diet history method. Plasma lipoprotein subfractions were measured using a high-resolution ion mobility method. The principal component corresponding to the ALP was significantly associated with a higher intake of disaccharides, and inversely related to protein and alcohol consumption (P < 0·001 for all). The present findings indicate that the ALP may be improved by a low intake of disaccharides, and moderate intakes of protein and alcohol.

Department/s

  • Nutrition Epidemiology
  • Diabetes - Cardiovascular Disease
  • Cardiovascular Research - Immunity and Atherosclerosis
  • Cardiovascular Research - Epidemiology
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2012

Language

English

Pages

1062-1069

Publication/Series

British Journal of Nutrition

Volume

107

Document type

Journal article

Publisher

Cambridge University Press

Topic

  • Nutrition and Dietetics

Status

Published

Research group

  • Nutrition Epidemiology
  • Diabetes - Cardiovascular Disease
  • Cardiovascular Research - Immunity and Atherosclerosis
  • Cardiovascular Research - Epidemiology

ISBN/ISSN/Other

  • ISSN: 1475-2662