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Jan Nilsson

Professor

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Chronic Inflammation and Atherosclerosis

Author

  • Jan Nilsson
  • Isabel Gonçalves
  • Andreas Edsfeldt

Editor

  • Peter M. Nilsson
  • Michael H. Olsen
  • Stéphane Laurent

Summary, in English

Inflammation is a vital response and necessary for maintaining homeostasis. Inflammation protects against tissue damage and pathogens-but is also one of the main driving forces of the atherosclerotic plaque progression. How and why the inflammatory response is initiated in the atherosclerotic disease is not fully known, but evidence suggests modified lipids as potential antigens activating the immune response, according to the response-to-retention theory. The inflammatory response is an intricate interplay between the innate and adaptive immune system, tightly regulated by pro-inflammatory and anti-inflammatory mechanisms. Besides its role in the formation of the atherosclerotic plaque many studies also point toward inflammation as a driving force of plaque vulnerability and eventually plaque rupture.

Department/s

  • Cardiovascular Research - Immunity and Atherosclerosis
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2015-01-01

Language

English

Pages

157-167

Publication/Series

Early Vascular Aging (EVA) : New Directions in Cardiovascular Protection

Document type

Book chapter

Publisher

Elsevier Science Publishers B.V.

Topic

  • Immunology in the medical area

Keywords

  • B-cell
  • Cytokine
  • Inflammation
  • Macrophage
  • Risk factor
  • T-cell

Status

Published

Research group

  • Cardiovascular Research - Immunity and Atherosclerosis

ISBN/ISSN/Other

  • ISBN: 9780128016763
  • ISBN: 9780128013878