
Jan Nilsson
Professor

Inflammation and cholesterol
Author
Summary, in English
Atherosclerosis develops as a result of a chronic arterial inflammation and intimal Fibrosis. The disease represents in many respects a vascular repair process activated in response to injury caused by toxic breakdown products of aggregated and oxidized lipoproteins. The initial response of the artery involves expression of adhesion molecules and recruitment of leukocytes. Degenerated lipoproteins are removed front the extracellular space by macrophages. If lipoproteins continue to I process becomes chronic and accumulate. the inflammatory cytokines stimulate smooth muscle to migrate into the intima. These cells proliferate and form an atherosclerotic plaque. Plaque cell death and inflammation in response to oxidized lipids and other toxic factors May Cause plaques to rupture.
Department/s
- Cardiovascular Research - Immunity and Atherosclerosis
- Stem Cell Center
Publishing year
2002
Language
English
Pages
18-25
Publication/Series
European Heart Journal Supplements
Volume
4
Issue
Suppl A
Links
Document type
Journal article
Publisher
Oxford University Press
Topic
- Cardiac and Cardiovascular Systems
Keywords
- lipoproteins
- atherosclerosis
- macrophages
- immunity
- smooth muscle
- cells
Status
Published
Research group
- Cardiovascular Research - Immunity and Atherosclerosis
ISBN/ISSN/Other
- ISSN: 1520-765X