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Use of Vascular Assessments and Novel Biomarkers to Predict Cardiovascular Events in Type 2 Diabetes : The SUMMIT VIP Study

  • Angela C Shore
  • Helen M Colhoun
  • Andrea Natali
  • Carlo Palombo
  • Faisel Khan
  • Gerd Östling
  • Kunihiko Aizawa
  • Cecilia Kennbäck
  • Francesco Casanova
  • Margaretha Persson
  • Kim Gooding
  • Phillip E Gates
  • Helen Looker
  • Fiona Dove
  • Jill Belch
  • Silvia Pinnola
  • Elena Venturi
  • Michaela Kozakova
  • Isabel Goncalves
  • Jasmina Kravic
  • Harry Björkbacka
  • Jan Nilsson
Publishing year: 2018-10
Language: English
Pages: 2212-2219
Publication/Series: Diabetes Care
Volume: 41
Issue: 10
Document type: Journal article
Publisher: American Diabetes Association

Abstract english

OBJECTIVE: Cardiovascular disease (CVD) risk prediction represents an increasing clinical challenge in the treatment of diabetes. We used a panel of vascular imaging, functional assessments, and biomarkers reflecting different disease mechanisms to identify clinically useful markers of risk for cardiovascular (CV) events in subjects with type 2 diabetes (T2D) with or without manifest CVD.

RESEARCH DESIGN AND METHODS: The study cohort consisted of 936 subjects with T2D recruited at four European centers. Carotid intima-media thickness and plaque area, ankle-brachial pressure index, arterial stiffness, endothelial function, and circulating biomarkers were analyzed at baseline, and CV events were monitored during a 3-year follow-up period.

RESULTS: The CV event rate in subjects with T2D was higher in those with (n = 440) than in those without (n = 496) manifest CVD at baseline (5.53 vs. 2.15/100 life-years, P < 0.0001). New CV events in subjects with T2D with manifest CVD were associated with higher baseline levels of inflammatory biomarkers (interleukin 6, chemokine ligand 3, pentraxin 3, and hs-CRP) and endothelial mitogens (hepatocyte growth factor and vascular endothelial growth factor A), whereas CV events in subjects with T2D without manifest CVD were associated with more severe baseline atherosclerosis (median carotid plaque area 30.4 mm2 [16.1-92.2] vs. 19.5 mm2 [9.5-40.5], P = 0.01). Conventional risk factors, as well as measurements of arterial stiffness and endothelial reactivity, were not associated with CV events.

CONCLUSIONS: Our observations demonstrate that markers of inflammation and endothelial stress reflect CV risk in subjects with T2D with manifest CVD, whereas the risk for CV events in subjects with T2D without manifest CVD is primarily related to the severity of atherosclerosis.


  • Cardiac and Cardiovascular Systems
  • Endocrinology and Diabetes


  • Internal Medicine - Epidemiology
  • Cardiovascular Research - Translational Studies
  • Cardiovascular Research - Immunity and Atherosclerosis
  • Diabetic Complications
  • Genomics, Diabetes and Endocrinology
  • Cardiovascular Research - Cellular Metabolism and Inflammation
  • ISSN: 1935-5548
E-mail: jan [dot] nilsson [at] med [dot] lu [dot] se

Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00