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Jan Nilsson

Professor

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Plasma autoantibodies against apolipoprotein B-100 peptide 210 in subclinical atherosclerosis.

Author

  • Olga McLeod
  • Angela Silveira
  • Gunilla Nordin Fredrikson
  • Karl Gertow
  • Damiano Baldassarre
  • Fabrizio Veglia
  • Bengt Sennblad
  • Rona J Strawbridge
  • Malin Larsson
  • Karin Leander
  • Bruna Gigante
  • Jussi Kauhanen
  • Rainer Rauramaa
  • Andries J Smit
  • Elmo Mannarino
  • Philippe Giral
  • Steve E Humphries
  • Elena Tremoli
  • Ulf de Faire
  • John Ohrvik
  • Jan Nilsson
  • Anders Hamsten

Summary, in English

Experimental studies have suggested that autoimmunity is involved in atherosclerosis and provided evidence that both protective and pro-atherogenic immune responses exist. This concept has received support from small clinical studies implicating autoantibodies directed against apolipoprotein B-100 (apoB-100) in human atherosclerosis. We examined circulating autoantibodies directed against native and malondialdehyde (MDA)-modified epitope p210 of apoB-100 (IgG-p210nat and IgM-p210MDA) in relation to early atherosclerosis in a large, European longitudinal cohort study of healthy high-risk individuals.

Department/s

  • Cardiovascular Research - Immunity and Atherosclerosis
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2014

Language

English

Pages

242-248

Publication/Series

Atherosclerosis

Volume

232

Issue

1

Document type

Journal article

Publisher

Elsevier

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Cardiovascular Research - Immunity and Atherosclerosis

ISBN/ISSN/Other

  • ISSN: 1879-1484