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Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes.

  • Isabel Goncalves
  • Eva Bengtsson
  • Helen M Colhoun
  • Angela C Shore
  • Carlo Palombo
  • Andrea Natali
  • Andreas Edsfeldt
  • Pontus Dunér
  • Gunilla Nordin Fredrikson
  • Harry Björkbacka
  • Gerd Östling
  • Kunihiko Aizawa
  • Francesco Casanova
  • Margaretha Persson
  • Kim Gooding
  • David Strain
  • Faisel Kahn
  • Helen C Looker
  • Fiona Adams
  • Jill Belch
  • Silvia Pinnoli
  • Elena Venturi
  • Michaela Kozakova
  • Li-Ming Gan
  • Volker Schnecke
  • Jan Nilsson
Publishing year: 2015
Language: English
Pages: 1723-1731
Publication/Series: Arteriosclerosis, Thrombosis and Vascular Biology
Volume: 35
Issue: 7
Document type: Journal article
Publisher: Lippincott Williams Wilkins Hagerstown, MD

Abstract english

Matrix metalloproteinases (MMPs) degrade extracellular matrix proteins and play important roles in development and tissue repair. They have also been shown to have both protective and pathogenic effects in atherosclerosis, and experimental studies have suggested that MMP-12 contributes to plaque growth and destabilization. The objective of this study was to investigate the associations between circulating MMPs, atherosclerosis burden, and incidence of cardiovascular disease with a particular focus on type 2 diabetes mellitus.


  • Cardiac and Cardiovascular Systems


  • Cardiovascular Research - Immunity and Atherosclerosis
  • Cardiovascular Research - Matrix and Inflammation in Atherosclerosis
  • Internal Medicine - Epidemiology
  • ISSN: 1524-4636
E-mail: jan [dot] nilsson [at] med [dot] lu [dot] se

Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00