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Exploiting the vascular protective effects of high-density lipoprotein and its apolipoproteins - An idea whose time for testing is coming, Part II

Author:
  • Prediman K. Shah
  • Sanjay Kaul
  • Jan Nilsson
  • Bojan Cercek
Publishing year: 2001
Language: English
Pages: 2498-2502
Publication/Series: Circulation
Volume: 104
Issue: 20
Document type: Journal article
Publisher: Lippincott Williams and Wilkins

Abstract english

Despite the benefits of currently available preventative and therapeutic interventions, atherosclerotic vascular disease continues to be a major cause of morbidity and mortality in much of the Western World. This emphasize,,, the need for additional preventive and therapeutic interventions exploiting new targets to compliment and augment the results of LDL lowering and other current strategies. One such potential target is HDL and its apolipoproteins, A large body of experimental evidence suggests that augmenting the levels and/or function of HDL and its apolipoproteins can have major vascular protective effects ranging from prevention to stabilization and regression, independent of total or non-HDL cholesterol levels. Therefore, we think that the time is ripe for the development and clinical testing of this new frontier in antiatherogenic strategy. In the present article, We will review the structure/function of HDL and explore means of enhancing the levels and/or function of HDL and its apolipoproteins for vascular protection.

Keywords

  • Cardiac and Cardiovascular Systems
  • apolipoproteins
  • lipoproteins
  • atherosclerosis

Other

Published
  • Cardiovascular Research - Immunity and Athersosclerosis
  • ISSN: 1524-4539
E-mail: jan [dot] nilsson [at] med [dot] lu [dot] se

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