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Plasma variation and reproducibility of oxidized LDL-cholesterol and low-grade inflammation biomarkers among participants of the Malmö Diet and Cancer cohort

  • Joana Alves Dias
  • Sophie Hellstrand
  • Ulrika Ericson
  • B. Gullberg
  • Jan Nilsson
  • Ragnar Alm
  • Margaretha Persson
  • Gunnar Engström
  • Gunilla Nordin Fredrikson
  • B. Hedblad
  • Elisabet Wirfält
Publishing year: 2016-08-17
Language: English
Pages: 562-571
Publication/Series: Biomarkers
Volume: 21
Issue: 6
Document type: Journal article
Publisher: Taylor & Francis

Abstract english

Context: Large epidemiological studies often collect non-fasting samples, although the reliability of biomarkers may be uncertain. Objective: To explore the reliability and reproducibility of a single measurement of selected biomarkers in a sub-sample of the Malmö Diet and Cancer cohort. Methods: We estimated single- and average-measures intraclass correlation coefficients (ICC) for oxidized (ox)-LDL, interleukin (IL)-1β, IL-6, IL-8 and TNF-α. Results: Single-measures ICC in non-fasting samples of ox-LDL, IL-1β, IL-6, IL-8 and TNF-α were the following: 0.85, 0.71, 0.61, 0.78 and 0.66 for men, and 0.67, 0.81, 0.87, 0.69 and 0.81 for women. Biomarkers at non-fasting and fasting samples were highly correlated (all r > 0.80). Conclusions: The observed ICC suggest that most of the examined biomarkers (non-fasting blood) would allow meaningful analysis in epidemiological studies.


  • Nutrition and Dietetics
  • Biomarkers of inflammation
  • cytokines
  • epidemiology
  • ICC
  • variation


  • Nutrition Epidemiology
  • Diabetes - Cardiovascular Disease
  • Cardiovascular Research - Immunity and Athersosclerosis
  • Internal Medicine - Epidemiology
  • Cardiovascular Research - Epidemiology
  • ISSN: 1354-750X
E-mail: jan [dot] nilsson [at] med [dot] lu [dot] se

Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00