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Immunomodulation of Atherosclerosis. Implications for Vaccine Development.

Author:
  • Jan Nilsson
  • Göran K Hansson
  • Prediman K Shah
Publishing year: 2005
Language: English
Pages: 18-28
Publication/Series: Arteriosclerosis, Thrombosis and Vascular Biology
Volume: 25
Issue: 1
Document type: Journal article review
Publisher: Lippincott Williams Wilkins Hagerstown, MD

Abstract english

A number of studies have shown activation of the immune system throughout various stages of atherosclerosis. Recent observations have suggested that activation of immune responses may promote atherosclerosis on one hand by inducing and perpetuating arterial inflammation, whereas on the other hand, selective activation of certain immune functions may inhibit atherosclerosis and arterial inflammation. These observations suggest the possibility that selective suppression of proatherogenic immune responses or selective activation of antiatherogenic immune responses may provide new approaches for atherosclerosis prevention and treatment. Several antigens activating immune responses affecting development of atherosclerosis have been identified. These immune responses may be modulated by presenting the antigens together with different types of adjuvants as well as through the route of administration. In this review, we summarize recent experimental studies using immunomodulatory approaches for treatment of atherosclerosis.

Keywords

  • Cardiac and Cardiovascular Systems
  • heat shock proteins
  • immunity
  • atherosclerosis
  • vaccine
  • lipoproteins

Other

Published
  • Cardiovascular Research - Immunity and Atherosclerosis
  • ISSN: 1524-4636
E-mail: jan [dot] nilsson [at] med [dot] lu [dot] se

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