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Inhibition of nuclear factor of activated T-cells (NFAT) suppresses accelerated atherosclerosis in diabetic mice.

Author:
  • Anna Zetterqvist
  • Lisa Berglund
  • Fabiana Blanco
  • Eliana Garcia Vaz
  • Maria Wigren
  • Pontus Dunér
  • Anna-Maria Dutius Andersson
  • Fong To
  • Peter Spégel
  • Jan Nilsson
  • Eva Bengtsson
  • Maria Gomez
Publishing year: 2013
Language: English
Publication/Series: PLoS ONE
Volume: 8
Issue: 6
Document type: Journal article
Publisher: Public Library of Science

Abstract english

Diabetic patients have a much more widespread and aggressive form of atherosclerosis and therefore, higher risk for myocardial infarction, peripheral vascular disease and stroke, but the molecular mechanisms leading to accelerated damage are still unclear. Recently, we showed that hyperglycemia activates the transcription factor NFAT in the arterial wall, inducing the expression of the pro-atherosclerotic protein osteopontin. Here we investigate whether NFAT activation may be a link between diabetes and atherogenesis.

Keywords

  • Cardiac and Cardiovascular Systems
  • Clinical Medicine
  • Endocrinology and Diabetes

Other

Published
  • Cardiovascular Research - Immunity and Atherosclerosis
  • Diabetic Complications
  • Diabetes - Molecular Metabolism
  • ISSN: 1932-6203
E-mail: jan [dot] nilsson [at] med [dot] lu [dot] se

Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00