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Jan Nilsson

Professor

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IL-22 affects smooth muscle cell phenotype and plaque formation in apolipoprotein E knockout mice.

Author

  • Sara Rattik
  • Karin Hultman
  • Uwe Rauch
  • Ingrid Söderberg
  • Lena Sundius
  • Irena Ljungcrantz
  • Anna Hultgårdh
  • Maria Wigren
  • Harry Björkbacka
  • Gunilla Nordin Fredrikson
  • Jan Nilsson
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Summary, in English

IL-22 is a recently discovered cytokine that belongs to the family of IL-10 related cytokines. It is produced by activated T-cells and innate lymphoid cells and has been suggested to be involved in tissue repair. As both inflammation and repair play important roles in atherosclerosis we investigated if IL-22 deficiency influences the disease process in Apoe(-/-) mice.

Department/s

  • Cardiovascular Research - Immunity and Atherosclerosis
  • Vessel Wall Biology
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2015

Language

English

Pages

506-514

Publication/Series

Atherosclerosis

Volume

242

Issue

2

Document type

Journal article

Publisher

Elsevier

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Cardiovascular Research - Immunity and Atherosclerosis
  • Vessel Wall Biology

ISBN/ISSN/Other

  • ISSN: 1879-1484