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IL-22 affects smooth muscle cell phenotype and plaque formation in apolipoprotein E knockout mice.

  • Sara Rattik
  • Karin Hultman
  • Uwe Rauch
  • Ingrid Söderberg
  • Lena Sundius
  • Irena Ljungcrantz
  • Anna Hultgårdh
  • Maria Wigren
  • Harry Björkbacka
  • Gunilla Nordin Fredrikson
  • Jan Nilsson
Publishing year: 2015
Language: English
Pages: 506-514
Publication/Series: Atherosclerosis
Volume: 242
Issue: 2
Document type: Journal article
Publisher: Elsevier

Abstract english

IL-22 is a recently discovered cytokine that belongs to the family of IL-10 related cytokines. It is produced by activated T-cells and innate lymphoid cells and has been suggested to be involved in tissue repair. As both inflammation and repair play important roles in atherosclerosis we investigated if IL-22 deficiency influences the disease process in Apoe(-/-) mice.


  • Cardiac and Cardiovascular Systems


  • Cardiovascular Research - Immunity and Atherosclerosis
  • Vessel Wall Biology
  • ISSN: 1879-1484
E-mail: jan [dot] nilsson [at] med [dot] lu [dot] se

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