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Development and validation of a path length calculation for carotid-femoral pulse wave velocity measurement : A TASCFORCE, SUMMIT, and caerphilly collaborative venture

  • Jonathan R. Weir-McCall
  • Liam Brown
  • Jennifer Summersgill
  • Piotr Talarczyk
  • Michael Bonnici-Mallia
  • Sook C. Chin
  • Faisel Khan
  • Allan D. Struthers
  • Frank Sullivan
  • Helen M. Colhoun
  • Angela C. Shore
  • Kunihiko Aizawa
  • Leif Groop
  • Jan Nilsson
  • John R. Cockcroft
  • Carmel M. McEniery
  • Ian B. Wilkinson
  • Yoav Ben-Shlomo
  • J. Graeme Houston
Publishing year: 2018
Language: English
Pages: 937-945
Publication/Series: Hypertension
Volume: 71
Issue: 5
Document type: Journal article
Publisher: Lippincott Williams & Wilkins

Abstract english

Current distance measurement techniques for pulse wave velocity (PWV) calculation are susceptible to intercenter variability. The aim of this study was to derive and validate a formula for this distance measurement. Based on carotid femoral distance in 1183 whole-body magnetic resonance angiograms, a formula was derived for calculating distance. This was compared with distance measurements in 128 whole-body magnetic resonance angiograms from a second study. The effects of recalculation of PWV using the new formula on association with risk factors, disease discrimination, and prediction of major adverse cardiovascular events were examined within 1242 participants from the multicenter SUMMIT study (Surrogate Markers of Micro- and Macrovascular Hard End-Points for Innovative Diabetes Tools) and 825 participants from the Caerphilly Prospective Study. The distance formula yielded a mean error of 7.8 mm (limits of agreement =-41.1 to 56.7 mm; P<0.001) compared with the second whole-body magnetic resonance angiogram group. Compared with an external distance measurement, the distance formula did not change associations between PWV and age, blood pressure, or creatinine (P<0.01) but did remove significant associations between PWV and body mass index (BMI). After accounting for differences in age, sex, and mean arterial pressure, intercenter differences in PWV persisted using the external distance measurement (F=4.6; P=0.004), whereas there was a loss of between center difference using the distance formula (F=1.4; P=0.24). PWV odds ratios for cardiovascular mortality remained the same using both the external distance measurement (1.14; 95% confidence interval, 1.06-1.24; P=0.001) and the distance formula (1.17; 95% confidence interval, 1.08-1.28; P<0.001). A population-derived automatic distance calculation for PWV obtained from routinely collected clinical information is accurate and removes intercenter measurement variability without impacting the diagnostic utility of carotid-femoral PWV.


  • Cardiac and Cardiovascular Systems
  • arteriosclerosis
  • atherosclerosis
  • cardiovascular diseases
  • hypertension
  • magnetic resonance angiography
  • pulse wave analysis


  • Genomics, Diabetes and Endocrinology
  • Cardiovascular Research - Immunity and Atherosclerosis
  • ISSN: 0194-911X
E-mail: jan [dot] nilsson [at] med [dot] lu [dot] se

Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00