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Associations of Interleukin-5 With Plaque Development and Cardiovascular Events

  • Anki Knutsson
  • Harry Björkbacka
  • Pontus Dunér
  • Gunnar Engström
  • Christoph J. Binder
  • Anna Hultgårdh Nilsson
  • Jan Nilsson
Publishing year: 2019
Language: English
Pages: 891-902
Publication/Series: JACC: Basic to Translational Science
Volume: 4
Issue: 8
Document type: Journal article
Publisher: Elsevier Inc.

Abstract english

Experimental studies have suggested an atheroprotective role of interleukin (IL)-5 through the stimulation of natural immunoglobulin M antibody expression. In the present study we show that there are no associations between baseline levels of IL-5 and risk for development of coronary events or stroke during a 15.7 ± 6.3 years follow-up of 696 subjects randomly sampled from the Malmö Diet and Cancer study. However, presence of a plaque at the carotid bifurcation was associated with lower IL-5 and IL-5 deficiency resulted in increased plaque development at sites of oscillatory blood flow in Apoe−/− mice suggesting a protective role for IL-5 in plaque development.


  • Cardiac and Cardiovascular Systems
  • atherosclerosis
  • interleukin 5
  • myocardial infarction
  • stroke


  • Vessel Wall Biology
  • Cardiovascular Research - Cellular Metabolism and Inflammation
  • Cardiovascular Research - Matrix and Inflammation in Atherosclerosis
  • Cardiovascular Research - Epidemiology
  • Cardiovascular Research - Immunity and Atherosclerosis
  • ISSN: 2452-302X
E-mail: jan [dot] nilsson [at] med [dot] lu [dot] se

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