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Jan Nilsson

Professor

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Interleukin-25 (IL-25) has a protective role in atherosclerosis development in the aortic arch in mice

Author

  • Polyxeni T. Mantani
  • Pontus Dunér
  • Eva Bengtsson
  • Irena Ljungcrantz
  • Lena Sundius
  • Fong To
  • Jan Nilsson
  • Harry Björkbacka
  • Gunilla Nordin Fredrikson

Summary, in English

Atherosclerosis is a chronic inflammatory disease characterized by the entrapment of apolipoprotein B– containing lipoproteins in the arterial intima, leading to local inflammation. T helper (Th) cell 1–mediated immune responses have been associated with atherosclerosis, and the cytokine interleukin-25 (IL-25 or IL-17E) has been reported to potentially regulate Th1 cell– and Th17 cell–related immune responses. In this study, we evaluated the effects of complete IL-25 deficiency or of a temporal IL-25 blockade on atherosclerosis development in apolipoprotein E– deficient (Apoe/) mice. Mice deficient in both apolipoprotein E and IL-25 (Apoe//IL-25/) had more Th1 cells in the spleen, along with elevated plasma levels of IL-17 and an increased release of splenic interferon- (INF-). In support of this observation, a 4-week-long treatment of young Apoe/ mice (at 10 –14 weeks of age) with an IL-25– blocking antibody increased the release of Th1/Th17-associated cytokines in the spleen. In both mouse models, these findings were associated with increased atherosclerotic plaque formation in the aortic arch. We conclude that complete IL-25 deficiency and a temporal IL-25 blockade during early plaque development aggravate atherosclerosis development in the aortic arch of Apoe/ mice, accompanied by an increase in Th1/Th17-mediated immune responses. Our finding that endogenous IL-25 has an atheroprotective role in the murine aortic arch has potential implications for atherosclerosis development and management in humans.

Department/s

  • EpiHealth: Epidemiology for Health

Publishing year

2018-01-01

Language

English

Pages

6791-6801

Publication/Series

Journal of Biological Chemistry

Volume

293

Issue

18

Document type

Journal article

Publisher

ASBMB

Topic

  • Immunology in the medical area
  • Cardiac and Cardiovascular Systems

Status

Published

ISBN/ISSN/Other

  • ISSN: 0021-9258