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Jan Nilsson

Professor

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The associations of self-rated health with cardiovascular risk proteins : A proteomics approach

Author

  • Xue Bao
  • Yan Borné
  • Songjiang Yin
  • Kaijun Niu
  • Marju Orho-Melander
  • Jan Nilsson
  • Olle Melander
  • Gunnar Engström

Summary, in English

Background: Though subjective, poor self-rated health (SRH) has consistently been shown to predict cardiovascular disease (CVD). The underlying mechanism is unclear. This study evaluates the associations of SRH with biomarkers for CVD, aiming to explore potential pathways between poor SRH and CVD.

Methods: Based on the Malmö Diet and Cancer Cardiovascular Cohort study, a targeted proteomics approach was used to assess the associations of SRH with 88 cardiovascular risk proteins, measured in plasma from 4521 participants without CVD. The false discovery rate (FDR) was controlled using the Benjamini and Hochberg method. Covariates taken into consideration were age, sex, traditional CVD risk factors (low-density lipoprotein cholesterol, systolic blood pressure, anti-hypertensive medication, diabetes, body mass index, smoking), comorbidity, life-style and psycho-social factors (education level, living alone, alcohol consumption, low physical activity, psychiatric medication, sleep duration, and unemployment).

Results: Age and sex-adjusted associations with SRH was found for 34 plasma proteins. Nine of them remained significant after adjustments for traditional CVD risk factors. After further adjustment for comorbidity, life-style and psycho-social factors, only leptin (β = - 0.035, corrected p = 0.016) and C-C motif chemokine 20 (CCL20; β = - 0.054, corrected p = 0.016) were significantly associated with SRH.

Conclusions: Poor SRH was associated with raised concentrations of many plasma proteins. However, the relationships were largely attenuated by adjustments for CVD risk factors, comorbidity and psycho-social factors. Leptin and CCL20 were associated with poor SRH in the present study and could potentially be involved in the SRH-CVD link.

Department/s

  • Cardiovascular Research - Epidemiology
  • EpiHealth: Epidemiology for Health
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • Genomics, Diabetes and Endocrinology
  • Diabetes - Cardiovascular Disease
  • Cardiovascular Research - Immunity and Atherosclerosis
  • Cardiovascular Research - Hypertension

Publishing year

2019-11-18

Language

English

Publication/Series

Clinical Proteomics

Volume

16

Document type

Journal article

Publisher

Humana Press

Topic

  • Public Health, Global Health, Social Medicine and Epidemiology

Keywords

  • C-C motif chemokine 20
  • Leptin
  • Proteomic
  • Self-rated health

Status

Published

Research group

  • Cardiovascular Research - Epidemiology
  • Genomics, Diabetes and Endocrinology
  • Diabetes - Cardiovascular Disease
  • Cardiovascular Research - Immunity and Atherosclerosis
  • Cardiovascular Research - Hypertension

ISBN/ISSN/Other

  • ISSN: 1542-6416