The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here:

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Default user image.

Jan Nilsson


Default user image.

Detecting the vulnerable carotid plaque : The Carotid Artery Multimodality imaging Prognostic study design


  • Luna Gargani
  • Matteo Baldini
  • Raffaella Berchiolli
  • Ida Rebecca Bort
  • Giancarlo Casolo
  • Dante Chiappino
  • Mirco Cosottini
  • Gennaro D'Angelo
  • Mariella De Santis
  • Paola Erba
  • Iacopo Fabiani
  • Plinio Fabiani
  • Ilaria Gabbriellini
  • Gian Giacomo Galeotti
  • Irene Ghicopulos
  • Isabel Goncalves
  • Simone Lapi
  • Gabriele Masini
  • Carmela Morizzo
  • Vinicio Napoli
  • Jan Nilsson
  • Giovanni Orlandi
  • Carlo Palombo
  • Francesco Pieraccini
  • Stefano Ricci
  • Gabriele Siciliano
  • Riemer H.J.A. Slart
  • Raffaele De Caterina

Summary, in English

BackgroundCarotid artery disease is highly prevalent and a main cause of ischemic stroke and vascular dementia. There is a paucity of information on predictors of serious vascular events. Besides percentage diameter stenosis, international guidelines also recommend the evaluation of qualitative characteristics of carotid artery disease as a guide to treatment, but with no agreement on which qualitative features to assess. This inadequate knowledge leads to a poor ability to identify patients at risk, dispersion of medical resources, and unproven use of expensive and resource-consuming techniques, such as magnetic resonance imaging, positron emission tomography, and computed tomography.ObjectivesThe Carotid Artery Multimodality imaging Prognostic (CAMP) study will: prospectively determine the best predictors of silent and overt ischemic stroke and vascular dementia in patients with asymptomatic subcritical carotid artery disease by identifying the noninvasive diagnostic features of the 'vulnerable carotid plaque'; assess whether 'smart' use of low-cost diagnostic methods such as ultrasound-based evaluations may yield at least the same level of prospective information as more expensive techniques.Study designWe will compare the prognostic/predictive value of all proposed techniques with regard to silent or clinically manifest ischemic stroke and vascular dementia. The study will include ≥300 patients with asymptomatic, unilateral, intermediate degree (40-60% diameter) common or internal carotid artery stenosis detected at carotid ultrasound, with a 2-year follow-up. The study design has been registered on on December 17, 2020 (ID number NCT04679727).


  • EpiHealth: Epidemiology for Health
  • Cardiovascular Research - Translational Studies
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • Cardiovascular Research - Immunity and Atherosclerosis

Publishing year







Journal of Cardiovascular Medicine





Document type

Journal article


Lippincott Williams & Wilkins


  • Cardiac and Cardiovascular Systems


  • atherosclerosis
  • carotid artery disease
  • carotid artery plaque
  • carotid ultrasound
  • magnetic resonance imaging
  • stroke
  • vascular dementia
  • vascular imaging



Research group

  • Cardiovascular Research - Translational Studies
  • Cardiovascular Research - Immunity and Atherosclerosis


  • ISSN: 1558-2027