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Jan Nilsson

Professor

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Induction of T helper 2 responses against human Apolipoprotein B100 does not affect atherosclerosis in ApoE-/- mice.

Author

  • Daniel Engelbertsen
  • Sara Rattik
  • Anki Knutsson
  • Harry Björkbacka
  • Eva Bengtsson
  • Jan Nilsson

Summary, in English

Immune responses against LDL antigens have been found to play an important modulatory role in atherosclerosis. Immunization with homologous oxidized LDL, as well as human apolipoprotein B100 (ApoB)-derived peptides, inhibit atherosclerosis in hypercholesterolemic animal models of atherosclerosis. However, the role of antigen-specific Th2 responses in atherosclerosis remains to be fully clarified.

Department/s

  • Cardiovascular Research - Immunity and Atherosclerosis
  • Vessel Wall Biology
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2014-05-27

Language

English

Publication/Series

Cardiovascular Research

Document type

Journal article

Publisher

Oxford University Press

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Cardiovascular Research - Immunity and Atherosclerosis
  • Vessel Wall Biology

ISBN/ISSN/Other

  • ISSN: 1755-3245