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Induction of T helper 2 responses against human Apolipoprotein B100 does not affect atherosclerosis in ApoE-/- mice.

  • Daniel Engelbertsen
  • Sara Rattik
  • Anki Knutsson
  • Harry Björkbacka
  • Eva Bengtsson
  • Jan Nilsson
Publishing year: 2014-05-27
Language: English
Publication/Series: Cardiovascular Research
Document type: Journal article
Publisher: Elsevier

Abstract english

Immune responses against LDL antigens have been found to play an important modulatory role in atherosclerosis. Immunization with homologous oxidized LDL, as well as human apolipoprotein B100 (ApoB)-derived peptides, inhibit atherosclerosis in hypercholesterolemic animal models of atherosclerosis. However, the role of antigen-specific Th2 responses in atherosclerosis remains to be fully clarified.


  • Cardiac and Cardiovascular Systems


  • Cardiovascular Research - Immunity and Atherosclerosis
  • Vessel Wall Biology
  • ISSN: 1755-3245
E-mail: jan [dot] nilsson [at] med [dot] lu [dot] se

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